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Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome.

Zhan W, Hsu HC, Morgan T, Ouellette T, Burns-Huang K, Hara R, Wright AG, Imaeda T, Okamoto R, Sato K, Michino M, Ramjee M, Aso K, Meinke PT, Foley M, Nathan CF, Li H, Lin G.

J Med Chem. 2019 Oct 15. doi: 10.1021/acs.jmedchem.9b01187. [Epub ahead of print]


Reduction of the Cytotoxicity of Copper (II) Oxide Nanoparticles by Coating with a Surface-Binding Peptide.

Ishida N, Hosokawa Y, Imaeda T, Hatanaka T.

Appl Biochem Biotechnol. 2019 Aug 17. doi: 10.1007/s12010-019-03108-9. [Epub ahead of print]


Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.

Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano Y, Hashizume S, Aida J, Imaeda T, Okamoto R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinke P, Glickman JF, Patel DJ, Tuschl T.

Nat Commun. 2019 May 21;10(1):2261. doi: 10.1038/s41467-019-08620-4.


Establishing extracorporeal membrane oxygenation team increased number of patients and improved data recording.

Komindr A, Abe R, Tateishi Y, Takahashi Y, Goto J, Wada K, Furukawa Y, Sugiura A, Imaeda T, Suga N, Hattori N, Oda S.

J Intensive Care. 2019 Feb 7;7:11. doi: 10.1186/s40560-019-0366-4. eCollection 2019.


Decreased total iron binding capacity upon intensive care unit admission predicts red blood cell transfusion in critically ill patients.

Imaeda T, Nakada TA, Abe R, Oda S.

PLoS One. 2019 Jan 23;14(1):e0210067. doi: 10.1371/journal.pone.0210067. eCollection 2019.


Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.

Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6863-E6870. doi: 10.1073/pnas.1806109115. Epub 2018 Jul 2.


Factors impacting the efficacy of venlafaxine extended release 75-225 mg/day in patients with major depressive disorder: exploratory post hoc subgroup analyses of a randomized, double-blind, placebo-controlled study in Japan.

Watanabe Y, Asami Y, Hirano Y, Kuribayashi K, Itamura R, Imaeda T.

Neuropsychiatr Dis Treat. 2018 May 16;14:1261-1272. doi: 10.2147/NDT.S146428. eCollection 2018.


Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M.

Nat Commun. 2017 Nov 23;8(1):1827. doi: 10.1038/s41467-017-01770-3.


Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.

Vincent J, Adura C, Gao P, Luz A, Lama L, Asano Y, Okamoto R, Imaeda T, Aida J, Rothamel K, Gogakos T, Steinberg J, Reasoner S, Aso K, Tuschl T, Patel DJ, Glickman JF, Ascano M.

Nat Commun. 2017 Sep 29;8(1):750. doi: 10.1038/s41467-017-00833-9. Erratum in: Nat Commun. 2017 Nov 23;8(1):1827.


Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as potassium-competitive acid blockers.

Imaeda T, Ono K, Nakai K, Hori Y, Matsukawa J, Takagi T, Fujioka Y, Tarui N, Kondo M, Imanishi A, Inatomi N, Kajino M, Itoh F, Nishida H.

Bioorg Med Chem. 2017 Jul 15;25(14):3719-3735. doi: 10.1016/j.bmc.2017.05.012. Epub 2017 May 6.


Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action.

Nishida H, Arikawa Y, Hirase K, Imaeda T, Inatomi N, Hori Y, Matsukawa J, Fujioka Y, Hamada T, Iida M, Nishitani M, Imanishi A, Fukui H, Itoh F, Kajino M.

Bioorg Med Chem. 2017 Jul 1;25(13):3298-3314. doi: 10.1016/j.bmc.2017.04.014. Epub 2017 Apr 13.


Postoperative improvement in DASH score, clinical findings, and nerve conduction velocity in patients with cubital tunnel syndrome.

Ido Y, Uchiyama S, Nakamura K, Itsubo T, Hayashi M, Hata Y, Imaeda T, Kato H.

Sci Rep. 2016 Jun 6;6:27497. doi: 10.1038/srep27497.


Veno-arterial extracorporeal membrane oxygenation for Streptococcus pyogenes toxic shock syndrome in pregnancy.

Imaeda T, Nakada TA, Abe R, Tateishi Y, Oda S.

J Artif Organs. 2016 Jun;19(2):200-3. doi: 10.1007/s10047-015-0884-3. Epub 2016 Jan 12.


A randomized, double-blinded, placebo-controlled study to evaluate the efficacy and safety of venlafaxine extended release and a long-term extension study for patients with major depressive disorder in Japan.

