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Items: 46


Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges.

Shibata-Germanos S, Goodman JR, Grieg A, Trivedi CA, Benson BC, Foti SC, Faro A, Castellan RFP, Correra RM, Barber M, Ruhrberg C, Weller RO, Lashley T, Iliff JJ, Hawkins TA, Rihel J.

Acta Neuropathol. 2019 Nov 6. doi: 10.1007/s00401-019-02091-z. [Epub ahead of print]


Vasomotor influences on glymphatic-lymphatic coupling and solute trafficking in the central nervous system.

Goodman JR, Iliff JJ.

J Cereb Blood Flow Metab. 2019 Sep 10:271678X19874134. doi: 10.1177/0271678X19874134. [Epub ahead of print]


Sleep as a Therapeutic Target in the Aging Brain.

Bah TM, Goodman J, Iliff JJ.

Neurotherapeutics. 2019 Jul;16(3):554-568. doi: 10.1007/s13311-019-00769-6. Review.


In response to "Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow?"

Ray L, Iliff JJ, Heys JJ.

Fluids Barriers CNS. 2019 Jul 12;16(1):23. doi: 10.1186/s12987-019-0143-8.


Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis.

Methner C, Mishra A, Golgotiu K, Li Y, Wei W, Yanez ND, Zlokovic B, Wang RK, Alkayed NJ, Kaul S, Iliff JJ.

Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H255-H263. doi: 10.1152/ajpheart.00097.2019. Epub 2019 May 24.


When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow.

Plog BA, Lou N, Pierre CA, Cove A, Kenney HM, Hitomi E, Kang H, Iliff JJ, Zeppenfeld DM, Nedergaard M, Vates GE.

J Neurosurg. 2019 May 17:1-14. doi: 10.3171/2019.2.JNS182675. [Epub ahead of print]


Analysis of convective and diffusive transport in the brain interstitium.

Ray L, Iliff JJ, Heys JJ.

Fluids Barriers CNS. 2019 Mar 6;16(1):6. doi: 10.1186/s12987-019-0126-9.


Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M.

Elife. 2018 Dec 18;7. pii: e40070. doi: 10.7554/eLife.40070.


Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer's Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer's Disease.

Boespflug EL, Simon MJ, Leonard E, Grafe M, Woltjer R, Silbert LC, Kaye JA, Iliff JJ.

J Alzheimers Dis. 2018;66(4):1587-1597. doi: 10.3233/JAD-180367.


Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology.

Simon MJ, Wang MX, Murchison CF, Roese NE, Boespflug EL, Woltjer RL, Iliff JJ.

Sci Rep. 2018 Aug 17;8(1):12389. doi: 10.1038/s41598-018-30779-x.


Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer's dementia subjects.

Goodman JR, Adham ZO, Woltjer RL, Lund AW, Iliff JJ.

Brain Behav Immun. 2018 Oct;73:34-40. doi: 10.1016/j.bbi.2018.07.020. Epub 2018 Jul 25.


The Emerging Relationship Between Interstitial Fluid-Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep.

Boespflug EL, Iliff JJ.

Biol Psychiatry. 2018 Feb 15;83(4):328-336. doi: 10.1016/j.biopsych.2017.11.031. Epub 2017 Dec 7. Review.


The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease.

Burfeind KG, Murchison CF, Westaway SK, Simon MJ, Erten-Lyons D, Kaye JA, Quinn JF, Iliff JJ.

Alzheimers Dement (N Y). 2017 May 26;3(3):348-359. doi: 10.1016/j.trci.2017.05.001. eCollection 2017 Sep.


MR Imaging-based Multimodal Autoidentification of Perivascular Spaces (mMAPS): Automated Morphologic Segmentation of Enlarged Perivascular Spaces at Clinical Field Strength.

Boespflug EL, Schwartz DL, Lahna D, Pollock J, Iliff JJ, Kaye JA, Rooney W, Silbert LC.

Radiology. 2018 Feb;286(2):632-642. doi: 10.1148/radiol.2017170205. Epub 2017 Aug 29.


A transcriptome-based assessment of the astrocytic dystrophin-associated complex in the developing human brain.

