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Items: 1 to 50 of 288

1.

[Current Status and Challenges of Clinical Practice for Hereditary Tumor Syndromes].

Imoto I, Takaiso N.

Gan To Kagaku Ryoho. 2019 Jul;46(7):1093-1096. Japanese.

PMID:
31296809
2.

Attitudes of clinical geneticists and certified genetic counselors to genome editing and its clinical applications: A nation-wide questionnaire survey in Japan.

Taguchi I, Yamada T, Akaishi R, Imoto I, Kurosawa K, Nakatani K, Nomura F, Hamanoue H, Hyodo M, Murakami H, Yoshihashi H, Yotsumoto J, Kosugi S.

J Hum Genet. 2019 Jul 5. doi: 10.1038/s10038-019-0635-z. [Epub ahead of print]

PMID:
31273322
3.

Prognostic significance of GAD1 overexpression in patients with resected lung adenocarcinoma.

Tsuboi M, Kondo K, Masuda K, Tange S, Kajiura K, Kohmoto T, Takizawa H, Imoto I, Tangoku A.

Cancer Med. 2019 Jun 17. doi: 10.1002/cam4.2345. [Epub ahead of print]

4.

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer.

Kikuchi-Koike R, Nagasaka K, Tsuda H, Ishii Y, Sakamoto M, Kikuchi Y, Fukui S, Miyagawa Y, Hiraike H, Kobayashi T, Kinoshita T, Kanai Y, Shibata T, Imoto I, Inazawa J, Matsubara O, Ayabe T.

BMC Cancer. 2019 May 30;19(1):521. doi: 10.1186/s12885-019-5737-7.

5.

Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis.

Fukuda D, Nishimoto S, Aini K, Tanaka A, Nishiguchi T, Kim-Kaneyama JR, Lei XF, Masuda K, Naruto T, Tanaka K, Higashikuni Y, Hirata Y, Yagi S, Kusunose K, Yamada H, Soeki T, Imoto I, Akasaka T, Shimabukuro M, Sata M.

J Am Heart Assoc. 2019 Apr 2;8(7):e010860. doi: 10.1161/JAHA.118.010860.

6.

Novel compound heterozygous CDH23 variants in a patient with Usher syndrome type I.

Okano S, Makita Y, Katada A, Harabuchi Y, Kohmoto T, Naruto T, Masuda K, Imoto I.

Hum Genome Var. 2019 Jan 28;6:8. doi: 10.1038/s41439-019-0037-y. eCollection 2019.

7.

Genome-Wide Association Study to Identify a New Susceptibility Locus for Central Serous Chorioretinopathy in the Japanese Population.

Miki A, Sakurada Y, Tanaka K, Semba K, Mitamura Y, Yuzawa M, Tajima A, Nakatochi M, Yamamoto K, Matsuo K, Imoto I, Honda S.

Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5542-5547. doi: 10.1167/iovs.18-25497.

PMID:
30480742
8.

Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.

Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, Inazawa J, Oze I, Sato N, Tanioka F, Sugimura H, Hirose H, Yoshida T, Matsuo K, Kubo M, Matsuda K.

Cancer Sci. 2018 Dec;109(12):4015-4024. doi: 10.1111/cas.13815. Epub 2018 Oct 31.

9.

Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice.

Hara T, Phuong PT, Fukuda D, Yamaguchi K, Murata C, Nishimoto S, Yagi S, Kusunose K, Yamada H, Soeki T, Wakatsuki T, Imoto I, Shimabukuro M, Sata M.

Circulation. 2018 Oct 16;138(16):1706-1719. doi: 10.1161/CIRCULATIONAHA.118.033544.

PMID:
29700120
10.

Primary microcephaly caused by novel compound heterozygous mutations in ASPM.

Okamoto N, Kohmoto T, Naruto T, Masuda K, Imoto I.

Hum Genome Var. 2018 Apr 5;5:18015. doi: 10.1038/hgv.2018.15. eCollection 2018.

