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Items: 1 to 50 of 253

1.

Ktedonoketone and 2'-oxosattabacin, benzenoid metabolites from a thermophilic bacterium Thermosporothrix hazakensis in the phylum Chloroflexi.

Igarashi Y, Yamamoto K, Ueno C, Yamada N, Saito K, Takahashi K, Enomoto M, Kuwahara S, Oikawa T, Tashiro E, Imoto M, Xiaohanyao Y, Zhou T, Harunari E, Oku N.

J Antibiot (Tokyo). 2019 Jun 5. doi: 10.1038/s41429-019-0195-7. [Epub ahead of print]

PMID:
31164714
2.

Chemistry and biology for the small molecules targeting characteristics of cancer cells.

Imoto M.

Biosci Biotechnol Biochem. 2018 Sep 24:1-10. doi: 10.1080/09168451.2018.1518704. [Epub ahead of print]

PMID:
30247093
3.

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy.

Tsugawa H, Mori H, Matsuzaki J, Sato A, Saito Y, Imoto M, Suematsu M, Suzuki H.

Autophagy. 2019 Feb;15(2):242-258. doi: 10.1080/15548627.2018.1515530. Epub 2018 Sep 10.

PMID:
30176157
4.

14-3-3εa directs the pulsatile transport of basal factors toward the apical domain for lumen growth in tubulogenesis.

Mizotani Y, Suzuki M, Hotta K, Watanabe H, Shiba K, Inaba K, Tashiro E, Oka K, Imoto M.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8873-E8881. doi: 10.1073/pnas.1808756115. Epub 2018 Aug 29.

5.

Rupture of a Calyceal Diverticulum Secondary to Ureteroscopy: A Rare Complication.

Yamasaki T, Yoshioka T, Imoto M, Aoki H, Fujio K, Uehara S, Otsuki H.

Case Rep Urol. 2018 Jul 9;2018:9285671. doi: 10.1155/2018/9285671. eCollection 2018.

6.

Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines.

Hanaki Y, Shikata Y, Kikumori M, Hotta N, Imoto M, Irie K.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):438-445. doi: 10.1016/j.bbrc.2017.11.052. Epub 2017 Nov 9.

PMID:
29129688
7.

Professor Hamao Umezawa opened up a new road for the development of molecularly targeted therapeutic drugs for cancers.

Imoto M.

J Antibiot (Tokyo). 2017 Nov 1. doi: 10.1038/ja.2017.139. [Epub ahead of print] Review.

PMID:
29089596
8.

A Case of Waldenstrom Macroglobulinemia with Temporary Appearance of 7S IgM Half Molecule.

Imoto M, Yoshida K, Maeda Y, Nakae KI, Kudo M, Sakurabayashi I, Yamada T, Kamisako T.

Clin Lab. 2017 May 1;63(5):983-989. doi: 10.7754/Clin.Lab.2017.170106.

PMID:
28627827
9.

Transition-Metal-Free and Oxidant-Free Cross-Coupling of Arylhydrazines with Disulfides: Base-Promoted Synthesis of Unsymmetrical Aryl Sulfides.

Taniguchi T, Naka T, Imoto M, Takeda M, Nakai T, Mihara M, Mizuno T, Nomoto A, Ogawa A.

J Org Chem. 2017 Jul 7;82(13):6647-6655. doi: 10.1021/acs.joc.7b00767. Epub 2017 Jun 23.

PMID:
28616985
10.

Exosomes in mammals with greater habitat variability contain more proteins and RNAs.

Takemoto K, Imoto M.

R Soc Open Sci. 2017 Apr 26;4(4):170162. doi: 10.1098/rsos.170162. eCollection 2017 Apr.

11.

Antarlides F-H, new members of the antarlide family produced by Streptomyces sp. BB47.

Saito S, Fujimaki T, Panbangred W, Sawa R, Igarashi Y, Imoto M.

J Antibiot (Tokyo). 2017 May;70(5):595-600. doi: 10.1038/ja.2017.6. Epub 2017 Feb 8.

PMID:
28174422
12.

Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor.

Shikata Y, Yoshimaru T, Komatsu M, Katoh H, Sato R, Kanagaki S, Okazaki Y, Toyokuni S, Tashiro E, Ishikawa S, Katagiri T, Imoto M.

Cancer Sci. 2017 Apr;108(4):785-794. doi: 10.1111/cas.13175. Epub 2017 Apr 20.

13.

Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells.

Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, Imoto M.

Cancer Sci. 2017 Apr;108(4):772-784. doi: 10.1111/cas.13172.

14.

Arabilin overcomes resistance to AR-targeted therapy.

Fujimaki T, Saito S, Imoto M.

J Antibiot (Tokyo). 2017 Mar;70(3):328-330. doi: 10.1038/ja.2016.162. Epub 2017 Jan 11. No abstract available.

PMID:
28074047
15.

Involvement of the MEK/ERK pathway in EGF-induced E-cadherin down-regulation.

Tashiro E, Henmi S, Odake H, Ino S, Imoto M.

Biochem Biophys Res Commun. 2016 Sep 2;477(4):801-806. doi: 10.1016/j.bbrc.2016.06.138. Epub 2016 Jun 29.

PMID:
27369075
16.

Metacycloprodigiosin induced cell death selectively in β-catenin-mutated tumor cells.

Ikeda H, Shikata Y, Watanapokasin R, Tashiro E, Imoto M.

J Antibiot (Tokyo). 2017 Jan;70(1):109-112. doi: 10.1038/ja.2016.75. Epub 2016 Jun 22. No abstract available.

PMID:
27328865
17.

Synthesis of Firefly Luciferin Analogues and Evaluation of the Luminescent Properties.

Ioka S, Saitoh T, Iwano S, Suzuki K, Maki SA, Miyawaki A, Imoto M, Nishiyama S.

Chemistry. 2016 Jun 27;22(27):9330-7. doi: 10.1002/chem.201600278. Epub 2016 May 24.

PMID:
27220106
18.

Screening and target identification of bioactive compounds that modulate cell migration and autophagy.

Tashiro E, Imoto M.

Bioorg Med Chem. 2016 Aug 1;24(15):3283-90. doi: 10.1016/j.bmc.2016.04.014. Epub 2016 Apr 7. Review.

PMID:
27094149
19.

Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

Igarashi Y, Asano D, Sawamura M, In Y, Ishida T, Imoto M.

Org Lett. 2016 Apr 1;18(7):1658-61. doi: 10.1021/acs.orglett.6b00531. Epub 2016 Mar 21.

PMID:
26998643
20.

Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells.

Kritsanawong S, Innajak S, Imoto M, Watanapokasin R.

Int J Oncol. 2016 May;48(5):2155-65. doi: 10.3892/ijo.2016.3399. Epub 2016 Feb 18.

PMID:
26892433
21.

Biological activities of unique isoflavones prepared from Apios americana Medik.

Kaneta H, Koda M, Saito S, Imoto M, Kawada M, Yamazaki Y, Momose I, Shindo K.

Biosci Biotechnol Biochem. 2016;80(4):774-8. doi: 10.1080/09168451.2015.1127132. Epub 2016 Jan 25.

PMID:
26806328
22.

Antarlides: A New Type of Androgen Receptor (AR) Antagonist that Overcomes Resistance to AR-Targeted Therapy.

Saito S, Fujimaki T, Panbangred W, Igarashi Y, Imoto M.

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2728-32. doi: 10.1002/anie.201510079. Epub 2016 Jan 25.

PMID:
26805525
23.

[Metabolomics and molecular targeted therapy of cancer].

Tashiro E, Imoto M.

Nihon Rinsho. 2015 Aug;73(8):1268-72. Review. Japanese.

PMID:
26281677
24.

Chemical biology of compounds obtained from screening using disease models.

Tashiro E, Imoto M.

Arch Pharm Res. 2015 Sep;38(9):1651-60. doi: 10.1007/s12272-015-0633-4. Epub 2015 Jul 17. Review.

PMID:
26177809
25.

