Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 114

1.

Development of novel lithocholic acid derivatives as vitamin D receptor agonists.

Masuno H, Kazui Y, Tanatani A, Fujii S, Kawachi E, Ikura T, Ito N, Yamamoto K, Kagechika H.

Bioorg Med Chem. 2019 Aug 15;27(16):3674-3681. doi: 10.1016/j.bmc.2019.07.003. Epub 2019 Jul 3.

PMID:
31300316
2.

Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism.

Nakayama S, Shimonaka S, Elahi M, Nishioka K, Oji Y, Matsumoto SE, Li Y, Yoshino H, Mogushi K, Hatano T, Sato T, Ikura T, Ito N, Motoi Y, Hattori N.

Neurobiol Aging. 2019 Mar 1. pii: S0197-4580(19)30066-1. doi: 10.1016/j.neurobiolaging.2019.02.016. [Epub ahead of print]

PMID:
31027853
3.

Epigenetic interplays between DNA demethylation and histone methylation for protecting oncogenesis.

Furuya K, Ikura M, Ikura T.

J Biochem. 2019 Apr 1;165(4):297-299. doi: 10.1093/jb/mvy124. Review.

PMID:
30605533
4.

Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα).

Miyashita Y, Numoto N, Arulmozhiraja S, Nakano S, Matsuo N, Shimizu K, Shibahara O, Fujihara M, Kakuta H, Ito S, Ikura T, Ito N, Tokiwa H.

FEBS Lett. 2019 Jan;593(2):242-250. doi: 10.1002/1873-3468.13301. Epub 2018 Dec 21.

PMID:
30565665
5.

The trans isomer of Tau peptide is prone to aggregate, and the WW domain of Pin1 drastically decreases its aggregation.

Ikura T, Tochio N, Kawasaki R, Matsuzaki M, Narita A, Kikumoto M, Utsunomiya-Tate N, Tate SI, Ito N.

FEBS Lett. 2018 Sep;592(18):3082-3091. doi: 10.1002/1873-3468.13218. Epub 2018 Aug 13.

6.

Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome.

Arimura Y, Ikura M, Fujita R, Noda M, Kobayashi W, Horikoshi N, Sun J, Shi L, Kusakabe M, Harata M, Ohkawa Y, Tashiro S, Kimura H, Ikura T, Kurumizaka H.

Nucleic Acids Res. 2018 Nov 2;46(19):10007-10018. doi: 10.1093/nar/gky661.

7.

25 S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex.

Otero R, Ishizawa M, Numoto N, Ikura T, Ito N, Tokiwa H, Mouriño A, Makishima M, Yamada S.

J Med Chem. 2018 Aug 9;61(15):6658-6673. doi: 10.1021/acs.jmedchem.8b00427. Epub 2018 Jul 23.

PMID:
29989817
8.

Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.

Sun J, Shi L, Kinomura A, Fukuto A, Horikoshi Y, Oma Y, Harata M, Ikura M, Ikura T, Kanaar R, Tashiro S.

Elife. 2018 May 8;7. pii: e32222. doi: 10.7554/eLife.32222.

9.

An Overlapping Region between the Two Terminal Folding Units of the Outer Surface Protein A (OspA) Controls Its Folding Behavior.

Makabe K, Nakamura T, Dhar D, Ikura T, Koide S, Kuwajima K.

J Mol Biol. 2018 Jun 8;430(12):1799-1813. doi: 10.1016/j.jmb.2018.04.025. Epub 2018 Apr 27.

PMID:
29709572
10.

The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress.

Wakida T, Ikura M, Kuriya K, Ito S, Shiroiwa Y, Habu T, Kawamoto T, Okumura K, Ikura T, Furuya K.

Elife. 2017 Dec 19;6. pii: e29953. doi: 10.7554/eLife.29953.

11.

SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites.

Fukuto A, Ikura M, Ikura T, Sun J, Horikoshi Y, Shima H, Igarashi K, Kusakabe M, Harata M, Horikoshi N, Kurumizaka H, Kiuchi Y, Tashiro S.

Nucleus. 2018 Jan 1;9(1):87-94. doi: 10.1080/19491034.2017.1395543. Epub 2017 Dec 14.

12.

Regional cerebral glucose metabolism in systemic lupus erythematosus patients with major depressive disorder.

Saito T, Tamura M, Chiba Y, Katsuse O, Suda A, Kamada A, Ikura T, Abe K, Ogawa M, Minegishi K, Yoshimi R, Kirino Y, Ihata A, Hirayasu Y.

