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Items: 1 to 50 of 117

1.

Kanechlor 500-mediated changes in serum and hepatic thyroxine levels primarily occur in a transthyretin-unrelated manner.

Kato Y, Tamaki S, Haraguchi K, Ikushiro SI, Fujii Y, Ohta C, Atobe K, Kimura O, Endo T, Koga N, Yamada S, Degawa M.

J Appl Toxicol. 2019 Sep 9. doi: 10.1002/jat.3895. [Epub ahead of print]

PMID:
31498458
2.

Dynamics of the cellular metabolism of leptosperin found in manuka honey.

Kato Y, Kawai M, Kawai S, Okano Y, Rokkaku N, Ishisaka A, Murota K, Nakamura T, Nakamura Y, Ikushiro S.

J Agric Food Chem. 2019 Sep 8. doi: 10.1021/acs.jafc.9b03894. [Epub ahead of print]

PMID:
31496237
3.

Comprehensive Analyses of Quercetin Conjugates by LC/MS/MS Revealed That Isorhamnetin-7- O-glucuronide-4'- O-sulfate Is a Major Metabolite in Plasma of Rats Fed with Quercetin Glucosides.

Tanaka S, Trakooncharoenvit A, Nishikawa M, Ikushiro S, Hara H.

J Agric Food Chem. 2019 Apr 17;67(15):4240-4249. doi: 10.1021/acs.jafc.8b06929. Epub 2019 Apr 3.

PMID:
30895786
4.

Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques.

Uno Y, Takahira R, Murayama N, Onozeki S, Kawamura S, Uehara S, Ikenaka Y, Ishizuka M, Ikushiro S, Yamazaki H.

Biochem Pharmacol. 2019 May;163:335-344. doi: 10.1016/j.bcp.2019.03.002. Epub 2019 Mar 2.

PMID:
30836059
5.

Sulfate conjugates are the major metabolites in rats administrated with sesamin.

Yasuda K, Okamoto K, Ueno S, Itoh K, Nishikawa M, Ikushiro S, Sakaki T.

Drug Metab Pharmacokinet. 2019 Apr;34(2):134-140. doi: 10.1016/j.dmpk.2018.12.004. Epub 2018 Dec 31.

PMID:
30770184
6.

Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator.

Mano H, Takano M, Ikushiro S, Kittaka A, Sakaki T.

Biochem Biophys Res Commun. 2018 Oct 28;505(2):460-465. doi: 10.1016/j.bbrc.2018.09.122. Epub 2018 Sep 26.

PMID:
30268505
7.

Simultaneous collection of the portal and superior vena cava blood in conscious rats defined that intestinal epithelium is the major site of glucuronidation, but not sulfation and methylation, of quercetin.

Tanaka S, Oyama M, Nishikawa M, Ikushiro S, Hara H.

Biosci Biotechnol Biochem. 2018 Dec;82(12):2118-2129. doi: 10.1080/09168451.2018.1515615. Epub 2018 Sep 10.

PMID:
30200823
8.

Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes.

Nishikawa M, Yasuda K, Takamatsu M, Abe K, Nakagawa K, Tsugawa N, Hirota Y, Tanaka K, Yamashita S, Ikushiro S, Suda T, Okano T, Sakaki T.

J Steroid Biochem Mol Biol. 2019 Jan;185:71-79. doi: 10.1016/j.jsbmb.2018.07.012. Epub 2018 Jul 18.

PMID:
30031146
9.

Novel split luciferase-based biosensors for evaluation of vitamin D receptor ligands and their application to estimate CYP27B1 activity in living cells.

Mano H, Ikushiro S, Sakaki T.

J Steroid Biochem Mol Biol. 2018 Oct;183:221-227. doi: 10.1016/j.jsbmb.2018.06.017. Epub 2018 Jul 9.

PMID:
30004013
10.

Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques.

Uno Y, Takahira R, Murayama N, Ishii Y, Ikenaka Y, Ishizuka M, Yamazaki H, Ikushiro S.

Biochem Pharmacol. 2018 Sep;155:172-181. doi: 10.1016/j.bcp.2018.06.027. Epub 2018 Jun 23.

PMID:
29944869
11.

Limited expression of functional cytochrome p450 2c subtypes in the liver and small intestine of domestic cats.

Ono Y, Sugiyama S, Matsushita M, Kitazawa T, Amano T, Uno Y, Ikushiro S, Teraoka H.

Xenobiotica. 2019 Jun;49(6):627-635. doi: 10.1080/00498254.2018.1483543. Epub 2018 Jul 13.

PMID:
29848168
12.

Microbial production of novel sulphated alkaloids for drug discovery.

Matsumura E, Nakagawa A, Tomabechi Y, Ikushiro S, Sakaki T, Katayama T, Yamamoto K, Kumagai H, Sato F, Minami H.