Higuchi T, Kamijima K, Nakagome K, Itamura R, Asami Y, Kuribayashi K, Imaeda T.

Int Clin Psychopharmacol. 2016 Jan;31(1):8-19. doi: 10.1097/YIC.0000000000000105.


Effect of synovial transthyretin amyloid deposition on preoperative symptoms and postoperative recovery of median nerve function among patients with idiopathic carpal tunnel syndrome.

Uchiyama S, Sekijima Y, Tojo K, Sano K, Imaeda T, Moriizumi T, Ikeda S, Kato H.

J Orthop Sci. 2014 Nov;19(6):913-9. doi: 10.1007/s00776-014-0635-y. Epub 2014 Aug 22.


Reliability of the Hand20 questionnaire: comparison with the 36-Item Short-Form Health Survey.

Moritomo H, Imaeda T, Gotani H, Momose T, Abe Y, Oi H, Omokawa S, Sawaizumi T, Nemoto K; Functional Evaluation Committee of Japanese Society for Surgery of Hand.

Hand Surg. 2014;19(1):1-6. doi: 10.1142/S0218810414500014.


Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.

Kono M, Matsumoto T, Imaeda T, Kawamura T, Fujimoto S, Kosugi Y, Odani T, Shimizu Y, Matsui H, Shimojo M, Kori M.

Bioorg Med Chem. 2014 Feb 15;22(4):1468-78. doi: 10.1016/j.bmc.2013.12.023. Epub 2013 Dec 20.


The effect of vascular pedicle preservation on blood flow and clinical outcome following ulnar nerve transposition.

Nakamura K, Uchiyama S, Ido Y, Itsubo T, Hayashi M, Murakami H, Sato N, Imaeda T, Kato H.

J Hand Surg Am. 2014 Feb;39(2):291-302. doi: 10.1016/j.jhsa.2013.10.029. Epub 2013 Dec 15.


Effect of early administration of alendronate after surgery for distal radial fragility fracture on radiological fracture healing time.

Uchiyama S, Itsubo T, Nakamura K, Fujinaga Y, Sato N, Imaeda T, Kadoya M, Kato H.

Bone Joint J. 2013 Nov;95-B(11):1544-50. doi: 10.1302/0301-620X.95B11.31652.


Work-related musculoskeletal disorders in the upper extremity among the staff of a Japanese university hospital.

Onishi T, Kurimoto S, Suzuki M, Imaeda T, Hirata H.

Int Arch Occup Environ Health. 2014 Jul;87(5):547-55. doi: 10.1007/s00420-013-0898-1. Epub 2013 Jul 28.


The impact of lunate morphology on Kienböck's disease.

Tatebe M, Imaeda T, Hirata H.

J Hand Surg Eur Vol. 2015 Jun;40(5):534-6. doi: 10.1177/1753193413491235. Epub 2013 May 27. No abstract available.


Technical difficulties and their prediction in 2-portal endoscopic carpal tunnel release for idiopathic carpal tunnel syndrome.

Uchiyama S, Nakamura K, Itsubo T, Murakami H, Hayashi M, Imaeda T, Kato H.

Arthroscopy. 2013 May;29(5):860-9. doi: 10.1016/j.arthro.2013.01.027. Epub 2013 Mar 26.


Extracorporeal membrane oxygenation is indicated for status asthmaticus refractory to maximal conventional therapy.

Iwamoto T, Ikeda K, Nakajima H, Suga M, Kumano K, Hiraguri M, Imaeda T, Harada D, Shiga Y, Oku R, Nakanishi K.

Ann Allergy Asthma Immunol. 2013 Apr;110(4):300-1. doi: 10.1016/j.anai.2012.12.025. Epub 2013 Jan 29. No abstract available.


Results of ulnar shortening osteotomy for ulnocarpal abutment after malunited distal radius fracture.

Tatebe M, Shinohara T, Okui N, Yamamoto M, Imaeda T, Hirata H.

Acta Orthop Belg. 2012 Dec;78(6):714-8.


Clinical, radiographic, and arthroscopic outcomes after ulnar shortening osteotomy: a long-term follow-up study.

Tatebe M, Shinohara T, Okui N, Yamamoto M, Hirata H, Imaeda T.

J Hand Surg Am. 2012 Dec;37(12):2468-74. doi: 10.1016/j.jhsa.2012.09.011.


Responsiveness of the Japanese version of the patient-rated wrist evaluation (PRWE-J) and physical impairment measurements in evaluating recovery after treatment of ulnocarpal abutment syndrome.

