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Novel approaches for the treatment of ventricular tachycardia.

Spartalis M, Spartalis E, Tzatzaki E, Tsilimigras DI, Moris D, Kontogiannis C, Livanis E, Iliopoulos DC, Voudris V, Theodorakis GN.

World J Cardiol. 2018 Jul 26;10(7):52-59. doi: 10.4330/wjc.v10.i7.52. Review.


Quantitative analysis and study of the mRNA expression levels of apoptotic genes BCL2, BAX and BCL2L12 in the articular cartilage of an animal model of osteoarthritis.

Kourtis A, Adamopoulos PG, Papalois A, Iliopoulos DC, Babis GC, Scorilas A.

Ann Transl Med. 2018 Jun;6(12):243. doi: 10.21037/atm.2018.05.47.


Epigenetics of gastrointestinal diseases: notes from a workshop.

Marks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME.

Epigenetics. 2018 Jul 30:1-9. doi: 10.1080/15592294.2018.1464351. [Epub ahead of print]


Chios mastic gum decreases renin levels and ameliorates vascular remodeling in renovascular hypertensive rats.

Tzani AI, Doulamis IP, Konstantopoulos PS, Pasiou ED, Daskalopoulou A, Iliopoulos DC, Georgiadis IV, Kavantzas N, Kourkoulis SK, Perrea DN.

Biomed Pharmacother. 2018 Sep;105:899-906. doi: 10.1016/j.biopha.2018.06.067. Epub 2018 Jun 19.


Effect of Aneurysm and Bicuspid Aortic Valve on Layer-Specific Ascending Aorta Mechanics.

Deveja RP, Iliopoulos DC, Kritharis EP, Angouras DC, Sfyris D, Papadodima SA, Sokolis DP.

Ann Thorac Surg. 2018 Jun 28. pii: S0003-4975(18)30890-7. doi: 10.1016/j.athoracsur.2018.05.071. [Epub ahead of print]


Rotablation for Stent Underexpansion: An Effective Alternative.

Spartalis M, Tsilimigras DI, Moris D, Kontogiannis C, Iliopoulos DC, Spartalis E.

Cardiol Res. 2018 Jun;9(3):171-172. doi: 10.14740/cr670w. Epub 2018 Jun 6.


Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice.

Mitchell J, Kim SJ, Koukos G, Seelmann A, Veit B, Shepard B, Blumer-Schuette S, Winter HS, Iliopoulos D, Pothoulakis C, Im E, Rhee SH.

Inflamm Bowel Dis. 2018 Jul 12;24(8):1718-1732. doi: 10.1093/ibd/izy124.


The Role of Angiogenesis Inhibitors in Hypertension: Following "Ariadne's Thread".

Sanidas E, Papadopoulos DP, Velliou M, Tsioufis K, Mantzourani M, Iliopoulos D, Perrea D, Barbetseas J, Papademetriou V.

Am J Hypertens. 2018 Aug 3;31(9):961-969. doi: 10.1093/ajh/hpy087.


MKAD-21 Suppresses the Oncogenic Activity of the miR-21/PPP2R2A/ERK Molecular Network in Bladder Cancer.

Koutsioumpa M, Chen HW, O'Brien N, Koinis F, Mahurkar-Joshi S, Vorvis C, Soroosh A, Luo T, Issakhanian S, Pantuck AJ, Georgoulias V, Iliopoulos D, Slamon DJ, Drakaki A.

Mol Cancer Ther. 2018 Jul;17(7):1430-1440. doi: 10.1158/1535-7163.MCT-17-1049. Epub 2018 Apr 27.


Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation.

Videlock EJ, Mahurkar-Joshi S, Hoffman JM, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L.

Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G140-G157. doi: 10.1152/ajpgi.00288.2017. Epub 2018 Mar 22.


Acute transient myocardial ischemia: A common pathophysiological mechanism in takotsubo syndrome. Is it still a cardiomyopathy?

Spartalis M, Voudris V, Iliopoulos DC, Spartalis E, Siasos G.

J Cardiol. 2018 Aug;72(2):176. doi: 10.1016/j.jjcc.2018.01.008. Epub 2018 Feb 17. No abstract available.


The paradox of increased risk of atrial fibrillation following bariatric surgery.

Spartalis M, Voudris V, Iliopoulos DC, Spartalis E, Siasos G.

