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Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis.

Morad G, Carman CV, Hagedorn EJ, Perlin JR, Zon LI, Mustafaoglu N, Park TE, Ingber DE, Daisy CC, Moses MA.

ACS Nano. 2019 Sep 10. doi: 10.1021/acsnano.9b04397. [Epub ahead of print]


Controllable Fabrication of Inhomogeneous Microcapsules for Triggered Release by Osmotic Pressure.

Zhang W, Qu L, Pei H, Qin Z, Didier J, Wu Z, Bobe F, Ingber DE, Weitz DA.

Small. 2019 Oct;15(42):e1903087. doi: 10.1002/smll.201903087. Epub 2019 Aug 25.


Broad-spectrum capture of clinical pathogens using engineered Fc-mannose-binding lectin enhanced by antibiotic treatment.

Seiler BT, Cartwright M, Dinis ALM, Duffy S, Lombardo P, Cartwright D, Super EH, Lanzaro J, Dugas K, Super M, Ingber DE.

F1000Res. 2019 Jan 25;8:108. doi: 10.12688/f1000research.17447.1. eCollection 2019.


Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip.

Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE, Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE.

Nat Biomed Eng. 2019 Jul;3(7):583. doi: 10.1038/s41551-019-0428-x.


Cellular nanoscale stiffness patterns governed by intracellular forces.

Mandriota N, Friedsam C, Jones-Molina JA, Tatem KV, Ingber DE, Sahin O.

Nat Mater. 2019 Oct;18(10):1071-1077. doi: 10.1038/s41563-019-0391-7. Epub 2019 Jun 17.


Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies.

Park TE, Mustafaoglu N, Herland A, Hasselkus R, Mannix R, FitzGerald EA, Prantil-Baun R, Watters A, Henry O, Benz M, Sanchez H, McCrea HJ, Goumnerova LC, Song HW, Palecek SP, Shusta E, Ingber DE.

Nat Commun. 2019 Jun 13;10(1):2621. doi: 10.1038/s41467-019-10588-0.


Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip.

Shin W, Hinojosa CD, Ingber DE, Kim HJ.

iScience. 2019 May 31;15:391-406. doi: 10.1016/j.isci.2019.04.037. Epub 2019 May 3.


A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip.

Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE, Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE.

Nat Biomed Eng. 2019 Jul;3(7):520-531. doi: 10.1038/s41551-019-0397-0. Epub 2019 May 13. Erratum in: Nat Biomed Eng. 2019 Jun 18;:.


Seeing Your Way to New Insights in Biology.

Reilly C, Ingber DE.

J Mol Biol. 2019 Jun 28;431(14):2485-2486. doi: 10.1016/j.jmb.2019.04.033. Epub 2019 Apr 26. No abstract available.


Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites.

Tovaglieri A, Sontheimer-Phelps A, Geirnaert A, Prantil-Baun R, Camacho DM, Chou DB, Jalili-Firoozinezhad S, de Wouters T, Kasendra M, Super M, Cartwright MJ, Richmond CA, Breault DT, Lacroix C, Ingber DE.

Microbiome. 2019 Mar 20;7(1):43. doi: 10.1186/s40168-019-0650-5.


Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models.

Papa AL, Jiang A, Korin N, Chen MB, Langan ET, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto A, Mammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaau5898. doi: 10.1126/scitranslmed.aau5898.


Modelling cancer in microfluidic human organs-on-chips.

Sontheimer-Phelps A, Hassell BA, Ingber DE.

Nat Rev Cancer. 2019 Feb;19(2):65-81. doi: 10.1038/s41568-018-0104-6. Review.


Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy.

van der Helm MW, Henry OYF, Bein A, Hamkins-Indik T, Cronce MJ, Leineweber WD, Odijk M, van der Meer AD, Eijkel JCT, Ingber DE, van den Berg A, Segerink LI.

Lab Chip. 2019 Jan 29;19(3):452-463. doi: 10.1039/c8lc00129d.


Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips.