11.

Retraction: A significant causal association between C-reactive protein levels and schizophrenia.

Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Nakataki M, Ikeda M, Maruyama S, Yamamori H, Kanazawa T, Shimodera S, Hashimoto R, Imoto I, Yoneda H, Iwata N, Ohmori T.

Sci Rep. 2018 Feb 21;8:46947. doi: 10.1038/srep46947.

12.

Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men.

Sato Y, Tajima A, Sato T, Nozawa S, Yoshiike M, Imoto I, Yamauchi A, Iwamoto T.

J Med Genet. 2018 Jun;55(6):415-421. doi: 10.1136/jmedgenet-2017-104991. Epub 2018 Feb 16.

13.

APOB codon 4311 polymorphism is associated with hepatitis C virus infection through altered lipid metabolism.

Harada R, Kimura M, Sato Y, Taniguchi T, Tomonari T, Tanaka T, Tanaka H, Muguruma N, Shinomiya H, Honda H, Imoto I, Sogabe M, Okahisa T, Takayama T.

BMC Gastroenterol. 2018 Jan 30;18(1):24. doi: 10.1186/s12876-018-0747-5.

14.

Three patients with Schaaf-Yang syndrome exhibiting arthrogryposis and endocrinological abnormalities.

Enya T, Okamoto N, Iba Y, Miyazawa T, Okada M, Ida S, Naruto T, Imoto I, Fujita A, Miyake N, Matsumoto N, Sugimoto K, Takemura T.

Am J Med Genet A. 2018 Mar;176(3):707-711. doi: 10.1002/ajmg.a.38606. Epub 2018 Jan 23.

PMID:
29359444
15.

Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer.

Hirasawa A, Imoto I, Naruto T, Akahane T, Yamagami W, Nomura H, Masuda K, Susumu N, Tsuda H, Aoki D.

Oncotarget. 2017 Nov 28;8(68):112258-112267. doi: 10.18632/oncotarget.22733. eCollection 2017 Dec 22.

16.

A rare male patient with classic Rett syndrome caused by MeCP2_e1 mutation.

Tokaji N, Ito H, Kohmoto T, Naruto T, Takahashi R, Goji A, Mori T, Toda Y, Saito M, Tange S, Masuda K, Kagami S, Imoto I.

Am J Med Genet A. 2018 Mar;176(3):699-702. doi: 10.1002/ajmg.a.38595. Epub 2018 Jan 17.

PMID:
29341476
17.

Manifestation of recessive combined D-2-, L-2-hydroxyglutaric aciduria in combination with 22q11.2 deletion syndrome.

Eguchi M, Ozaki E, Yamauchi T, Ohta M, Higaki T, Masuda K, Imoto I, Ishii E, Eguchi-Ishimae M.

Am J Med Genet A. 2018 Feb;176(2):351-358. doi: 10.1002/ajmg.a.38578. Epub 2017 Dec 19. Review.

PMID:
29265763
18.

KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression.

Fujita Y, Masuda K, Hamada J, Shoda K, Naruto T, Hamada S, Miyakami Y, Kohmoto T, Watanabe M, Takahashi R, Tange S, Saito M, Kudo Y, Fujiwara H, Ichikawa D, Tangoku A, Otsuji E, Imoto I.

Oncotarget. 2017 Sep 15;8(60):101130-101145. doi: 10.18632/oncotarget.20926. eCollection 2017 Nov 24.

19.

Construction of a combinatorial pipeline using two somatic variant  calling  methods  for whole exome sequence data of gastric cancer.

Kohmoto T, Masuda K, Naruto T, Tange S, Shoda K, Hamada J, Saito M, Ichikawa D, Tajima A, Otsuji E, Imoto I.

J Med Invest. 2017;64(3.4):233-240. doi: 10.2152/jmi.64.233.

20.

Frequent silencing of RASSF1A by DNA methylation in thymic neuroendocrine tumours.