J Cardiol. 2018 Jul;72(1):87. doi: 10.1016/j.jjcc.2018.01.003. Epub 2018 Feb 13. No abstract available.


MicroRNA-31-3p Is Involved in Substance P (SP)-Associated Inflammation in Human Colonic Epithelial Cells and Experimental Colitis.

Fang K, Law IKM, Padua D, Sideri A, Huang V, Kevil CG, Iliopoulos D, Pothoulakis C.

Am J Pathol. 2018 Mar;188(3):586-599. doi: 10.1016/j.ajpath.2017.10.023. Epub 2017 Dec 16.


Functional role and therapeutic targeting of microRNAs in inflammatory bowel disease.

Soroosh A, Koutsioumpa M, Pothoulakis C, Iliopoulos D.

Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G256-G262. doi: 10.1152/ajpgi.00268.2017. Epub 2017 Nov 16.


Environmental triggers in IBD: a review of progress and evidence.

Ananthakrishnan AN, Bernstein CN, Iliopoulos D, Macpherson A, Neurath MF, Ali RAR, Vavricka SR, Fiocchi C.

Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):39-49. doi: 10.1038/nrgastro.2017.136. Epub 2017 Oct 11. Review.


Per os colchicine administration in cholesterol fed rabbits: Triglycerides lowering effects without affecting atherosclerosis progress.

Kaminiotis VV, Agrogiannis G, Konstantopoulos P, Androutsopoulou V, Korou LM, Vlachos IS, Dontas IA, Perrea D, Iliopoulos DC.

Lipids Health Dis. 2017 Sep 26;16(1):184. doi: 10.1186/s12944-017-0573-8.


The IBD interactome: an integrated view of aetiology, pathogenesis and therapy.

de Souza HSP, Fiocchi C, Iliopoulos D.

Nat Rev Gastroenterol Hepatol. 2017 Dec;14(12):739-749. doi: 10.1038/nrgastro.2017.110. Epub 2017 Aug 23. Review.


Role of G protein-coupled receptors-microRNA interactions in gastrointestinal pathophysiology.

Law IKM, Padua DM, Iliopoulos D, Pothoulakis C.

Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G361-G372. doi: 10.1152/ajpgi.00144.2017. Epub 2017 Aug 3. Review.


Unique microRNA expression in the colonic mucosa during chronic HIV-1 infection.

Fulcher JA, Koukos G, Koutsioumpa M, Elliott J, Drakaki A, Iliopoulos D, Anton PA.

AIDS. 2017 Sep 10;31(14):1925-1934. doi: 10.1097/QAD.0000000000001582.


Identification of Circulating MicroRNA Signatures in Crohn's Disease Using the Nanostring nCounter Technology.

Oikonomopoulos A, Polytarchou C, Joshi S, Hommes DW, Iliopoulos D.

Inflamm Bowel Dis. 2016 Sep;22(9):2063-9. doi: 10.1097/MIB.0000000000000883.


A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation.

Padua D, Mahurkar-Joshi S, Law IK, Polytarchou C, Vu JP, Pisegna JR, Shih D, Iliopoulos D, Pothoulakis C.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G446-57. doi: 10.1152/ajpgi.00212.2016. Epub 2016 Aug 4.


A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma.

Palumbo T, Poultsides GA, Kouraklis G, Liakakos T, Drakaki A, Peros G, Hatziapostolou M, Iliopoulos D.

BMC Cancer. 2016 Jun 3;16:353. doi: 10.1186/s12885-016-2384-0.


Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer.

Vorvis C, Hatziapostolou M, Mahurkar-Joshi S, Koutsioumpa M, Williams J, Donahue TR, Poultsides GA, Eibl G, Iliopoulos D.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1124-37. doi: 10.1152/ajpgi.00035.2016. Epub 2016 May 5.


Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1α-miR-210 Signaling.

Bakirtzi K, Law IK, Xue X, Iliopoulos D, Shah YM, Pothoulakis C.

J Immunol. 2016 May 15;196(10):4311-21. doi: 10.4049/jimmunol.1501443. Epub 2016 Apr 13.


The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression.

Videlock EJ, Shih W, Adeyemo M, Mahurkar-Joshi S, Presson AP, Polytarchou C, Alberto M, Iliopoulos D, Mayer EA, Chang L.

Psychoneuroendocrinology. 2016 Jul;69:67-76. doi: 10.1016/j.psyneuen.2016.03.016. Epub 2016 Mar 26.


