Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 349

1.

Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus.

Lindsay CB, Zolezzi JM, Rivera DS, Cisternas P, Bozinovic F, Inestrosa NC.

Mol Neurobiol. 2019 Nov 7. doi: 10.1007/s12035-019-01784-6. [Epub ahead of print]

PMID:
31701436
2.

Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.

Arancibia D, Lira M, Cruz Y, Barrera DP, Montenegro-Venegas C, Godoy JA, Garner CC, Inestrosa NC, Gundelfinger ED, Zamorano P, Torres VI.

Cells. 2019 Oct 29;8(11). pii: E1333. doi: 10.3390/cells8111333.

3.

Cognitive impairment in heart failure is associated with altered Wnt signaling in the hippocampus.

Toledo C, Lucero C, Andrade DC, Díaz HS, Schwarz KG, Pereyra KV, Arce-Álvarez A, López NA, Martinez M, Inestrosa NC, Del Rio R.

Aging (Albany NY). 2019 Aug 25;11(16):5924-5942. doi: 10.18632/aging.102150. Epub 2019 Aug 25.

4.

Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer's Disease.

Cisternas P, Oliva CA, Torres VI, Barrera DP, Inestrosa NC.

Front Cell Neurosci. 2019 Jul 18;13:295. doi: 10.3389/fncel.2019.00295. eCollection 2019.

5.

Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.

Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C.

Nat Cell Biol. 2019 Jul;21(7):913. doi: 10.1038/s41556-019-0355-9.

PMID:
31201389
6.

Diterpenes and the crosstalk with the arachidonic acid pathways, relevance in neurodegeneration.

Zolezzi JM, Inestrosa NC.

Neural Regen Res. 2019 Oct;14(10):1705-1706. doi: 10.4103/1673-5374.257521. No abstract available.

7.

Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment.

Toledo C, Andrade DC, Díaz HS, Inestrosa NC, Del Rio R.

Mol Neurobiol. 2019 Dec;56(12):8035-8051. doi: 10.1007/s12035-019-01655-0. Epub 2019 Jun 5. Review.

PMID:
31165973
8.

Wnt Signaling Upregulates Teneurin-3 Expression via Canonical and Non-canonical Wnt Pathway Crosstalk.

Bastías-Candia S, Martínez M, Zolezzi JM, Inestrosa NC.

Front Neurosci. 2019 May 17;13:505. doi: 10.3389/fnins.2019.00505. eCollection 2019.

9.

GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies.

Pardo E, Barake F, Godoy JA, Oyanadel C, Espinoza S, Metz C, Retamal C, Massardo L, Tapia-Rojas C, Inestrosa NC, Soza A, González A.

Mol Neurobiol. 2019 Nov;56(11):7774-7788. doi: 10.1007/s12035-019-1621-3. Epub 2019 May 22.

PMID:
31119556
10.

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.

Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C.

Nat Cell Biol. 2019 Jun;21(6):755-767. doi: 10.1038/s41556-019-0329-y. Epub 2019 May 20. Erratum in: Nat Cell Biol. 2019 Jun 14;:.

PMID:
31110288
11.

Modulating Wnt signaling at the root: Porcupine and Wnt acylation.

Torres VI, Godoy JA, Inestrosa NC.

Pharmacol Ther. 2019 Jun;198:34-45. doi: 10.1016/j.pharmthera.2019.02.009. Epub 2019 Feb 18.

PMID:
30790642
12.

New Insights into the Spontaneous Human Alzheimer's Disease-Like Model Octodon degus: Unraveling Amyloid-β Peptide Aggregation and Age-Related Amyloid Pathology.

Cisternas P, Zolezzi JM, Lindsay C, Rivera DS, Martinez A, Bozinovic F, Inestrosa NC.

J Alzheimers Dis. 2018;66(3):1145-1163. doi: 10.3233/JAD-180729.

PMID:
30412496
13.

The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons.

Lira M, Arancibia D, Orrego PR, Montenegro-Venegas C, Cruz Y, García J, Leal-Ortiz S, Godoy JA, Gundelfinger ED, Inestrosa NC, Garner CC, Zamorano P, Torres VI.