Kajiura K, Takizawa H, Morimoto Y, Masuda K, Tsuboi M, Kishibuchi R, Wusiman N, Sawada T, Kawakita N, Toba H, Yoshida M, Kawakami Y, Naruto T, Imoto I, Tangoku A, Kondo K.

Lung Cancer. 2017 Sep;111:116-123. doi: 10.1016/j.lungcan.2017.05.019. Epub 2017 May 25.

PMID:
28838380
21.

Novel CLCN7 compound heterozygous mutations in intermediate autosomal recessive osteopetrosis.

Okamoto N, Kohmoto T, Naruto T, Masuda K, Komori T, Imoto I.

Hum Genome Var. 2017 Aug 17;4:17036. doi: 10.1038/hgv.2017.36. eCollection 2017.

22.

The first Japanese patient with mandibular hypoplasia, deafness, progeroid features and lipodystrophy diagnosed via POLD1 mutation detection.

Okada A, Kohmoto T, Naruto T, Yokota I, Kotani Y, Shimada A, Miyamoto Y, Takahashi R, Goji A, Masuda K, Kagami S, Imoto I.

Hum Genome Var. 2017 Aug 3;4:17031. doi: 10.1038/hgv.2017.31. eCollection 2017.

23.

An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies.

Sato Y, Tajima A, Katsurayama M, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.

Hum Reprod Open. 2017 Jun 14;2017(1):hox002. doi: 10.1093/hropen/hox002. eCollection 2017. Erratum in: Hum Reprod Open. 2017 Jun 14;2017(1):hox005.

24.

Erratum: An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies.

Sato Y, Tajima A, Katsurayama M, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.

Hum Reprod Open. 2017 Jun 14;2017(1):hox005. doi: 10.1093/hropen/hox005. eCollection 2017.

25.

De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity.

Nishi A, Numata S, Tajima A, Zhu X, Ito K, Saito A, Kato Y, Kinoshita M, Shimodera S, Ono S, Ochi S, Imamura A, Kurotaki N, Ueno SI, Iwata N, Fukui K, Imoto I, Kamiya A, Ohmori T.

Sci Rep. 2017 Jun 6;7(1):2887. doi: 10.1038/s41598-017-02792-z.

26.

A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells.

Yoshimaru T, Ono M, Bando Y, Chen YA, Mizuguchi K, Shima H, Komatsu M, Imoto I, Izumi K, Honda J, Miyoshi Y, Sasa M, Katagiri T.

Nat Commun. 2017 May 30;8:15427. doi: 10.1038/ncomms15427.

27.

A case with concurrent duplication, triplication, and uniparental isodisomy at 1q42.12-qter supporting microhomology-mediated break-induced replication model for replicative rearrangements.

Kohmoto T, Okamoto N, Naruto T, Murata C, Ouchi Y, Fujita N, Inagaki H, Satomura S, Okamoto N, Saito M, Masuda K, Kurahashi H, Imoto I.

Mol Cytogenet. 2017 Apr 28;10:15. doi: 10.1186/s13039-017-0316-6. eCollection 2017.

28.

Clinical utility of circulating cell-free Epstein-Barr virus DNA in patients with gastric cancer.

Shoda K, Ichikawa D, Fujita Y, Masuda K, Hiramoto H, Hamada J, Arita T, Konishi H, Kosuga T, Komatsu S, Shiozaki A, Okamoto K, Imoto I, Otsuji E.

Oncotarget. 2017 Apr 25;8(17):28796-28804. doi: 10.18632/oncotarget.15675.

29.

Detection of 1p36 deletion by clinical exome-first diagnostic approach.

Watanabe M, Hayabuchi Y, Ono A, Naruto T, Horikawa H, Kohmoto T, Masuda K, Nakagawa R, Ito H, Kagami S, Imoto I.

Hum Genome Var. 2016 May 12;3:16006. doi: 10.1038/hgv.2016.6. eCollection 2016.

