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Items: 29

1.

Polyglutamine tracts regulate autophagy.

Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC.

Autophagy. 2017 Sep 2;13(9):1613-1614. doi: 10.1080/15548627.2017.1336278. Epub 2017 Jul 19.

2.

Polyglutamine tracts regulate beclin 1-dependent autophagy.

Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC.

Nature. 2017 May 4;545(7652):108-111. doi: 10.1038/nature22078. Epub 2017 Apr 26.

3.

CCT complex restricts neuropathogenic protein aggregation via autophagy.

Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC.

Nat Commun. 2016 Dec 8;7:13821. doi: 10.1038/ncomms13821.

4.

siRNA screen identifies QPCT as a druggable target for Huntington's disease.

Jimenez-Sanchez M, Lam W, Hannus M, Sönnichsen B, Imarisio S, Fleming A, Tarditi A, Menzies F, Dami TE, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F, Diamanti D, Massai L, Satagopam VP, Marconi G, Caramelli C, Nencini A, Andreini M, Sardone GL, Caradonna NP, Porcari V, Scali C, Schneider R, Pollio G, O'Kane CJ, Caricasole A, Rubinsztein DC.

Nat Chem Biol. 2015 May;11(5):347-354. doi: 10.1038/nchembio.1790. Epub 2015 Apr 6.

5.

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.

Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA, Rao MV, Lam W, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O'Kane CJ, Rubinsztein DC.

Cell Death Differ. 2015 Mar;22(3):433-44. doi: 10.1038/cdd.2014.151. Epub 2014 Sep 26.

6.

PICALM modulates autophagy activity and tau accumulation.

Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, Bento CF, Puri C, Zavodszky E, Siddiqi F, Lavau CP, Betton M, O'Kane CJ, Wechsler DS, Rubinsztein DC.

Nat Commun. 2014 Sep 22;5:4998. doi: 10.1038/ncomms5998.

7.

Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity.

Speretta E, Jahn TR, Tartaglia GG, Favrin G, Barros TP, Imarisio S, Lomas DA, Luheshi LM, Crowther DC, Dobson CM.

J Biol Chem. 2012 Jun 8;287(24):20748-54. doi: 10.1074/jbc.M112.350124. Epub 2012 Mar 29.

8.

Complex inhibitory effects of nitric oxide on autophagy.

Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O'Kane CJ, Rubinsztein DC.

Mol Cell. 2011 Jul 8;43(1):19-32. doi: 10.1016/j.molcel.2011.04.029.

9.

Modeling serpin conformational diseases in Drosophila melanogaster.

Jahn TR, Malzer E, Roote J, Vishnivetskaya A, Imarisio S, Giannakou M, Panser K, Marciniak S, Crowther DC.

Methods Enzymol. 2011;499:227-58. doi: 10.1016/B978-0-12-386471-0.00012-2.

PMID:
21683257
10.

Lysosomal positioning coordinates cellular nutrient responses.

Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC.

Nat Cell Biol. 2011 Apr;13(4):453-60. doi: 10.1038/ncb2204. Epub 2011 Mar 13.

11.

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

Winslow AR, Chen CW, Corrochano S, Acevedo-Arozena A, Gordon DE, Peden AA, Lichtenberg M, Menzies FM, Ravikumar B, Imarisio S, Brown S, O'Kane CJ, Rubinsztein DC.

J Cell Biol. 2010 Sep 20;190(6):1023-37. doi: 10.1083/jcb.201003122.

12.

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.

Menzies FM, Hourez R, Imarisio S, Raspe M, Sadiq O, Chandraratna D, O'Kane C, Rock KL, Reits E, Goldberg AL, Rubinsztein DC.

Hum Mol Genet. 2010 Dec 1;19(23):4573-86. doi: 10.1093/hmg/ddq385. Epub 2010 Sep 9.

13.

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.

Underwood BR, Imarisio S, Fleming A, Rose C, Krishna G, Heard P, Quick M, Korolchuk VI, Renna M, Sarkar S, García-Arencibia M, O'Kane CJ, Murphy MP, Rubinsztein DC.