Developments in miRNA gene signaling pathways in pancreatic cancer.

Vorvis C, Koutsioumpa M, Iliopoulos D.

Future Oncol. 2016 May;12(9):1135-50. doi: 10.2217/fon-2015-0050. Epub 2016 Mar 17. Review.


Genome-wide DNA methylation profiling of peripheral blood mononuclear cells in irritable bowel syndrome.

Mahurkar S, Polytarchou C, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L.

Neurogastroenterol Motil. 2016 Mar;28(3):410-22. doi: 10.1111/nmo.12741. Epub 2015 Dec 16.


Identification of a novel substance P (SP)-neurokinin-1 receptor (NK-1R) microRNA-221-5p inflammatory network in human colonic epithelial cells.

Fang K, Sideri A, Law IK, Bakirtzi K, Polytarchou C, Iliopoulos D, Pothoulakis C.

Cell Mol Gastroenterol Hepatol. 2015 Sep 1;1(5):503-515.


Micro-RNA analysis of renal biopsies in human lupus nephritis demonstrates up-regulated miR-422a driving reduction of kallikrein-related peptidase 4.

Krasoudaki E, Banos A, Stagakis E, Loupasakis K, Drakos E, Sinatkas V, Zampoulaki A, Papagianni A, Iliopoulos D, Boumpas DT, Bertsias GK.

Nephrol Dial Transplant. 2016 Oct;31(10):1676-86. doi: 10.1093/ndt/gfv374. Epub 2015 Nov 5.


Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.

Rodriguez JA, Huerta-Yepez S, Law IK, Baay-Guzman GJ, Tirado-Rodriguez B, Hoffman JM, Iliopoulos D, Hommes DW, Verspaget HW, Chang L, Pothoulakis C, Baritaki S.

Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):610-630.


Assessment of Circulating MicroRNAs for the Diagnosis and Disease Activity Evaluation in Patients with Ulcerative Colitis by Using the Nanostring Technology.

Polytarchou C, Oikonomopoulos A, Mahurkar S, Touroutoglou A, Koukos G, Hommes DW, Iliopoulos D.

Inflamm Bowel Dis. 2015 Nov;21(11):2533-9. doi: 10.1097/MIB.0000000000000547.


Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat.

Bradesi S, Karagiannides I, Bakirtzi K, Joshi SM, Koukos G, Iliopoulos D, Pothoulakis C, Mayer EA.

PLoS One. 2015 Jul 29;10(7):e0130938. doi: 10.1371/journal.pone.0130938. eCollection 2015.


Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway.

Drakaki A, Hatziapostolou M, Polytarchou C, Vorvis C, Poultsides GA, Souglakos J, Georgoulias V, Iliopoulos D.

BMC Cancer. 2015 Jul 24;15:542. doi: 10.1186/s12885-015-1562-9.


MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.

Polytarchou C, Hommes DW, Palumbo T, Hatziapostolou M, Koutsioumpa M, Koukos G, van der Meulen-de Jong AE, Oikonomopoulos A, van Deen WK, Vorvis C, Serebrennikova OB, Birli E, Choi J, Chang L, Anton PA, Tsichlis PN, Pothoulakis C, Verspaget HW, Iliopoulos D.

Gastroenterology. 2015 Oct;149(4):981-92.e11. doi: 10.1053/j.gastro.2015.05.057. Epub 2015 Jun 6.


A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium.

Koukos G, Polytarchou C, Kaplan JL, Oikonomopoulos A, Ziring D, Hommes DW, Wahed R, Kokkotou E, Pothoulakis C, Winter HS, Iliopoulos D.

Inflamm Bowel Dis. 2015 May;21(5):996-1005. doi: 10.1097/MIB.0000000000000339.


Latrodectus envenomation in Greece.

Antoniou GN, Iliopoulos D, Kalkouni R, Iliopoulou S, Rigakos G, Baka A.

Perm J. 2014 Fall;18(4):e155-8. doi: 10.7812/TPP/14-028.


The neurotensin-HIF-1α-VEGFα axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis.

Bakirtzi K, West G, Fiocchi C, Law IK, Iliopoulos D, Pothoulakis C.

Am J Pathol. 2014 Dec;184(12):3405-14. doi: 10.1016/j.ajpath.2014.08.015. Epub 2014 Oct 7.


Neurotensin--regulated miR-133α is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis.