30.

Comparison of the efficacy and safety of 10-mg empagliflozin every day versus every other day in Japanese patients with Type 2 Diabetes Mellitus: a pilot trial.

Obata F, Tani K, Yamaguchi H, Tabata R, Bando H, Imoto I.

J Med Invest. 2017;64(1.2):50-57. doi: 10.2152/jmi.64.50.

31.

Targeted exome sequencing and chromosomal microarray for the molecular diagnosis of nevoid basal cell carcinoma syndrome.

Matsudate Y, Naruto T, Hayashi Y, Minami M, Tohyama M, Yokota K, Yamada D, Imoto I, Kubo Y.

J Dermatol Sci. 2017 Jun;86(3):206-211. doi: 10.1016/j.jdermsci.2017.02.282. Epub 2017 Mar 11.

PMID:
28342698
32.

Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia.

Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T.

Int J Mol Sci. 2017 Mar 14;18(3). pii: E632. doi: 10.3390/ijms18030632.

33.

A 590 kb deletion caused by non-allelic homologous recombination between two LINE-1 elements in a patient with mesomelia-synostosis syndrome.

Kohmoto T, Naruto T, Watanabe M, Fujita Y, Ujiro S, Okamoto N, Horikawa H, Masuda K, Imoto I.

Am J Med Genet A. 2017 Apr;173(4):1082-1086. doi: 10.1002/ajmg.a.38122.

PMID:
28328141
34.

Genome-first approach diagnosed Cabezas syndrome via novel CUL4B mutation detection.

Okamoto N, Watanabe M, Naruto T, Matsuda K, Kohmoto T, Saito M, Masuda K, Imoto I.

Hum Genome Var. 2017 Jan 19;4:16045. doi: 10.1038/hgv.2016.45. eCollection 2017.

35.

Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma.

Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I.

Oncotarget. 2017 Jan 10;8(2):2890-2905. doi: 10.18632/oncotarget.13761.

36.

Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development.

Mitsui SN, Yasue A, Masuda K, Naruto T, Minegishi Y, Oyadomari S, Noji S, Imoto I, Tanaka E.

Sci Rep. 2016 Dec 5;6:38398. doi: 10.1038/srep38398.

37.

Exome-first approach identified a novel gloss deletion associated with Lowe syndrome.

Watanabe M, Nakagawa R, Kohmoto T, Naruto T, Suga KI, Goji A, Horikawa H, Masuda K, Kagami S, Imoto I.

Hum Genome Var. 2016 Nov 10;3:16037. eCollection 2016.

38.

Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk.

Kinoshita M, Numata S, Tajima A, Nishi A, Muraki S, Tsuchiya A, Umehara H, Watanabe SY, Imoto I, Ohmori T.

Psychiatry Res. 2016 Dec 30;246:833-837. doi: 10.1016/j.psychres.2016.10.017. Epub 2016 Oct 17.

PMID:
27810229
39.

A novel missense mutation of COL5A2 in a patient with Ehlers-Danlos syndrome.

Watanabe M, Nakagawa R, Naruto T, Kohmoto T, Suga K, Goji A, Kagami S, Masuda K, Imoto I.

Hum Genome Var. 2016 Sep 15;3:16030. doi: 10.1038/hgv.2016.30. eCollection 2016.

40.

Factors associated with regular dental visits among hemodialysis patients.

Yoshioka M, Shirayama Y, Imoto I, Hinode D, Yanagisawa S, Takeuchi Y, Bando T, Yokota N.

World J Nephrol. 2016 Sep 6;5(5):455-60. doi: 10.5527/wjn.v5.i5.455.

41.

Assay of serum E2 concentration in postmenopausal breast cancer patients using a high-sensitivity RIA method is generally useful.

Morimoto M, Takahashi M, Honda J, Yoshida T, Yoshida M, Toba H, Imoto I, Tangoku A, Sasa M.

J Med Invest. 2016;63(3-4):236-40. doi: 10.2152/jmi.63.236.

