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Items: 1 to 50 of 78

1.

Structure functional insights into calcium binding during the activation of coagulation factor XIII A.

Singh S, Dodt J, Volkers P, Hethershaw E, Philippou H, Ivaskevicius V, Imhof D, Oldenburg J, Biswas A.

Sci Rep. 2019 Aug 5;9(1):11324. doi: 10.1038/s41598-019-47815-z.

2.

NMR experiments on the transient interaction of the intrinsically disordered N-terminal peptide of cystathionine-β-synthase with heme.

Kumar A, Bellstedt P, Wiedemann C, Wißbrock A, Imhof D, Ramachandran R, Ohlenschläger O.

J Magn Reson. 2019 Jul 16:106561. doi: 10.1016/j.jmr.2019.07.048. [Epub ahead of print]

PMID:
31345774
3.

Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers.

Paul George AA, Heimer P, Leipold E, Schmitz T, Kaufmann D, Tietze D, Heinemann SH, Imhof D.

Mar Drugs. 2019 Jul 2;17(7). pii: E390. doi: 10.3390/md17070390.

4.

Coagulation Factor XIIIa Inhibitor Tridegin: On the Role of Disulfide Bonds for Folding, Stability, and Function.

Bäuml CA, Schmitz T, Paul George AA, Sudarsanam M, Hardes K, Steinmetzer T, Holle LA, Wolberg AS, Pötzsch B, Oldenburg J, Biswas A, Imhof D.

J Med Chem. 2019 Apr 11;62(7):3513-3523. doi: 10.1021/acs.jmedchem.8b01982. Epub 2019 Mar 21.

PMID:
30852892
5.

1H, 13C, and 15N resonance assignments of the cytokine interleukin-36β isoform-2.

Kumar A, Wißbrock A, Bellstedt P, Lang A, Ramachandran R, Wiedemann C, Imhof D, Ohlenschläger O.

Biomol NMR Assign. 2019 Apr;13(1):155-161. doi: 10.1007/s12104-018-09869-4. Epub 2019 Feb 13.

PMID:
30758717
6.

The molecular basis of transient heme-protein interactions: analysis, concept and implementation.

Wißbrock A, Paul George AA, Brewitz HH, Kühl T, Imhof D.

Biosci Rep. 2019 Jan 30;39(1). pii: BSR20181940. doi: 10.1042/BSR20181940. Print 2019 Jan 31. Review.

7.

Insights into the Folding of Disulfide-Rich μ-Conotoxins.

Paul George AA, Heimer P, Maaß A, Hamaekers J, Hofmann-Apitius M, Biswas A, Imhof D.

ACS Omega. 2018 Oct 31;3(10):12330-12340. doi: 10.1021/acsomega.8b01465. Epub 2018 Oct 1.

8.

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities.

Heimer P, Schmitz T, Bäuml CA, Imhof D.

J Vis Exp. 2018 Oct 2;(140). doi: 10.3791/58368.

PMID:
30346393
9.

Insights into mechanism and functional consequences of heme binding to hemolysin-activating lysine acyltransferase HlyC from Escherichia coli.

Peherstorfer S, Brewitz HH, Paul George AA, Wißbrock A, Adam JM, Schmitt L, Imhof D.

Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1964-1972. doi: 10.1016/j.bbagen.2018.06.012. Epub 2018 Jun 15.

PMID:
29908817
10.

Deciphering Specificity Determinants for FR900359-Derived Gq α Inhibitors Based on Computational and Structure-Activity Studies.

Reher R, Kühl T, Annala S, Benkel T, Kaufmann D, Nubbemeyer B, Odhiambo JP, Heimer P, Bäuml CA, Kehraus S, Crüsemann M, Kostenis E, Tietze D, König GM, Imhof D.

ChemMedChem. 2018 Aug 20;13(16):1634-1643. doi: 10.1002/cmdc.201800304. Epub 2018 Jul 3.

PMID:
29873888
11.

Quantification of amino acids and peptides in an ionic liquid based aqueous two-phase system by LC-MS analysis.

Oppermann S, Oppermann C, Böhm M, Kühl T, Imhof D, Kragl U.

AMB Express. 2018 Apr 25;8(1):66. doi: 10.1186/s13568-018-0596-1.

12.

HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.

Göder A, Emmerich C, Nikolova T, Kiweler N, Schreiber M, Kühl T, Imhof D, Christmann M, Heinzel T, Schneider G, Krämer OH.

Nat Commun. 2018 Feb 22;9(1):764. doi: 10.1038/s41467-018-03096-0.