Novak R, Didier M, Calamari E, Ng CF, Choe Y, Clauson SL, Nestor BA, Puerta J, Fleming R, Firoozinezhad SJ, Ingber DE.

J Vis Exp. 2018 Oct 20;(140). doi: 10.3791/58151. Erratum in: J Vis Exp. 2019 May 8;(147):.


From mechanobiology to developmentally inspired engineering.

Ingber DE.

Philos Trans R Soc Lond B Biol Sci. 2018 Sep 24;373(1759). pii: 20170323. doi: 10.1098/rstb.2017.0323. Review.


Collective Shape Actuation of Polymer Double Emulsions by Solvent Evaporation.

Shi W, Didier JE, Ingber DE, Weitz DA.

ACS Appl Mater Interfaces. 2018 Sep 26;10(38):31865-31869. doi: 10.1021/acsami.8b13216. Epub 2018 Sep 12.


A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.

Maoz BM, Herland A, FitzGerald EA, Grevesse T, Vidoudez C, Pacheco AR, Sheehy SP, Park TE, Dauth S, Mannix R, Budnik N, Shores K, Cho A, Nawroth JC, Segrè D, Budnik B, Ingber DE, Parker KK.

Nat Biotechnol. 2018 Oct;36(9):865-874. doi: 10.1038/nbt.4226. Epub 2018 Aug 20.


Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.

Musah S, Dimitrakakis N, Camacho DM, Church GM, Ingber DE.

Nat Protoc. 2018 Jul;13(7):1662-1685. doi: 10.1038/s41596-018-0007-8.


Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.

Hassell BA, Goyal G, Lee E, Sontheimer-Phelps A, Levy O, Chen CS, Ingber DE.

Cell Rep. 2018 Jun 19;23(12):3698. doi: 10.1016/j.celrep.2018.06.028. No abstract available.


Developmentally inspired human 'organs on chips'.

Ingber DE.

Development. 2018 May 18;145(16). pii: dev156125. doi: 10.1242/dev.156125.


Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape.

Bastings MMC, Anastassacos FM, Ponnuswamy N, Leifer FG, Cuneo G, Lin C, Ingber DE, Ryu JH, Shih WM.

Nano Lett. 2018 Jun 13;18(6):3557-3564. doi: 10.1021/acs.nanolett.8b00660. Epub 2018 May 22.


Microfluidic Organ-on-a-Chip Models of Human Intestine.

Bein A, Shin W, Jalili-Firoozinezhad S, Park MH, Sontheimer-Phelps A, Tovaglieri A, Chalkiadaki A, Kim HJ, Ingber DE.

Cell Mol Gastroenterol Hepatol. 2018 Apr 24;5(4):659-668. doi: 10.1016/j.jcmgh.2017.12.010. eCollection 2018. Review.


Rapid Prototyping of Thermoplastic Microfluidic Devices.

Novak R, Ng CF, Ingber DE.

Methods Mol Biol. 2018;1771:161-170. doi: 10.1007/978-1-4939-7792-5_13.


Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems.

Barrile R, van der Meer AD, Park H, Fraser JP, Simic D, Teng F, Conegliano D, Nguyen J, Jain A, Zhou M, Karalis K, Ingber DE, Hamilton GA, Otieno MA.

Clin Pharmacol Ther. 2018 Dec;104(6):1240-1248. doi: 10.1002/cpt.1054. Epub 2018 Apr 30.


Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip.

Jalili-Firoozinezhad S, Prantil-Baun R, Jiang A, Potla R, Mammoto T, Weaver JC, Ferrante TC, Kim HJ, Cabral JMS, Levy O, Ingber DE.

Cell Death Dis. 2018 Feb 14;9(2):223. doi: 10.1038/s41419-018-0304-8.


Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids.

Kasendra M, Tovaglieri A, Sontheimer-Phelps A, Jalili-Firoozinezhad S, Bein A, Chalkiadaki A, Scholl W, Zhang C, Rickner H, Richmond CA, Li H, Breault DT, Ingber DE.