42.

Thirty percent of ductal carcinoma in situ of the breast in Japan is extremely low-grade ER(+)/HER2(-) type without comedo necrosis.

Kanematsu M, Morimoto M, Takahashi M, Honda J, Bando Y, Moriya T, Tadokoro Y, Nakagawa M, Takechi H, Yoshida T, Toba H, Yoshida M, Kajikawa A, Tangoku A, Imoto I, Sasa M.

J Med Invest. 2016;63(3-4):192-8. doi: 10.2152/jmi.63.192.

43.

Conformational plasticity of JRAB/MICAL-L2 provides "law and order" in collective cell migration.

Sakane A, Yoshizawa S, Nishimura M, Tsuchiya Y, Matsushita N, Miyake K, Horikawa K, Imoto I, Mizuguchi C, Saito H, Ueno T, Matsushita S, Haga H, Deguchi S, Mizuguchi K, Yokota H, Sasaki T.

Mol Biol Cell. 2016 Oct 15;27(20):3095-3108. Epub 2016 Aug 31.

44.

A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men.

Sato Y, Tajima A, Katsurayama M, Nozawa S, Yoshiike M, Koh E, Kanaya J, Namiki M, Matsumiya K, Tsujimura A, Komatsu K, Itoh N, Eguchi J, Imoto I, Yamauchi A, Iwamoto T.

J Hum Genet. 2016 Nov;61(11):911-915. doi: 10.1038/jhg.2016.82. Epub 2016 Jun 30.

PMID:
27357427
45.

Ancestral Y-linked genes were maintained by translocation to the X and Y chromosomes fused to an autosomal pair in the Okinawa spiny rat Tokudaia muenninki.

Murata C, Kuroki Y, Imoto I, Kuroiwa A.

Chromosome Res. 2016 Sep;24(3):407-19. doi: 10.1007/s10577-016-9531-y. Epub 2016 Jun 22.

46.

Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder.

Umehara H, Numata S, Tajima A, Nishi A, Nakataki M, Imoto I, Sumitani S, Ohmori T.

PLoS One. 2016 Jun 9;11(6):e0157232. doi: 10.1371/journal.pone.0157232. eCollection 2016.

47.

A significant causal association between C-reactive protein levels and schizophrenia.

Inoshita M, Numata S, Tajima A, Kinoshita M, Umehara H, Nakataki M, Ikeda M, Maruyama S, Yamamori H, Kanazawa T, Shimodera S, Hashimoto R, Imoto I, Yoneda H, Iwata N, Ohmori T.

Sci Rep. 2016 May 19;6:26105. doi: 10.1038/srep26105. Retraction in: Sci Rep. 2018 Feb 21;8:46947.

48.

A novel frameshift mutation of CHD7 in a Japanese patient with CHARGE syndrome.

Kohmoto T, Shono M, Naruto T, Watanabe M, Suga K, Nakagawa R, Kagami S, Masuda K, Imoto I.

Hum Genome Var. 2016 Apr 7;3:16004. doi: 10.1038/hgv.2016.4. eCollection 2016.

49.

A novel COL11A1 missense mutation in siblings with non-ocular Stickler syndrome.

Kohmoto T, Tsuji A, Morita K, Naruto T, Masuda K, Kashimada K, Enomoto K, Morio T, Harada H, Imoto I.

Hum Genome Var. 2016 Apr 7;3:16003. doi: 10.1038/hgv.2016.3. eCollection 2016.

50.

Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance.

Nishimoto S, Fukuda D, Higashikuni Y, Tanaka K, Hirata Y, Murata C, Kim-Kaneyama JR, Sato F, Bando M, Yagi S, Soeki T, Hayashi T, Imoto I, Sakaue H, Shimabukuro M, Sata M.

Sci Adv. 2016 Mar 25;2(3):e1501332. doi: 10.1126/sciadv.1501332. eCollection 2016 Mar.

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