Chemistry and biology of the compounds that modulate cell migration.

Tashiro E, Imoto M.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):213-9. doi: 10.1007/s10295-015-1654-1. Epub 2015 Jul 15. Review.

PMID:
26173498
26.

Evaluation of drug toxicity profiles based on the phenotypes of ascidian Ciona intestinalis.

Mizotani Y, Itoh S, Hotta K, Tashiro E, Oka K, Imoto M.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):656-60. doi: 10.1016/j.bbrc.2015.05.119. Epub 2015 Jun 1.

PMID:
26043689
27.

Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells by gambogic acid.

Krajarng A, Imoto M, Tashiro E, Fujimaki T, Shinjo S, Watanapokasin R.

BMC Complement Altern Med. 2015 Feb 15;15:26. doi: 10.1186/s12906-015-0544-4.

28.

SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in β-catenin-mutated tumors.

Kiga M, Nakayama A, Shikata Y, Sasazawa Y, Murakami R, Nakanishi T, Tashiro E, Imoto M.

Sci Rep. 2015 Feb 2;5:8155. doi: 10.1038/srep08155.

29.

Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions.

Yoshimaru T, Komatsu M, Tashiro E, Imoto M, Osada H, Miyoshi Y, Honda J, Sasa M, Katagiri T.

Sci Rep. 2014 Dec 8;4:7355. doi: 10.1038/srep07355.

30.

Effects of persistent organochlorine exposure on the liver transcriptome of the common minke whale (Balaenoptera acutorostrata) from the North Pacific.

Niimi S, Imoto M, Kunisue T, Watanabe MX, Kim EY, Nakayama K, Yasunaga G, Fujise Y, Tanabe S, Iwata H.

Ecotoxicol Environ Saf. 2014 Oct;108:95-105. doi: 10.1016/j.ecoenv.2014.06.028. Epub 2014 Jul 19.

PMID:
25046851
31.

Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease.

Fujimaki T, Saiki S, Tashiro E, Yamada D, Kitagawa M, Hattori N, Imoto M.

PLoS One. 2014 Jun 24;9(6):e100395. doi: 10.1371/journal.pone.0100395. eCollection 2014.

32.

Chemical genomic-based pathway analyses for epidermal growth factor-mediated signaling in migrating cancer cells.

Magi S, Saeki Y, Kasamatsu M, Tashiro E, Imoto M.

PLoS One. 2014 May 12;9(5):e96776. doi: 10.1371/journal.pone.0096776. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e105243.

33.

Neovessel formation promotes liver fibrosis via providing latent transforming growth factor-β.

Sakata K, Eda S, Lee ES, Hara M, Imoto M, Kojima S.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):950-6. doi: 10.1016/j.bbrc.2013.12.074. Epub 2013 Dec 19.

PMID:
24361885
34.

5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation.

Magi S, Takemoto Y, Kobayashi H, Kasamatsu M, Akita T, Tanaka A, Takano K, Tashiro E, Igarashi Y, Imoto M.

Cancer Sci. 2014 Mar;105(3):290-6. doi: 10.1111/cas.12340. Epub 2014 Jan 28.

35.

HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor.

Sakata K, Hara M, Terada T, Watanabe N, Takaya D, Yaguchi S, Matsumoto T, Matsuura T, Shirouzu M, Yokoyama S, Yamaguchi T, Miyazawa K, Aizaki H, Suzuki T, Wakita T, Imoto M, Kojima S.

Sci Rep. 2013 Nov 22;3:3243. doi: 10.1038/srep03243.

36.

[The 15th result of screening for antineoplastic agents].

Yamori T, Uehara Y, Fukazawa H, Yoshida M, Imoto M, Kiyomiya H, Mashima T, Manakami T, Kawata M, Nagata H, Dan S, Matsuura M, Kakeya H, Tomita A.

Gan To Kagaku Ryoho. 2013 Apr;40 Suppl 1:116-47. No abstract available.

PMID:
24171229
37.

[The 14th result of screening for antineoplastic agents].

