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Cystine import is a valuable but risky process whose hazards Escherichia coli minimizes by inducing a cysteine exporter.

Korshunov S, Imlay KRC, Imlay JA.

Mol Microbiol. 2020 Jan;113(1):22-39. doi: 10.1111/mmi.14403. Epub 2019 Nov 11.


Evolutionary adaptations that enable enzymes to tolerate oxidative stress.

Imlay JA, Sethu R, Rohaun SK.

Free Radic Biol Med. 2019 Aug 20;140:4-13. doi: 10.1016/j.freeradbiomed.2019.01.048. Epub 2019 Feb 6. Review.


Where in the world do bacteria experience oxidative stress?

Imlay JA.

Environ Microbiol. 2019 Feb;21(2):521-530. doi: 10.1111/1462-2920.14445. Epub 2018 Nov 19. Review.


Quantification of Hydrogen Sulfide and Cysteine Excreted by Bacterial Cells.

Korshunov S, Imlay JA.

Bio Protoc. 2018 May 20;8(10). pii: e2847. doi: 10.21769/BioProtoc.2847.


Endogenous superoxide is a key effector of the oxygen sensitivity of a model obligate anaerobe.

Lu Z, Sethu R, Imlay JA.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3266-E3275. doi: 10.1073/pnas.1800120115. Epub 2018 Mar 20.


Improved measurements of scant hydrogen peroxide enable experiments that define its threshold of toxicity for Escherichia coli.

Li X, Imlay JA.

Free Radic Biol Med. 2018 May 20;120:217-227. doi: 10.1016/j.freeradbiomed.2018.03.025. Epub 2018 Mar 14.


4-Hydroxybenzaldehyde sensitizes Acinetobacter baumannii to amphenicols.

Shin B, Park C, Imlay JA, Park W.

Appl Microbiol Biotechnol. 2018 Mar;102(5):2323-2335. doi: 10.1007/s00253-018-8791-1. Epub 2018 Feb 1.


Escherichia coli cytochrome c peroxidase is a respiratory oxidase that enables the use of hydrogen peroxide as a terminal electron acceptor.

Khademian M, Imlay JA.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6922-E6931. doi: 10.1073/pnas.1701587114. Epub 2017 Jul 10.


Lineage-specific SoxR-mediated Regulation of an Endoribonuclease Protects Non-enteric Bacteria from Redox-active Compounds.

Kim J, Park C, Imlay JA, Park W.

J Biol Chem. 2017 Jan 6;292(1):121-133. doi: 10.1074/jbc.M116.757500. Epub 2016 Nov 28.


Bacterial Porphyrin Extraction and Quantification by LC/MS/MS Analysis.

Mancini S, Imlay JA.

Bio Protoc. 2015 Oct 5;5(19). pii: e1616.


The cytochrome bd oxidase of Escherichia coli prevents respiratory inhibition by endogenous and exogenous hydrogen sulfide.

Korshunov S, Imlay KR, Imlay JA.

Mol Microbiol. 2016 Jul;101(1):62-77. doi: 10.1111/mmi.13372. Epub 2016 May 2.


Physiological Roles and Adverse Effects of the Two Cystine Importers of Escherichia coli.

Chonoles Imlay KR, Korshunov S, Imlay JA.

J Bacteriol. 2015 Dec;197(23):3629-44. doi: 10.1128/JB.00277-15. Epub 2015 Sep 8.


Transcription Factors That Defend Bacteria Against Reactive Oxygen Species.

Imlay JA.

Annu Rev Microbiol. 2015;69:93-108. doi: 10.1146/annurev-micro-091014-104322. Epub 2015 Jun 11. Review.


The Escherichia coli small protein MntS and exporter MntP optimize the intracellular concentration of manganese.

Martin JE, Waters LS, Storz G, Imlay JA.

PLoS Genet. 2015 Mar 16;11(3):e1004977. doi: 10.1371/journal.pgen.1004977. eCollection 2015 Mar. Erratum in: PLoS Genet. 2015 Jun;11(6):e1005322.


