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Items: 1 to 50 of 523

1.

FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children.

Viisanen T, Gazali AM, Ihantola EL, Ekman I, Näntö-Salonen K, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

Front Immunol. 2019 Jan 22;10:19. doi: 10.3389/fimmu.2019.00019. eCollection 2019.

2.

Publisher Correction: Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.

Vatanen T, Plichta DR, Somani J, Münch PC, Arthur TD, Hall AB, Rudolf S, Oakeley EJ, Ke X, Young RA, Haiser HJ, Kolde R, Yassour M, Luopajärvi K, Siljander H, Virtanen SM, Ilonen J, Uibo R, Tillmann V, Mokurov S, Dorshakova N, Porter JA, McHardy AC, Lähdesmäki H, Vlamakis H, Huttenhower C, Knip M, Xavier RJ.

Nat Microbiol. 2019 Feb 5. doi: 10.1038/s41564-019-0393-x. [Epub ahead of print]

PMID:
30723264
3.

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Dickens AM, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Biomolecules. 2019 Jan 21;9(1). pii: E33. doi: 10.3390/biom9010033.

4.

Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes.

Mäkinen M, Löyttyniemi E, Koskinen M, Vähä-Mäkilä M, Siljander H, Nurmio M, Mykkänen J, Virtanen SM, Simell O, Hyöty H, Ilonen J, Knip M, Veijola R, Toppari J.

J Clin Endocrinol Metab. 2019 Jan 16. doi: 10.1210/jc.2018-02094. [Epub ahead of print]

PMID:
30657906
5.

Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.

Vatanen T, Plichta DR, Somani J, Münch PC, Arthur TD, Hall AB, Rudolf S, Oakeley EJ, Ke X, Young RA, Haiser HJ, Kolde R, Yassour M, Luopajärvi K, Siljander H, Virtanen SM, Ilonen J, Uibo R, Tillmann V, Mokurov S, Dorshakova N, Porter JA, McHardy AC, Lähdesmäki H, Vlamakis H, Huttenhower C, Knip M, Xavier RJ.

Nat Microbiol. 2018 Dec 17. doi: 10.1038/s41564-018-0321-5. [Epub ahead of print] Erratum in: Nat Microbiol. 2019 Feb 5;:.

PMID:
30559407
6.

No evidence of the role of early chemical exposure in the development of β-cell autoimmunity.

Salo HM, Koponen J, Kiviranta H, Rantakokko P, Honkanen J, Härkönen T, Ilonen J, Virtanen SM, Tillmann V, Knip M, Vaarala O; DIABIMMUNE Study Group.

Environ Sci Pollut Res Int. 2019 Jan;26(2):1370-1378. doi: 10.1007/s11356-018-3659-6. Epub 2018 Nov 13.

7.

A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Sci Data. 2018 Nov 13;5:180250. doi: 10.1038/sdata.2018.250.

8.

No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort.

Jääskeläinen AJ, Nurminen N, Kolehmainen P, Smura T, Tauriainen S, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H, Vapalahti O, Kallio-Kokko H.

Pediatr Infect Dis J. 2019 Mar;38(3):314-316. doi: 10.1097/INF.0000000000002201.

PMID:
30346370
9.

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.

Ekman I, Vuorinen T, Knip M, Veijola R, Toppari J, Hyöty H, Kinnunen T, Ilonen J, Lempainen J.

Pediatr Diabetes. 2019 Feb;20(1):73-77. doi: 10.1111/pedi.12788. Epub 2018 Nov 19.

PMID:
30338642
10.

Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption.

Prasad M, Takkinen HM, Uusitalo L, Tapanainen H, Ovaskainen ML, Alfthan G, Erlund I, Ahonen S, Åkerlund M, Toppari J, Ilonen J, Knip M, Veijola R, Virtanen SM.

Nutrients. 2018 Oct 17;10(10). pii: E1533. doi: 10.3390/nu10101533.

11.

Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring.

Korhonen L, Seiskari T, Lehtonen J, Puustinen L, Surcel HM, Haapala AM, Niemelä O, Virtanen SM, Honkanen H, Karjalainen M, Ilonen J, Veijola R, Knip M, Lönnrot M, Hyöty H.

Clin Exp Allergy. 2018 Dec;48(12):1698-1704. doi: 10.1111/cea.13280. Epub 2018 Oct 16.

PMID:
30230072
12.

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP).