Simon MJ, Murchison C, Iliff JJ.

J Neurosci Res. 2018 Feb;96(2):180-193. doi: 10.1002/jnr.24082. Epub 2017 May 16.


Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts.

Wang M, Ding F, Deng S, Guo X, Wang W, Iliff JJ, Nedergaard M.

J Neurosci. 2017 Mar 15;37(11):2870-2877. doi: 10.1523/JNEUROSCI.2112-16.2017. Epub 2017 Feb 10.


Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains.

Zeppenfeld DM, Simon M, Haswell JD, D'Abreo D, Murchison C, Quinn JF, Grafe MR, Woltjer RL, Kaye J, Iliff JJ.

JAMA Neurol. 2017 Jan 1;74(1):91-99. doi: 10.1001/jamaneurol.2016.4370.


Methamphetamine induces the release of endothelin.

Seo JW, Jones SM, Hostetter TA, Iliff JJ, West GA.

J Neurosci Res. 2016 Feb;94(2):170-8. doi: 10.1002/jnr.23697. Epub 2015 Nov 16.


Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease.

Simon MJ, Iliff JJ.

Biochim Biophys Acta. 2016 Mar;1862(3):442-51. doi: 10.1016/j.bbadis.2015.10.014. Epub 2015 Oct 22. Review.


Implications of the discovery of brain lymphatic pathways.

Iliff JJ, Goldman SA, Nedergaard M.

Lancet Neurol. 2015 Oct;14(10):977-9. doi: 10.1016/S1474-4422(15)00221-5. No abstract available.


The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy.

Petraglia AL, Plog BA, Dayawansa S, Dashnaw ML, Czerniecka K, Walker CT, Chen M, Hyrien O, Iliff JJ, Deane R, Huang JH, Nedergaard M.

Surg Neurol Int. 2014 Dec 23;5:184. doi: 10.4103/2152-7806.147566. eCollection 2014.


Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.

Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, Yang L, Singh I, Deane R, Nedergaard M.

J Neurosci. 2014 Dec 3;34(49):16180-93. doi: 10.1523/JNEUROSCI.3020-14.2014.


Impairment of paravascular clearance pathways in the aging brain.

Kress BT, Iliff JJ, Xia M, Wang M, Wei HS, Zeppenfeld D, Xie L, Kang H, Xu Q, Liew JA, Plog BA, Ding F, Deane R, Nedergaard M.

Ann Neurol. 2014 Dec;76(6):845-61. doi: 10.1002/ana.24271. Epub 2014 Sep 26.


The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy.

Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JJ, Deane R, Nedergaard M, Huang JH.

J Neurotrauma. 2014 Jul 1;31(13):1211-24. doi: 10.1089/neu.2013.3255. Epub 2014 Jun 12.


A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation.

Plog BA, Moll KM, Kang H, Iliff JJ, Dashnaw ML, Nedergaard M, Vates GE.

J Neurosci Methods. 2014 May 30;229:44-52. doi: 10.1016/j.jneumeth.2014.04.001. Epub 2014 Apr 13.


Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain.

Iliff JJ, Wang M, Zeppenfeld DM, Venkataraman A, Plog BA, Liao Y, Deane R, Nedergaard M.

J Neurosci. 2013 Nov 13;33(46):18190-9. doi: 10.1523/JNEUROSCI.1592-13.2013.


Sleep drives metabolite clearance from the adult brain.

Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M.

Science. 2013 Oct 18;342(6156):373-7. doi: 10.1126/science.1241224.


Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain.

Rangroo Thrane V, Thrane AS, Plog BA, Thiyagarajan M, Iliff JJ, Deane R, Nagelhus EA, Nedergaard M.

Sci Rep. 2013;3:2582. doi: 10.1038/srep02582.


Is there a cerebral lymphatic system?

Iliff JJ, Nedergaard M.

Stroke. 2013 Jun;44(6 Suppl 1):S93-5. doi: 10.1161/STROKEAHA.112.678698. Review. No abstract available.


Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer.

Yang L, Kress BT, Weber HJ, Thiyagarajan M, Wang B, Deane R, Benveniste H, Iliff JJ, Nedergaard M.