Diagnosing oxidative stress in bacteria: not as easy as you might think.

Imlay JA.

Curr Opin Microbiol. 2015 Apr;24:124-31. doi: 10.1016/j.mib.2015.01.004. Epub 2015 Feb 6. Review.


The mismetallation of enzymes during oxidative stress.

Imlay JA.

J Biol Chem. 2014 Oct 10;289(41):28121-8. doi: 10.1074/jbc.R114.588814. Epub 2014 Aug 26. Review.


An anaerobic bacterium, Bacteroides thetaiotaomicron, uses a consortium of enzymes to scavenge hydrogen peroxide.

Mishra S, Imlay JA.

Mol Microbiol. 2013 Dec;90(6):1356-71. doi: 10.1111/mmi.12438. Epub 2013 Nov 20.


Comparative study of SoxR activation by redox-active compounds.

Singh AK, Shin JH, Lee KL, Imlay JA, Roe JH.

Mol Microbiol. 2013 Dec;90(5):983-96. doi: 10.1111/mmi.12410. Epub 2013 Oct 17.


How Escherichia coli tolerates profuse hydrogen peroxide formation by a catabolic pathway.

Ravindra Kumar S, Imlay JA.

J Bacteriol. 2013 Oct;195(20):4569-79. doi: 10.1128/JB.00737-13. Epub 2013 Aug 2.


The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium.

Imlay JA.

Nat Rev Microbiol. 2013 Jul;11(7):443-54. doi: 10.1038/nrmicro3032. Epub 2013 May 28. Review.


Superoxide poisons mononuclear iron enzymes by causing mismetallation.

Gu M, Imlay JA.

Mol Microbiol. 2013 Jul;89(1):123-34. doi: 10.1111/mmi.12263. Epub 2013 Jun 7.


Cell death from antibiotics without the involvement of reactive oxygen species.

Liu Y, Imlay JA.

Science. 2013 Mar 8;339(6124):1210-3. doi: 10.1126/science.1232751.


Why do bacteria use so many enzymes to scavenge hydrogen peroxide?

Mishra S, Imlay J.

Arch Biochem Biophys. 2012 Sep 15;525(2):145-60. doi: 10.1016/ Epub 2012 May 16. Review.


Mononuclear iron enzymes are primary targets of hydrogen peroxide stress.

Anjem A, Imlay JA.

J Biol Chem. 2012 May 4;287(19):15544-56. doi: 10.1074/jbc.M111.330365. Epub 2012 Mar 12.


Silver(I), mercury(II), cadmium(II), and zinc(II) target exposed enzymic iron-sulfur clusters when they toxify Escherichia coli.

Xu FF, Imlay JA.

Appl Environ Microbiol. 2012 May;78(10):3614-21. doi: 10.1128/AEM.07368-11. Epub 2012 Feb 17.


Rapid identification of bacteria with a disposable colorimetric sensing array.

Carey JR, Suslick KS, Hulkower KI, Imlay JA, Imlay KR, Ingison CK, Ponder JB, Sen A, Wittrig AE.

J Am Chem Soc. 2011 May 18;133(19):7571-6. doi: 10.1021/ja201634d. Epub 2011 Apr 27.


Many plants and bacteria excrete redox-cycling compounds.

Imlay J, Gu M.

Free Radic Biol Med. 2011 Jun 15;50(12):1814-5. doi: 10.1016/j.freeradbiomed.2011.03.034. Epub 2011 Apr 3. No abstract available.


Iron enzyme ribulose-5-phosphate 3-epimerase in Escherichia coli is rapidly damaged by hydrogen peroxide but can be protected by manganese.

Sobota JM, Imlay JA.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5402-7. doi: 10.1073/pnas.1100410108. Epub 2011 Mar 14.


The Escherichia coli BtuE protein functions as a resistance determinant against reactive oxygen species.

