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Nuclear transport adapts to varying heat stress in a multistep mechanism.

Ogawa Y, Imamoto N.

J Cell Biol. 2018 Jul 2;217(7):2341-2352. doi: 10.1083/jcb.201712042. Epub 2018 May 10.


Enlargement of sacral subcutaneous meningocele associated with retained medullary cord.

Shirozu N, Morioka T, Inoha S, Imamoto N, Sasaguri T.

Childs Nerv Syst. 2018 Sep;34(9):1785-1790. doi: 10.1007/s00381-018-3812-z. Epub 2018 Apr 27.


Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-1.

Matsumoto K, Kose S, Kuwahara I, Yoshimura M, Imamoto N, Yoshida M.

Sci Rep. 2018 Apr 18;8(1):6198. doi: 10.1038/s41598-018-24401-3.


Heat stress-induced nuclear transport mediated by Hikeshi confers nuclear function of Hsp70s.

Imamoto N.

Curr Opin Cell Biol. 2018 Jun;52:82-87. doi: 10.1016/ Epub 2018 Feb 25. Review.


Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms.

Takagi M, Ono T, Natsume T, Sakamoto C, Nakao M, Saitoh N, Kanemaki MT, Hirano T, Imamoto N.

J Cell Sci. 2018 Mar 22;131(6). pii: jcs212092. doi: 10.1242/jcs.212092.


Regulating β-Catenin Nuclear Import with the Small GTPase Rap.

Imamoto N.

Dev Cell. 2018 Jan 22;44(2):135-136. doi: 10.1016/j.devcel.2018.01.004.


A statistical image analysis framework for pore-free islands derived from heterogeneity distribution of nuclear pore complexes.

Mimura Y, Takemoto S, Tachibana T, Ogawa Y, Nishimura M, Yokota H, Imamoto N.

Sci Rep. 2017 Nov 24;7(1):16315. doi: 10.1038/s41598-017-16386-2.


Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s.

Rahman KMZ, Mamada H, Takagi M, Kose S, Imamoto N.

Genes Cells. 2017 Nov;22(11):968-976. doi: 10.1111/gtc.12536. Epub 2017 Oct 5.


The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.

Izumi M, Mizuno T, Yanagi KI, Sugimura K, Okumura K, Imamoto N, Abe T, Hanaoka F.

J Biol Chem. 2017 Aug 4;292(31):13008-13021. doi: 10.1074/jbc.M117.779371. Epub 2017 Jun 22.


Extensive cargo identification reveals distinct biological roles of the 12 importin pathways.

Kimura M, Morinaka Y, Imai K, Kose S, Horton P, Imamoto N.

Elife. 2017 Jan 24;6. pii: e21184. doi: 10.7554/eLife.21184.


ELYS regulates the localization of LBR by modulating its phosphorylation state.

Mimura Y, Takagi M, Clever M, Imamoto N.

J Cell Sci. 2016 Nov 15;129(22):4200-4212. Epub 2016 Oct 6.


Perichromosomal protein Ki67 supports mitotic chromosome architecture.

Takagi M, Natsume T, Kanemaki MT, Imamoto N.

Genes Cells. 2016 Oct;21(10):1113-1124. doi: 10.1111/gtc.12420. Epub 2016 Sep 9.


Longitudinal imaging of the availability of dopamine transporter and D2 receptor in rat striatum following mild ischemia.

Momosaki S, Ito M, Yamato H, Iimori H, Sumiyoshi H, Morimoto K, Imamoto N, Watabe T, Shimosegawa E, Hatazawa J, Abe K.

J Cereb Blood Flow Metab. 2017 Feb;37(2):605-613. doi: 10.1177/0271678X16635183. Epub 2016 Jul 20.


Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells.

Shrestha R, Tatsukawa H, Shrestha R, Ishibashi N, Matsuura T, Kagechika H, Kose S, Hitomi K, Imamoto N, Kojima S.

