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Items: 1 to 50 of 54

1.

The generation and use of recombinant extracellular vesicles as biological reference material.

Geeurickx E, Tulkens J, Dhondt B, Van Deun J, Lippens L, Vergauwen G, Heyrman E, De Sutter D, Gevaert K, Impens F, Miinalainen I, Van Bockstal PJ, De Beer T, Wauben MHM, Nolte-'t-Hoen ENM, Bloch K, Swinnen JV, van der Pol E, Nieuwland R, Braems G, Callewaert N, Mestdagh P, Vandesompele J, Denys H, Eyckerman S, De Wever O, Hendrix A.

Nat Commun. 2019 Jul 23;10(1):3288. doi: 10.1038/s41467-019-11182-0.

2.

Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection.

Van Cleemput J, Poelaert KCK, Laval K, Impens F, Van den Broeck W, Gevaert K, Nauwynck HJ.

Sci Rep. 2019 Mar 18;9(1):4787. doi: 10.1038/s41598-019-41305-y.

3.

Fast quantum control in dissipative systems using dissipationless solutions.

Impens F, Guéry-Odelin D.

Sci Rep. 2019 Mar 11;9(1):4048. doi: 10.1038/s41598-019-39731-z.

4.

Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase.

Van Leene J, Han C, Gadeyne A, Eeckhout D, Matthijs C, Cannoot B, De Winne N, Persiau G, Van De Slijke E, Van de Cotte B, Stes E, Van Bel M, Storme V, Impens F, Gevaert K, Vandepoele K, De Smet I, De Jaeger G.

Nat Plants. 2019 Mar;5(3):316-327. doi: 10.1038/s41477-019-0378-z. Epub 2019 Mar 4.

PMID:
30833711
5.

PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome.

Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):277-286. doi: 10.1073/pnas.1811938116. Epub 2018 Dec 21.

6.

Update on the moFF Algorithm for Label-Free Quantitative Proteomics.

Argentini A, Staes A, Grüning B, Mehta S, Easterly C, Griffin TJ, Jagtap P, Impens F, Martens L.

J Proteome Res. 2019 Feb 1;18(2):728-731. doi: 10.1021/acs.jproteome.8b00708. Epub 2018 Dec 14.

PMID:
30511867
7.

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.

Steklov M, Pandolfi S, Baietti MF, Batiuk A, Carai P, Najm P, Zhang M, Jang H, Renzi F, Cai Y, Abbasi Asbagh L, Pastor T, De Troyer M, Simicek M, Radaelli E, Brems H, Legius E, Tavernier J, Gevaert K, Impens F, Messiaen L, Nussinov R, Heymans S, Eyckerman S, Sablina AA.

Science. 2018 Dec 7;362(6419):1177-1182. doi: 10.1126/science.aap7607. Epub 2018 Nov 15.

PMID:
30442762
8.

The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages.

Mylka V, Deckers J, Ratman D, De Cauwer L, Thommis J, De Rycke R, Impens F, Libert C, Tavernier J, Vanden Berghe W, Gevaert K, De Bosscher K.

Autophagy. 2018;14(12):2049-2064. doi: 10.1080/15548627.2018.1495681. Epub 2018 Sep 14.

PMID:
30215534
9.

N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in Saccharomyces cerevisiae.

Varland S, Aksnes H, Kryuchkov F, Impens F, Van Haver D, Jonckheere V, Ziegler M, Gevaert K, Van Damme P, Arnesen T.

Mol Cell Proteomics. 2018 Dec;17(12):2309-2323. doi: 10.1074/mcp.RA118.000982. Epub 2018 Aug 27.

10.

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquière B, Schoonjans L, Li X, Mazzone M, Carmeliet P.

Cell Metab. 2018 Dec 4;28(6):866-880.e15. doi: 10.1016/j.cmet.2018.07.019. Epub 2018 Aug 23.

PMID:
30146486
11.

Author Correction: N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes.

Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P.

Nat Microbiol. 2018 Aug;3(8):962. doi: 10.1038/s41564-018-0197-4.

PMID:
29941881
12.

Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature.

Morel JD, Paatero AO, Wei J, Yewdell JW, Guenin-Macé L, Van Haver D, Impens F, Pietrosemoli N, Paavilainen VO, Demangel C.

Mol Cell Proteomics. 2018 Sep;17(9):1750-1765. doi: 10.1074/mcp.RA118.000824. Epub 2018 Jun 18.

PMID:
29915147
13.