Mol Neurobiol. 2019 Jul;56(7):4620-4638. doi: 10.1007/s12035-018-1378-0. Epub 2018 Oct 29.

PMID:
30374940
14.

Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease.

Cisternas P, Zolezzi JM, Martinez M, Torres VI, Wong GW, Inestrosa NC.

J Neurochem. 2019 Apr;149(1):54-72. doi: 10.1111/jnc.14608. Epub 2018 Dec 5.

PMID:
30300917
15.

Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease.

Tapia-Rojas C, Inestrosa NC.

Neural Regen Res. 2018 Oct;13(10):1705-1710. doi: 10.4103/1673-5374.238606. Review.

16.

Fructose and prostate cancer: toward an integrated view of cancer cell metabolism.

Carreño D, Corro N, Torres-Estay V, Véliz LP, Jaimovich R, Cisternas P, San Francisco IF, Sotomayor PC, Tanasova M, Inestrosa NC, Godoy AS.

Prostate Cancer Prostatic Dis. 2019 Mar;22(1):49-58. doi: 10.1038/s41391-018-0072-7. Epub 2018 Aug 13.

PMID:
30104655
17.

Modulation of Glucose Metabolism in Hippocampal Neurons by Adiponectin and Resistin.

Cisternas P, Martinez M, Ahima RS, William Wong G, Inestrosa NC.

Mol Neurobiol. 2019 Apr;56(4):3024-3037. doi: 10.1007/s12035-018-1271-x. Epub 2018 Aug 3.

PMID:
30076527
18.

Hypothyroidism and Cognitive Disorders during Development and Adulthood: Implications in the Central Nervous System.

Salazar P, Cisternas P, Martinez M, Inestrosa NC.

Mol Neurobiol. 2019 Apr;56(4):2952-2963. doi: 10.1007/s12035-018-1270-y. Epub 2018 Aug 2. Review.

PMID:
30073507
19.

Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling.

Ramos-Fernández E, Tapia-Rojas C, Ramírez VT, Inestrosa NC.

Mol Neurobiol. 2019 Mar;56(3):1870-1882. doi: 10.1007/s12035-018-1162-1. Epub 2018 Jul 2.

PMID:
29967987
20.

Revisiting the Paraquat-Induced Sporadic Parkinson's Disease-Like Model.

Bastías-Candia S, Zolezzi JM, Inestrosa NC.

Mol Neurobiol. 2019 Feb;56(2):1044-1055. doi: 10.1007/s12035-018-1148-z. Epub 2018 Jun 3. Review.

PMID:
29862459
21.

Neuroprotective Effects of Ferruginol, Jatrophone, and Junicedric Acid Against Amyloid-β Injury in Hippocampal Neurons.

Zolezzi JM, Lindsay CB, Serrano FG, Ureta RC, Theoduloz C, Schmeda-Hirschmann G, Inestrosa NC.

J Alzheimers Dis. 2018;63(2):705-723. doi: 10.3233/JAD-170701.

PMID:
29660932
22.

Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus.

Rivera DS, Lindsay CB, Codocedo JF, Carreño LE, Cabrera D, Arrese MA, Vio CP, Bozinovic F, Inestrosa NC.

Mol Neurobiol. 2018 Dec;55(12):9169-9187. doi: 10.1007/s12035-018-0969-0. Epub 2018 Apr 13.

PMID:
29654490
23.

Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis.

Ríos JA, Godoy JA, Inestrosa NC.

Cell Commun Signal. 2018 Apr 11;16(1):15. doi: 10.1186/s12964-018-0227-0.

24.

Nicotine Modulates Mitochondrial Dynamics in Hippocampal Neurons.

Godoy JA, Valdivieso AG, Inestrosa NC.

Mol Neurobiol. 2018 Dec;55(12):8965-8977. doi: 10.1007/s12035-018-1034-8. Epub 2018 Apr 4.

PMID:
29619740
25.

Wnt Signaling in the Central Nervous System: New Insights in Health and Disease.

