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Items: 1 to 50 of 255

1.

Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study.

Lepsik M, Sommer R, Kuhaudomlarp S, Lelimousin M, Paci E, Varrot A, Titz A, Imberty A.

Eur J Med Chem. 2019 Sep 1;177:212-220. doi: 10.1016/j.ejmech.2019.05.049. Epub 2019 May 18.

PMID:
31146126
2.

A Bioinformatics View of Glycan⁻Virus Interactions.

Le Mercier P, Mariethoz J, Lascano-Maillard J, Bonnardel F, Imberty A, Ricard-Blum S, Lisacek F.

Viruses. 2019 Apr 23;11(4). pii: E374. doi: 10.3390/v11040374. Review.

3.

Selective high-resolution DNP-enhanced NMR of biomolecular binding sites.

Marin-Montesinos I, Goyard D, Gillon E, Renaudet O, Imberty A, Hediger S, De Paëpe G.

Chem Sci. 2019 Feb 1;10(11):3366-3374. doi: 10.1039/c8sc05696j. eCollection 2019 Mar 21.

4.

Architecture and Evolution of Blade Assembly in β-propeller Lectins.

Bonnardel F, Kumar A, Wimmerova M, Lahmann M, Perez S, Varrot A, Lisacek F, Imberty A.

Structure. 2019 May 7;27(5):764-775.e3. doi: 10.1016/j.str.2019.02.002. Epub 2019 Mar 7.

PMID:
30853410
5.

Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins.

Wilhelm I, Levit-Zerdoun E, Jakob J, Villringer S, Frensch M, Übelhart R, Landi A, Müller P, Imberty A, Thuenauer R, Claudinon J, Jumaa H, Reth M, Eibel H, Hobeika E, Römer W.

Sci Signal. 2019 Mar 5;12(571). pii: eaao7194. doi: 10.1126/scisignal.aao7194.

PMID:
30837305
6.

Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside-LecA Interactions.

Denavit V, Lainé D, Bouzriba C, Shanina E, Gillon É, Fortin S, Rademacher C, Imberty A, Giguère D.

Chemistry. 2019 Mar 21;25(17):4478-4490. doi: 10.1002/chem.201806197. Epub 2019 Feb 27.

PMID:
30690814
7.

Expeditious Synthesis of C-Glycosyl Barbiturate Ligands of Bacterial Lectins: From Monomer Design to Glycoclusters and Glycopolymers.

Portier F, Imberty A, Halila S.

Bioconjug Chem. 2019 Mar 20;30(3):647-656. doi: 10.1021/acs.bioconjchem.8b00847. Epub 2019 Jan 10.

PMID:
30590917
8.

Tetraphenylethylene-based glycoclusters with aggregation-induced emission (AIE) properties as high-affinity ligands of bacterial lectins.

Donnier-Maréchal M, Abdullayev S, Bauduin M, Pascal Y, Fu MQ, He XP, Gillon E, Imberty A, Kipnis E, Dessein R, Vidal S.

Org Biomol Chem. 2018 Nov 21;16(45):8804-8809. doi: 10.1039/c8ob02035c.

PMID:
30403242
9.

Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells.

Ribeiro JP, Villringer S, Goyard D, Coche-Guerente L, Höferlin M, Renaudet O, Römer W, Imberty A.

Chem Sci. 2018 Aug 14;9(39):7634-7641. doi: 10.1039/c8sc02730g. eCollection 2018 Oct 21.

10.

Human Bronchial Epithelial Cells Inhibit Aspergillus fumigatus Germination of Extracellular Conidia via FleA Recognition.

Richard N, Marti L, Varrot A, Guillot L, Guitard J, Hennequin C, Imberty A, Corvol H, Chignard M, Balloy V.

Sci Rep. 2018 Oct 24;8(1):15699. doi: 10.1038/s41598-018-33902-0.

11.

Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches.

Soleilhac E, Brillet-Guéguen L, Roussel V, Prudent R, Touquet B, Dass S, Aci-Sèche S, Kasam V, Barette C, Imberty A, Breton V, Vantard M, Horvath D, Botté C, Tardieux I, Roy S, Maréchal E, Lafanechère L.

Int J Mol Sci. 2018 Oct 9;19(10). pii: E3085. doi: 10.3390/ijms19103085.

12.

UniLectin3D, a database of carbohydrate binding proteins with curated information on 3D structures and interacting ligands.

Bonnardel F, Mariethoz J, Salentin S, Robin X, Schroeder M, Perez S, Lisacek F, Imberty A.

Nucleic Acids Res. 2019 Jan 8;47(D1):D1236-D1244. doi: 10.1093/nar/gky832.

13.

Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin.