13.

Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase.

Kumar A, Wißbrock A, Goradia N, Bellstedt P, Ramachandran R, Imhof D, Ohlenschläger O.

Sci Rep. 2018 Feb 6;8(1):2474. doi: 10.1038/s41598-018-20841-z.

14.

Conformational μ-Conotoxin PIIIA Isomers Revisited: Impact of Cysteine Pairing on Disulfide-Bond Assignment and Structure Elucidation.

Heimer P, Tietze AA, Bäuml CA, Resemann A, Mayer FJ, Suckau D, Ohlenschläger O, Tietze D, Imhof D.

Anal Chem. 2018 Mar 6;90(5):3321-3327. doi: 10.1021/acs.analchem.7b04854. Epub 2018 Feb 8.

PMID:
29397705
15.

Lack of beta-arrestin signaling in the absence of active G proteins.

Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E.

Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3.

16.

New insights into the mechanism of nickel superoxide degradation from studies of model peptides.

Tietze D, Sartorius J, Koley Seth B, Herr K, Heimer P, Imhof D, Mollenhauer D, Buntkowsky G.

Sci Rep. 2017 Dec 8;7(1):17194. doi: 10.1038/s41598-017-17446-3.

17.

CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).

Gessner G, Sahoo N, Swain SM, Hirth G, Schönherr R, Mede R, Westerhausen M, Brewitz HH, Heimer P, Imhof D, Hoshi T, Heinemann SH.

Eur J Pharmacol. 2017 Nov 15;815:33-41. doi: 10.1016/j.ejphar.2017.10.006. Epub 2017 Oct 5.

18.

A Tough Nut to Crack: Intracellular Detection and Quantification of Heme in Malaria Parasites by a Genetically Encoded Protein Sensor.

Wißbrock A, Imhof D.

Chembiochem. 2017 Aug 17;18(16):1561-1564. doi: 10.1002/cbic.201700274. Epub 2017 Jul 5.

PMID:
28547798
19.

Structural and functional diversity of transient heme binding to bacterial proteins.

Brewitz HH, Hagelueken G, Imhof D.

Biochim Biophys Acta Gen Subj. 2017 Mar;1861(3):683-697. doi: 10.1016/j.bbagen.2016.12.021. Epub 2016 Dec 22. Review.

PMID:
28012743
20.

Synthesis and Evaluation of Amyloid β Derived and Amyloid β Independent Enhancers of the Peroxidase-like Activity of Heme.

Wißbrock A, Kühl T, Silbermann K, Becker AJ, Ohlenschläger O, Imhof D.

J Med Chem. 2017 Jan 12;60(1):373-385. doi: 10.1021/acs.jmedchem.6b01432. Epub 2016 Dec 15.

PMID:
27976903
21.

Subtype-specific block of voltage-gated K+ channels by μ-conopeptides.

Leipold E, Ullrich F, Thiele M, Tietze AA, Terlau H, Imhof D, Heinemann SH.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1135-1140. doi: 10.1016/j.bbrc.2016.11.170. Epub 2016 Dec 2.

PMID:
27916464
22.

Encapsulation of the HDACi Ex527 into Liposomes and Polymer-Based Particles.

Hennig D, Imhof D.

Methods Mol Biol. 2017;1510:387-398.

PMID:
27761837
23.

C-Terminal Alpha-1 Antitrypsin Peptide: A New Sepsis Biomarker with Immunomodulatory Function.

Blaurock N, Schmerler D, Hünniger K, Kurzai O, Ludewig K, Baier M, Brunkhorst FM, Imhof D, Kiehntopf M.

Mediators Inflamm. 2016;2016:6129437. doi: 10.1155/2016/6129437. Epub 2016 Jun 13.

24.

(1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36α.

Goradia N, Wißbrock A, Wiedemann C, Bordusa F, Ramachandran R, Imhof D, Ohlenschläger O.

Biomol NMR Assign. 2016 Oct;10(2):329-33. doi: 10.1007/s12104-016-9694-7. Epub 2016 Jun 28.

PMID:
27351892
25.

Studies on the X-Ray and Solution Structure of FeoB from Escherichia coli BL21.

Hagelueken G, Hoffmann J, Schubert E, Duthie FG, Florin N, Konrad L, Imhof D, Behrmann E, Morgner N, Schiemann O.

Biophys J. 2016 Jun 21;110(12):2642-2650. doi: 10.1016/j.bpj.2016.05.018.

26.