Quantitative proteomics and systems analysis of cultured H9C2 cardiomyoblasts during differentiation over time supports a 'function follows form' model of differentiation.

Kankeu C, Clarke K, Van Haver D, Gevaert K, Impens F, Dittrich A, Roderick HL, Passante E, Huber HJ.

Mol Omics. 2018 Jun 12;14(3):181-196. doi: 10.1039/c8mo00036k.

PMID:
29770421
14.

Rapid Remodeling of the Host Epithelial Cell Proteome by the Listeriolysin O (LLO) Pore-forming Toxin.

Malet JK, Impens F, Carvalho F, Hamon MA, Cossart P, Ribet D.

Mol Cell Proteomics. 2018 Aug;17(8):1627-1636. doi: 10.1074/mcp.RA118.000767. Epub 2018 May 11.

15.

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.

Ballegeer M, Van Looveren K, Timmermans S, Eggermont M, Vandevyver S, Thery F, Dendoncker K, Souffriau J, Vandewalle J, Van Wyngene L, De Rycke R, Takahashi N, Vandenabeele P, Tuckermann J, Reichardt HM, Impens F, Beyaert R, De Bosscher K, Vandenbroucke RE, Libert C.

J Clin Invest. 2018 Aug 1;128(8):3265-3279. doi: 10.1172/JCI96636. Epub 2018 Jun 25.

16.

Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.

Pereira JM, Chevalier C, Chaze T, Gianetto Q, Impens F, Matondo M, Cossart P, Hamon MA.

Cell Rep. 2018 Apr 24;23(4):1124-1137. doi: 10.1016/j.celrep.2018.03.116.

17.

GSyellow, a Multifaceted Tag for Functional Protein Analysis in Monocot and Dicot Plants.

Besbrugge N, Van Leene J, Eeckhout D, Cannoot B, Kulkarni SR, De Winne N, Persiau G, Van De Slijke E, Bontinck M, Aesaert S, Impens F, Gevaert K, Van Damme D, Van Lijsebettens M, Inzé D, Vandepoele K, Nelissen H, De Jaeger G.

Plant Physiol. 2018 Jun;177(2):447-464. doi: 10.1104/pp.18.00175. Epub 2018 Apr 20.

18.

NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

Drazic A, Aksnes H, Marie M, Boczkowska M, Varland S, Timmerman E, Foyn H, Glomnes N, Rebowski G, Impens F, Gevaert K, Dominguez R, Arnesen T.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4399-4404. doi: 10.1073/pnas.1718336115. Epub 2018 Mar 26.

19.

Matter wave speckle observed in an out-of-equilibrium quantum fluid.

Tavares PES, Fritsch AR, Telles GD, Hussein MS, Impens F, Kaiser R, Bagnato VS.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12691-12695. doi: 10.1073/pnas.1713693114. Epub 2017 Nov 13.

20.

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages.

Escoll P, Song OR, Viana F, Steiner B, Lagache T, Olivo-Marin JC, Impens F, Brodin P, Hilbi H, Buchrieser C.

Cell Host Microbe. 2017 Sep 13;22(3):302-316.e7. doi: 10.1016/j.chom.2017.07.020. Epub 2017 Aug 31.

21.

Quality control in mass spectrometry-based proteomics.

Bittremieux W, Tabb DL, Impens F, Staes A, Timmerman E, Martens L, Laukens K.

Mass Spectrom Rev. 2018 Sep;37(5):697-711. doi: 10.1002/mas.21544. Epub 2017 Sep 7. Review.

PMID:
28802010
22.

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export.

Grotzke JE, Kozik P, Morel JD, Impens F, Pietrosemoli N, Cresswell P, Amigorena S, Demangel C.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5910-E5919. doi: 10.1073/pnas.1705242114. Epub 2017 Jul 5.

23.

Protease Substrate Profiling by N-Terminal COFRADIC.

Staes A, Van Damme P, Timmerman E, Ruttens B, Stes E, Gevaert K, Impens F.

Methods Mol Biol. 2017;1574:51-76. doi: 10.1007/978-1-4939-6850-3_5.

PMID:
28315243
24.

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.

Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L.

Mol Cell. 2017 Mar 16;65(6):1044-1055.e5. doi: 10.1016/j.molcel.2017.02.013.

25.

The Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system.

Sahr T, Rusniok C, Impens F, Oliva G, Sismeiro O, Coppée JY, Buchrieser C.