Omokawa S, Imaeda T, Sawaizumi T, Momose T, Gotani H, Abe Y, Moritomo H, Kanaya F.

J Orthop Sci. 2012 Sep;17(5):551-5. doi: 10.1007/s00776-012-0265-1. Epub 2012 Jul 19.


Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines.

Kamata M, Yamashita T, Imaeda T, Tanaka T, Masada S, Kamaura M, Kasai S, Hara R, Sasaki S, Takekawa S, Asami A, Kaisho T, Suzuki N, Ashina S, Ogino H, Nakano Y, Nagisa Y, Kato K, Kato K, Ishihara Y.

J Med Chem. 2012 Mar 8;55(5):2353-66. doi: 10.1021/jm201596h. Epub 2012 Feb 22.


Transgenic sweet potato expressing thionin from barley gives resistance to black rot disease caused by Ceratocystis fimbriata in leaves and storage roots.

Muramoto N, Tanaka T, Shimamura T, Mitsukawa N, Hori E, Koda K, Otani M, Hirai M, Nakamura K, Imaeda T.

Plant Cell Rep. 2012 Jun;31(6):987-97. doi: 10.1007/s00299-011-1217-5. Epub 2012 Jan 3.


Deglycosylation of cellulosomal enzyme enhances cellulosome assembly in Saccharomyces cerevisiae.

Suzuki H, Imaeda T, Kitagawa T, Kohda K.

J Biotechnol. 2012 Jan;157(1):64-70. doi: 10.1016/j.jbiotec.2011.11.015. Epub 2011 Nov 29.


A case of fulminant myocarditis ultimately diagnosed by tenascin C staining.

Kataoka A, Takano H, Imaeda T, Lee K, Ueda M, Funabashi N, Oda S, Komuro I, Kobayashi Y.

Int J Cardiol. 2012 May 31;157(2):e33-4. doi: 10.1016/j.ijcard.2011.09.068. Epub 2011 Oct 10. No abstract available.


[Current and future views from pharmaceutical industry perspectives on development of antidepressants].

Arano I, Imaeda T.

Nihon Shinkei Seishin Yakurigaku Zasshi. 2011 Aug;31(4):181-6. Review. Japanese.


Development and validation of a ten-item questionnaire with explanatory illustrations to assess upper extremity disorders: favorable effect of illustrations in the item reduction process.

Kurimoto S, Suzuki M, Yamamoto M, Okui N, Imaeda T, Hirata H.

J Orthop Sci. 2011 Nov;16(6):737-44. doi: 10.1007/s00776-011-0148-x. Epub 2011 Sep 10.


Arthroscopic findings of Kienböck's disease.

Tatebe M, Hirata H, Shinohara T, Yamamoto M, Okui N, Kurimoto S, Imaeda T.

J Orthop Sci. 2011 Nov;16(6):745-8. doi: 10.1007/s00776-011-0146-z. Epub 2011 Aug 25.


Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists.

Kamata M, Yamashita T, Imaeda T, Tanaka T, Terauchi J, Miyamoto M, Ora T, Tawada M, Endo S, Takekawa S, Asami A, Suzuki N, Nagisa Y, Nakano Y, Watanabe K, Ogino H, Kato K, Kato K, Ishihara Y.

Bioorg Med Chem. 2011 Sep 15;19(18):5539-52. doi: 10.1016/j.bmc.2011.07.038. Epub 2011 Jul 26.


BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats.

Yukitake H, Kimura H, Suzuki H, Tajima Y, Sato Y, Imaeda T, Kajino M, Takizawa M.

PLoS One. 2011;6(8):e23256. doi: 10.1371/journal.pone.0023256. Epub 2011 Aug 10.


High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly.

Sekijima Y, Uchiyama S, Tojo K, Sano K, Shimizu Y, Imaeda T, Hoshii Y, Kato H, Ikeda S.

Hum Pathol. 2011 Nov;42(11):1785-91. doi: 10.1016/j.humpath.2011.03.004.


BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.

Kimura H, Sato Y, Tajima Y, Suzuki H, Yukitake H, Imaeda T, Kajino M, Oki H, Takizawa M, Tanida S.

Chem Biol. 2010 Dec 22;17(12):1282-94. doi: 10.1016/j.chembiol.2010.10.011.


Identification of genes that enhance cellulase protein production in yeast.

Kitagawa T, Kohda K, Tokuhiro K, Hoshida H, Akada R, Takahashi H, Imaeda T.

J Biotechnol. 2011 Jan 20;151(2):194-203. doi: 10.1016/j.jbiotec.2010.12.002. Epub 2010 Dec 15.


