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Page 1
Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation.
Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C. Scheibe K, et al. Gastroenterology. 2019 Mar;156(4):1082-1097.e11. doi: 10.1053/j.gastro.2018.11.029. Epub 2018 Nov 16. Gastroenterology. 2019. PMID: 30452921
We studied the expression of IL36 and its receptor, interleukin 1 receptor like 2 (IL1RL2 or IL36R) in the development of intestinal fibrosis in human tissues and mice. ...Bone marrow cells were transplanted from Il1rl2(-/-) to irradiated wild-type mice and intestin …
We studied the expression of IL36 and its receptor, interleukin 1 receptor like 2 (IL1RL2 or IL36R) in the development of intestinal …
Proteomic and molecular evidences of Il1rl2, Ric8a, Krt18 and Hsp90b1 modulation during experimental hepatic fibrosis and pomegranate supplementation.
Husain H, Waseem M, Ahmad R. Husain H, et al. Int J Biol Macromol. 2021 Aug 31;185:696-707. doi: 10.1016/j.ijbiomac.2021.06.091. Epub 2021 Jun 24. Int J Biol Macromol. 2021. PMID: 34174316
Several genes found relevant after MALDI analysis were evaluated by real-time PCR (RTPCR). Our data revealed CYP2b15, HSP70, TRFE, HPT, Il1rl2, Ric8a, Krt18, Hsp90b1 and iNOS as novel biomarkers for the mechanism of pomegranate against liver fibrosis. ...
Several genes found relevant after MALDI analysis were evaluated by real-time PCR (RTPCR). Our data revealed CYP2b15, HSP70, TRFE, HPT, I …
Interleukin-38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2-p38 pathway-dependent manner.
Kurose S, Matsubara Y, Yoshino S, Yoshiya K, Morisaki K, Furuyama T, Hoshino T, Yoshizumi T. Kurose S, et al. Physiol Rep. 2023 Jan;11(2):e15581. doi: 10.14814/phy2.15581. Physiol Rep. 2023. PMID: 36708509 Free PMC article.
Interleukin-38 (IL-38) is a member of the IL-1 family, which binds to IL-36 receptor (IL1RL2) and has an anti-inflammation effect. Because macrophages express IL1RL2, we hypothesized that IL-38 suppresses AAA formation by controlling macrophages. ...To clarify wheth …
Interleukin-38 (IL-38) is a member of the IL-1 family, which binds to IL-36 receptor (IL1RL2) and has an anti-inflammation effect. Be …
IL-36 cytokines and gut immunity.
Ngo VL, Kuczma M, Maxim E, Denning TL. Ngo VL, et al. Immunology. 2021 Jun;163(2):145-154. doi: 10.1111/imm.13310. Epub 2021 Feb 24. Immunology. 2021. PMID: 33501638 Free PMC article. Review.
Altered expression of IL36gamma and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung's disease.
Tomuschat C, O'Donnell AM, Coyle D, Puri P. Tomuschat C, et al. Pediatr Surg Int. 2017 Feb;33(2):181-186. doi: 10.1007/s00383-016-4011-1. Epub 2016 Nov 16. Pediatr Surg Int. 2017. PMID: 27853811
Animal data suggests that IL1RL2 is involved in mucosal healing. We designed this study to investigate the hypothesis that the IL-36gamma axis is altered in HSCR. METHODS: We investigated IL-36gamma and IL1RL2 expression in ganglionic and aganglionic bowel of HSCR p …
Animal data suggests that IL1RL2 is involved in mucosal healing. We designed this study to investigate the hypothesis that the IL-36g …
Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.
Dale M, Nicklin MJ. Dale M, et al. Genomics. 1999 Apr 1;57(1):177-9. doi: 10.1006/geno.1999.5767. Genomics. 1999. PMID: 10191101
The contig contains the genes (cen --> tel), in the order given, for the type II interleukin-1 (IL-1) receptor (IL1R2), the type I IL-1 receptor (IL1R1), the IL-1 receptor-related protein 2 (IL1RL2), T1/ST2/fit-1 (IL1RL1), and the IL-1 receptor-related protein 1, which …
The contig contains the genes (cen --> tel), in the order given, for the type II interleukin-1 (IL-1) receptor (IL1R2), the type I IL-1 r …
Immune-related gene-based prognostic index for predicting survival and immunotherapy outcomes in colorectal carcinoma.
Liang Z, Sun R, Tu P, Liang Y, Liang L, Liu F, Bian Y, Yin G, Zhao F, Jiang M, Gu J, Tang D. Liang Z, et al. Front Immunol. 2022 Dec 13;13:944286. doi: 10.3389/fimmu.2022.944286. eCollection 2022. Front Immunol. 2022. PMID: 36591255 Free PMC article.
RESULTS: The IRGPI was constructed based on the following 11 hub genes: ADIPOQ, CD36, CCL24, INHBE, UCN, IL1RL2, TRIM58, RBCK1, MC1R, PPARGC1A, and LGALS2. Patients with CRC in the high-risk subgroup showed longer overall survival than those in the low-risk subgroup, which …
RESULTS: The IRGPI was constructed based on the following 11 hub genes: ADIPOQ, CD36, CCL24, INHBE, UCN, IL1RL2, TRIM58, RBCK1, MC1R, …
Development of an immune-related gene prognostic risk model and identification of an immune infiltration signature in the tumor microenvironment of colon cancer.
Hao M, Li H, Yi M, Zhu Y, Wang K, Liu Y, Liang X, Ding L. Hao M, et al. BMC Gastroenterol. 2023 Mar 8;23(1):58. doi: 10.1186/s12876-023-02679-6. BMC Gastroenterol. 2023. PMID: 36890467 Free PMC article.
We developed and validated twelve immune gene models for colon cancer, including SLC10A2, FABP4, FGF2, CCL28, IGKV1-6, IGLV6-57, ESM1, UCN, UTS2, VIP, IL1RL2, NGFR. The model was proved to be an independent prognostic variable with good prognostic ability. ...CONCLUSION: W …
We developed and validated twelve immune gene models for colon cancer, including SLC10A2, FABP4, FGF2, CCL28, IGKV1-6, IGLV6-57, ESM1, UCN, …
55 results