Dingjan T, Gillon É, Imberty A, Pérez S, Titz A, Ramsland PA, Yuriev E.

J Chem Inf Model. 2018 Sep 24;58(9):1976-1989. doi: 10.1021/acs.jcim.8b00185. Epub 2018 Sep 4.

PMID:
30075071
14.

Effect of Noncanonical Amino Acids on Protein-Carbohydrate Interactions: Structure, Dynamics, and Carbohydrate Affinity of a Lectin Engineered with Fluorinated Tryptophan Analogs.

Tobola F, Lelimousin M, Varrot A, Gillon E, Darnhofer B, Blixt O, Birner-Gruenberger R, Imberty A, Wiltschi B.

ACS Chem Biol. 2018 Aug 17;13(8):2211-2219. doi: 10.1021/acschembio.8b00377. Epub 2018 Jun 12.

15.

Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion.

Villringer S, Madl J, Sych T, Manner C, Imberty A, Römer W.

Sci Rep. 2018 Jan 31;8(1):1932. doi: 10.1038/s41598-018-20230-6.

16.

Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa.

Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff EC, Schreiber J, Ryckmans T, Brunner T, Rademacher C, Hartmann RW, Brönstrup M, Imberty A, Titz A.

J Am Chem Soc. 2018 Feb 21;140(7):2537-2545. doi: 10.1021/jacs.7b11133. Epub 2018 Jan 22.

PMID:
29272578
17.

Multivalent Glycomimetics with Affinity and Selectivity toward Fucose-Binding Receptors from Emerging Pathogens.

Goyard D, Baldoneschi V, Varrot A, Fiore M, Imberty A, Richichi B, Renaudet O, Nativi C.

Bioconjug Chem. 2018 Jan 17;29(1):83-88. doi: 10.1021/acs.bioconjchem.7b00616. Epub 2017 Dec 26.

PMID:
29240403
18.

Perylenediimide-based glycoclusters as high affinity ligands of bacterial lectins: synthesis, binding studies and anti-adhesive properties.

Donnier-Maréchal M, Galanos N, Grandjean T, Pascal Y, Ji DK, Dong L, Gillon E, He XP, Imberty A, Kipnis E, Dessein R, Vidal S.

Org Biomol Chem. 2017 Dec 6;15(47):10037-10043. doi: 10.1039/c7ob02749d.

PMID:
29165489
19.

Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging.

Wagner S, Hauck D, Hoffmann M, Sommer R, Joachim I, Müller R, Imberty A, Varrot A, Titz A.

Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16559-16564. doi: 10.1002/anie.201709368. Epub 2017 Nov 28.

20.

Structural Biology of Glycan Recognition.

Imberty A, H. Prestegard J.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 30.
2017.

21.

Molecular Simulations of Carbohydrates with a Fucose-Binding Burkholderia ambifaria Lectin Suggest Modulation by Surface Residues Outside the Fucose-Binding Pocket.

Dingjan T, Imberty A, Pérez S, Yuriev E, Ramsland PA.

Front Pharmacol. 2017 Jun 21;8:393. doi: 10.3389/fphar.2017.00393. eCollection 2017.

22.

Histo-blood group antigens as mediators of infections.

Heggelund JE, Varrot A, Imberty A, Krengel U.

Curr Opin Struct Biol. 2017 Jun;44:190-200. doi: 10.1016/j.sbi.2017.04.001. Epub 2017 May 23. Review.

PMID:
28544984
23.

Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells.

Machida T, Novoa A, Gillon É, Zheng S, Claudinon J, Eierhoff T, Imberty A, Römer W, Winssinger N.

Angew Chem Int Ed Engl. 2017 Jun 6;56(24):6762-6766. doi: 10.1002/anie.201700813. Epub 2017 May 15.

PMID:
28504473
24.

The Pseudomonas aeruginosa lectin LecA triggers host cell signalling by glycosphingolipid-dependent phosphorylation of the adaptor protein CrkII.

Zheng S, Eierhoff T, Aigal S, Brandel A, Thuenauer R, de Bentzmann S, Imberty A, Römer W.

Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1236-1245. doi: 10.1016/j.bbamcr.2017.04.005. Epub 2017 Apr 17.

25.

Biophysical characterization and structural determination of the potent cytotoxic Psathyrella asperospora lectin.

Ribeiro JP, Ali Abol Hassan M, Rouf R, Tiralongo E, May TW, Day CJ, Imberty A, Tiralongo J, Varrot A.

Proteins. 2017 May;85(5):969-975. doi: 10.1002/prot.25265. Epub 2017 Mar 7.

PMID:
28168856
26.

O-Alkylated heavy atom carbohydrate probes for protein X-ray crystallography: Studies towards the synthesis of methyl 2-O-methyl-L-selenofucopyranoside.