Oliva CA, Montecinos-Oliva C, Inestrosa NC.

Prog Mol Biol Transl Sci. 2018 Jan;153:81-130. doi: 10.1016/bs.pmbts.2017.11.018. Epub 2018 Jan 8. Review.

PMID:
29389523
26.

APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models.

Bignante EA, Ponce NE, Heredia F, Musso J, Krawczyk MC, Millán J, Pigino GF, Inestrosa NC, Boccia MM, Lorenzo A.

Neurobiol Aging. 2018 Apr;64:44-57. doi: 10.1016/j.neurobiolaging.2017.12.013. Epub 2017 Dec 20.

PMID:
29331876
27.

Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus.

Salech F, Varela-Nallar L, Arredondo SB, Bustamante DB, Andaur GA, Cisneros R, Ponce DP, Ayala P, Inestrosa NC, Valdés JL, I Behrens M, Couve A.

J Gerontol A Biol Sci Med Sci. 2019 Jun 18;74(7):1043-1051. doi: 10.1093/gerona/glx248.

PMID:
29300914
28.

Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice.

Tapia-Rojas C, Inestrosa NC.

J Neurochem. 2018 Feb;144(4):443-465. doi: 10.1111/jnc.14278. Epub 2018 Jan 26.

29.

Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice.

Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, Härtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B.

Brain. 2017 Dec 1;140(12):3252-3268. doi: 10.1093/brain/awx272.

30.

Vertebrate Presynaptic Active Zone Assembly: a Role Accomplished by Diverse Molecular and Cellular Mechanisms.

Torres VI, Inestrosa NC.

Mol Neurobiol. 2018 Jun;55(6):4513-4528. doi: 10.1007/s12035-017-0661-9. Epub 2017 Jul 6. Review.

PMID:
28685386
31.

INT131 increases dendritic arborization and protects against Aβ toxicity by inducing mitochondrial changes in hippocampal neurons.

Godoy JA, Zolezzi JM, Inestrosa NC.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):955-962. doi: 10.1016/j.bbrc.2017.06.146. Epub 2017 Jun 24.

PMID:
28655613
32.

Brain glucose metabolism: Role of Wnt signaling in the metabolic impairment in Alzheimer's disease.

Cisternas P, Inestrosa NC.

Neurosci Biobehav Rev. 2017 Sep;80:316-328. doi: 10.1016/j.neubiorev.2017.06.004. Epub 2017 Jun 15. Review.

PMID:
28624434
33.

Corrigendum: Identification of Cerebral Metal Ion Imbalance in the Brain of Ageing Octodon degus.

Braidy N, Poljak A, Marjo C, Rutlidge H, Rich A, Jugder BE, Jayasena T, Inestrosa NC, Sachdev PS.

Front Aging Neurosci. 2017 May 15;9:134. doi: 10.3389/fnagi.2017.00134. eCollection 2017.

34.

Identification of Cerebral Metal Ion Imbalance in the Brain of Aging Octodon degus.

Braidy N, Poljak A, Marjo C, Rutlidge H, Rich A, Jugder BE, Jayasena T, Inestrosa NC, Sachdev PS.

Front Aging Neurosci. 2017 Mar 29;9:66. doi: 10.3389/fnagi.2017.00066. eCollection 2017. Erratum in: Front Aging Neurosci. 2017 May 15;9:134.

35.

Emerging Synaptic Molecules as Candidates in the Etiology of Neurological Disorders.

Torres VI, Vallejo D, Inestrosa NC.

Neural Plast. 2017;2017:8081758. doi: 10.1155/2017/8081758. Epub 2017 Feb 26. Review.

36.

Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer's Disease.

Zolezzi JM, Inestrosa NC.

Front Immunol. 2017 Feb 24;8:187. doi: 10.3389/fimmu.2017.00187. eCollection 2017. Review.

37.

PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation.

Zolezzi JM, Santos MJ, Bastías-Candia S, Pinto C, Godoy JA, Inestrosa NC.

