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Parkin expression reverses mitochondrial dysfunction in fused in sarcoma-induced amyotrophic lateral sclerosis.

Cha SJ, Choi HJ, Kim HJ, Choi EJ, Song KH, Im DS, Kim K.

Insect Mol Biol. 2019 Jul 10. doi: 10.1111/imb.12608. [Epub ahead of print]


Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties.

Luo K, Lim SW, Jin J, Jin L, Gil HW, Im DS, Hwang HS, Yang CW.

BMC Nephrol. 2019 Jun 14;20(1):221. doi: 10.1186/s12882-019-1399-6.


Lodoxamide Attenuates Hepatic Fibrosis in Mice: Involvement of GPR35?

Kim MJ, Park SJ, Nam SY, Im DS.

Biomol Ther (Seoul). 2019 Jun 13. doi: 10.4062/biomolther.2018.227. [Epub ahead of print]


An Algal Metabolite-Based PPAR-γ Agonist Displayed Anti-Inflammatory Effect via Inhibition of the NF-κB Pathway.

Ju Z, Su M, Li D, Hong J, Im DS, Kim S, Kim E, Jung JH.

Mar Drugs. 2019 May 30;17(6). pii: E321. doi: 10.3390/md17060321.


Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept.

Chung HY, Kim DH, Lee EK, Chung KW, Chung S, Lee B, Seo AY, Chung JH, Jung YS, Im E, Lee J, Kim ND, Choi YJ, Im DS, Yu BP.

Aging Dis. 2019 Apr 1;10(2):367-382. doi: 10.14336/AD.2018.0324. eCollection 2019 Apr. Review.


The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors.

Huang T, González YR, Qu D, Huang E, Safarpour F, Wang E, Joselin A, Im DS, Callaghan SM, Boonying W, Julian L, Dunwoodie SL, Slack RS, Park DS.

J Biol Chem. 2019 May 24;294(21):8617-8629. doi: 10.1074/jbc.RA119.007941. Epub 2019 Apr 9.


Pro-Inflammatory Role of S1P3 in Macrophages.

Heo JY, Im DS.

Biomol Ther (Seoul). 2019 Jul 1;27(4):373-380. doi: 10.4062/biomolther.2018.215.


Stabilization of E2-EPF UCP protein is implicated in hepatitis B virus-associated hepatocellular carcinoma progression.

Lim JH, Kim DG, Yu DY, Kang HM, Noh KH, Kim DS, Park D, Chang TK, Im DS, Jung CR.

Cell Mol Life Sci. 2019 Jul;76(13):2647-2662. doi: 10.1007/s00018-019-03066-9. Epub 2019 Mar 22.


Suppressive effects of type I angiotensin receptor antagonists, candesartan and irbesartan on allergic asthma.

Kim MJ, Im DS.

Eur J Pharmacol. 2019 Jun 5;852:25-33. doi: 10.1016/j.ejphar.2019.02.035. Epub 2019 Feb 21.


Blockage of sphingosine-1-phosphate receptor 2 attenuates allergic asthma in mice.

Park SJ, Im DS.

Br J Pharmacol. 2019 Apr;176(7):938-949. doi: 10.1111/bph.14597. Epub 2019 Mar 14.


Anti-allergic effects of salvianolic acid A and tanshinone IIA from Salvia miltiorrhiza determined using in vivo and in vitro experiments.

Heo JY, Im DS.

Int Immunopharmacol. 2019 Feb;67:69-77. doi: 10.1016/j.intimp.2018.12.010. Epub 2018 Dec 8.


Protective effect of lodoxamide on hepatic steatosis through GPR35.

Nam SY, Park SJ, Im DS.

Cell Signal. 2019 Jan;53:190-200. doi: 10.1016/j.cellsig.2018.10.001. Epub 2018 Oct 7.


Deficiency of Sphingosine-1-Phosphate Receptor 2 (S1P2) Attenuates Bleomycin-Induced Pulmonary Fibrosis.

