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Items: 1 to 50 of 168

1.

Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice.

Sugahara M, Tanaka S, Tanaka T, Saito H, Ishimoto Y, Wakashima T, Ueda M, Fukui K, Shimizu A, Inagi R, Yamauchi T, Kadowaki T, Nangaku M.

J Am Soc Nephrol. 2020 Jan 29. pii: ASN.2019060582. doi: 10.1681/ASN.2019060582. [Epub ahead of print]

PMID:
31996409
2.

Pathophysiological Role of Organelle Stress/Crosstalk in AKI-to-CKD Transition.

Maekawa H, Inagi R.

Semin Nephrol. 2019 Nov;39(6):581-588. doi: 10.1016/j.semnephrol.2019.10.007. Review.

3.

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.

Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, Fujii R, Ishidate F, Tanaka T, Tanaka Y, Hirokawa N, Nangaku M, Inagi R.

Cell Rep. 2019 Oct 29;29(5):1261-1273.e6. doi: 10.1016/j.celrep.2019.09.050.

4.

Neuroimmune interactions and kidney disease.

Hasegawa S, Inoue T, Inagi R.

Kidney Res Clin Pract. 2019 Sep 30;38(3):282-294. doi: 10.23876/j.krcp.19.014. Review.

5.

Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction.

Nishi H, Higashihara T, Inagi R.

Nutrients. 2019 Jul 20;11(7). pii: E1664. doi: 10.3390/nu11071664. Review.

6.

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes.

Ducasa GM, Mitrofanova A, Mallela SK, Liu X, Molina J, Sloan A, Pedigo CE, Ge M, Santos JV, Hernandez Y, Kim JJ, Maugeais C, Mendez AJ, Nair V, Kretzler M, Burke GW, Nelson RG, Ishimoto Y, Inagi R, Banerjee S, Liu S, Szeto HH, Merscher S, Fontanesi F, Fornoni A.

J Clin Invest. 2019 Jul 22;129(8):3387-3400. doi: 10.1172/JCI125316. eCollection 2019 Jul 22.

7.

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease.

Mitrofanova A, Mallela SK, Ducasa GM, Yoo TH, Rosenfeld-Gur E, Zelnik ID, Molina J, Varona Santos J, Ge M, Sloan A, Kim JJ, Pedigo C, Bryn J, Volosenco I, Faul C, Zeidan YH, Garcia Hernandez C, Mendez AJ, Leibiger I, Burke GW, Futerman AH, Barisoni L, Ishimoto Y, Inagi R, Merscher S, Fornoni A.

Nat Commun. 2019 Jun 19;10(1):2692. doi: 10.1038/s41467-019-10584-4.

8.

Organelle crosstalk in the kidney.

Inoue T, Maekawa H, Inagi R.

Kidney Int. 2019 Jun;95(6):1318-1325. doi: 10.1016/j.kint.2018.11.035. Epub 2019 Mar 4. Review.

9.

Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney.

Inoue T, Abe C, Kohro T, Tanaka S, Huang L, Yao J, Zheng S, Ye H, Inagi R, Stornetta RL, Rosin DL, Nangaku M, Wada Y, Okusa MD.

Kidney Int. 2019 Mar;95(3):563-576. doi: 10.1016/j.kint.2018.09.020. Epub 2019 Jan 19.

PMID:
30670317
10.

A simple and effective preparation of quercetin pentamethyl ether from quercetin.

Tatsuzaki J, Ohwada T, Otani Y, Inagi R, Ishikawa T.

Beilstein J Org Chem. 2018 Dec 28;14:3112-3121. doi: 10.3762/bjoc.14.291. eCollection 2018.

11.

ATF6╬▒ downregulation of PPAR╬▒ promotes lipotoxicity-induced tubulointerstitial fibrosis.

Jao TM, Nangaku M, Wu CH, Sugahara M, Saito H, Maekawa H, Ishimoto Y, Aoe M, Inoue T, Tanaka T, Staels B, Mori K, Inagi R.