Biol Rev Camb Philos Soc. 2017 Nov;92(4):2046-2069. doi: 10.1111/brv.12320. Epub 2017 Feb 20. Review.

PMID:
28220655
38.

Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity.

Salazar P, Cisternas P, Codocedo JF, Inestrosa NC.

Biochim Biophys Acta Mol Basis Dis. 2017 Apr;1863(4):870-883. doi: 10.1016/j.bbadis.2017.01.002. Epub 2017 Jan 11.

39.

Wnt Signaling Prevents the Aβ Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons.

Arrázola MS, Ramos-Fernández E, Cisternas P, Ordenes D, Inestrosa NC.

PLoS One. 2017 Jan 6;12(1):e0168840. doi: 10.1371/journal.pone.0168840. eCollection 2017.

40.

Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity.

Guivernau B, Bonet J, Valls-Comamala V, Bosch-Morató M, Godoy JA, Inestrosa NC, Perálvarez-Marín A, Fernández-Busquets X, Andreu D, Oliva B, Muñoz FJ.

J Neurosci. 2016 Nov 16;36(46):11693-11703.

41.

Corrigendum to "β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats".

Cuevas CA, Tapia-Rojas C, Cespedes C, Inestrosa NC, Vio CP.

Biomed Res Int. 2016;2016:9672429. Epub 2016 Oct 10.

42.

Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and Aβ Aggregates in Hippocampal Neurons: the Role of Mitochondria.

Godoy JA, Lindsay CB, Quintanilla RA, Carvajal FJ, Cerpa W, Inestrosa NC.

Mol Neurobiol. 2017 Nov;54(9):7116-7128. doi: 10.1007/s12035-016-0203-x. Epub 2016 Oct 28.

PMID:
27796749
43.
44.

Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis.

Cisternas P, Salazar P, Silva-Álvarez C, Barros LF, Inestrosa NC.

J Biol Chem. 2016 Dec 9;291(50):25950-25964. Epub 2016 Oct 4.

45.

Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons.

Cisternas P, Salazar P, Silva-Álvarez C, Barros LF, Inestrosa NC.

Neural Plast. 2016;2016:9839348. Epub 2016 Sep 5.

46.

Reduction of Blood Amyloid-β Oligomers in Alzheimer's Disease Transgenic Mice by c-Abl Kinase Inhibition.

Estrada LD, Chamorro D, Yañez MJ, Gonzalez M, Leal N, von Bernhardi R, Dulcey AE, Marugan J, Ferrer M, Soto C, Zanlungo S, Inestrosa NC, Alvarez AR.

J Alzheimers Dis. 2016 Oct 4;54(3):1193-1205.

PMID:
27567806
47.

CDK5 downregulation enhances synaptic plasticity.

Posada-Duque RA, Ramirez O, Härtel S, Inestrosa NC, Bodaleo F, González-Billault C, Kirkwood A, Cardona-Gómez GP.

Cell Mol Life Sci. 2017 Jan;74(1):153-172. doi: 10.1007/s00018-016-2333-8. Epub 2016 Aug 9.

PMID:
27506619
48.

Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus).

Rivera DS, Lindsay C, Codocedo JF, Morel I, Pinto C, Cisternas P, Bozinovic F, Inestrosa NC.

Neurobiol Aging. 2016 Oct;46:204-20. doi: 10.1016/j.neurobiolaging.2016.06.021. Epub 2016 Jul 5.

PMID:
27505720
49.

Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation.

Ramírez VT, Ramos-Fernández E, Henríquez JP, Lorenzo A, Inestrosa NC.

J Biol Chem. 2016 Sep 2;291(36):19092-107. doi: 10.1074/jbc.M116.722132. Epub 2016 Jul 11.

50.

Tetrahydrohyperforin (IDN5706) targets the endoplasmic reticulum for autophagy activation: potential mechanism for Alzheimer's disease therapy.

González A, Cavieres VA, Inestrosa NC, Burgos PV.

Neural Regen Res. 2016 Feb;11(2):242-3. doi: 10.4103/1673-5374.177728. No abstract available.

Supplemental Content

Loading ...
Support Center