Park SJ, Im DS.

Biomol Ther (Seoul). 2019 May 1;27(3):318-326. doi: 10.4062/biomolther.2018.131.


Bacterial ornithine lipid, a surrogate membrane lipid under phosphate-limiting conditions, plays important roles in bacterial persistence and interaction with host.

Kim SK, Park SJ, Li XH, Choi YS, Im DS, Lee JH.

Environ Microbiol. 2018 Nov;20(11):3992-4008. doi: 10.1111/1462-2920.14430. Epub 2018 Oct 28.


A bile acid derivative with PPARγ-mediated anti-inflammatory activity.

Liu S, Wang Y, Su M, Song SJ, Hong J, Kim S, Im DS, Jung JH.

Steroids. 2018 Sep;137:40-46. doi: 10.1016/j.steroids.2018.07.011. Epub 2018 Aug 4.


Suppressive Effect of 4-Hydroxy-2-(4-Hydroxyphenethyl) Isoindoline-1,3-Dione on Ovalbumin-Induced Allergic Asthma.

Huang J, Su M, Lee BK, Kim MJ, Jung JH, Im DS.

Biomol Ther (Seoul). 2018 Nov 1;26(6):539-545. doi: 10.4062/biomolther.2018.006.


Ginsenoside Rg3 promotes inflammation resolution through M2 macrophage polarization.

Kang S, Park SJ, Lee AY, Huang J, Chung HY, Im DS.

J Ginseng Res. 2018 Jan;42(1):68-74. doi: 10.1016/j.jgr.2016.12.012. Epub 2017 Jan 1.


Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments.

Lee BK, Park SJ, Nam SY, Kang S, Hwang J, Lee SJ, Im DS.

J Ethnopharmacol. 2018 Mar 1;213:256-261. doi: 10.1016/j.jep.2017.11.018. Epub 2017 Nov 20.


Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).

Kang S, Huang J, Lee BK, Jung YS, Im E, Koh JM, Im DS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Feb;1863(2):105-116. doi: 10.1016/j.bbalip.2017.11.002. Epub 2017 Nov 7.


Inhibition of collagenase and melanogenesis by ethanol extracts of Orostachys japonicus A. Berger: possible involvement of Erk and Akt signaling pathways in melanoma cells.

Im DS, Lee JM, Lee J, Shin HJ, No KT, Park SH, Kim K.

Acta Biochim Biophys Sin (Shanghai). 2017 Oct 1;49(10):945-953. doi: 10.1093/abbs/gmx090.


Free Fatty Acid Receptor 4 Mediates the Beneficial Effects of n-3 Fatty Acids on Body Composition in Mice.

Cho HJ, Ahn SH, Lee YS, Lee SH, Im DS, Kim I, Koh JM, Kim S, Kim BJ.

Calcif Tissue Int. 2017 Dec;101(6):654-662. doi: 10.1007/s00223-017-0323-y. Epub 2017 Sep 12.


FFA4 (GPR120) as a fatty acid sensor involved in appetite control, insulin sensitivity and inflammation regulation.

Im DS.

Mol Aspects Med. 2018 Dec;64:92-108. doi: 10.1016/j.mam.2017.09.001. Epub 2017 Oct 12. Review.


Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo.

Jung HR, Kang HM, Ryu JW, Kim DS, Noh KH, Kim ES, Lee HJ, Chung KS, Cho HS, Kim NS, Im DS, Lim JH, Jung CR.

Sci Rep. 2017 Sep 5;7(1):10499. doi: 10.1038/s41598-017-10828-7.


β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR.

Science. 2017 Sep 1;357(6354):891-898. doi: 10.1126/science.aaf3934.


Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes.

Huang J, Kang S, Park SJ, Im DS.

Cell Signal. 2017 Nov;39:84-94. doi: 10.1016/j.cellsig.2017.08.003. Epub 2017 Aug 15.


Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo.

Iyirhiaro GO, Im DS, Boonying W, Callaghan SM, During MJ, Slack RS, Park DS.

J Neurosci. 2017 Jul 12;37(28):6729-6740. doi: 10.1523/JNEUROSCI.3017-16.2017. Epub 2017 Jun 12.


The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis.

Chung KW, Kim KM, Choi YJ, An HJ, Lee B, Kim DH, Lee EK, Im E, Lee J, Im DS, Yu BP, Chung HY.

Autophagy. 2017 Jul 3;13(7):1113-1129. doi: 10.1080/15548627.2017.1319040. Epub 2017 Jun 2.


Determination of the Mechanisms that Cause Sarcopenia through cDNA Microarray.

Jeong HO, Park D, Im E, Lee J, Im DS, Chung HY.

J Frailty Aging. 2017;6(2):97-102. doi: 10.14283/jfa.2017.13.


Cilastatin attenuates vancomycin-induced nephrotoxicity via P-glycoprotein.

Im DS, Shin HJ, Yang KJ, Jung SY, Song HY, Hwang HS, Gil HW.

Toxicol Lett. 2017 Aug 5;277:9-17. doi: 10.1016/j.toxlet.2017.05.023. Epub 2017 May 23.


ω-3 Polyunsaturated fatty acids accelerate airway repair by activating FFA4 in club cells.

Lee KP, Park SJ, Kang S, Koh JM, Sato K, Chung HY, Okajima F, Im DS.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L835-L844. doi: 10.1152/ajplung.00350.2016. Epub 2017 Mar 17.


The In Vitro and In Vivo Anti-Inflammatory Effects of a Phthalimide PPAR-γ Agonist.

Su M, Cao J, Huang J, Liu S, Im DS, Yoo JW, Jung JH.

Mar Drugs. 2017 Jan 4;15(1). pii: E7. doi: 10.3390/md15010007.


Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery.

Park SJ, Im DS.

Biomol Ther (Seoul). 2017 Jan 1;25(1):80-90. doi: 10.4062/biomolther.2016.160. Review.


Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis.

Altanbyek V, Cha SJ, Kang GU, Im DS, Lee S, Kim HJ, Kim K.

Biochem Biophys Res Commun. 2016 Dec 9;481(3-4):259-264. doi: 10.1016/j.bbrc.2016.10.134. Epub 2016 Oct 31.


Gelation Behaviors and Mechanism of Silk Fibroin According to the Addition of Nitrate Salts.

Im DS, Kim MH, Yoon YI, Park WH.

Int J Mol Sci. 2016 Oct 10;17(10). pii: E1697.


E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue.

Lim JH, Shin HW, Chung KS, Kim NS, Kim JH, Jung HR, Im DS, Jung CR.

PLoS One. 2016 Sep 29;11(9):e0163710. doi: 10.1371/journal.pone.0163710. eCollection 2016.


β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation.

Bae HR, Kim DH, Park MH, Lee B, Kim MJ, Lee EK, Chung KW, Kim SM, Im DS, Chung HY.

Oncotarget. 2016 Oct 11;7(41):66444-66454. doi: 10.18632/oncotarget.12119.


Calcium Signaling of Lysophosphatidylethanolamine through LPA1 in Human SH-SY5Y Neuroblastoma Cells.

Lee JM, Park SJ, Im DS.

Biomol Ther (Seoul). 2017 Mar 1;25(2):194-201. doi: 10.4062/biomolther.2016.046.


Trauma as a Contributor to Violence in Autism Spectrum Disorder.

Im DS.

J Am Acad Psychiatry Law. 2016 Jun;44(2):184-92. Review.


RNA-Seq analysis reveals new evidence for inflammation-related changes in aged kidney.

Park D, Kim BC, Kim CH, Choi YJ, Jeong HO, Kim ME, Lee JS, Park MH, Chung KW, Kim DH, Lee J, Im DS, Yoon S, Lee S, Yu BP, Bhak J, Chung HY.