Differentiation of pseudodyskinesis of inferior left ventricular wall from inferior myocardial infarction by assessment of regional myocardial strain using two-dimensional speckle tracking echocardiography.

Kataoka A, Funabashi N, Yajima R, Takahashi M, Takahashi A, Saito M, Yamaguchi C, Imaeda T, Lee K, Komuro I.

Int J Cardiol. 2011 Nov 3;152(3):362-8. doi: 10.1016/j.ijcard.2010.08.006. Epub 2010 Sep 9.


Reliability, validity, and responsiveness of the Japanese version of the Patient-Rated Wrist Evaluation.

Imaeda T, Uchiyama S, Wada T, Okinaga S, Sawaizumi T, Omokawa S, Momose T, Moritomo H, Gotani H, Abe Y, Nishida J, Kanaya F; Clinical Outcomes Committee of the Japanese Orthopaedic Association and the Functional Evaluation Committee of the Japanese Society for Surgery of the Hand.

J Orthop Sci. 2010 Jul;15(4):509-17. doi: 10.1007/s00776-010-1477-x. Epub 2010 Aug 19.


Development and validation of an illustrated questionnaire to evaluate disabilities of the upper limb.

Suzuki M, Kurimoto S, Shinohara T, Tatebe M, Imaeda T, Hirata H.

J Bone Joint Surg Br. 2010 Jul;92(7):963-9. doi: 10.1302/0301-620X.92B7.23410.


Construction of a beta-glucosidase expression system using the multistress-tolerant yeast Issatchenkia orientalis.

Kitagawa T, Tokuhiro K, Sugiyama H, Kohda K, Isono N, Hisamatsu M, Takahashi H, Imaeda T.

Appl Microbiol Biotechnol. 2010 Aug;87(5):1841-53. doi: 10.1007/s00253-010-2629-9. Epub 2010 May 14.


Long-term clinical and radiographic outcomes after open reduction for missed Monteggia fracture-dislocations in children.

Nakamura K, Hirachi K, Uchiyama S, Takahara M, Minami A, Imaeda T, Kato H.

J Bone Joint Surg Am. 2009 Jun;91(6):1394-404. doi: 10.2106/JBJS.H.00644.


Electrophysiological responsiveness and quality of life (QuickDASH, CTSI) evaluation of surgically treated carpal tunnel syndrome.

Itsubo T, Uchiyama S, Momose T, Yasutomi T, Imaeda T, Kato H.

J Orthop Sci. 2009 Jan;14(1):17-23. doi: 10.1007/s00776-008-1290-y. Epub 2009 Feb 13.


Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells.

Yano K, Imaeda T, Niimi T.

Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G336-43. Epub 2007 Nov 21.


Construct validity of the Enneking score for measuring function in patients with malignant or aggressive benign tumours of the upper limb.

Wada T, Kawai A, Ihara K, Sasaki M, Sonoda T, Imaeda T, Yamashita T.

J Bone Joint Surg Br. 2007 May;89(5):659-63.


Comparison of responsiveness of the Japanese Society for Surgery of the Hand version of the carpal tunnel syndrome instrument to surgical treatment with DASH, SF-36, and physical findings.

Uchiyama S, Imaeda T, Toh S, Kusunose K, Sawaizumi T, Wada T, Okinaga S, Nishida J, Omokawa S; Clinical Outcomes Committee of the Japanese Orthopaedic Association; Impairment Evaluation Committee of the Japanese Society for Surgery of the Hand.

J Orthop Sci. 2007 May;12(3):249-53. Epub 2007 May 31.


Repair of the triangular fibrocartilage complex after ulnar-shortening osteotomy: second-look arthroscopy.

Tatebe M, Horii E, Nakao E, Shinohara T, Imaeda T, Nakamura R, Hirata H.

J Hand Surg Am. 2007 Apr;32(4):445-9.


Validation of the Japanese Society for Surgery of the Hand version of the Carpal Tunnel Syndrome Instrument.

Imaeda T, Uchiyama S, Toh S, Wada T, Okinaga S, Sawaizumi T, Nishida J, Kusunose K, Omokawa S; Clinical Outcomes Committee of the Japanese Orthopaedic Association and the Impairment Evaluation Committee of the Japanese Society for Surgery of the Hand.

J Orthop Sci. 2007 Jan;12(1):14-21. Epub 2007 Jan 31.


[Pharmacological, pharmacokinetic, and clinical profile of sertraline hydrochloride (J ZOLOFT)].

Harada Y, Kohara N, Imaeda T.

Nihon Yakurigaku Zasshi. 2006 Dec;128(6):417-24. Review. Japanese. No abstract available.


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