Lamichhane S, Ahonen L, Dyrlund TS, Kemppainen E, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Sci Rep. 2018 Jul 13;8(1):10635. doi: 10.1038/s41598-018-28907-8.

13.

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes.

Ihantola EL, Viisanen T, Gazali AM, Näntö-Salonen K, Juutilainen A, Moilanen L, Rintamäki R, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

J Immunol. 2018 Aug 15;201(4):1144-1153. doi: 10.4049/jimmunol.1701199. Epub 2018 Jul 13.

PMID:
30006377
14.

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.

Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ.

Cell Host Microbe. 2018 Jul 11;24(1):146-154.e4. doi: 10.1016/j.chom.2018.06.007.

PMID:
30001517
15.

Sex as a determinant of type 1 diabetes at diagnosis.

Turtinen M, Härkönen T, Parkkola A, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Nov;19(7):1221-1228. doi: 10.1111/pedi.12697. Epub 2018 Jun 17.

PMID:
29862628
16.

Early fecal microbiota composition in children who later develop celiac disease and associated autoimmunity.

Rintala A, Riikonen I, Toivonen A, Pietilä S, Munukka E, Pursiheimo JP, Elo LL, Arikoski P, Luopajärvi K, Schwab U, Uusitupa M, Heinonen S, Savilahti E, Eerola E, Ilonen J.

Scand J Gastroenterol. 2018 Apr;53(4):403-409. doi: 10.1080/00365521.2018.1444788. Epub 2018 Mar 5.

PMID:
29504486
17.

Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.

Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vähä-Mäkilä M, Ilonen J, Veijola R, Knip M, Hyöty H.

Diabetologia. 2018 May;61(5):1193-1202. doi: 10.1007/s00125-018-4561-y. Epub 2018 Feb 5.

PMID:
29404673
18.

Infant Feeding in Relation to the Risk of Advanced Islet Autoimmunity and Type 1 Diabetes in Children With Increased Genetic Susceptibility: A Cohort Study.

Hakola L, Takkinen HM, Niinistö S, Ahonen S, Nevalainen J, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM.

Am J Epidemiol. 2018 Jan 1;187(1):34-44. doi: 10.1093/aje/kwx191.

PMID:
29309515
19.

Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.

Koskinen MK, Lempainen J, Löyttyniemi E, Helminen O, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Ilonen J, Toppari J, Veijola R.

J Clin Endocrinol Metab. 2018 Aug 1;103(8):2870-2878. doi: 10.1210/jc.2017-02040.

20.

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial.

Writing Group for the TRIGR Study Group, Knip M, Åkerblom HK, Al Taji E, Becker D, Bruining J, Castano L, Danne T, de Beaufort C, Dosch HM, Dupre J, Fraser WD, Howard N, Ilonen J, Konrad D, Kordonouri O, Krischer JP, Lawson ML, Ludvigsson J, Madacsy L, Mahon JL, Ormisson A, Palmer JP, Pozzilli P, Savilahti E, Serrano-Rios M, Songini M, Taback S, Vaarala O, White NH, Virtanen SM, Wasikowa R.

JAMA. 2018 Jan 2;319(1):38-48. doi: 10.1001/jama.2017.19826.

21.

Celiac Disease by the Age of 13 Years Is Not Associated With Probiotics Administration in Infancy.

Savilahti EM, Ilonen J, Kukkonen AK, Savilahti E, Kuitunen M.

J Pediatr Gastroenterol Nutr. 2018 Jun;66(6):937-940. doi: 10.1097/MPG.0000000000001846.

PMID:
29210921
22.

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes.

Parkkola A, Laine AP, Karhunen M, Härkönen T, Ryhänen SJ, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

PLoS One. 2017 Nov 28;12(11):e0188402. doi: 10.1371/journal.pone.0188402. eCollection 2017.

23.

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes.

Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL.

Diabetologia. 2018 Feb;61(2):381-388. doi: 10.1007/s00125-017-4460-7. Epub 2017 Nov 8.

PMID:
29119244
24.

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.

Kondrashova A, Nurminen N, Lehtonen J, Hyöty M, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H.

Pediatr Diabetes. 2018 May;19(3):398-402. doi: 10.1111/pedi.12592. Epub 2017 Oct 17.

PMID:
29044779
25.

Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study.

Viskari H, Oikarinen S, Hoppu S, Vuorinen T, Huhtala H, Toppari J, Veijola R, Ilonen J, Knip M, Hyöty H.