Law IK, Bakirtzi K, Polytarchou C, Oikonomopoulos A, Hommes D, Iliopoulos D, Pothoulakis C.

Gut. 2015 Jul;64(7):1095-104. doi: 10.1136/gutjnl-2014-307329. Epub 2014 Aug 11.


Systems biology in inflammatory bowel diseases: ready for prime time.

Polytarchou C, Koukos G, Iliopoulos D.

Curr Opin Gastroenterol. 2014 Jul;30(4):339-46. doi: 10.1097/MOG.0000000000000081. Review.


Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats.

Karagiannides I, Golovatscka V, Bakirtzi K, Sideri A, Salas M, Stavrakis D, Polytarchou C, Iliopoulos D, Pothoulakis C, Bradesi S.

Physiol Rep. 2014 May 12;2(5):e00284. doi: 10.14814/phy2.284. Print 2014.


Effects of aneurysm on the mechanical properties and histologic structure of aortic sinuses.

Kritharis EP, Iliopoulos DC, Papadodima SA, Sokolis DP.

Ann Thorac Surg. 2014 Jul;98(1):72-9. doi: 10.1016/j.athoracsur.2014.03.016. Epub 2014 May 6.


A case of imported Middle East Respiratory Syndrome coronavirus infection and public health response, Greece, April 2014.

Tsiodras S, Baka A, Mentis A, Iliopoulos D, Dedoukou X, Papamavrou G, Karadima S, Emmanouil M, Kossyvakis A, Spanakis N, Pavli A, Maltezou H, Karageorgou A, Spala G, Pitiriga V, Kosmas E, Tsiagklis S, Gkatzias S, Koulouris N, Koutsoukou A, Bakakos P, Markozanhs E, Dionellis G, Pontikis K, Rovina N, Kyriakopoulou M, Efstathiou P, Papadimitriou T, Kremastinou J, Tsakris A, Saroglou G.

Euro Surveill. 2014 Apr 24;19(16):20782. Erratum in: Euro Surveill. 2014;19(17):pii/20786.


XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.

Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt MB, Hatziapostolou M, Lim E, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu DZ, Adoro S, Hu B, Song M, Tan C, Landis MD, Ferrari M, Shin SJ, Brown M, Chang JC, Liu XS, Glimcher LH.

Nature. 2014 Apr 3;508(7494):103-107. doi: 10.1038/nature13119. Epub 2014 Mar 23.


MicroRNA circuits regulate the cancer-inflammation link.

Iliopoulos D.

Sci Signal. 2014 Mar 25;7(318):pe8. doi: 10.1126/scisignal.2005053.


Impaired mechanics and matrix metalloproteinases/inhibitors expression in female ascending thoracic aortic aneurysms.

Sokolis DP, Iliopoulos DC.

J Mech Behav Biomed Mater. 2014 Jun;34:154-64. doi: 10.1016/j.jmbbm.2014.02.015. Epub 2014 Feb 15.


Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN.

Mol Cell. 2014 Feb 20;53(4):577-90. doi: 10.1016/j.molcel.2013.12.018. Epub 2014 Jan 23.


MicroRNA-gene signaling pathways in pancreatic cancer.

Drakaki A, Iliopoulos D.

Biomed J. 2013 Sep-Oct;36(5):200-8. doi: 10.4103/2319-4170.119690. Review.


Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling.

He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M.

Cell. 2013 Oct 10;155(2):384-96. doi: 10.1016/j.cell.2013.09.031.


MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis.

Koukos G, Polytarchou C, Kaplan JL, Morley-Fletcher A, Gras-Miralles B, Kokkotou E, Baril-Dore M, Pothoulakis C, Winter HS, Iliopoulos D.

Gastroenterology. 2013 Oct;145(4):842-52.e2. doi: 10.1053/j.gastro.2013.07.001. Epub 2013 Jul 12.


Re-emergence of animal rabies in northern Greece and subsequent human exposure, October 2012 - March 2013.

Tsiodras S, Dougas G, Baka A, Billinis C, Doudounakis S, Balaska A, Georgakopoulou T, Rigakos G, Kontos V, Tasioudi KE, Tzani M, Tsarouxa P, Iliadou P, Mangana-Vougiouka O, Iliopoulos D, Sapounas S, Efstathiou P, Tsakris A, Hadjichristodoulou C, Kremastinou J.

Euro Surveill. 2013 May 2;18(18):20474.

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