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CK2-Dependent Phosphorylation of the Brg1 Chromatin Remodeling Enzyme Occurs during Mitosis.

Padilla-Benavides T, Haokip DT, Yoon Y, Reyes-Gutierrez P, Rivera-Pérez JA, Imbalzano AN.

Int J Mol Sci. 2020 Jan 30;21(3). pii: E923. doi: 10.3390/ijms21030923.


The classic metal-sensing transcription factor MTF1 promotes myogenesis in response to copper.

Tavera-Montañez C, Hainer SJ, Cangussu D, Gordon SJV, Xiao Y, Reyes-Gutierrez P, Imbalzano AN, Navea JG, Fazzio TG, Padilla-Benavides T.

FASEB J. 2019 Dec;33(12):14556-14574. doi: 10.1096/fj.201901606R. Epub 2019 Nov 5.


Promotion of adipogenesis by JMJD6 requires the AT hook-like domain and is independent of its catalytic function.

Reyes-Gutierrez P, Carrasquillo-Rodríguez JW, Imbalzano AN.

PLoS One. 2019 Aug 20;14(8):e0216015. doi: 10.1371/journal.pone.0216015. eCollection 2019.


Calcineurin Broadly Regulates the Initiation of Skeletal Muscle-Specific Gene Expression by Binding Target Promoters and Facilitating the Interaction of the SWI/SNF Chromatin Remodeling Enzyme.

Witwicka H, Nogami J, Syed SA, Maehara K, Padilla-Benavides T, Ohkawa Y, Imbalzano AN.

Mol Cell Biol. 2019 Sep 11;39(19). pii: e00063-19. doi: 10.1128/MCB.00063-19. Print 2019 Oct 1.


Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer.

Fritz AJ, Gillis NE, Gerrard DL, Rodriguez PD, Hong D, Rose JT, Ghule PN, Bolf EL, Gordon JA, Tye CE, Boyd JR, Tracy KM, Nickerson JA, van Wijnen AJ, Imbalzano AN, Heath JL, Frietze SE, Zaidi SK, Carr FE, Lian JB, Stein JL, Stein GS.

Genes Chromosomes Cancer. 2019 Jul;58(7):484-499. doi: 10.1002/gcc.22731. Epub 2019 Mar 15. Review.


BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer.

Muthuswami R, Bailey L, Rakesh R, Imbalzano AN, Nickerson JA, Hockensmith JW.

J Cell Physiol. 2019 Jan 22. doi: 10.1002/jcp.28161. [Epub ahead of print]


RUNX1-dependent mechanisms in biological control and dysregulation in cancer.

Hong D, Fritz AJ, Gordon JA, Tye CE, Boyd JR, Tracy KM, Frietze SE, Carr FE, Nickerson JA, Van Wijnen AJ, Imbalzano AN, Zaidi SK, Lian JB, Stein JL, Stein GS.

J Cell Physiol. 2019 Jun;234(6):8597-8609. doi: 10.1002/jcp.27841. Epub 2018 Dec 4. Review.


Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes.

Zaidi SK, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS.

Mol Cancer Res. 2018 Nov;16(11):1617-1624. doi: 10.1158/1541-7786.MCR-18-0415. Epub 2018 Jul 12. Review.


Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity.

Hong D, Fritz AJ, Zaidi SK, van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS.

J Cell Physiol. 2018 Dec;233(12):9136-9144. doi: 10.1002/jcp.26847. Epub 2018 Jul 3. Review.


Nuclear organization mediates cancer-compromised genetic and epigenetic control.

Zaidi SK, Fritz AJ, Tracy KM, Gordon JA, Tye CE, Boyd J, Van Wijnen AJ, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS.

Adv Biol Regul. 2018 Aug;69:1-10. doi: 10.1016/j.jbior.2018.05.001. Epub 2018 May 9. Review.


Temporal regulation of chromatin during myoblast differentiation.

Harada A, Ohkawa Y, Imbalzano AN.

Semin Cell Dev Biol. 2017 Dec;72:77-86. doi: 10.1016/j.semcdb.2017.10.022. Epub 2017 Oct 28. Review.


Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition.

