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Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption.

Napimoga MH, Rocha EP, Trindade-da-Silva CA, Demasi APD, Martinez EF, Macedo CG, Abdalla HB, Bettaieb A, Haj FG, Clemente-Napimoga JT, Inceoglu B, Hammock BD.

J Periodontal Res. 2018 Oct;53(5):743-749. doi: 10.1111/jre.12559. Epub 2018 May 31.


LC-MS/MS Analysis of the Epoxides and Diols Derived from the Endocannabinoid Arachidonoyl Ethanolamide.

Rand AA, Helmer PO, Inceoglu B, Hammock BD, Morisseau C.

Methods Mol Biol. 2018;1730:123-133. doi: 10.1007/978-1-4939-7592-1_10.


Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors.

Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD.

Prostaglandins Other Lipid Mediat. 2017 Nov;133:68-78. doi: 10.1016/j.prostaglandins.2017.08.003. Epub 2017 Aug 25. Review.


Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia.

Bettaieb A, Koike S, Hsu MF, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KSS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2758-2765. doi: 10.1016/j.bbagen.2017.07.021. Epub 2017 Jul 27.


Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers.

Goswami SK, Rand AA, Wan D, Yang J, Inceoglu B, Thomas M, Morisseau C, Yang GY, Hammock BD.

Life Sci. 2017 Jul 1;180:114-122. doi: 10.1016/j.lfs.2017.05.018. Epub 2017 May 15.


Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales.

Kitamura S, Morisseau C, Harris TR, Inceoglu B, Hammock BD.

PLoS One. 2017 May 4;12(5):e0176571. doi: 10.1371/journal.pone.0176571. eCollection 2017.


Sensitive Immunoassay for Detection and Quantification of the Neurotoxin, Tetramethylenedisulfotetramine.

Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD.

Anal Chem. 2017 May 16;89(10):5612-5619. doi: 10.1021/acs.analchem.7b00846. Epub 2017 Apr 24.


Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis.

Trindade-da-Silva CA, Bettaieb A, Napimoga MH, Lee KSS, Inceoglu B, Ueira-Vieira C, Bruun D, Goswami SK, Haj FG, Hammock BD.

J Pharmacol Exp Ther. 2017 Jun;361(3):408-416. doi: 10.1124/jpet.116.238113. Epub 2017 Mar 29.


Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats.

Islam O, Patil P, Goswami SK, Razdan R, Inamdar MN, Rizwan M, Mathew J, Inceoglu B, Stephen Lee KS, Hwang SH, Hammock BD.

Cardiovasc Ther. 2017 Jun;35(3). doi: 10.1111/1755-5922.12259.


Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes.

Supp DM, Hahn JM, McFarland KL, Combs KA, Lee KS, Inceoglu B, Wan D, Boyce ST, Hammock BD.

Plast Reconstr Surg Glob Open. 2016 Dec 20;4(12):e1151. doi: 10.1097/GOX.0000000000001151. eCollection 2016 Dec.


Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension.

Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD.

J Clin Toxicol. 2016 Jun;6(3). pii: 1000300. doi: 10.4172/2161-0495.1000300. Epub 2016 May 30.


Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit.

McLellan GJ, Aktas Z, Hennes-Beean E, Kolb AW, Larsen IV, Schmitz EJ, Clausius HR, Yang J, Hwang SH, Morisseau C, Inceoglu B, Hammock BD, Brandt CR.

J Ocul Biol. 2016 Jan;4(1). doi: 10.13188/2334-2838.1000024. Epub 2016 Jan 12.


Evaluation of Optic Canal and Surrounding Structures Using Cone Beam Computed Tomography: Considerations for Maxillofacial Surgery.

Sinanoglu A, Orhan K, Kursun S, Inceoglu B, Oztas B.

J Craniofac Surg. 2016 Jul;27(5):1327-30. doi: 10.1097/SCS.0000000000002726.


Anti-Ulcer Efficacy of Soluble Epoxide Hydrolase Inhibitor TPPU on Diclofenac-Induced Intestinal Ulcers.

Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang GY, Inceoglu B, Hammock BD.