Sci Rep. 2018 May 22;8(1):7980. doi: 10.1038/s41598-018-26306-7.

13.

Lymphatic metabolites of quercetin after intestinal administration of quercetin-3-glucoside and its aglycone in rats.

Nakamura T, Kinjo C, Nakamura Y, Kato Y, Nishikawa M, Hamada M, Nakajima N, Ikushiro S, Murota K.

Arch Biochem Biophys. 2018 May 1;645:126-136. doi: 10.1016/j.abb.2018.03.024. Epub 2018 Mar 22.

PMID:
29574052
14.

[Metabolism of Sesamin and Drug-Sesamin Interaction].

Sakaki T, Yasuda K, Nishikawa M, Ikushiro S.

Yakugaku Zasshi. 2018;138(3):357-363. doi: 10.1248/yakushi.17-00191-4. Japanese.

15.

Metabolism of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3 by CYP24A1 and biological activity of its 24R-hydroxylated metabolite.

Yasuda K, Tohyama E, Takano M, Kittaka A, Ohta M, Ikushiro S, Sakaki T.

J Steroid Biochem Mol Biol. 2018 Apr;178:333-339. doi: 10.1016/j.jsbmb.2018.02.001. Epub 2018 Feb 6.

PMID:
29425808
16.

Whole-cell-dependent biosynthesis of sulfo-conjugate using human sulfotransferase expressing budding yeast.

Nishikawa M, Masuyama Y, Nunome M, Yasuda K, Sakaki T, Ikushiro S.

Appl Microbiol Biotechnol. 2018 Jan;102(2):723-732. doi: 10.1007/s00253-017-8621-x. Epub 2017 Nov 13.

PMID:
29134333
17.

Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique.

Mano H, Ikushiro S, Saito N, Kittaka A, Sakaki T.

J Steroid Biochem Mol Biol. 2018 Apr;178:55-59. doi: 10.1016/j.jsbmb.2017.10.024. Epub 2017 Nov 1.

PMID:
29101064
18.

S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic β-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing β-Cell Function in Male Mice.

Horiuchi H, Usami A, Shirai R, Harada N, Ikushiro S, Sakaki T, Nakano Y, Inui H, Yamaji R.

J Nutr. 2017 Sep;147(9):1631-1639. doi: 10.3945/jn.117.250860. Epub 2017 Aug 2.

PMID:
28768836
19.

Protein engineering of CYP105s for their industrial uses.

Yasuda K, Sugimoto H, Hayashi K, Takita T, Yasukawa K, Ohta M, Kamakura M, Ikushiro S, Shiro Y, Sakaki T.

Biochim Biophys Acta Proteins Proteom. 2018 Jan;1866(1):23-31. doi: 10.1016/j.bbapap.2017.05.014. Epub 2017 Jun 2. Review.

PMID:
28583351
20.

In vivo absorption and metabolism of leptosperin and methyl syringate, abundantly present in manuka honey.

Ishisaka A, Ikushiro S, Takeuchi M, Araki Y, Juri M, Yoshiki Y, Kawai Y, Niwa T, Kitamoto N, Sakaki T, Ishikawa H, Kato Y.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700122. Epub 2017 Jun 12.

PMID:
28444960
21.

Production of an active form of vitamin D2 by genetically engineered CYP105A1.

Yasuda K, Yogo Y, Sugimoto H, Mano H, Takita T, Ohta M, Kamakura M, Ikushiro S, Yasukawa K, Shiro Y, Sakaki T.

Biochem Biophys Res Commun. 2017 Apr 29;486(2):336-341. doi: 10.1016/j.bbrc.2017.03.040. Epub 2017 Mar 14.

PMID:
28302483
22.

Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.

Kurita A, Miyauchi Y, Ikushiro S, Mackenzie PI, Yamada H, Ishii Y.

J Pharmacol Exp Ther. 2017 May;361(2):199-208. doi: 10.1124/jpet.117.240382. Epub 2017 Feb 22.

PMID:
28228532
23.

Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor.

Mano H, Nishikawa M, Yasuda K, Ikushiro S, Saito N, Sawada D, Honzawa S, Takano M, Kittaka A, Sakaki T.

J Steroid Biochem Mol Biol. 2017 Mar;167:61-66. doi: 10.1016/j.jsbmb.2016.11.008. Epub 2016 Nov 15.

PMID:
27864003
24.

Biosynthesis of Drug Glucuronide Metabolites in the Budding Yeast Saccharomyces cerevisiae.

Ikushiro S, Nishikawa M, Masuyama Y, Shouji T, Fujii M, Hamada M, Nakajima N, Finel M, Yasuda K, Kamakura M, Sakaki T.