Padilla-Benavides T, Nasipak BT, Paskavitz AL, Haokip DT, Schnabl JM, Nickerson JA, Imbalzano AN.

J Biol Chem. 2017 Nov 10;292(45):18592-18607. doi: 10.1074/jbc.M117.799676. Epub 2017 Sep 22.


Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer.

Zaidi SK, Frietze SE, Gordon JA, Heath JL, Messier T, Hong D, Boyd JR, Kang M, Imbalzano AN, Lian JB, Stein JL, Stein GS.

Mol Cell Biol. 2017 Nov 13;37(23). pii: e00352-17. doi: 10.1128/MCB.00352-17. Print 2017 Dec 1. Review.


The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer.

Wu Q, Lian JB, Stein JL, Stein GS, Nickerson JA, Imbalzano AN.

Epigenomics. 2017 Jun;9(6):919-931. doi: 10.2217/epi-2017-0034. Epub 2017 May 19. Review.


Intranuclear and higher-order chromatin organization of the major histone gene cluster in breast cancer.

Fritz AJ, Ghule PN, Boyd JR, Tye CE, Page NA, Hong D, Shirley DJ, Weinheimer AS, Barutcu AR, Gerrard DL, Frietze S, van Wijnen AJ, Zaidi SK, Imbalzano AN, Lian JB, Stein JL, Stein GS.

J Cell Physiol. 2018 Feb;233(2):1278-1290. doi: 10.1002/jcp.25996. Epub 2017 Jun 22.


Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming.

Nickerson JA, Wu Q, Imbalzano AN.

Front Oncol. 2017 Apr 4;7:49. doi: 10.3389/fonc.2017.00049. eCollection 2017. Review.


The connection between BRG1, CTCF and topoisomerases at TAD boundaries.

Barutcu AR, Lian JB, Stein JL, Stein GS, Imbalzano AN.

Nucleus. 2017 Mar 4;8(2):150-155. doi: 10.1080/19491034.2016.1276145. Epub 2017 Jan 6. Review.


The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation.

Wu Q, Madany P, Dobson JR, Schnabl JM, Sharma S, Smith TC, van Wijnen AJ, Stein JL, Lian JB, Stein GS, Muthuswami R, Imbalzano AN, Nickerson JA.

Oncotarget. 2016 Jun 21;7(25):38270-38281. doi: 10.18632/oncotarget.9505.


RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.

Barutcu AR, Hong D, Lajoie BR, McCord RP, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS.

Biochim Biophys Acta. 2016 Nov;1859(11):1389-1397. doi: 10.1016/j.bbagrm.2016.08.003. Epub 2016 Aug 9.


Identifying Nuclear Matrix-Attached DNA Across the Genome.

Dobson JR, Hong D, Barutcu AR, Wu H, Imbalzano AN, Lian JB, Stein JL, van Wijnen AJ, Nickerson JA, Stein GS.

J Cell Physiol. 2017 Jun;232(6):1295-1305. doi: 10.1002/jcp.25596. Epub 2017 Jan 5.


SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells.

Barutcu AR, Lajoie BR, Fritz AJ, McCord RP, Nickerson JA, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Stein GS, Imbalzano AN.

Genome Res. 2016 Sep;26(9):1188-201. doi: 10.1101/gr.201624.115. Epub 2016 Jul 19.


Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.

Gerstenberger BS, Trzupek JD, Tallant C, Fedorov O, Filippakopoulos P, Brennan PE, Fedele V, Martin S, Picaud S, Rogers C, Parikh M, Taylor A, Samas B, O'Mahony A, Berg E, Pallares G, Torrey AD, Treiber DK, Samardjiev IJ, Nasipak BT, Padilla-Benavides T, Wu Q, Imbalzano AN, Nickerson JA, Bunnage ME, Müller S, Knapp S, Owen DR.

J Med Chem. 2016 May 26;59(10):4800-11. doi: 10.1021/acs.jmedchem.6b00012. Epub 2016 May 3.


Global gene expression profiling of JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts.

Hu YJ, Imbalzano AN.

Sci Data. 2016 Apr 12;3:160022. doi: 10.1038/sdata.2016.22.


Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells.

Wu Q, Sharma S, Cui H, LeBlanc SE, Zhang H, Muthuswami R, Nickerson JA, Imbalzano AN.

