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Items: 21


Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.

Heitmeier MR, Hresko RC, Edwards RL, Prinsen MJ, Ilagan MXG, Odom John AR, Hruz PW.

PLoS One. 2019 May 9;14(5):e0216457. doi: 10.1371/journal.pone.0216457. eCollection 2019.


A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface.

Liu G, Nash PJ, Johnson B, Pietzsch C, Ilagan MX, Bukreyev A, Basler CF, Bowlin TL, Moir DT, Leung DW, Amarasinghe GK.

ACS Infect Dis. 2017 Mar 10;3(3):190-198. doi: 10.1021/acsinfecdis.6b00209. Epub 2017 Feb 9.


A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose Transporters.

Kraft TE, Heitmeier MR, Putanko M, Edwards RL, Ilagan MX, Payne MA, Autry JM, Thomas DD, Odom AR, Hruz PW.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7407-7414. Print 2016 Dec.


RNF4-Dependent Oncogene Activation by Protein Stabilization.

Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilagan MXG, Benhamou D, Dittmar G, Kopan R, Birchmeier W, Schwartz AL, Orian A.

Cell Rep. 2016 Sep 20;16(12):3388-3400. doi: 10.1016/j.celrep.2016.08.024.


Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays.

Ilagan MX, Kopan R.

Methods Mol Biol. 2014;1187:155-68. doi: 10.1007/978-1-4939-1139-4_12.


Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays.

Ilagan MX, Kopan R.

Methods Mol Biol. 2014;1187:143-54. doi: 10.1007/978-1-4939-1139-4_11. Review.


Structural analysis uncovers lipid-binding properties of Notch ligands.

Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM.

Cell Rep. 2013 Nov 27;5(4):861-7. doi: 10.1016/j.celrep.2013.10.029. Epub 2013 Nov 14.


The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.

Liu Z, Chen S, Boyle S, Zhu Y, Zhang A, Piwnica-Worms DR, Ilagan MX, Kopan R.

Dev Cell. 2013 Jun 24;25(6):585-98. doi: 10.1016/j.devcel.2013.05.022.


Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch?

Ilagan MX, Kopan R.

Cancer Cell. 2013 Mar 18;23(3):267-9. doi: 10.1016/j.ccr.2013.02.020.


Real-time imaging of notch activation with a luciferase complementation-based reporter.

Ilagan MX, Lim S, Fulbright M, Piwnica-Worms D, Kopan R.

Sci Signal. 2011 Jul 12;4(181):rs7. doi: 10.1126/scisignal.2001656.


An overview of notch signaling in adult tissue renewal and maintenance.

Sato C, Zhao G, Ilagan MX.

Curr Alzheimer Res. 2012 Feb;9(2):227-40. Review.


Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.

Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC.

Nat Struct Mol Biol. 2010 Nov;17(11):1312-7. doi: 10.1038/nsmb.1938. Epub 2010 Oct 24.


Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.

Zhao G, Liu Z, Ilagan MX, Kopan R.

J Neurosci. 2010 Feb 3;30(5):1648-56. doi: 10.1523/JNEUROSCI.3826-09.2010.


The canonical Notch signaling pathway: unfolding the activation mechanism.

Kopan R, Ilagan MX.

Cell. 2009 Apr 17;137(2):216-33. doi: 10.1016/j.cell.2009.03.045. Review.


Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor.

Yang KS, Ilagan MX, Piwnica-Worms D, Pike LJ.

J Biol Chem. 2009 Mar 20;284(12):7474-82. doi: 10.1074/jbc.M808041200. Epub 2009 Jan 26.


SnapShot: notch signaling pathway.

Ilagan MX, Kopan R.

Cell. 2007 Mar 23;128(6):1246. No abstract available.


Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch.

Lubman OY, Ilagan MX, Kopan R, Barrick D.

J Mol Biol. 2007 Jan 19;365(3):577-89. Epub 2006 Oct 3.


Gamma-secretase: proteasome of the membrane?

Kopan R, Ilagan MX.

Nat Rev Mol Cell Biol. 2004 Jun;5(6):499-504. doi: 10.1038/nrm1406. Review. No abstract available.


A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.

Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, Shearman M, Kopan R.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13075-80. Epub 2003 Oct 17.

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