Yamori T, Uehara Y, Fukazawa H, Yoshida M, Imoto M, Kiyomiya H, Minakami T, Kawata M, Nagata H, Matsuura M.

Gan To Kagaku Ryoho. 2013 Apr;40 Suppl 1:18-114. No abstract available.

PMID:
24171228
38.

Establishment of a new detection system for the dimerization of IRE1α by BiFC assay.

Shinjo S, Tashiro E, Imoto M.

Biosci Biotechnol Biochem. 2013;77(6):1333-6. Epub 2013 Jun 7.

39.

Expression and secretion of cholera toxin B subunit in lactobacilli.

Okuno T, Kashige N, Satho T, Irie K, Hiramatsu Y, Sharmin T, Fukumitsu Y, Uyeda S, Yamada S, Harakuni T, Miyata T, Arakawa T, Imoto M, Toda A, Nakashima Y, Miake F.

Biol Pharm Bull. 2013;36(6):952-8.

40.

Sophisticated design of PVC membrane ion-selective electrodes based on the mixed potential theory.

Imoto M, Sakaki T, Osakai T.

Anal Chem. 2013 May 7;85(9):4753-60. doi: 10.1021/ac400427p. Epub 2013 Apr 17.

PMID:
23594104
41.

Pyriproxyfen enhances the immunoglobulin G immune response in mice.

Sharmin T, Satho T, Irie K, Watanabe M, Hosokawa M, Hiramatsu Y, Talukder P, Okuno T, Tsuruda S, Uyeda S, Fukmits Y, Tamura Y, Nakashima Y, Imoto M, Toda A, Kashige N, Miake F.

Microbiol Immunol. 2013 Apr;57(4):316-22. doi: 10.1111/1348-0421.12035.

42.

Comparative analysis of the expression patterns of UPR-target genes caused by UPR-inducing compounds.

Shinjo S, Mizotani Y, Tashiro E, Imoto M.

Biosci Biotechnol Biochem. 2013;77(4):729-35. Epub 2013 Apr 7.

43.

[Screening for the drug-seeds of antitumor agents].

Fujimaki T, Imoto M.

Nihon Rinsho. 2012 Nov;70 Suppl 8:303-7. Japanese. No abstract available.

PMID:
23513856
44.

Novel isoflavone glucosides in groundnut (Apios americana Medik) and their antiandrogenic activities.

Ichige M, Fukuda E, Miida S, Hattan J, Misawa N, Saito S, Fujimaki T, Imoto M, Shindo K.

J Agric Food Chem. 2013 Mar 6;61(9):2183-7. doi: 10.1021/jf305233t. Epub 2013 Feb 21.

PMID:
23402539
45.

[Divergence between measured values of total IgG and subclass IgGs (sum of IgG1-IgG4) in IgG4-related disease].

Imoto M, Watanabe K, Tatsumi Y, Nakae K, Kamisako T.

Rinsho Byori. 2012 Nov;60(11):1053-7. Japanese.

PMID:
23383573
46.

Novel derivatives of aclacinomycin A block cancer cell migration through inhibition of farnesyl transferase.

Magi S, Shitara T, Takemoto Y, Sawada M, Kitagawa M, Tashiro E, Takahashi Y, Imoto M.

J Antibiot (Tokyo). 2013 Mar;66(3):165-70. doi: 10.1038/ja.2012.108. Epub 2013 Jan 30.

PMID:
23361358
47.

A chemical genomic study identifying diversity in cell migration signaling in cancer cells.

Magi S, Tashiro E, Imoto M.

Sci Rep. 2012;2:823. doi: 10.1038/srep00823. Epub 2012 Nov 8.

48.

Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017.

Kimura T, Kanagaki S, Matsui Y, Imoto M, Watanabe T, Shibasaki M.

Org Lett. 2012 Sep 7;14(17):4418-21. doi: 10.1021/ol3019314. Epub 2012 Aug 23.

PMID:
22917065
49.

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.

Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S.

Blood Cancer J. 2012 Jul;2(7):e79. doi: 10.1038/bcj.2012.26. Epub 2012 Jul 20.

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