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Items: 35


Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.

Smith DG, Martinelli R, Besra GS, Illarionov PA, Szatmari I, Brazda P, Allen MA, Xu W, Wang X, Nagy L, Dowell RD, Rook GAW, Rosa Brunet L, Lowry CA.

Psychopharmacology (Berl). 2019 May;236(5):1653-1670. doi: 10.1007/s00213-019-05253-9. Epub 2019 May 22.


A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production.

Birkholz AM, Girardi E, Wingender G, Khurana A, Wang J, Zhao M, Zahner S, Illarionov PA, Wen X, Li M, Yuan W, Porcelli SA, Besra GS, Zajonc DM, Kronenberg M.

J Immunol. 2015 Aug 1;195(3):924-33. doi: 10.4049/jimmunol.1500070. Epub 2015 Jun 15.


Peroxisome proliferator-activated receptor γ-regulated cathepsin D is required for lipid antigen presentation by dendritic cells.

Nakken B, Varga T, Szatmari I, Szeles L, Gyongyosi A, Illarionov PA, Dezso B, Gogolak P, Rajnavolgyi E, Nagy L.

J Immunol. 2011 Jul 1;187(1):240-7. doi: 10.4049/jimmunol.1002421. Epub 2011 Jun 1.


A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids.

Arora P, Venkataswamy MM, Baena A, Bricard G, Li Q, Veerapen N, Ndonye R, Park JJ, Lee JH, Seo KC, Howell AR, Chang YT, Illarionov PA, Besra GS, Chung SK, Porcelli SA.

J Am Chem Soc. 2011 Apr 13;133(14):5198-201. doi: 10.1021/ja200070u. Epub 2011 Mar 22.


A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells.

Wun KS, Cameron G, Patel O, Pang SS, Pellicci DG, Sullivan LC, Keshipeddy S, Young MH, Uldrich AP, Thakur MS, Richardson SK, Howell AR, Illarionov PA, Brooks AG, Besra GS, McCluskey J, Gapin L, Porcelli SA, Godfrey DI, Rossjohn J.

Immunity. 2011 Mar 25;34(3):327-39. doi: 10.1016/j.immuni.2011.02.001. Epub 2011 Mar 3.


Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents.

Bricard G, Venkataswamy MM, Yu KO, Im JS, Ndonye RM, Howell AR, Veerapen N, Illarionov PA, Besra GS, Li Q, Chang YT, Porcelli SA.

PLoS One. 2010 Dec 17;5(12):e14374. doi: 10.1371/journal.pone.0014374.


Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.

Im JS, Arora P, Bricard G, Molano A, Venkataswamy MM, Baine I, Jerud ES, Goldberg MF, Baena A, Yu KO, Ndonye RM, Howell AR, Yuan W, Cresswell P, Chang YT, Illarionov PA, Besra GS, Porcelli SA.

Immunity. 2009 Jun 19;30(6):888-98. doi: 10.1016/j.immuni.2009.03.022.


Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration.

Kuns RD, Morris ES, Macdonald KP, Markey KA, Morris HM, Raffelt NC, Banovic T, Don AL, Rowe V, Burman AC, Clouston AD, Farah C, Besra GS, Illarionov PA, Smyth MJ, Porcelli SA, Hill GR.

Blood. 2009 Jun 4;113(23):5999-6010. doi: 10.1182/blood-2008-10-183335. Epub 2009 Apr 15.


Identification of distinct human invariant natural killer T-cell response phenotypes to alpha-galactosylceramide.

Croudace JE, Curbishley SM, Mura M, Willcox CR, Illarionov PA, Besra GS, Adams DH, Lammas DA.

BMC Immunol. 2008 Dec 3;9:71. doi: 10.1186/1471-2172-9-71.


Serum lipids regulate dendritic cell CD1 expression and function.

Leslie DS, Dascher CC, Cembrola K, Townes MA, Hava DL, Hugendubler LC, Mueller E, Fox L, Roura-Mir C, Moody DB, Vincent MS, Gumperz JE, Illarionov PA, Besra GS, Reynolds CG, Brenner MB.

Immunology. 2008 Nov;125(3):289-301. doi: 10.1111/j.1365-2567.2008.02842.x. Epub 2008 Apr 28.


Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections.

Im JS, Kang TJ, Lee SB, Kim CH, Lee SH, Venkataswamy MM, Serfass ER, Chen B, Illarionov PA, Besra GS, Jacobs WR Jr, Chae GT, Porcelli SA.

Clin Immunol. 2008 May;127(2):214-24. doi: 10.1016/j.clim.2007.12.005. Epub 2008 Mar 4.


Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase.

Molano A, Illarionov PA, Besra GS, Putterman C, Porcelli SA.

Immunol Lett. 2008 Apr 15;117(1):81-90. doi: 10.1016/j.imlet.2007.12.013. Epub 2008 Jan 28.


Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules.

Denkberg G, Stronge VS, Zahavi E, Pittoni P, Oren R, Shepherd D, Salio M, McCarthy C, Illarionov PA, van der Merwe A, Besra GS, Dellabona P, Casorati G, Cerundolo V, Reiter Y.

Eur J Immunol. 2008 Mar;38(3):829-40. doi: 10.1002/eji.200737518.


Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.

Salio M, Speak AO, Shepherd D, Polzella P, Illarionov PA, Veerapen N, Besra GS, Platt FM, Cerundolo V.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20490-5. Epub 2007 Dec 11.


Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries.