Cell Death Dis. 2015 Dec 3;6:e2002. doi: 10.1038/cddis.2015.339.


Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.

Edvardson S, Kose S, Jalas C, Fattal-Valevski A, Watanabe A, Ogawa Y, Mamada H, Fedick AM, Ben-Shachar S, Treff NR, Shaag A, Bale S, Gärtner J, Imamoto N, Elpeleg O.

J Med Genet. 2016 Feb;53(2):132-7. doi: 10.1136/jmedgenet-2015-103232. Epub 2015 Nov 6.


Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome.

Miyake N, Tsukaguchi H, Koshimizu E, Shono A, Matsunaga S, Shiina M, Mimura Y, Imamura S, Hirose T, Okudela K, Nozu K, Akioka Y, Hattori M, Yoshikawa N, Kitamura A, Cheong HI, Kagami S, Yamashita M, Fujita A, Miyatake S, Tsurusaki Y, Nakashima M, Saitsu H, Ohashi K, Imamoto N, Ryo A, Ogata K, Iijima K, Matsumoto N.

Am J Hum Genet. 2015 Oct 1;97(4):555-66. doi: 10.1016/j.ajhg.2015.08.013. Epub 2015 Sep 24.


Imaging of reactive oxygen species using [(3)H]hydromethidine in mice with cisplatin-induced nephrotoxicity.

Takai N, Abe K, Tonomura M, Imamoto N, Fukumoto K, Ito M, Momosaki S, Fujisawa K, Morimoto K, Takasu N, Inoue O.

EJNMMI Res. 2015 Dec;5(1):116. doi: 10.1186/s13550-015-0116-0. Epub 2015 Jul 11.


Imaging of reactive oxygen species in focal ischemic mouse brain using a radical trapping tracer [(3)H]hydromethidine.

Abe K, Tonomura M, Ito M, Takai N, Imamoto N, Rokugawa T, Momosaki S, Fukumoto K, Morimoto K, Inoue O.

EJNMMI Res. 2015 Dec;5(1):115. doi: 10.1186/s13550-015-0115-1. Epub 2015 Jun 26.


Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s.

Song J, Kose S, Watanabe A, Son SY, Choi S, Hong H, Yamashita E, Park IY, Imamoto N, Lee SJ.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):473-83. doi: 10.1107/S1399004714026881. Epub 2015 Feb 26.


Reconstitution of nucleocytoplasmic transport using digitonin-permeabilized cells.

Kose S, Funakoshi T, Imamoto N.

Methods Mol Biol. 2015;1262:291-303. doi: 10.1007/978-1-4939-2253-6_18.


In vivo imaging of reactive oxygen species in mouse brain by using [3H]hydromethidine as a potential radical trapping radiotracer.

Abe K, Takai N, Fukumoto K, Imamoto N, Tonomura M, Ito M, Kanegawa N, Sakai K, Morimoto K, Todoroki K, Inoue O.

J Cereb Blood Flow Metab. 2014 Dec;34(12):1907-13. doi: 10.1038/jcbfm.2014.160. Epub 2014 Sep 17.


Analytic 3D imaging of mammalian nucleus at nanoscale using coherent x-rays and optical fluorescence microscopy.

Song C, Takagi M, Park J, Xu R, Gallagher-Jones M, Imamoto N, Ishikawa T.

Biophys J. 2014 Sep 2;107(5):1074-1081. doi: 10.1016/j.bpj.2014.07.028.


RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes.

Tanaka KJ, Ogawa K, Takagi M, Imamoto N, Matsumoto K, Tsujimoto M.

J Biol Chem. 2014 Jul 25;289(30):20490. No abstract available.


Ki67 antigen contributes to the timely accumulation of protein phosphatase 1γ on anaphase chromosomes.

Takagi M, Nishiyama Y, Taguchi A, Imamoto N.

J Biol Chem. 2014 Aug 15;289(33):22877-87. doi: 10.1074/jbc.M114.556647. Epub 2014 Jul 10.


Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery.