Diabetologia. 2018 Jan;61(1):203-209. doi: 10.1007/s00125-017-4410-4. Epub 2017 Sep 2.

PMID:
28866779
26.

Vitamin D intake during the first 4 years and onset of asthma by age 5: A nested case-control study.

Nwaru BI, Hadkhale K, Hämäläinen N, Takkinen HM, Ahonen S, Ilonen J, Toppari J, Niemelä O, Haapala AM, Veijola R, Knip M, Virtanen SM.

Pediatr Allergy Immunol. 2017 Nov;28(7):641-648. doi: 10.1111/pai.12773. Epub 2017 Sep 8.

PMID:
28815786
27.

Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members.

Parkkola A, Härkönen T, Ryhänen SJ, Uibo R, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Mar;19(2):305-313. doi: 10.1111/pedi.12563. Epub 2017 Jul 26.

PMID:
28745034
28.

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.

Zhao G, Vatanen T, Droit L, Park A, Kostic AD, Poon TW, Vlamakis H, Siljander H, Härkönen T, Hämäläinen AM, Peet A, Tillmann V, Ilonen J, Wang D, Knip M, Xavier RJ, Virgin HW.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6166-E6175. doi: 10.1073/pnas.1706359114. Epub 2017 Jul 10. Erratum in: Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11426.

29.

Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial.

Hyytinen M, Savilahti E, Virtanen SM, Härkönen T, Ilonen J, Luopajärvi K, Uibo R, Vaarala O, Åkerblom HK, Knip M; Finnish TRIGR Pilot Study Group.

Gastroenterology. 2017 Oct;153(4):961-970.e3. doi: 10.1053/j.gastro.2017.06.049. Epub 2017 Jul 5.

PMID:
28687275
30.

Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.

Mustonen N, Siljander H, Peet A, Tillmann V, Härkönen T, Ilonen J, Hyöty H, Knip M; DIABIMMUNE Study Group.

Pediatr Diabetes. 2018 Mar;19(2):293-299. doi: 10.1111/pedi.12547. Epub 2017 Jun 9.

PMID:
28597957
31.

Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.

Ilonen J, Lempainen J, Hammais A, Laine AP, Härkönen T, Toppari J, Veijola R, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Mar;19(2):284-292. doi: 10.1111/pedi.12545. Epub 2017 Jun 9.

PMID:
28597949
32.

Ketoacidosis at diagnosis of type 1 diabetes: Effect of prospective studies with newborn genetic screening and follow up of risk children.

Hekkala AM, Ilonen J, Toppari J, Knip M, Veijola R.

Pediatr Diabetes. 2018 Mar;19(2):314-319. doi: 10.1111/pedi.12541. Epub 2017 May 23.

PMID:
28544185
33.

Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity.

Niinistö S, Takkinen HM, Erlund I, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Vaarala O, Virtanen SM.

Diabetologia. 2017 Jul;60(7):1223-1233. doi: 10.1007/s00125-017-4280-9. Epub 2017 May 4.

PMID:
28474159
34.

Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility.

Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Vähäsalo P, Ilonen J, Siljander H, Knip M.

Diabetologia. 2017 Jul;60(7):1284-1293. doi: 10.1007/s00125-017-4258-7. Epub 2017 Mar 31.

PMID:
28364254
35.

Eliminating cows' milk, but not wheat, barley or rye, increases the risk of growth deceleration and nutritional inadequacies.

Tuokkola J, Luukkainen P, Nevalainen J, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Virtanen SM, Kaila M.

Acta Paediatr. 2017 Jul;106(7):1142-1149. doi: 10.1111/apa.13846. Epub 2017 Apr 25.

PMID:
28345135
36.

Serum carotenoid and tocopherol concentrations and risk of asthma in childhood: a nested case-control study.

Hämäläinen N, Nwaru BI, Erlund I, Takkinen HM, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Kaila M, Virtanen SM.

Clin Exp Allergy. 2017 Mar;47(3):401-409. doi: 10.1111/cea.12904.

PMID:
28198577
37.

The association of the HLA-A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in Finns.

Mikk ML, Heikkinen T, El-Amir MI, Kiviniemi M, Laine AP, Härkönen T, Veijola R, Toppari J, Knip M, Ilonen J; Finnish Paediatric Diabetes Register.

HLA. 2017 Apr;89(4):215-224. doi: 10.1111/tan.12967. Epub 2017 Feb 10.

PMID:
28185422
38.