Kidney Int. 2019 Mar;95(3):577-589. doi: 10.1016/j.kint.2018.09.023. Epub 2019 Jan 11.

12.

Physiological and pathophysiological role of reactive oxygen species and reactive nitrogen species in the kidney.

Ishimoto Y, Tanaka T, Yoshida Y, Inagi R.

Clin Exp Pharmacol Physiol. 2018 Nov;45(11):1097-1105. doi: 10.1111/1440-1681.13018. Epub 2018 Aug 13. Review.

13.

Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice.

Tanaka S, Sugiura Y, Saito H, Sugahara M, Higashijima Y, Yamaguchi J, Inagi R, Suematsu M, Nangaku M, Tanaka T.

Kidney Int. 2018 Nov;94(5):912-925. doi: 10.1016/j.kint.2018.04.025. Epub 2018 Jul 16.

PMID:
30021702
14.

Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response.

Anusornvongchai T, Nangaku M, Jao TM, Wu CH, Ishimoto Y, Maekawa H, Tanaka T, Shimizu A, Yamamoto M, Suzuki N, Sassa R, Inagi R.

Kidney Int. 2018 Sep;94(3):536-550. doi: 10.1016/j.kint.2018.03.011. Epub 2018 Jun 7.

15.

Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease.

Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, Takeda N, Wake M, Honda K, Zhou J, Nangaku M.

Mol Cell Biol. 2017 Nov 28;37(24). pii: e00337-17. doi: 10.1128/MCB.00337-17. Print 2017 Dec 15.

16.

Foreseeing the future of glomerular disease through slits: miR-NPNT axis.

Inagi R, Ishimoto Y, Jao TM.

Kidney Int. 2017 Oct;92(4):782-784. doi: 10.1016/j.kint.2017.04.036.

PMID:
28938947
17.

D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation.

Okada A, Nangaku M, Jao TM, Maekawa H, Ishimono Y, Kawakami T, Inagi R.

Sci Rep. 2017 Sep 11;7(1):11168. doi: 10.1038/s41598-017-11049-8.

18.

Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney.

Sasaki M, Sasako T, Kubota N, Sakurai Y, Takamoto I, Kubota T, Inagi R, Seki G, Goto M, Ueki K, Nangaku M, Jomori T, Kadowaki T.

Diabetes. 2017 Sep;66(9):2339-2350. doi: 10.2337/db16-1602. Epub 2017 Jun 19.

19.

Epigenetic Changes in the Acute Kidney Injury-to-Chronic Kidney Disease Transition.

Nangaku M, Hirakawa Y, Mimura I, Inagi R, Tanaka T.

Nephron. 2017;137(4):256-259. doi: 10.1159/000476078. Epub 2017 Jun 9. Review.

20.

Pathophysiology and therapeutics of premature ageing in chronic kidney disease, with a focus on glycative stress.

Hirakawa Y, Jao TM, Inagi R.

Clin Exp Pharmacol Physiol. 2017 Dec;44 Suppl 1:70-77. doi: 10.1111/1440-1681.12777. Epub 2017 Sep 20. Review.

PMID:
28467603
21.

Dietary Metabolites and Chronic Kidney Disease.

Hasegawa S, Jao TM, Inagi R.

Nutrients. 2017 Apr 4;9(4). pii: E358. doi: 10.3390/nu9040358. Review.

22.

Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.

Tanaka S, Tanaka T, Kawakami T, Takano H, Sugahara M, Saito H, Higashijima Y, Yamaguchi J, Inagi R, Nangaku M.

Kidney Int. 2017 Jul;92(1):154-164. doi: 10.1016/j.kint.2017.01.014. Epub 2017 Mar 17.

PMID:
28318627
23.

Stress Signal Network between Hypoxia and ER Stress in Chronic Kidney Disease.