PLoS Genet. 2017 Feb 17;13(2):e1006629. doi: 10.1371/journal.pgen.1006629. eCollection 2017 Feb.

26.

N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes.

Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P.

Nat Microbiol. 2017 Feb 13;2:17005. doi: 10.1038/nmicrobiol.2017.5. Erratum in: Nat Microbiol. 2018 Aug;3(8):962.

27.

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency.

Tharkeshwar AK, Trekker J, Vermeire W, Pauwels J, Sannerud R, Priestman DA, Te Vruchte D, Vints K, Baatsen P, Decuypere JP, Lu H, Martin S, Vangheluwe P, Swinnen JV, Lagae L, Impens F, Platt FM, Gevaert K, Annaert W.

Sci Rep. 2017 Jan 30;7:41408. doi: 10.1038/srep41408.

28.

Mycolactone subverts immunity by selectively blocking the Sec61 translocon.

Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C.

J Exp Med. 2016 Dec 12;213(13):2885-2896. Epub 2016 Nov 7.

29.

Intelligent Mixing of Proteomes for Elimination of False Positives in Affinity Purification-Mass Spectrometry.

Eyckerman S, Impens F, Van Quickelberghe E, Samyn N, Vandemoortele G, De Sutter D, Tavernier J, Gevaert K.

J Proteome Res. 2016 Oct 7;15(10):3929-3937. Epub 2016 Sep 28.

PMID:
27640904
30.

ISG15 counteracts Listeria monocytogenes infection.

Radoshevich L, Impens F, Ribet D, Quereda JJ, Nam Tham T, Nahori MA, Bierne H, Dussurget O, Pizarro-Cerdá J, Knobeloch KP, Cossart P.

Elife. 2015 Aug 11;4. doi: 10.7554/eLife.06848.

31.

Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S.

Vizovišek M, Vidmar R, Van Quickelberghe E, Impens F, Andjelković U, Sobotič B, Stoka V, Gevaert K, Turk B, Fonović M.

Proteomics. 2015 Jul;15(14):2479-90. doi: 10.1002/pmic.201400460. Epub 2015 Mar 9.

PMID:
25626674
32.

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

Impens F, Radoshevich L, Cossart P, Ribet D.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12432-7. doi: 10.1073/pnas.1413825111. Epub 2014 Aug 11.

33.

A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis.

Van Impe K, Bethuyne J, Cool S, Impens F, Ruano-Gallego D, De Wever O, Vanloo B, Van Troys M, Lambein K, Boucherie C, Martens E, Zwaenepoel O, Hassanzadeh-Ghassabeh G, Vandekerckhove J, Gevaert K, Fernández LÁ, Sanders NN, Gettemans J.

Breast Cancer Res. 2013 Dec 13;15(6):R116. doi: 10.1186/bcr3585.

34.

A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection.

Eskandarian HA, Impens F, Nahori MA, Soubigou G, Coppée JY, Cossart P, Hamon MA.

Science. 2013 Aug 2;341(6145):1238858. doi: 10.1126/science.1238858.

35.

Mapping proteolytic processing in the secretome of gastric cancer-associated myofibroblasts reveals activation of MMP-1, MMP-2, and MMP-3.

Holmberg C, Ghesquière B, Impens F, Gevaert K, Kumar JD, Cash N, Kandola S, Hegyi P, Wang TC, Dockray GJ, Varro A.

J Proteome Res. 2013 Jul 5;12(7):3413-22. doi: 10.1021/pr400270q. Epub 2013 Jun 5.

36.

The Online Protein Processing Resource (TOPPR): a database and analysis platform for protein processing events.

Colaert N, Maddelein D, Impens F, Van Damme P, Plasman K, Helsens K, Hulstaert N, Vandekerckhove J, Gevaert K, Martens L.

Nucleic Acids Res. 2013 Jan;41(Database issue):D333-7. doi: 10.1093/nar/gks998. Epub 2012 Oct 23.

37.

A catalogue of putative HIV-1 protease host cell substrates.

Impens F, Timmerman E, Staes A, Moens K, Ariën KK, Verhasselt B, Vandekerckhove J, Gevaert K.

Biol Chem. 2012 Sep;393(9):915-31. doi: 10.1515/hsz-2012-0168.

PMID:
22944692
38.

Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike.

Wejda M, Impens F, Takahashi N, Van Damme P, Gevaert K, Vandenabeele P.

J Biol Chem. 2012 Oct 5;287(41):33983-95. doi: 10.1074/jbc.M112.384552. Epub 2012 Jul 23.