J Transl Med. 2013 May 1;11:107. doi: 10.1186/1479-5876-11-107.


'Hit & Run' model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation.

Ren Z, Iliff JJ, Yang L, Yang J, Chen X, Chen MJ, Giese RN, Wang B, Shi X, Nedergaard M.

J Cereb Blood Flow Metab. 2013 Jun;33(6):834-45. doi: 10.1038/jcbfm.2013.30. Epub 2013 Feb 27.


Brain-wide pathway for waste clearance captured by contrast-enhanced MRI.

Iliff JJ, Lee H, Yu M, Feng T, Logan J, Nedergaard M, Benveniste H.

J Clin Invest. 2013 Mar;123(3):1299-309. doi: 10.1172/JCI67677. Epub 2013 Feb 22.


Cognitive deficits and delayed neuronal loss in a mouse model of multiple microinfarcts.

Wang M, Iliff JJ, Liao Y, Chen MJ, Shinseki MS, Venkataraman A, Cheung J, Wang W, Nedergaard M.

J Neurosci. 2012 Dec 12;32(50):17948-60. doi: 10.1523/JNEUROSCI.1860-12.2012.


A link between glial Ca2+ signaling and hypoxia in aging?

Iliff JJ, Nedergaard M.

J Cereb Blood Flow Metab. 2013 Feb;33(2):170. doi: 10.1038/jcbfm.2012.182. Epub 2012 Dec 5. No abstract available.


A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M.

Sci Transl Med. 2012 Aug 15;4(147):147ra111. doi: 10.1126/scitranslmed.3003748.


Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons.

Iliff JJ, Fairbanks SL, Balkowiec A, Alkayed NJ.

J Neurochem. 2010 Dec;115(6):1530-42. doi: 10.1111/j.1471-4159.2010.07059.x. Epub 2010 Nov 19.


Epoxyeicosanoid signaling in CNS function and disease.

Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ.

Prostaglandins Other Lipid Mediat. 2010 Apr;91(3-4):68-84. doi: 10.1016/j.prostaglandins.2009.06.004. Epub 2009 Jun 21. Review.


Brainstem control of cerebral blood flow and application to acute vasospasm following experimental subarachnoid hemorrhage.

Cetas JS, Lee DR, Alkayed NJ, Wang R, Iliff JJ, Heinricher MM.

Neuroscience. 2009 Oct 6;163(2):719-29. doi: 10.1016/j.neuroscience.2009.06.031. Epub 2009 Jun 17.


Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia.

Zhang W, Iliff JJ, Campbell CJ, Wang RK, Hurn PD, Alkayed NJ.

J Cereb Blood Flow Metab. 2009 Aug;29(8):1475-81. doi: 10.1038/jcbfm.2009.65. Epub 2009 May 27.


Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels.

Iliff JJ, Wang R, Zeldin DC, Alkayed NJ.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1352-63. doi: 10.1152/ajpheart.00950.2008. Epub 2009 Mar 20.


In vivo cerebrovascular effects of cocaine- and amphetamine-regulated transcript (CART) peptide.

Iliff JJ, Alkayed NJ, Golshani KJ, Weinstein J, Traystman RJ, West GA.

J Cardiovasc Pharmacol. 2008 Jul;52(1):82-9. doi: 10.1097/FJC.0b013e31817f9379.


Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ.

Stroke. 2008 Jul;39(7):2073-8. doi: 10.1161/STROKEAHA.107.508325. Epub 2008 Mar 27.


A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat.

Iliff JJ, Close LN, Selden NR, Alkayed NJ.

Exp Physiol. 2007 Jul;92(4):653-8.


Cocaine- and amphetamine-regulated transcript (CART) peptide: a vasoactive role in the cerebral circulation.

Iliff JJ, Alkayed NJ, Gloshani KJ, Traystman RJ, West GA.

J Cereb Blood Flow Metab. 2005 Oct;25(10):1376-85.


Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex.

Iliff JJ, D'Ambrosio R, Ngai AC, Winn HR.

Am J Physiol Heart Circ Physiol. 2003 May;284(5):H1631-7. Epub 2003 Jan 23.

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