Maekawa H, Inagi R.

Front Physiol. 2017 Feb 8;8:74. doi: 10.3389/fphys.2017.00074. eCollection 2017. Review.

24.

Glycative Stress and Its Defense Machinery Glyoxalase 1 in Renal Pathogenesis.

Hirakawa Y, Inagi R.

Int J Mol Sci. 2017 Jan 17;18(1). pii: E174. doi: 10.3390/ijms18010174. Review.

25.

Effect of AST-120 in Chronic Kidney Disease Treatment: Still a Controversy?

Yamaguchi J, Tanaka T, Inagi R.

Nephron. 2017;135(3):201-206. doi: 10.1159/000453673. Epub 2016 Dec 14. Review.

26.

RAGE and glyoxalase in kidney disease.

Inagi R.

Glycoconj J. 2016 Aug;33(4):619-26. doi: 10.1007/s10719-016-9689-8. Epub 2016 Jun 6. Review.

PMID:
27270765
27.

Epigenetic Regulation Through SIRT1 in Podocytes.

Nakatani Y, Inagi R.

Curr Hypertens Rev. 2016;12(2):89-94. Review.

PMID:
26931472
28.

The gut-kidney connection in advanced chronic kidney disease.

Inagi R.

Kidney Res Clin Pract. 2015 Dec;34(4):191-3. doi: 10.1016/j.krcp.2015.08.007. Epub 2015 Oct 2. No abstract available.

29.

Mitochondria: a therapeutic target in acute kidney injury.

Ishimoto Y, Inagi R.

Nephrol Dial Transplant. 2016 Jul;31(7):1062-9. doi: 10.1093/ndt/gfv317. Epub 2015 Sep 1. Review.

PMID:
26333547
30.

Adenosine A2 a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without affecting oxidative stress.

Persson P, Friederich-Persson M, Fasching A, Hansell P, Inagi R, Palm F.

Acta Physiol (Oxf). 2015 Jul;214(3):311-8. doi: 10.1111/apha.12511. Epub 2015 May 6.

PMID:
25891445
31.

Epigenetic Changes Induced by Hypoxia-Inducible Factor: a Long Way Still To Go as a Target for Therapy?

Nangaku M, Inagi R, Mimura I, Tanaka T.

J Am Soc Nephrol. 2015 Jul;26(7):1478-80. doi: 10.1681/ASN.2014121161. Epub 2015 Jan 13. No abstract available.

32.

Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes.

Motonishi S, Nangaku M, Wada T, Ishimoto Y, Ohse T, Matsusaka T, Kubota N, Shimizu A, Kadowaki T, Tobe K, Inagi R.

J Am Soc Nephrol. 2015 Aug;26(8):1939-59. doi: 10.1681/ASN.2014030289. Epub 2014 Nov 25.

33.

Proteostasis in endoplasmic reticulum--new mechanisms in kidney disease.

Inagi R, Ishimoto Y, Nangaku M.

Nat Rev Nephrol. 2014 Jul;10(7):369-78. doi: 10.1038/nrneph.2014.67. Epub 2014 Apr 22. Review.

PMID:
24752014
34.

Glycative stress and glyoxalase in kidney disease and aging.

Inagi R.

Biochem Soc Trans. 2014 Apr;42(2):457-60. doi: 10.1042/BST20140007. Review.

PMID:
24646260
35.

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation.

Jo-Watanabe A, Ohse T, Nishimatsu H, Takahashi M, Ikeda Y, Wada T, Shirakawa J, Nagai R, Miyata T, Nagano T, Hirata Y, Inagi R, Nangaku M.

Aging Cell. 2014 Jun;13(3):519-28. doi: 10.1111/acel.12204. Epub 2014 Feb 24.

36.

Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma.

Shoji K, Murayama T, Mimura I, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M.

Am J Pathol. 2013 Jun;182(6):2191-203. doi: 10.1016/j.ajpath.2013.02.024. Epub 2013 Apr 17.