39.

The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential.

Melzer IM, Fernández SB, Bösser S, Lohrig K, Lewandrowski U, Wolters D, Kehrloesser S, Brezniceanu ML, Theos AC, Irusta PM, Impens F, Gevaert K, Zörnig M.

Cell Death Differ. 2012 Sep;19(9):1435-45. doi: 10.1038/cdd.2012.17. Epub 2012 Mar 2.

40.

Selecting protein N-terminal peptides by combined fractional diagonal chromatography.

Staes A, Impens F, Van Damme P, Ruttens B, Goethals M, Demol H, Timmerman E, Vandekerckhove J, Gevaert K.

Nat Protoc. 2011 Jul 14;6(8):1130-41. doi: 10.1038/nprot.2011.355.

PMID:
21799483
41.

m-Calpain activation in vitro does not require autolysis or subunit dissociation.

Chou JS, Impens F, Gevaert K, Davies PL.

Biochim Biophys Acta. 2011 Jul;1814(7):864-72. doi: 10.1016/j.bbapap.2011.04.007. Epub 2011 Apr 28.

PMID:
21549862
42.

The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma.

Mestdagh P, Boström AK, Impens F, Fredlund E, Van Peer G, De Antonellis P, von Stedingk K, Ghesquière B, Schulte S, Dews M, Thomas-Tikhonenko A, Schulte JH, Zollo M, Schramm A, Gevaert K, Axelson H, Speleman F, Vandesompele J.

Mol Cell. 2010 Dec 10;40(5):762-73. doi: 10.1016/j.molcel.2010.11.038.

43.

Probing the efficiency of proteolytic events by positional proteomics.

Plasman K, Van Damme P, Kaiserman D, Impens F, Demeyer K, Helsens K, Goethals M, Bird PI, Vandekerckhove J, Gevaert K.

Mol Cell Proteomics. 2011 Feb;10(2):M110.003301. doi: 10.1074/mcp.M110.003301. Epub 2010 Nov 3.

44.

Who gets cut during cell death?

Impens F, Vandekerckhove J, Gevaert K.

Curr Opin Cell Biol. 2010 Dec;22(6):859-64. doi: 10.1016/j.ceb.2010.08.021. Epub 2010 Sep 16. Review.

PMID:
20846840
45.

A quantitative proteomics design for systematic identification of protease cleavage events.

Impens F, Colaert N, Helsens K, Ghesquière B, Timmerman E, De Bock PJ, Chain BM, Vandekerckhove J, Gevaert K.

Mol Cell Proteomics. 2010 Oct;9(10):2327-33. doi: 10.1074/mcp.M110.001271. Epub 2010 Jul 13.

46.

Listeria monocytogenes impairs SUMOylation for efficient infection.

Ribet D, Hamon M, Gouin E, Nahori MA, Impens F, Neyret-Kahn H, Gevaert K, Vandekerckhove J, Dejean A, Cossart P.

Nature. 2010 Apr 22;464(7292):1192-5. doi: 10.1038/nature08963.

47.

MS-driven protease substrate degradomics.

Impens F, Colaert N, Helsens K, Plasman K, Van Damme P, Vandekerckhove J, Gevaert K.

Proteomics. 2010 Mar;10(6):1284-96. doi: 10.1002/pmic.200900418. Review. Erratum in: Proteomics. 2010 Jul;10(13):2560.

PMID:
20058249
48.

Rover: a tool to visualize and validate quantitative proteomics data from different sources.

Colaert N, Helsens K, Impens F, Vandekerckhove J, Gevaert K.

Proteomics. 2010 Mar;10(6):1226-9. doi: 10.1002/pmic.200900379.

PMID:
20058247
49.

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity.

Demon D, Van Damme P, Vanden Berghe T, Deceuninck A, Van Durme J, Verspurten J, Helsens K, Impens F, Wejda M, Schymkowitz J, Rousseau F, Madder A, Vandekerckhove J, Declercq W, Gevaert K, Vandenabeele P.

Mol Cell Proteomics. 2009 Dec;8(12):2700-14. doi: 10.1074/mcp.M900310-MCP200. Epub 2009 Sep 16.

50.

Stable isotopic labeling in proteomics.

Gevaert K, Impens F, Ghesquière B, Van Damme P, Lambrechts A, Vandekerckhove J.

Proteomics. 2008 Dec;8(23-24):4873-85. doi: 10.1002/pmic.200800421. Review.

PMID:
19003869

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