J Pharmacol Exp Ther. 2016 Jun;357(3):529-36. doi: 10.1124/jpet.116.232108. Epub 2016 Mar 17.


Antigenic Cross-Reactivity Anti-Birtoxin Antibody against Androctonus crassicauda Venom.

Van Zoelen SA, Ozkan O, Inceoglu B.

J Arthropod Borne Dis. 2015 Mar 11;9(2):176-83. eCollection 2015 Dec.


Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model.

Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, da Silva CA, Morisseau C, Hammock BD.

Toxicol Appl Pharmacol. 2015 Dec 15;289(3):419-27. doi: 10.1016/j.taap.2015.10.018. Epub 2015 Nov 10.


Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain.

Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9082-7. doi: 10.1073/pnas.1510137112. Epub 2015 Jul 6.


Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.

Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ.

Neuropharmacology. 2015 Aug;95:332-42. doi: 10.1016/j.neuropharm.2015.03.035. Epub 2015 Apr 14.


Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive.

Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D.

Pharmacol Res. 2015 Jul;97:7-15. doi: 10.1016/j.phrs.2015.04.001. Epub 2015 Apr 14.


Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo.

Kitamura S, Morisseau C, Inceoglu B, Kamita SG, De Nicola GR, Nyegue M, Hammock BD.

PLoS One. 2015 Feb 6;10(2):e0117438. doi: 10.1371/journal.pone.0117438. eCollection 2015.


Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication.

Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ.

Toxicol Appl Pharmacol. 2014 Dec 1;281(2):185-94. doi: 10.1016/j.taap.2014.10.001. Epub 2014 Oct 14.


TRPV1 channels are involved in niacin-induced cutaneous vasodilation in mice.

Clifton HL, Inceoglu B, Ma L, Zheng J, Schaefer S.

J Cardiovasc Pharmacol. 2015 Feb;65(2):184-91. doi: 10.1097/FJC.0000000000000181.


The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling.

Wagner K, Vito S, Inceoglu B, Hammock BD.

Prostaglandins Other Lipid Mediat. 2014 Oct;113-115:2-12. doi: 10.1016/j.prostaglandins.2014.09.001. Epub 2014 Sep 18. Review.


Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy.

Wagner K, Yang J, Inceoglu B, Hammock BD.

J Pain. 2014 Sep;15(9):907-14. doi: 10.1016/j.jpain.2014.05.008. Epub 2014 Jun 9.


Mature form of ameloblastic fibrodentinoma: a case report.

Unsal H, Eren H, Inceoglu B, Oncul AM.

J Craniofac Surg. 2014 May;25(3):e299-301. doi: 10.1097/SCS.0000000000000728.


Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures.

Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD.

PLoS One. 2013 Dec 11;8(12):e80922. doi: 10.1371/journal.pone.0080922. eCollection 2013.


Epoxyeicosanoids promote organ and tissue regeneration.

Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13528-33. doi: 10.1073/pnas.1311565110. Epub 2013 Jul 29.


Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie.

Poli G, Corda E, Martino PA, Dall'ara P, Bareggi SR, Bondiolotti G, Iulini B, Mazza M, Casalone C, Hwang SH, Hammock BD, Inceoglu B.

Life Sci. 2013 Jun 21;92(23):1145-50. doi: 10.1016/j.lfs.2013.04.014. Epub 2013 May 5.


Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models.

Wagner K, Inceoglu B, Dong H, Yang J, Hwang SH, Jones P, Morisseau C, Hammock BD.

Eur J Pharmacol. 2013 Jan 30;700(1-3):93-101. doi: 10.1016/j.ejphar.2012.12.015. Epub 2012 Dec 28.


Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes.

Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb NH, Hwang SH, Morisseau C, Haj FG, Hammock BD.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11390-5. doi: 10.1073/pnas.1208708109. Epub 2012 Jun 25.


Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine.

Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA.

J Pharmacol Exp Ther. 2012 May;341(2):435-46. doi: 10.1124/jpet.111.190579. Epub 2012 Feb 10.


The soluble epoxide hydrolase as a pharmaceutical target for pain management.

Hammock BD, Wagner K, Inceoglu B.

Pain Manag. 2011 Sep;1(5):383-6. doi: 10.2217/pmt.11.47. No abstract available.


Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception.

Wagner K, Inceoglu B, Hammock BD.

Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):76-83. doi: 10.1016/j.prostaglandins.2011.08.001. Epub 2011 Aug 10. Review.


Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP.

Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5093-7. doi: 10.1073/pnas.1101073108. Epub 2011 Mar 7.


Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects.

Schebb NH, Inceoglu B, Ahn KC, Morisseau C, Gee SJ, Hammock BD.

Environ Sci Technol. 2011 Apr 1;45(7):3109-15. doi: 10.1021/es103650m. Epub 2011 Mar 7.


Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures.

Abdu E, Bruun DA, Yang D, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ.

J Neurochem. 2011 May;117(4):632-42. doi: 10.1111/j.1471-4159.2010.07139.x. Epub 2011 Jan 24.


Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction.

Wagner K, Inceoglu B, Gill SS, Hammock BD.

J Agric Food Chem. 2011 Apr 13;59(7):2816-24. doi: 10.1021/jf102559q. Epub 2010 Oct 19.


1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain.

Rose TE, Morisseau C, Liu JY, Inceoglu B, Jones PD, Sanborn JR, Hammock BD.

J Med Chem. 2010 Oct 14;53(19):7067-75. doi: 10.1021/jm100691c.


Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids.

Morisseau C, Inceoglu B, Schmelzer K, Tsai HJ, Jinks SL, Hegedus CM, Hammock BD.

J Lipid Res. 2010 Dec;51(12):3481-90. doi: 10.1194/jlr.M006007. Epub 2010 Jul 27.


Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model.

Liu JY, Yang J, Inceoglu B, Qiu H, Ulu A, Hwang SH, Chiamvimonvat N, Hammock BD.

Biochem Pharmacol. 2010 Mar 15;79(6):880-7. doi: 10.1016/j.bcp.2009.10.025. Epub 2009 Nov 5.


Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase.

Luria A, Morisseau C, Tsai HJ, Yang J, Inceoglu B, De Taeye B, Watkins SM, Wiest MM, German JB, Hammock BD.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E375-83. doi: 10.1152/ajpendo.00131.2009. Epub 2009 May 19.


Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways.

Inceoglu B, Jinks SL, Ulu A, Hegedus CM, Georgi K, Schmelzer KR, Wagner K, Jones PD, Morisseau C, Hammock BD.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18901-6. doi: 10.1073/pnas.0809765105. Epub 2008 Nov 21.


Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model.

Ulu A, Davis BB, Tsai HJ, Kim IH, Morisseau C, Inceoglu B, Fiehn O, Hammock BD, Weiss RH.

J Cardiovasc Pharmacol. 2008 Oct;52(4):314-23. doi: 10.1097/FJC.0b013e318185fa3c.


The effect of p.Arg25Cys alteration in NKX2-5 on conotruncal heart anomalies: mutation or polymorphism?

Akçaboy MI, Cengiz FB, Inceoğlu B, Uçar T, Atalay S, Tutar E, Tekin M.

Pediatr Cardiol. 2008 Jan;29(1):126-9. Epub 2007 Sep 22.


Epidemiological and clinical characteristics of scorpionism in children in Sanliurfa, Turkey.

Adiguzel S, Ozkan O, Inceoglu B.

Toxicon. 2007 May;49(6):875-80. Epub 2007 Jan 10.


Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia.

Tekin M, Hişmi BO, Fitoz S, Ozdağ H, Cengiz FB, Sirmaci A, Aslan I, Inceoğlu B, Yüksel-Konuk EB, Yilmaz ST, Yasun O, Akar N.

Am J Hum Genet. 2007 Feb;80(2):338-44. Epub 2006 Dec 27.


Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs).

Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD.

Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):42-9. Epub 2006 Jul 5. Review.


Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain.

Inceoglu B, Jinks SL, Schmelzer KR, Waite T, Kim IH, Hammock BD.

Life Sci. 2006 Nov 10;79(24):2311-9. Epub 2006 Aug 2.


Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors.

Schmelzer KR, Inceoglu B, Kubala L, Kim IH, Jinks SL, Eiserich JP, Hammock BD.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13646-51. Epub 2006 Sep 1.

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