Oncotarget. 2016 May 10;7(19):27158-75. doi: 10.18632/oncotarget.8384.


Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase.

LeBlanc SE, Wu Q, Lamba P, Sif S, Imbalzano AN.

Nucleic Acids Res. 2016 Jun 20;44(11):5133-47. doi: 10.1093/nar/gkw129. Epub 2016 Mar 1.


Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells.

Barutcu AR, Lajoie BR, McCord RP, Tye CE, Hong D, Messier TL, Browne G, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS.

Genome Biol. 2015 Sep 28;16:214. doi: 10.1186/s13059-015-0768-0.


Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus.

Fritz AJ, Barutcu AR, Martin-Buley L, van Wijnen AJ, Zaidi SK, Imbalzano AN, Lian JB, Stein JL, Stein GS.

J Cell Biochem. 2016 Jan;117(1):9-19. doi: 10.1002/jcb.25280.


Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.

Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN.

Nucleic Acids Res. 2015 Sep 18;43(16):7790-804. doi: 10.1093/nar/gkv645. Epub 2015 Jun 27.


Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme.

Nasipak BT, Padilla-Benavides T, Green KM, Leszyk JD, Mao W, Konda S, Sif S, Shaffer SA, Ohkawa Y, Imbalzano AN.

Nat Commun. 2015 Jun 17;6:7441. doi: 10.1038/ncomms8441.


C-ing the Genome: A Compendium of Chromosome Conformation Capture Methods to Study Higher-Order Chromatin Organization.

Barutcu AR, Fritz AJ, Zaidi SK, van Wijnen AJ, Lian JB, Stein JL, Nickerson JA, Imbalzano AN, Stein GS.

J Cell Physiol. 2016 Jan;231(1):31-5. doi: 10.1002/jcp.25062. Review.


Brg1 Controls the Expression of Pax7 to Promote Viability and Proliferation of Mouse Primary Myoblasts.

Padilla-Benavides T, Nasipak BT, Imbalzano AN.

J Cell Physiol. 2015 Dec;230(12):2990-7. doi: 10.1002/jcp.25031.


The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.

Wu Q, Madany P, Akech J, Dobson JR, Douthwright S, Browne G, Colby JL, Winter GE, Bradner JE, Pratap J, Sluder G, Bhargava R, Chiosea SI, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Nickerson JA, Imbalzano AN.

J Cell Physiol. 2015 Nov;230(11):2683-94. doi: 10.1002/jcp.24991.


Spatial re-organization of myogenic regulatory sequences temporally controls gene expression.

Harada A, Mallappa C, Okada S, Butler JT, Baker SP, Lawrence JB, Ohkawa Y, Imbalzano AN.

Nucleic Acids Res. 2015 Feb 27;43(4):2008-21. doi: 10.1093/nar/gkv046. Epub 2015 Feb 4.


Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response.

Yang S, Quaresma AJ, Nickerson JA, Green KM, Shaffer SA, Imbalzano AN, Martin-Buley LA, Lian JB, Stein JL, van Wijnen AJ, Stein GS.

J Cell Sci. 2015 Feb 15;128(4):728-40. doi: 10.1242/jcs.160051. Epub 2015 Jan 20.


Contrasting roles for MyoD in organizing myogenic promoter structures during embryonic skeletal muscle development.

Cho OH, Mallappa C, Hernández-Hernández JM, Rivera-Pérez JA, Imbalzano AN.

Dev Dyn. 2015 Jan;244(1):43-55. doi: 10.1002/dvdy.24217. Epub 2014 Nov 3.


The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter.

Barutcu AR, Tai PW, Wu H, Gordon JA, Whitfield TW, Dobson JR, Imbalzano AN, Lian JB, van Wijnen AJ, Stein JL, Stein GS.

Nucleic Acids Res. 2014;42(16):10360-72. doi: 10.1093/nar/gku712. Epub 2014 Aug 12.


The PPARγ locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner.

LeBlanc SE, Wu Q, Barutcu AR, Xiao H, Ohkawa Y, Imbalzano AN.

PLoS One. 2014 Jan 20;9(1):e86140. doi: 10.1371/journal.pone.0086140. eCollection 2014.