Booth DG, Takagi M, Sanchez-Pulido L, Petfalski E, Vargiu G, Samejima K, Imamoto N, Ponting CP, Tollervey D, Earnshaw WC, Vagnarelli P.

Elife. 2014 May 27;3:e01641. doi: 10.7554/eLife.01641.


Novel approaches for the identification of nuclear transport receptor substrates.

Kimura M, Thakar K, Karaca S, Imamoto N, Kehlenbach RH.

Methods Cell Biol. 2014;122:353-78. doi: 10.1016/B978-0-12-417160-2.00016-3.


Analysis of nucleocytoplasmic transport in digitonin-permeabilized cells under different cellular conditions.

Furuta M, Kose S, Kehlenbach RH, Imamoto N.

Methods Cell Biol. 2014;122:331-52. doi: 10.1016/B978-0-12-417160-2.00015-1.


Cell-fusion method to visualize interphase nuclear pore formation.

Maeshima K, Funakoshi T, Imamoto N.

Methods Cell Biol. 2014;122:239-54. doi: 10.1016/B978-0-12-417160-2.00011-4.


Nucleocytoplasmic transport under stress conditions and its role in HSP70 chaperone systems.

Kose S, Imamoto N.

Biochim Biophys Acta. 2014 Sep;1840(9):2953-60. doi: 10.1016/j.bbagen.2014.04.022. Epub 2014 May 2. Review.


The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts.

Oda Y, Kimura M, Kose S, Fasken MB, Corbett AH, Imamoto N.

FEBS Lett. 2014 May 21;588(10):1899-905. doi: 10.1016/j.febslet.2014.04.018. Epub 2014 Apr 24.


Biological significance of the importin-β family-dependent nucleocytoplasmic transport pathways.

Kimura M, Imamoto N.

Traffic. 2014 Jul;15(7):727-48. doi: 10.1111/tra.12174. Epub 2014 May 23. Review.


Control of nuclear size by NPC proteins.

Takagi M, Imamoto N.

Adv Exp Med Biol. 2014;773:571-91. doi: 10.1007/978-1-4899-8032-8_26. Review.


A novel facility for 3D micro-irradiation of living cells in a controlled environment by MeV ions.

Mäckel V, Meissl W, Ikeda T, Clever M, Meissl E, Kobayashi T, Kojima TM, Imamoto N, Ogiwara K, Yamazaki Y.

Rev Sci Instrum. 2014 Jan;85(1):014302. doi: 10.1063/1.4859499.


Identification of cargo proteins specific for importin-β with importin-α applying a stable isotope labeling by amino acids in cell culture (SILAC)-based in vitro transport system.

Kimura M, Okumura N, Kose S, Takao T, Imamoto N.

J Biol Chem. 2013 Aug 23;288(34):24540-9. doi: 10.1074/jbc.M113.489286. Epub 2013 Jul 11.


[11C]PK11195 PET imaging of spinal glial activation after nerve injury in rats.

Imamoto N, Momosaki S, Fujita M, Omachi S, Yamato H, Kimura M, Kanegawa N, Shinohara S, Abe K.

Neuroimage. 2013 Oct 1;79:121-8. doi: 10.1016/j.neuroimage.2013.04.039. Epub 2013 Apr 21.


Cargo recognition explains nuclear transport regulation induced by nuclear pore complex reorganization.

Imamoto N.

J Mol Biol. 2013 Jun 12;425(11):1849-1851. doi: 10.1016/j.jmb.2013.03.037. Epub 2013 Mar 28. No abstract available.


Regulation and coordination of nuclear envelope and nuclear pore complex assembly.

Clever M, Mimura Y, Funakoshi T, Imamoto N.

Nucleus. 2013 Mar-Apr;4(2):105-14. doi: 10.4161/nucl.23796. Epub 2013 Feb 14.


Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.

Chinen T, Kazami S, Nagumo Y, Hayakawa I, Ikedo A, Takagi M, Yokosuka A, Imamoto N, Mimaki Y, Kigoshi H, Osada H, Usui T.