Oncotarget. 2016 May 24;7(21):30037-48. doi: 10.18632/oncotarget.9152.


Free Fatty Acid Receptor 4 (GPR120) Stimulates Bone Formation and Suppresses Bone Resorption in the Presence of Elevated n-3 Fatty Acid Levels.

Ahn SH, Park SY, Baek JE, Lee SY, Baek WY, Lee SY, Lee YS, Yoo HJ, Kim H, Lee SH, Im DS, Lee SK, Kim BJ, Koh JM.

Endocrinology. 2016 Jul;157(7):2621-35. doi: 10.1210/en.2015-1855. Epub 2016 May 4.


Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments.

Lee AY, Kang S, Park SJ, Huang J, Im DS.

Biomol Ther (Seoul). 2016 May 1;24(3):283-90. doi: 10.4062/biomolther.2016.071.


Template to Perpetrate: An Update on Violence in Autism Spectrum Disorder.

Im DS.

Harv Rev Psychiatry. 2016 Jan-Feb;24(1):14-35. doi: 10.1097/HRP.0000000000000087. Review.


Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity.

Choi YW, Lee KP, Kim JM, Kang S, Park SJ, Lee JM, Moon HR, Jung JH, Lee YG, Im DS.

J Ethnopharmacol. 2016 Feb 3;178:17-24. doi: 10.1016/j.jep.2015.12.010. Epub 2015 Dec 7.


BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival.

Qu D, Hage A, Don-Carolis K, Huang E, Joselin A, Safarpour F, Marcogliese PC, Rousseaux MW, Hewitt SJ, Huang T, Im DS, Callaghan S, Dewar-Darch D, Figeys D, Slack RS, Park DS.

J Biol Chem. 2015 Dec 18;290(51):30441-52. doi: 10.1074/jbc.M115.677815. Epub 2015 Nov 4.


E2-EPF UCP regulates stability and functions of missense mutant pVHL via ubiquitin mediated proteolysis.

Park KS, Kim JH, Shin HW, Chung KS, Im DS, Lim JH, Jung CR.

BMC Cancer. 2015 Oct 26;15:800. doi: 10.1186/s12885-015-1786-8.


Upregulation of Collagen Expression via PPARβ/δ Activation in Aged Skin by Magnesium Lithospermate B from Salvia miltiorrhiza.

Jung YR, Lee EK, Kim DH, Park CH, Park MH, Jeong HO, Yokozawa T, Tanaka T, Im DS, Kim ND, Yu BP, Mo SH, Chung HY.

J Nat Prod. 2015 Aug 28;78(8):2110-5. doi: 10.1021/acs.jnatprod.5b00348. Epub 2015 Aug 17.


Anti-allergic effect of α-cubebenoate isolated from Schisandra chinensis using in vivo and in vitro experiments.

Lee KP, Kang S, Park SJ, Kim JM, Lee JM, Lee AY, Chung HY, Choi YW, Lee YG, Im DS.

J Ethnopharmacol. 2015 Sep 15;173:361-9. doi: 10.1016/j.jep.2015.07.049. Epub 2015 Aug 4.


Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses.

Tobo A, Tobo M, Nakakura T, Ebara M, Tomura H, Mogi C, Im DS, Murata N, Kuwabara A, Ito S, Fukuda H, Arisawa M, Shuto S, Nakaya M, Kurose H, Sato K, Okajima F.

PLoS One. 2015 Jun 12;10(6):e0129334. doi: 10.1371/journal.pone.0129334. eCollection 2015.


Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4.

Kim JM, Lee KP, Park SJ, Kang S, Huang J, Lee JM, Sato K, Chung HY, Okajima F, Im DS.

Acta Pharmacol Sin. 2015 Jul;36(7):813-20. doi: 10.1038/aps.2015.29. Epub 2015 May 25.

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