Sommer R, Hauck D, Varrot A, Imberty A, Künzler M, Titz A.

Beilstein J Org Chem. 2016 Dec 22;12:2828-2833. doi: 10.3762/bjoc.12.282. eCollection 2016.

27.

Gb3-binding lectins as potential carriers for transcellular drug delivery.

Müller SK, Wilhelm I, Schubert T, Zittlau K, Imberty A, Madl J, Eierhoff T, Thuenauer R, Römer W.

Expert Opin Drug Deliv. 2017 Feb;14(2):141-153. doi: 10.1080/17425247.2017.1266327. Epub 2016 Dec 16.

PMID:
27935765
28.

Recombinant fungal lectin as a new tool to investigate O-GlcNAcylation processes.

Machon O, Baldini SF, Ribeiro JP, Steenackers A, Varrot A, Lefebvre T, Imberty A.

Glycobiology. 2017 Jan;27(2):123-128. doi: 10.1093/glycob/cww105. Epub 2016 Oct 18.

PMID:
27798069
29.

Biochemical and structural characterization of the novel sialic acid-binding site of Escherichia coli heat-labile enterotoxin LT-IIb.

Zalem D, Ribeiro JP, Varrot A, Lebens M, Imberty A, Teneberg S.

Biochem J. 2016 Nov 1;473(21):3923-3936. Epub 2016 Aug 25.

PMID:
27562297
30.

"Rules of Engagement" of Protein-Glycoconjugate Interactions: A Molecular View Achievable by using NMR Spectroscopy and Molecular Modeling.

Marchetti R, Perez S, Arda A, Imberty A, Jimenez-Barbero J, Silipo A, Molinaro A.

ChemistryOpen. 2016 Jun 7;5(4):274-96. doi: 10.1002/open.201600024. eCollection 2016 Aug. Review.

31.

The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery.

Sommer R, Wagner S, Varrot A, Nycholat CM, Khaledi A, Häussler S, Paulson JC, Imberty A, Titz A.

Chem Sci. 2016 Aug 1;7(8):4990-5001. doi: 10.1039/c6sc00696e. Epub 2016 May 11.

32.

Cinnamide Derivatives of d-Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa.

Sommer R, Hauck D, Varrot A, Wagner S, Audfray A, Prestel A, Möller HM, Imberty A, Titz A.

ChemistryOpen. 2015 Oct 13;4(6):756-67. doi: 10.1002/open.201500162. eCollection 2015 Dec.

33.

Genomic Rearrangements and Functional Diversification of lecA and lecB Lectin-Coding Regions Impacting the Efficacy of Glycomimetics Directed against Pseudomonas aeruginosa.

Boukerb AM, Decor A, Ribun S, Tabaroni R, Rousset A, Commin L, Buff S, Doléans-Jordheim A, Vidal S, Varrot A, Imberty A, Cournoyer B.

Front Microbiol. 2016 May 31;7:811. doi: 10.3389/fmicb.2016.00811. eCollection 2016.

34.

Characterization of a high-affinity sialic acid-specific CBM40 from Clostridium perfringens and engineering of a divalent form.

Ribeiro JP, Pau W, Pifferi C, Renaudet O, Varrot A, Mahal LK, Imberty A.

Biochem J. 2016 Jul 15;473(14):2109-18. doi: 10.1042/BCJ20160340. Epub 2016 May 17.

PMID:
27208171
35.

The Hidden Conformation of Lewis x, a Human Histo-Blood Group Antigen, Is a Determinant for Recognition by Pathogen Lectins.

Topin J, Lelimousin M, Arnaud J, Audfray A, Pérez S, Varrot A, Imberty A.

ACS Chem Biol. 2016 Jul 15;11(7):2011-20. doi: 10.1021/acschembio.6b00333. Epub 2016 May 20.

PMID:
27198630
36.

Pentavalent pillar[5]arene-based glycoclusters and their multivalent binding to pathogenic bacterial lectins.

Galanos N, Gillon E, Imberty A, Matthews SE, Vidal S.

Org Biomol Chem. 2016 Apr 7;14(13):3476-81. doi: 10.1039/c6ob00220j. Epub 2016 Mar 14.

PMID:
26972051
37.

Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin).

Breiman A, López Robles MD, de Carné Trécesson S, Echasserieau K, Bernardeau K, Drickamer K, Imberty A, Barillé-Nion S, Altare F, Le Pendu J.

Oncotarget. 2016 Mar 22;7(12):14064-82. doi: 10.18632/oncotarget.7476.

38.

Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation.