Li Q, Ndonye RM, Illarionov PA, Yu KO, Jerud ES, Diaz K, Bricard G, Porcelli SA, Besra GS, Chang YT, Howell AR.

J Comb Chem. 2007 Nov-Dec;9(6):1084-93. Epub 2007 Sep 27.


The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.

McCarthy C, Shepherd D, Fleire S, Stronge VS, Koch M, Illarionov PA, Bossi G, Salio M, Denkberg G, Reddington F, Tarlton A, Reddy BG, Schmidt RR, Reiter Y, Griffiths GM, van der Merwe PA, Besra GS, Jones EY, Batista FD, Cerundolo V.

J Exp Med. 2007 May 14;204(5):1131-44. Epub 2007 May 7.


Distinct endosomal trafficking requirements for presentation of autoantigens and exogenous lipids by human CD1d molecules.

Chen X, Wang X, Keaton JM, Reddington F, Illarionov PA, Besra GS, Gumperz JE.

J Immunol. 2007 May 15;178(10):6181-90.


Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d.

Yu KO, Im JS, Illarionov PA, Ndonye RM, Howell AR, Besra GS, Porcelli SA.

J Immunol Methods. 2007 May 31;323(1):11-23. Epub 2007 Apr 5.


Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules.

Yuan W, Qi X, Tsang P, Kang SJ, Illarionov PA, Besra GS, Gumperz J, Cresswell P.

Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5551-6. Epub 2007 Mar 19. Erratum in: Proc Natl Acad Sci U S A. 2007 May 22;104(21):9099. Illaniorov, Petr A [corrected to Illarionov, Petr A].


Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis.

Tatituri RV, Illarionov PA, Dover LG, Nigou J, Gilleron M, Hitchen P, Krumbach K, Morris HR, Spencer N, Dell A, Eggeling L, Besra GS.

J Biol Chem. 2007 Feb 16;282(7):4561-72. Epub 2006 Dec 19.


An N-linked glycan modulates the interaction between the CD1d heavy chain and beta 2-microglobulin.

Paduraru C, Spiridon L, Yuan W, Bricard G, Valencia X, Porcelli SA, Illarionov PA, Besra GS, Petrescu SM, Petrescu AJ, Cresswell P.

J Biol Chem. 2006 Dec 29;281(52):40369-78. Epub 2006 Oct 27.


Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells.

Im JS, Tapinos N, Chae GT, Illarionov PA, Besra GS, DeVries GH, Modlin RL, Sieling PA, Rambukkana A, Porcelli SA.

J Immunol. 2006 Oct 15;177(8):5226-35.


Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.

Gadola SD, Silk JD, Jeans A, Illarionov PA, Salio M, Besra GS, Dwek R, Butters TD, Platt FM, Cerundolo V.

J Exp Med. 2006 Oct 2;203(10):2293-303. Epub 2006 Sep 18.


PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.

Szatmari I, Pap A, Rühl R, Ma JX, Illarionov PA, Besra GS, Rajnavolgyi E, Dezso B, Nagy L.

J Exp Med. 2006 Oct 2;203(10):2351-62. Epub 2006 Sep 18.


Apolipoprotein-mediated pathways of lipid antigen presentation.

van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB.

Nature. 2005 Oct 6;437(7060):906-10.


Interplay of cytokines and microbial signals in regulation of CD1d expression and NKT cell activation.

Sköld M, Xiong X, Illarionov PA, Besra GS, Behar SM.

J Immunol. 2005 Sep 15;175(6):3584-93.


Expansion and hyperactivity of CD1d-restricted NKT cells during the progression of systemic lupus erythematosus in (New Zealand Black x New Zealand White)F1 mice.

Forestier C, Molano A, Im JS, Dutronc Y, Diamond B, Davidson A, Illarionov PA, Besra GS, Porcelli SA.

J Immunol. 2005 Jul 15;175(2):763-70.


BCR targeting of biotin-{alpha}-galactosylceramide leads to enhanced presentation on CD1d and requires transport of BCR to CD1d-containing endocytic compartments.

Lang GA, Illarionov PA, Glatman-Freedman A, Besra GS, Lang ML.

Int Immunol. 2005 Jul;17(7):899-908. Epub 2005 Jun 20.


Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides.

Yu KO, Im JS, Molano A, Dutronc Y, Illarionov PA, Forestier C, Fujiwara N, Arias I, Miyake S, Yamamura T, Chang YT, Besra GS, Porcelli SA.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3383-8. Epub 2005 Feb 18.


A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan.

Amprey JL, Im JS, Turco SJ, Murray HW, Illarionov PA, Besra GS, Porcelli SA, Späth GF.

J Exp Med. 2004 Oct 4;200(7):895-904.


CD1d-restricted T cell activation by nonlipidic small molecules.

Van Rhijn I, Young DC, Im JS, Levery SB, Illarionov PA, Besra GS, Porcelli SA, Gumperz J, Cheng TY, Moody DB.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13578-83. Epub 2004 Sep 1.


Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.

Guy MR, Illarionov PA, Gurcha SS, Dover LG, Gibson KJ, Smith PW, Minnikin DE, Besra GS.

Biochem J. 2004 Sep 15;382(Pt 3):905-12.


Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):373-6.


Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS.

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3685-8.


Direct measurement of antigen binding properties of CD1 proteins using fluorescent lipid probes.

Im JS, Yu KO, Illarionov PA, LeClair KP, Storey JR, Kennedy MW, Besra GS, Porcelli SA.

J Biol Chem. 2004 Jan 2;279(1):299-310. Epub 2003 Oct 9.

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