Arenas FA, Covarrubias PC, Sandoval JM, Pérez-Donoso JM, Imlay JA, Vásquez CC.

PLoS One. 2011 Jan 10;6(1):e15979. doi: 10.1371/journal.pone.0015979.


The SoxRS response of Escherichia coli is directly activated by redox-cycling drugs rather than by superoxide.

Gu M, Imlay JA.

Mol Microbiol. 2011 Mar;79(5):1136-50. doi: 10.1111/j.1365-2958.2010.07520.x. Epub 2011 Jan 12.


Hydrogen peroxide inactivates the Escherichia coli Isc iron-sulphur assembly system, and OxyR induces the Suf system to compensate.

Jang S, Imlay JA.

Mol Microbiol. 2010 Dec;78(6):1448-67. doi: 10.1111/j.1365-2958.2010.07418.x. Epub 2010 Oct 29.


A small RNA promotes siderophore production through transcriptional and metabolic remodeling.

Salvail H, Lanthier-Bourbonnais P, Sobota JM, Caza M, Benjamin JA, Mendieta ME, Lépine F, Dozois CM, Imlay J, Massé E.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15223-8. doi: 10.1073/pnas.1007805107. Epub 2010 Aug 9.


Mechanism of Escherichia coli inactivation on palladium-modified nitrogen-doped titanium dioxide.

Wu P, Imlay JA, Shang JK.

Biomaterials. 2010 Oct;31(29):7526-33. doi: 10.1016/j.biomaterials.2010.06.032. Epub 2010 Jul 16.


The Escherichia coli btuE gene, encodes a glutathione peroxidase that is induced under oxidative stress conditions.

Arenas FA, Díaz WA, Leal CA, Pérez-Donoso JM, Imlay JA, Vásquez CC.

Biochem Biophys Res Commun. 2010 Aug 6;398(4):690-4. doi: 10.1016/j.bbrc.2010.07.002. Epub 2010 Jul 16.


Redox pioneer: professor Irwin Fridovich.

Imlay JA.

Antioxid Redox Signal. 2011 Feb 1;14(3):335-40. doi: 10.1089/ars.2010.3264. Epub 2010 Aug 18.


Iron homeostasis affects antibiotic-mediated cell death in Pseudomonas species.

Yeom J, Imlay JA, Park W.

J Biol Chem. 2010 Jul 16;285(29):22689-95. doi: 10.1074/jbc.M110.127456. Epub 2010 May 17.


Two sources of endogenous hydrogen peroxide in Escherichia coli.

Korshunov S, Imlay JA.

Mol Microbiol. 2010 Mar;75(6):1389-401. doi: 10.1111/j.1365-2958.2010.07059.x. Epub 2010 Feb 8.


Oxidative Stress.

Imlay JA.

EcoSal Plus. 2009 Aug;3(2). doi: 10.1128/ecosalplus.5.4.4.


The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity.

Macomber L, Imlay JA.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8344-9. doi: 10.1073/pnas.0812808106. Epub 2009 May 4.


Manganese import is a key element of the OxyR response to hydrogen peroxide in Escherichia coli.

Anjem A, Varghese S, Imlay JA.

Mol Microbiol. 2009 May;72(4):844-58. doi: 10.1111/j.1365-2958.2009.06699.x. Epub 2009 Apr 21.


How obligatory is anaerobiosis?

Imlay JA.

Mol Microbiol. 2008 May;68(4):801-4. doi: 10.1111/j.1365-2958.2008.06213.x. Epub 2008 Mar 19.


Cellular defenses against superoxide and hydrogen peroxide.

Imlay JA.

Annu Rev Biochem. 2008;77:755-76. doi: 10.1146/annurev.biochem.77.061606.161055. Review.


Bactericidal antibiotics and oxidative stress: a radical proposal.

Hassett DJ, Imlay JA.

ACS Chem Biol. 2007 Nov 20;2(11):708-10.


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