Sci Rep. 2018 Feb 13;8(1):2871. doi: 10.1038/s41598-018-21201-7.


PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.

De Ceunynck K, Peters CG, Jain A, Higgins SJ, Aisiku O, Fitch-Tewfik JL, Chaudhry SA, Dockendorff C, Parikh SM, Ingber DE, Flaumenhaft R.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E982-E991. doi: 10.1073/pnas.1718600115. Epub 2018 Jan 17.


The Wyss institute: A new model for medical technology innovation and translation across the academic-industrial interface.

Tolikas M, Antoniou A, Ingber DE.

Bioeng Transl Med. 2017 Sep 5;2(3):247-257. doi: 10.1002/btm2.10076. eCollection 2017 Sep. Review.


Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips.

Prantil-Baun R, Novak R, Das D, Somayaji MR, Przekwas A, Ingber DE.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:37-64. doi: 10.1146/annurev-pharmtox-010716-104748. Review.


A Biologically Inspired, Functionally Graded End Effector for Soft Robotics Applications.

Kumar K, Liu J, Christianson C, Ali M, Tolley MT, Aizenberg J, Ingber DE, Weaver JC, Bertoldi K.

Soft Robot. 2017 Dec;4(4):317-323. doi: 10.1089/soro.2017.0002. Epub 2017 Oct 12.


Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale.

Reilly C, Ingber DE.

ACS Nano. 2017 Dec 26;11(12):12156-12166. doi: 10.1021/acsnano.7b05266. Epub 2017 Oct 18.


Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip.

Musah S, Mammoto A, Ferrante TC, Jeanty SSF, Hirano-Kobayashi M, Mammoto T, Roberts K, Chung S, Novak R, Ingram M, Fatanat-Didar T, Koshy S, Weaver JC, Church GM, Ingber DE.

Nat Biomed Eng. 2017;1. pii: 0069. doi: 10.1038/s41551-017-0069. Epub 2017 May 10.


Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.

Hassell BA, Goyal G, Lee E, Sontheimer-Phelps A, Levy O, Chen CS, Ingber DE.

Cell Rep. 2017 Oct 10;21(2):508-516. doi: 10.1016/j.celrep.2017.09.043. Erratum in: Cell Rep. 2018 Jun 19;23(12):3698.


Mechanical induction of dentin-like differentiation by adult mouse bone marrow stromal cells using compressive scaffolds.

Hashmi B, Mammoto T, Weaver J, Ferrante T, Jiang A, Jiang E, Feliz J, Ingber DE.

Stem Cell Res. 2017 Oct;24:55-60. doi: 10.1016/j.scr.2017.08.011. Epub 2017 Aug 17.


Human Lung Small Airway-on-a-Chip Protocol.

Benam KH, Mazur M, Choe Y, Ferrante TC, Novak R, Ingber DE.

Methods Mol Biol. 2017;1612:345-365. doi: 10.1007/978-1-4939-7021-6_25.


Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery.

Papa AL, Korin N, Kanapathipillai M, Mammoto A, Mammoto T, Jiang A, Mannix R, Uzun O, Johnson C, Bhatta D, Cuneo G, Ingber DE.

Biomaterials. 2017 Sep;139:187-194. doi: 10.1016/j.biomaterials.2017.06.003. Epub 2017 Jun 6.


Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities.

Maoz BM, Herland A, Henry OYF, Leineweber WD, Yadid M, Doyle J, Mannix R, Kujala VJ, FitzGerald EA, Parker KK, Ingber DE.

Lab Chip. 2017 Jun 27;17(13):2294-2302. doi: 10.1039/c7lc00412e.


Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function.

Henry OYF, Villenave R, Cronce MJ, Leineweber WD, Benz MA, Ingber DE.

Lab Chip. 2017 Jun 27;17(13):2264-2271. doi: 10.1039/c7lc00155j.


Reproductive endocrinology: Cycling through the menstrual cycle - an out-of-body experience.

Ingber DE.