Molecular interaction of δ-conopeptide EVIA with voltage-gated Na(+) channels.

Tietze D, Leipold E, Heimer P, Böhm M, Winschel W, Imhof D, Heinemann SH, Tietze AA.

Biochim Biophys Acta. 2016 Sep;1860(9):2053-63. doi: 10.1016/j.bbagen.2016.06.013. Epub 2016 Jun 15. No abstract available.

PMID:
27316322
27.

Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis.

Coburger I, Schaub Y, Roeser D, Hardes K, Maeder P, Klee N, Steinmetzer T, Imhof D, Diederich WE, Than ME.

Microbiologyopen. 2016 Aug;5(4):637-46. doi: 10.1002/mbo3.358. Epub 2016 Apr 1.

28.

Heme interacts with histidine- and tyrosine-based protein motifs and inhibits enzymatic activity of chloramphenicol acetyltransferase from Escherichia coli.

Brewitz HH, Goradia N, Schubert E, Galler K, Kühl T, Syllwasschy B, Popp J, Neugebauer U, Hagelueken G, Schiemann O, Ohlenschläger O, Imhof D.

Biochim Biophys Acta. 2016 Jun;1860(6):1343-53. doi: 10.1016/j.bbagen.2016.03.027. Epub 2016 Mar 23.

PMID:
27015758
29.

Propylene carbonate quantification by its derivative 3,5-diacetyl-1,4-dihydro-2,6-lutidine.

Grizić D, Heimer P, Vranić E, Imhof D, Lamprecht A.

Talanta. 2016 May 1;151:75-82. doi: 10.1016/j.talanta.2016.01.022. Epub 2016 Jan 13.

PMID:
26946012
30.

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.

31.

Role of the Chemical Environment beyond the Coordination Site: Structural Insight into Fe(III) Protoporphyrin Binding to Cysteine-Based Heme-Regulatory Protein Motifs.

Brewitz HH, Kühl T, Goradia N, Galler K, Popp J, Neugebauer U, Ohlenschläger O, Imhof D.

Chembiochem. 2015 Oct 12;16(15):2216-24. doi: 10.1002/cbic.201500331. Epub 2015 Sep 7.

PMID:
26260099
32.

Spectroscopic studies on peptides and proteins with cysteine-containing heme regulatory motifs (HRM).

Schubert E, Florin N, Duthie F, Henning Brewitz H, Kühl T, Imhof D, Hagelueken G, Schiemann O.

J Inorg Biochem. 2015 Jul;148:49-56. doi: 10.1016/j.jinorgbio.2015.05.008. Epub 2015 May 22.

PMID:
26050879
33.

Synthetic strategies for polypeptides and proteins by chemical ligation.

Chen M, Heimer P, Imhof D.

Amino Acids. 2015 Jul;47(7):1283-99. doi: 10.1007/s00726-015-1982-5. Epub 2015 Apr 18. Review.

PMID:
25894893
34.

Novel insights into structure and function of factor XIIIa-inhibitor tridegin.

Böhm M, Bäuml CA, Hardes K, Steinmetzer T, Roeser D, Schaub Y, Than ME, Biswas A, Imhof D.

J Med Chem. 2014 Dec 26;57(24):10355-65. doi: 10.1021/jm501058g. Epub 2014 Dec 5.

PMID:
25415134
35.

Application of room-temperature aprotic and protic ionic liquids for oxidative folding of cysteine-rich peptides.

Heimer P, Tietze AA, Böhm M, Giernoth R, Kuchenbuch A, Stark A, Leipold E, Heinemann SH, Kandt C, Imhof D.

Chembiochem. 2014 Dec 15;15(18):2754-65. doi: 10.1002/cbic.201402356. Epub 2014 Nov 5.

PMID:
25376613
36.

Regulatory Fe(II/III) heme: the reconstruction of a molecule's biography.

Kühl T, Imhof D.

Chembiochem. 2014 Sep 22;15(14):2024-35. doi: 10.1002/cbic.201402218. Epub 2014 Sep 4. Review.

PMID:
25196849
37.

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.

Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.

38.

On the nature of interactions between ionic liquids and small amino-acid-based biomolecules.

Tietze AA, Bordusa F, Giernoth R, Imhof D, Lenzer T, Maass A, Mrestani-Klaus C, Neundorf I, Oum K, Reith D, Stark A.

Chemphyschem. 2013 Dec 16;14(18):4044-64. doi: 10.1002/cphc.201300736. Epub 2013 Nov 12. Review.

PMID:
24222640
39.