Correction: B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.

Kantola K, Hedman L, Tanner L, Simell V, Mäkinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyöty H, Toppari J, Simell O, Hedman K, Söderlund-Venermo M.

PLoS One. 2017 Feb 8;12(2):e0172078. doi: 10.1371/journal.pone.0172078. eCollection 2017.

39.

Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies.

Viisanen T, Ihantola EL, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

Diabetes. 2017 Feb;66(2):437-447. doi: 10.2337/db16-0714. Epub 2016 Oct 10.

40.

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.

Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Lecouturier V, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H, Knip M, Hyöty H.

Diabetologia. 2017 Mar;60(3):424-431. doi: 10.1007/s00125-016-4177-z. Epub 2017 Jan 9.

PMID:
28070615
41.

A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diabetes.

Salonen KM, Ryhänen SJ, Forbes JM, Härkönen T, Ilonen J, Simell O, Veijola R, Groop PH, Knip M.

Diabetes Metab Res Rev. 2017 May;33(4). doi: 10.1002/dmrr.2872. Epub 2017 Jan 23.

PMID:
27883367
42.

Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls.

Cinek O, Kramna L, Lin J, Oikarinen S, Kolarova K, Ilonen J, Simell O, Veijola R, Autio R, Hyöty H.

Pediatr Diabetes. 2017 Nov;18(7):588-598. doi: 10.1111/pedi.12468. Epub 2016 Nov 17.

PMID:
27860030
43.

Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study.

Seppälä E, Sillanpää S, Nurminen N, Huhtala H, Toppari J, Ilonen J, Veijola R, Knip M, Sipilä M, Laranne J, Oikarinen S, Hyöty H.

J Clin Virol. 2016 Dec;85:1-6. doi: 10.1016/j.jcv.2016.10.010. Epub 2016 Oct 20.

PMID:
27780081
44.

Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries: the prospective DIABIMMUNE study.

Simre K, Uibo O, Peet A, Tillmann V, Kool P, Hämäläinen AM, Härkönen T, Siljander H, Virtanen S, Ilonen J, Knip M, Uibo R; DIABIMMUNE Study Group.

Dig Liver Dis. 2016 Nov;48(11):1296-1301. doi: 10.1016/j.dld.2016.06.029. Epub 2016 Jul 6.

PMID:
27499360
45.

Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life.

Borges IC, Andrade DC, Cardoso MR, Toppari J, Vähä-Mäkilä M, Ilonen J, Knip M, Hyöty H, Veijola R, Simell O, Jartti T, Käyhty H, Ruuskanen O, Nascimento-Carvalho CM.

Clin Vaccine Immunol. 2016 Nov 4;23(11):878-883. Print 2016 Nov.

46.

Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus.

Helminen O, Pokka T, Tossavainen P, Ilonen J, Knip M, Veijola R.

Diabetes Res Clin Pract. 2016 Oct;120:89-96. doi: 10.1016/j.diabres.2016.07.027. Epub 2016 Aug 6.

PMID:
27525364
47.

Role of humoral beta-cell autoimmunity in type 1 diabetes.

Knip M, Siljander H, Ilonen J, Simell O, Veijola R.

Pediatr Diabetes. 2016 Jul;17 Suppl 22:17-24. doi: 10.1111/pedi.12386. Review.

PMID:
27411432
48.

Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity.

Ilonen J, Kiviniemi M, Lempainen J, Simell O, Toppari J, Veijola R, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2016 Jul;17 Suppl 22:8-16. doi: 10.1111/pedi.12327.

PMID:
27411431
49.

Correction: Vol. 18, No. 2.

Meriluoto M, Hedman L, Tanner L, Simell V, Mäkinen M, Simell S, Mykkänen J, Korpelainen J, Ruuskanen O, Ilonen J, Knip M, Simell O, Hedman K, Söderlund-Venermo M.

Emerg Infect Dis. 2016 Sep;22(9):1695. doi: 10.3201/eid2209.C12209. Epub 2016 Sep 15. No abstract available.

50.

Maternal fatty acid intake during pregnancy and the development of childhood overweight: a birth cohort study.

Hakola L, Takkinen HM, Niinistö S, Ahonen S, Erlund I, Rautanen J, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM, Lehtinen-Jacks S.

Pediatr Obes. 2017 Aug;12 Suppl 1:26-37. doi: 10.1111/ijpo.12170. Epub 2016 Jul 5.

PMID:
27378525

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