ACS Chem Biol. 2013 May 17;8(5):884-9. doi: 10.1021/cb300641h. Epub 2013 Feb 22.


Local nucleosome dynamics facilitate chromatin accessibility in living mammalian cells.

Hihara S, Pack CG, Kaizu K, Tani T, Hanafusa T, Nozaki T, Takemoto S, Yoshimi T, Yokota H, Imamoto N, Sako Y, Kinjo M, Takahashi K, Nagai T, Maeshima K.

Cell Rep. 2012 Dec 27;2(6):1645-56. doi: 10.1016/j.celrep.2012.11.008. Epub 2012 Dec 13.


Identification of cargo proteins specific for the nucleocytoplasmic transport carrier transportin by combination of an in vitro transport system and stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics.

Kimura M, Kose S, Okumura N, Imai K, Furuta M, Sakiyama N, Tomii K, Horton P, Takao T, Imamoto N.

Mol Cell Proteomics. 2013 Jan;12(1):145-57. doi: 10.1074/mcp.M112.019414. Epub 2012 Oct 19.


Heat-shock stress activates a novel nuclear import pathway mediated by Hikeshi.

Imamoto N, Kose S.

Nucleus. 2012 Sep-Oct;3(5):422-8. doi: 10.4161/nucl.21713. Epub 2012 Aug 16.


Nuclear pore dynamics during the cell cycle.

Imamoto N, Funakoshi T.

Curr Opin Cell Biol. 2012 Aug;24(4):453-9. doi: 10.1016/ Epub 2012 Jul 5. Review.


The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells.

Clever M, Funakoshi T, Mimura Y, Takagi M, Imamoto N.

Nucleus. 2012 Mar 1;3(2):187-99. doi: 10.4161/nucl.19595. Epub 2012 Mar 1.


Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage.

Kose S, Furuta M, Imamoto N.

Cell. 2012 Apr 27;149(3):578-89. doi: 10.1016/j.cell.2012.02.058.


Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure.

Nishino Y, Eltsov M, Joti Y, Ito K, Takata H, Takahashi Y, Hihara S, Frangakis AS, Imamoto N, Ishikawa T, Maeshima K.

EMBO J. 2012 Apr 4;31(7):1644-53. doi: 10.1038/emboj.2012.35. Epub 2012 Feb 17.


Coil embolization for a ruptured posterior cerebral artery aneurysm with vertebrobasilar dolichoectasia.

Yamaguchi S, Ito O, Maeda Y, Murata H, Imamoto N, Yuhi F, Natori Y, Matsukado K.

Neurol Med Chir (Tokyo). 2011;51(9):657-60.


Nuclear size, nuclear pore number and cell cycle.

Maeshima K, Iino H, Hihara S, Imamoto N.

Nucleus. 2011 Mar-Apr;2(2):113-8. doi: 10.4161/nucl.2.2.15446.


Phosphorylation of nucleoporins: signal transduction-mediated regulation of their interaction with nuclear transport receptors.

Kosako H, Imamoto N.

Nucleus. 2010 Jul-Aug;1(4):309-13. doi: 10.4161/nucl.1.4.11744. Epub 2010 Mar 3.


[Coil embolization of a ruptured posterior cerebral artery aneurysm via the internal carotid artery and a posterior communicating artery: a case report].

Yamaguchi S, Ito O, Imamoto N, Murata H, Maeda Y, Yuhi F, Natori Y, Matsukado K.

No Shinkei Geka. 2011 Feb;39(2):171-6. Japanese.


Localization of Pom121 to the inner nuclear membrane is required for an early step of interphase nuclear pore complex assembly.

Funakoshi T, Clever M, Watanabe A, Imamoto N.

Mol Biol Cell. 2011 Apr;22(7):1058-69. doi: 10.1091/mbc.E10-07-0641. Epub 2011 Feb 2.

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