Novel insights into appropriate encapsulation methods for bioactive compounds into polymers: a study with peptides and HDAC inhibitors.

Hennig D, Schubert S, Dargatz H, Kostenis E, Fahr A, Schubert US, Heinzel T, Imhof D.

Macromol Biosci. 2014 Jan;14(1):69-80. doi: 10.1002/mabi.201300213. Epub 2013 Aug 21.

PMID:
23966296
40.

Analysis of Fe(III) heme binding to cysteine-containing heme-regulatory motifs in proteins.

Kühl T, Wißbrock A, Goradia N, Sahoo N, Galler K, Neugebauer U, Popp J, Heinemann SH, Ohlenschläger O, Imhof D.

ACS Chem Biol. 2013 Aug 16;8(8):1785-93. doi: 10.1021/cb400317x. Epub 2013 Jun 17.

PMID:
23730736
41.

Isomerization and epimerization of the aspartyl tetrapeptide Ala-Phe-Asp-GlyOH at pH 10-A CE study.

Brückner C, Bunz SC, Imhof D, Neusüss C, Scriba GK.

Electrophoresis. 2013 Sep;34(18):2666-73. doi: 10.1002/elps.201200685. Epub 2013 Jul 2.

PMID:
23533053
42.

Capillary electrophoretic study of the degradation pathways and kinetics of the aspartyl model tetrapeptide Gly-Phe-Asp-GlyOH in alkaline solution.

Brückner C, Imhof D, Scriba GK.

J Pharm Biomed Anal. 2013 Mar 25;76:96-103. doi: 10.1016/j.jpba.2012.12.012. Epub 2012 Dec 20.

PMID:
23298912
43.

Degradation kinetics of an aspartyl-tripeptide-derived diketopiperazine under forced conditions.

Brückner C, Fahr A, Imhof D, Scriba GK.

J Pharm Sci. 2012 Nov;101(11):4178-90. doi: 10.1002/jps.23272. Epub 2012 Aug 16.

PMID:
22899465
44.

Ionic liquid applications in peptide chemistry: synthesis, purification and analytical characterization processes.

Tietze AA, Heimer P, Stark A, Imhof D.

Molecules. 2012 Apr 5;17(4):4158-85. doi: 10.3390/molecules17044158. Review.

45.

Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV 1.4.

Tietze AA, Tietze D, Ohlenschläger O, Leipold E, Ullrich F, Kühl T, Mischo A, Buntkowsky G, Görlach M, Heinemann SH, Imhof D.

Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4058-61. doi: 10.1002/anie.201107011. Epub 2012 Mar 12. Review. No abstract available.

PMID:
22407516
46.

Synthesis and functional characterization of tridegin and its analogues: inhibitors and substrates of factor XIIIa.

Böhm M, Kühl T, Hardes K, Coch R, Arkona C, Schlott B, Steinmetzer T, Imhof D.

ChemMedChem. 2012 Feb 6;7(2):326-33. doi: 10.1002/cmdc.201100405. Epub 2011 Dec 7.

PMID:
22162181
47.

Determination of hemin-binding characteristics of proteins by a combinatorial peptide library approach.

Kühl T, Sahoo N, Nikolajski M, Schlott B, Heinemann SH, Imhof D.

Chembiochem. 2011 Dec 16;12(18):2846-55. doi: 10.1002/cbic.201100556. Epub 2011 Nov 2.

PMID:
22045633
48.

Satisfaction of staff of Swiss insurance companies with medical appraisals: a cross sectional study.

Eichler K, Imhof D, Bollag Y, Stöhr S, Gyr N, Auerbach H.

BMC Res Notes. 2011 Mar 28;4:83. doi: 10.1186/1756-0500-4-83.

49.

Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels.

Leipold E, Markgraf R, Miloslavina A, Kijas M, Schirmeyer J, Imhof D, Heinemann SH.

Neuropharmacology. 2011 Jul-Aug;61(1-2):105-11. doi: 10.1016/j.neuropharm.2011.03.008. Epub 2011 Mar 16.

PMID:
21419143
50.

Revealing the position of the substrate in nickel superoxide dismutase: a model study.

Tietze D, Voigt S, Mollenhauer D, Tischler M, Imhof D, Gutmann T, González L, Ohlenschläger O, Breitzke H, Görlach M, Buntkowsky G.

Angew Chem Int Ed Engl. 2011 Mar 21;50(13):2946-50. doi: 10.1002/anie.201005027. Epub 2011 Feb 25. No abstract available.

PMID:
21404375

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