Mol Pharm. 2016 Jul 5;13(7):2274-82. doi: 10.1021/acs.molpharmaceut.5b00954. Epub 2016 Jun 8.

PMID:
27241161
25.

Expression of UGT1A subfamily in rat brain.

Sakakibara Y, Katoh M, Imai K, Kondo Y, Asai Y, Ikushiro S, Nadai M.

Biopharm Drug Dispos. 2016 Jul;37(5):314-9. doi: 10.1002/bdd.2012.

PMID:
27061716
26.

Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1.

Hayashi K, Yasuda K, Yogo Y, Takita T, Yasukawa K, Ohta M, Kamakura M, Ikushiro S, Sakaki T.

Biochem Biophys Res Commun. 2016 May 13;473(4):853-858. doi: 10.1016/j.bbrc.2016.03.139. Epub 2016 Mar 30.

PMID:
27037023
27.

Activation of transient receptor potential ankyrin 1 by quercetin and its analogs.

Nakamura T, Miyoshi N, Ishii T, Nishikawa M, Ikushiro S, Watanabe T.

Biosci Biotechnol Biochem. 2016 May;80(5):949-54. doi: 10.1080/09168451.2015.1132148. Epub 2016 Jan 25.

PMID:
26806540
28.

Two Different UGT1A1 Mutations causing Crigler-Najjar Syndrome types I and II in an Iranian Family.

Maruo Y, Behnam M, Ikushiro S, Nakahara S, Nouri N, Salehi M.

J Gastrointestin Liver Dis. 2015 Dec;24(4):523-6. doi: 10.15403/jgld.2014.1121.244.ugt.

29.

Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis.

Yasuda K, Ueno S, Ueda E, Nishikawa M, Takeda K, Kamakura M, Ikushiro S, Sakaki T.

Pharmacol Res Perspect. 2015 Oct;3(5):e00174. doi: 10.1002/prp2.174. Epub 2015 Aug 25.

30.

Identification and in silico prediction of metabolites of the model compound, tebufenozide by human CYP3A4 and CYP2C19.

Shirotani N, Togawa M, Ikushiro S, Sakaki T, Harada T, Miyagawa H, Matsui M, Nagahori H, Mikata K, Nishioka K, Hirai N, Akamatsu M.

Bioorg Med Chem. 2015 Oct 15;23(20):6594-601. doi: 10.1016/j.bmc.2015.09.019. Epub 2015 Sep 11.

PMID:
26404412
31.

Development of Novel Bioluminescent Sensor to Detect and Discriminate between Vitamin D Receptor Agonists and Antagonists in Living Cells.

Mano H, Nishikawa M, Yasuda K, Ikushiro S, Saito N, Takano M, Kittaka A, Sakaki T.

Bioconjug Chem. 2015 Oct 21;26(10):2038-45. doi: 10.1021/acs.bioconjchem.5b00433. Epub 2015 Sep 18.

PMID:
26355700
32.

Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase.

Yasuda K, Iwanaga Y, Ogawa K, Mano H, Ueno S, Kimoto S, Ohta M, Kamakura M, Ikushiro S, Sakaki T.

Pharmacol Res Perspect. 2015 Mar;3(2):e00120. doi: 10.1002/prp2.120. Epub 2015 Feb 10.

33.

Partial cloning of CYP2C23a genes and hepatic protein expression in eight representative avian species.

Watanabe KP, Kawai YK, Nakayama SM, Ikenaka Y, Mizukawa H, Takaesu N, Ito M, Ikushiro SI, Sakaki T, Ishizuka M.

J Vet Pharmacol Ther. 2015 Apr;38(2):190-5. doi: 10.1111/jvp.12159. Epub 2014 Sep 17.

PMID:
25229839
34.

Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls.

Inui H, Itoh T, Yamamoto K, Ikushiro S, Sakaki T.

Int J Mol Sci. 2014 Aug 13;15(8):14044-57. doi: 10.3390/ijms150814044. Review.

35.

3,3',4,4'-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in C57BL/6 and DBA/2 mice occurs mainly through enhanced accumulation of thyroxine in the liver.

Kato Y, Haraguchi K, Onishi M, Ikushiro S, Endo T, Ohta C, Koga N, Yamada S, Degawa M.

Biol Pharm Bull. 2014;37(3):504-9. Epub 2013 Dec 17.

36.

Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells.

Munetsuna E, Kawanami R, Nishikawa M, Ikeda S, Nakabayashi S, Yasuda K, Ohta M, Kamakura M, Ikushiro S, Sakaki T.

Mol Cell Endocrinol. 2014 Feb 15;382(2):960-70. doi: 10.1016/j.mce.2013.11.014. Epub 2013 Nov 27.

PMID:
24291609
37.

Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.