Cott C, Thuenauer R, Landi A, Kühn K, Juillot S, Imberty A, Madl J, Eierhoff T, Römer W.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1106-18. doi: 10.1016/j.bbamcr.2016.02.004. Epub 2016 Feb 6.

39.

Pillar[5]arene-Based Glycoclusters: Synthesis and Multivalent Binding to Pathogenic Bacterial Lectins.

Buffet K, Nierengarten I, Galanos N, Gillon E, Holler M, Imberty A, Matthews SE, Vidal S, Vincent SP, Nierengarten JF.

Chemistry. 2016 Feb 24;22(9):2955-63. doi: 10.1002/chem.201504921. Epub 2016 Feb 4.

PMID:
26845383
40.

Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers.

Michaud G, Visini R, Bergmann M, Salerno G, Bosco R, Gillon E, Richichi B, Nativi C, Imberty A, Stocker A, Darbre T, Reymond JL.

Chem Sci. 2016 Jan 1;7(1):166-182. doi: 10.1039/c5sc03635f. Epub 2015 Nov 25.

41.

Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene-Containing [2]Rotaxane Scaffold.

Vincent SP, Buffet K, Nierengarten I, Imberty A, Nierengarten JF.

Chemistry. 2016 Jan 4;22(1):88-92. doi: 10.1002/chem.201504110. Epub 2015 Nov 3.

42.

Multivalency effects on Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA.

Bergmann M, Michaud G, Visini R, Jin X, Gillon E, Stocker A, Imberty A, Darbre T, Reymond JL.

Org Biomol Chem. 2016 Jan 7;14(1):138-48. doi: 10.1039/c5ob01682g. Epub 2015 Sep 29.

43.

Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA.

Visini R, Jin X, Bergmann M, Michaud G, Pertici F, Fu O, Pukin A, Branson TR, Thies-Weesie DM, Kemmink J, Gillon E, Imberty A, Stocker A, Darbre T, Pieters RJ, Reymond JL.

ACS Chem Biol. 2015 Nov 20;10(11):2455-62. doi: 10.1021/acschembio.5b00302. Epub 2015 Aug 28.

PMID:
26295304
44.

Multivalent thioglycopeptoids via photoclick chemistry: potent affinities towards LecA and BC2L-A lectins.

Caumes C, Gillon E, Legeret B, Taillefumier C, Imberty A, Faure S.

Chem Commun (Camb). 2015 Aug 7;51(61):12301-4. doi: 10.1039/c5cc04646g.

PMID:
26137967
45.

Mannose-centered aromatic galactoclusters inhibit the biofilm formation of Pseudomonas aeruginosa.

Ligeour C, Vidal O, Dupin L, Casoni F, Gillon E, Meyer A, Vidal S, Vergoten G, Lacroix JM, Souteyrand E, Imberty A, Vasseur JJ, Chevolot Y, Morvan F.

Org Biomol Chem. 2015 Aug 21;13(31):8433-44. doi: 10.1039/c5ob00948k.

PMID:
26090586
46.

A recombinant fungal lectin for labeling truncated glycans on human cancer cells.

Audfray A, Beldjoudi M, Breiman A, Hurbin A, Boos I, Unverzagt C, Bouras M, Lantuejoul S, Coll JL, Varrot A, Le Pendu J, Busser B, Imberty A.

PLoS One. 2015 Jun 4;10(6):e0128190. doi: 10.1371/journal.pone.0128190. eCollection 2015.

47.

Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins.

Buffet K, Gillon E, Holler M, Nierengarten JF, Imberty A, Vincent SP.

Org Biomol Chem. 2015 Jun 21;13(23):6482-92. doi: 10.1039/c5ob00689a. Epub 2015 May 13.

PMID:
25967393
48.

Structural insights into Aspergillus fumigatus lectin specificity: AFL binding sites are functionally non-equivalent.

Houser J, Komarek J, Cioci G, Varrot A, Imberty A, Wimmerova M.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):442-53. doi: 10.1107/S1399004714026595. Epub 2015 Feb 26.

PMID:
25760594
49.

Glyco3D: a portal for structural glycosciences.

Pérez S, Sarkar A, Rivet A, Breton C, Imberty A.

Methods Mol Biol. 2015;1273:241-58. doi: 10.1007/978-1-4939-2343-4_18.

PMID:
25753716
50.

Langerin-heparin interaction: two binding sites for small and large ligands as revealed by a combination of NMR spectroscopy and cross-linking mapping experiments.

Muñoz-García JC, Chabrol E, Vivès RR, Thomas A, de Paz JL, Rojo J, Imberty A, Fieschi F, Nieto PM, Angulo J.

J Am Chem Soc. 2015 Apr 1;137(12):4100-10. doi: 10.1021/ja511529x. Epub 2015 Mar 23.

PMID:
25747117

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