PMID:
23602831
37.

Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4.

Chiang CK, Nangaku M, Tanaka T, Iwawaki T, Inagi R.

Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C342-53. doi: 10.1152/ajpcell.00153.2012. Epub 2012 Dec 12.

38.

Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells.

Muratsu-Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R.

PLoS One. 2012;7(7):e41462. doi: 10.1371/journal.pone.0041462. Epub 2012 Jul 30.

39.

Glyoxalase I retards renal senescence.

Ikeda Y, Inagi R, Miyata T, Nagai R, Arai M, Miyashita M, Itokawa M, Fujita T, Nangaku M.

Am J Pathol. 2011 Dec;179(6):2810-21. doi: 10.1016/j.ajpath.2011.08.023. Epub 2011 Oct 12.

40.

Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner.

Chiang CK, Tanaka T, Inagi R, Fujita T, Nangaku M.

Lab Invest. 2011 Nov;91(11):1564-71. doi: 10.1038/labinvest.2011.114. Epub 2011 Aug 22.

41.

Inhibitors of advanced glycation and endoplasmic reticulum stress.

Inagi R.

Methods Enzymol. 2011;491:361-80. doi: 10.1016/B978-0-12-385928-0.00020-1.

PMID:
21329810
42.

Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions.

Nishi H, Inagi R, Kawada N, Yoshizato K, Mimura I, Fujita T, Nangaku M.

Am J Pathol. 2011 Jan;178(1):128-39. doi: 10.1016/j.ajpath.2010.11.011. Epub 2010 Dec 23.

43.

Cytoglobin, a novel globin, plays an antifibrotic role in the kidney.

Mimura I, Nangaku M, Nishi H, Inagi R, Tanaka T, Fujita T.

Am J Physiol Renal Physiol. 2010 Nov;299(5):F1120-33. doi: 10.1152/ajprenal.00145.2010. Epub 2010 Aug 18.

44.

Glomerular diseases: genetic causes and future therapeutics.

Chiang CK, Inagi R.

Nat Rev Nephrol. 2010 Sep;6(9):539-54. doi: 10.1038/nrneph.2010.103. Epub 2010 Jul 20. Review.

PMID:
20644582
45.

Indoxyl sulfate inhibits proliferation of human proximal tubular cells via endoplasmic reticulum stress.

Kawakami T, Inagi R, Wada T, Tanaka T, Fujita T, Nangaku M.

Am J Physiol Renal Physiol. 2010 Sep;299(3):F568-76. doi: 10.1152/ajprenal.00659.2009. Epub 2010 Jun 9.

46.

The role of glyoxalase system in renal hypoxia.

Inagi R, Kumagai T, Fujita T, Nangaku M.

Adv Exp Med Biol. 2010;662:49-55. doi: 10.1007/978-1-4419-1241-1_6.

PMID:
20204770
47.

Endoplasmic reticulum stress as a progression factor for kidney injury.

Inagi R.

Curr Opin Pharmacol. 2010 Apr;10(2):156-65. doi: 10.1016/j.coph.2009.11.006. Epub 2010 Jan 4. Review.

PMID:
20045381
48.

Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells.

Kawakami T, Inagi R, Takano H, Sato S, Ingelfinger JR, Fujita T, Nangaku M.

Nephrol Dial Transplant. 2009 Sep;24(9):2665-72. doi: 10.1093/ndt/gfp215. Epub 2009 May 19.

PMID:
19454529
49.

Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury.

Inagi R.

Nephron Exp Nephrol. 2009;112(1):e1-9. doi: 10.1159/000210573. Epub 2009 Apr 3. Review.

50.

Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression.

Eto N, Miyagishi M, Inagi R, Fujita T, Nangaku M.

Am J Pathol. 2009 Apr;174(4):1553-63. doi: 10.2353/ajpath.2009.080190. Epub 2009 Feb 26.

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