Hum Mol Genet. 2010 Sep 1;19(17):3413-29. doi: 10.1093/hmg/ddq253. Epub 2010 Jun 21.

14.

Alpha-helix targeting reduces amyloid-beta peptide toxicity.

Nerelius C, Sandegren A, Sargsyan H, Raunak R, Leijonmarck H, Chatterjee U, Fisahn A, Imarisio S, Lomas DA, Crowther DC, Strömberg R, Johansson J.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9191-6. doi: 10.1073/pnas.0810364106. Epub 2009 May 20.

15.

Huntington's disease: from pathology and genetics to potential therapies.

Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC.

Biochem J. 2008 Jun 1;412(2):191-209. doi: 10.1042/BJ20071619. Review.

PMID:
18466116
16.

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease.

Ravikumar B, Imarisio S, Sarkar S, O'Kane CJ, Rubinsztein DC.

J Cell Sci. 2008 May 15;121(Pt 10):1649-60. doi: 10.1242/jcs.025726. Epub 2008 Apr 22.

17.

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC.

Hum Mol Genet. 2008 Jan 15;17(2):170-8. Epub 2007 Oct 6.

PMID:
17921520
18.

The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.

Berto G, Camera P, Fusco C, Imarisio S, Ambrogio C, Chiarle R, Silengo L, Di Cunto F.

J Cell Sci. 2007 Jun 1;120(Pt 11):1859-67. Epub 2007 May 8.

19.

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC.

Nat Chem Biol. 2007 Jun;3(6):331-8. Epub 2007 May 7.

20.

Dyneins, autophagy, aggregation and neurodegeneration.

Rubinsztein DC, Ravikumar B, Acevedo-Arozena A, Imarisio S, O'Kane CJ, Brown SD.

Autophagy. 2005 Oct-Dec;1(3):177-8. Epub 2005 Oct 21. Review.

PMID:
16874055
21.

Lithium induces autophagy by inhibiting inositol monophosphatase.

Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC.

J Cell Biol. 2005 Sep 26;170(7):1101-11.

22.

Dynein mutations impair autophagic clearance of aggregate-prone proteins.

Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, O'Kane CJ, Brown SD, Rubinsztein DC.

Nat Genet. 2005 Jul;37(7):771-6. Epub 2005 Jun 26.

PMID:
15980862
23.

PAkt, cyclin D1 and p27/Kip.1 in glioblastomas with and without EGFR amplification and PTEN mutation.

Fiano V, Ghimenti C, Imarisio S, Silengo L, Schiffer D.

Anticancer Res. 2004 Sep-Oct;24(5A):2643-7.

24.

Drosophila citron kinase is required for the final steps of cytokinesis.

Naim V, Imarisio S, Di Cunto F, Gatti M, Bonaccorsi S.

Mol Biol Cell. 2004 Nov;15(11):5053-63. Epub 2004 Sep 15.

25.

Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation.

Camera P, da Silva JS, Griffiths G, Giuffrida MG, Ferrara L, Schubert V, Imarisio S, Silengo L, Dotti CG, Di Cunto F.

Nat Cell Biol. 2003 Dec;5(12):1071-8. Epub 2003 Nov 2.

PMID:
14595335
26.

Role of citron kinase in dendritic morphogenesis of cortical neurons.

Di Cunto F, Ferrara L, Curtetti R, Imarisio S, Guazzone S, Broccoli V, Bulfone A, Altruda F, Vercelli A, Silengo L.

Brain Res Bull. 2003 May 30;60(4):319-27.

PMID:
12781320
27.

Essential role of citron kinase in cytokinesis of spermatogenic precursors.

Cunto FD, Imarisio S, Camera P, Boitani C, Altruda F, Silengo L.

J Cell Sci. 2002 Dec 15;115(Pt 24):4819-26.

28.

Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes.

Liu H, Di Cunto F, Imarisio S, Reid LM.

J Biol Chem. 2003 Jan 24;278(4):2541-8. Epub 2002 Oct 30.

29.

Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.

Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F.

Neuron. 2000 Oct;28(1):115-27.

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