Ishii Y, Koba H, Kinoshita K, Oizaki T, Iwamoto Y, Takeda S, Miyauchi Y, Nishimura Y, Egoshi N, Taura F, Morimoto S, Ikushiro S, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H.

Drug Metab Dispos. 2014 Feb;42(2):229-38. doi: 10.1124/dmd.113.054833. Epub 2013 Nov 19.

PMID:
24255116
38.

Avian cytochrome P450 (CYP) 1-3 family genes: isoforms, evolutionary relationships, and mRNA expression in chicken liver.

Watanabe KP, Kawai YK, Ikenaka Y, Kawata M, Ikushiro S, Sakaki T, Ishizuka M.

PLoS One. 2013 Sep 30;8(9):e75689. doi: 10.1371/journal.pone.0075689. eCollection 2013.

39.

Plasma metabolites of dietary flavonoids after combination meal consumption with onion and tofu in humans.

Nakamura T, Murota K, Kumamoto S, Misumi K, Bando N, Ikushiro S, Takahashi N, Sekido K, Kato Y, Terao J.

Mol Nutr Food Res. 2014 Feb;58(2):310-7. doi: 10.1002/mnfr.201300234. Epub 2013 Sep 4.

PMID:
24039174
40.

A possible mechanism for 2,3',4,4',5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level in mice.

Kato Y, Onishi M, Haraguchi K, Ikushiro S, Ohta C, Koga N, Endo T, Yamada S, Degawa M.

Biol Pharm Bull. 2013;36(10):1594-601. Epub 2013 Jul 23.

41.

Possibility of application of cytochrome P450 to bioremediation of dioxins.

Sakaki T, Yamamoto K, Ikushiro S.

Biotechnol Appl Biochem. 2013 Jan-Feb;60(1):65-70. doi: 10.1002/bab.1067. Epub 2013 Jan 16. Review.

PMID:
23586993
42.

UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1.

Yasuda K, Endo M, Ikushiro S, Kamakura M, Ohta M, Sakaki T.

Biochem Biophys Res Commun. 2013 May 3;434(2):311-5. doi: 10.1016/j.bbrc.2013.02.124. Epub 2013 Mar 30.

PMID:
23548573
43.
44.

Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D(3) analogs.

Yasuda K, Ikushiro S, Kamakura M, Takano M, Saito N, Kittaka A, Chen TC, Ohta M, Sakaki T.

J Steroid Biochem Mol Biol. 2013 Jan;133:84-92. doi: 10.1016/j.jsbmb.2012.09.006. Epub 2012 Sep 13.

PMID:
22982757
45.

Comparative study on 2,2',4,5,5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level between C57BL/6 and its transthyretin-deficient mice.

Kato Y, Tamaki S, Haraguchi K, Ikushiro S, Sekimoto M, Ohta C, Endo T, Koga N, Yamada S, Degawa M.

Toxicol Appl Pharmacol. 2012 Sep 15;263(3):323-9. doi: 10.1016/j.taap.2012.07.004. Epub 2012 Jul 16.

PMID:
22800508
46.

Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics.

Zhang H, Patana AS, Mackenzie PI, Ikushiro S, Goldman A, Finel M.

Drug Metab Dispos. 2012 Oct;40(10):1935-44. doi: 10.1124/dmd.112.046086. Epub 2012 Jul 10.

PMID:
22782802
47.

The critical role of amino acid residue at position 117 of mouse UDP-glucuronosyltransfererase 1a6a and 1a6b in resveratrol glucuronidation.

Uchihashi S, Nishikawa M, Sakaki T, Ikushiro S.

J Biochem. 2012 Oct;152(4):331-40. Epub 2012 Jul 5.

PMID:
22774205
48.

Comparison of metabolism of sesamin and episesamin by drug-metabolizing enzymes in human liver.

Yasuda K, Ikushiro S, Wakayama S, Itoh T, Yamamoto K, Kamakura M, Munetsuna E, Ohta M, Sakaki T.

Drug Metab Dispos. 2012 Oct;40(10):1917-26. doi: 10.1124/dmd.112.045906. Epub 2012 Jun 29.

PMID:
22752007
49.

The effects of N-glycosylation on the glucuronidation of zidovudine and morphine by UGT2B7 expressed in HEK293 cells.

Nagaoka K, Hanioka N, Ikushiro S, Yamano S, Narimatsu S.

Drug Metab Pharmacokinet. 2012;27(4):388-97. Epub 2012 Jan 13.

50.

The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers.

Yamada A, Maeda K, Ishiguro N, Tsuda Y, Igarashi T, Ebner T, Roth W, Ikushiro S, Sugiyama Y.

Pharmacogenet Genomics. 2011 Sep;21(9):523-30. doi: 10.1097/FPC.0b013e3283482502.

PMID:
21829131

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