Nat Rev Endocrinol. 2017 Jul;13(7):380-382. doi: 10.1038/nrendo.2017.65. Epub 2017 May 26. No abstract available.


New anticoagulant coatings and hemostasis assessment tools to avoid complications with pediatric left ventricular assist devices.

Leslie DC, Waterhouse A, Ingber DE.

J Thorac Cardiovasc Surg. 2017 Oct;154(4):1364-1366. doi: 10.1016/j.jtcvs.2017.03.149. Epub 2017 Apr 24. No abstract available.


Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics.

Jain A, Barrile R, van der Meer AD, Mammoto A, Mammoto T, De Ceunynck K, Aisiku O, Otieno MA, Louden CS, Hamilton GA, Flaumenhaft R, Ingber DE.

Clin Pharmacol Ther. 2018 Feb;103(2):332-340. doi: 10.1002/cpt.742. Epub 2017 Jul 14.


Theory and associated phenomenology for intrinsic mortality arising from natural selection.

Werfel J, Ingber DE, Bar-Yam Y.

PLoS One. 2017 Mar 29;12(3):e0173677. doi: 10.1371/journal.pone.0173677. eCollection 2017.


Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro.

Villenave R, Wales SQ, Hamkins-Indik T, Papafragkou E, Weaver JC, Ferrante TC, Bahinski A, Elkins CA, Kulka M, Ingber DE.

PLoS One. 2017 Feb 1;12(2):e0169412. doi: 10.1371/journal.pone.0169412. eCollection 2017.


Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip.

Benam KH, Novak R, Nawroth J, Hirano-Kobayashi M, Ferrante TC, Choe Y, Prantil-Baun R, Weaver JC, Bahinski A, Parker KK, Ingber DE.

Cell Syst. 2016 Nov 23;3(5):456-466.e4. doi: 10.1016/j.cels.2016.10.003. Epub 2016 Oct 27.


Commendation for Exposing Key Advantage of Organ Chip Approach.

Benam KH, Ingber DE.

Cell Syst. 2016 Nov 23;3(5):411. doi: 10.1016/j.cels.2016.11.009. No abstract available.


Direct Bonding of Chitosan Biomaterials to Tissues Using Transglutaminase for Surgical Repair or Device Implantation.

Fernandez JG, Seetharam S, Ding C, Feliz J, Doherty E, Ingber DE.

Tissue Eng Part A. 2017 Feb;23(3-4):135-142. doi: 10.1089/ten.TEA.2016.0266. Epub 2016 Dec 19.


Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device.

Kim HJ, Lee J, Choi JH, Bahinski A, Ingber DE.

J Vis Exp. 2016 Aug 30;(114). doi: 10.3791/54344.


Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium.

Jain A, van der Meer AD, Papa AL, Barrile R, Lai A, Schlechter BL, Otieno MA, Louden CS, Hamilton GA, Michelson AD, Frelinger AL 3rd, Ingber DE.

Biomed Microdevices. 2016 Aug;18(4):73. doi: 10.1007/s10544-016-0095-6.


A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood.

Cartwright M, Rottman M, Shapiro NI, Seiler B, Lombardo P, Gamini N, Tomolonis J, Watters AL, Waterhouse A, Leslie D, Bolgen D, Graveline A, Kang JH, Didar T, Dimitrakakis N, Cartwright D, Super M, Ingber DE.

EBioMedicine. 2016 Jul;9:217-227. doi: 10.1016/j.ebiom.2016.06.014. Epub 2016 Jun 13.


Rapid Isolation of Staphylococcus aureus Pathogens from Infected Clinical Samples Using Magnetic Beads Coated with Fc-Mannose Binding Lectin.

Bicart-See A, Rottman M, Cartwright M, Seiler B, Gamini N, Rodas M, Penary M, Giordano G, Oswald E, Super M, Ingber DE.

PLoS One. 2016 Jun 8;11(6):e0156287. doi: 10.1371/journal.pone.0156287. eCollection 2016.

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