BRG1, a SWI/SNF chromatin remodeling enzyme ATPase, is required for maintenance of nuclear shape and integrity.

Imbalzano AN, Imbalzano KM, Nickerson JA.

Commun Integr Biol. 2013 Sep 1;6(5):e25153. doi: 10.4161/cib.25153. Epub 2013 Jun 4.


Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin.

Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM.

Oncogene. 2014 May 8;33(19):2441-53. doi: 10.1038/onc.2013.220. Epub 2013 Jun 17.


The Scaffold attachment factor b1 (Safb1) regulates myogenic differentiation by facilitating the transition of myogenic gene chromatin from a repressed to an activated state.

Hernández-Hernández JM, Mallappa C, Nasipak BT, Oesterreich S, Imbalzano AN.

Nucleic Acids Res. 2013 Jun;41(11):5704-16. doi: 10.1093/nar/gkt285. Epub 2013 Apr 22.


Nuclear shape changes are induced by knockdown of the SWI/SNF ATPase BRG1 and are independent of cytoskeletal connections.

Imbalzano KM, Cohet N, Wu Q, Underwood JM, Imbalzano AN, Nickerson JA.

PLoS One. 2013;8(2):e55628. doi: 10.1371/journal.pone.0055628. Epub 2013 Feb 6.


Prmt7 is dispensable in tissue culture models for adipogenic differentiation.

Hu YJ, Sif S, Imbalzano AN.

F1000Res. 2013 Dec 18;2:279. doi: 10.12688/f1000research.2-279.v1. eCollection 2013.


Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice.

Tortelote GG, Hernández-Hernández JM, Quaresma AJ, Nickerson JA, Imbalzano AN, Rivera-Pérez JA.

Dev Biol. 2013 Feb 1;374(1):164-73. doi: 10.1016/j.ydbio.2012.10.013. Epub 2012 Oct 16.


Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1.

Karkhanis V, Wang L, Tae S, Hu YJ, Imbalzano AN, Sif S.

J Biol Chem. 2012 Aug 24;287(35):29801-14. doi: 10.1074/jbc.M112.378281. Epub 2012 Jul 2.


Chd2 interacts with H3.3 to determine myogenic cell fate.

Harada A, Okada S, Konno D, Odawara J, Yoshimi T, Yoshimura S, Kumamaru H, Saiwai H, Tsubota T, Kurumizaka H, Akashi K, Tachibana T, Imbalzano AN, Ohkawa Y.

EMBO J. 2012 Jun 29;31(13):2994-3007. doi: 10.1038/emboj.2012.136. Epub 2012 May 8.


Protein arginine methyltransferase 5 (Prmt5) promotes gene expression of peroxisome proliferator-activated receptor γ2 (PPARγ2) and its target genes during adipogenesis.

LeBlanc SE, Konda S, Wu Q, Hu YJ, Oslowski CM, Sif S, Imbalzano AN.

Mol Endocrinol. 2012 Apr;26(4):583-97. doi: 10.1210/me.2011-1162. Epub 2012 Feb 23.


An improved restriction enzyme accessibility assay for analyzing changes in chromatin structure in samples of limited cell number.

Ohkawa Y, Mallappa C, Vallaster CS, Imbalzano AN.

Methods Mol Biol. 2012;798:531-42. doi: 10.1007/978-1-61779-343-1_32.


Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays.

Ohkawa Y, Mallappa C, Vallaster CS, Imbalzano AN.

Methods Mol Biol. 2012;798:517-30. doi: 10.1007/978-1-61779-343-1_31.


Versatility of PRMT5-induced methylation in growth control and development.

Karkhanis V, Hu YJ, Baiocchi RA, Imbalzano AN, Sif S.

Trends Biochem Sci. 2011 Dec;36(12):633-41. doi: 10.1016/j.tibs.2011.09.001. Epub 2011 Oct 3. Review.


Chromatin immunoprecipitation assay for tissue-specific genes using early-stage mouse embryos.

Cho OH, Rivera-Pérez JA, Imbalzano AN.

J Vis Exp. 2011 Apr 29;(50). pii: 2677. doi: 10.3791/2677.

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