J Neurol Sci. 2017 Aug 15;379:127-130. doi: 10.1016/j.jns.2017.05.059. Epub 2017 May 30.

PMID:
28716225
13.

Halophilic mechanism of the enzymatic function of a moderately halophilic dihydrofolate reductase from Haloarcula japonica strain TR-1.

Miyashita Y, Ohmae E, Ikura T, Nakasone K, Katayanagi K.

Extremophiles. 2017 May;21(3):591-602. doi: 10.1007/s00792-017-0928-0. Epub 2017 Mar 27.

PMID:
28349498
14.

Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3.

Kakumu E, Nakanishi S, Shiratori HM, Kato A, Kobayashi W, Machida S, Yasuda T, Adachi N, Saito N, Ikura T, Kurumizaka H, Kimura H, Yokoi M, Sakai W, Sugasawa K.

Genes Cells. 2017 Mar;22(3):310-327. doi: 10.1111/gtc.12479. Epub 2017 Feb 24.

15.

Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins.

Inaba S, Numoto N, Ogawa S, Morii H, Ikura T, Abe R, Ito N, Oda M.

J Biol Chem. 2017 Jan 20;292(3):1052-1060. doi: 10.1074/jbc.M116.755173. Epub 2016 Dec 6.

16.

Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.

Aihara H, Nakagawa T, Mizusaki H, Yoneda M, Kato M, Doiguchi M, Imamura Y, Higashi M, Ikura T, Hayashi T, Kodama Y, Oki M, Nakayama T, Cheung E, Aburatani H, Takayama KI, Koseki H, Inoue S, Takeshima Y, Ito T.

Mol Cell. 2016 Oct 6;64(1):176-188. doi: 10.1016/j.molcel.2016.09.012.

17.

Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.

Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H.

Sci Rep. 2016 Sep 22;6:33861. doi: 10.1038/srep33861.

18.

Evaluation of titers of antibodies against peptides of subunits NR1 and NR2B of glutamate receptor by enzyme-linked immunosorbent assay in psychiatric patients with anti-thyroid antibodies.

Ikura T, Katsuse O, Chiba Y, Takahashi Y, Fujishiro H, Kamada A, Saito T, Hirayasu Y.

Neurosci Lett. 2016 Aug 15;628:201-6. doi: 10.1016/j.neulet.2016.06.028. Epub 2016 Jun 16.

PMID:
27317996
19.

Selective inhibition of the kinase DYRK1A by targeting its folding process.

Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, Hagiwara M.

Nat Commun. 2016 Apr 22;7:11391. doi: 10.1038/ncomms11391.

20.

Histone H4 lysine 20 acetylation is associated with gene repression in human cells.

Kaimori JY, Maehara K, Hayashi-Takanaka Y, Harada A, Fukuda M, Yamamoto S, Ichimaru N, Umehara T, Yokoyama S, Matsuda R, Ikura T, Nagao K, Obuse C, Nozaki N, Takahara S, Takao T, Ohkawa Y, Kimura H, Isaka Y.

Sci Rep. 2016 Apr 11;6:24318. doi: 10.1038/srep24318.

21.

Coordinated Regulation of TIP60 and Poly(ADP-Ribose) Polymerase 1 in Damaged-Chromatin Dynamics.

Ikura M, Furuya K, Fukuto A, Matsuda R, Adachi J, Matsuda T, Kakizuka A, Ikura T.

Mol Cell Biol. 2016 May 2;36(10):1595-607. doi: 10.1128/MCB.01085-15. Print 2016 May 15.

22.

Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.

Matsuda S, Matsuda Y, Yanagisawa SY, Ikura M, Ikura T, Matsuda T.

Toxicol Sci. 2016 Jun;151(2):224-35. doi: 10.1093/toxsci/kfw039. Epub 2016 Feb 28.

PMID:
26928355
23.

SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation.

Doiguchi M, Nakagawa T, Imamura Y, Yoneda M, Higashi M, Kubota K, Yamashita S, Asahara H, Iida M, Fujii S, Ikura T, Liu Z, Nandu T, Kraus WL, Ueda H, Ito T.

Sci Rep. 2016 Feb 18;6:20179. doi: 10.1038/srep20179.

24.

Crystal Structure of the Vitamin D Receptor Ligand-Binding Domain with Lithocholic Acids.

Ikura T, Ito N.

Vitam Horm. 2016;100:117-36. doi: 10.1016/bs.vh.2015.10.004. Epub 2015 Dec 8. Review.

PMID:
26827950
25.

Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3.

Tanaka H, Muto A, Shima H, Katoh Y, Sax N, Tajima S, Brydun A, Ikura T, Yoshizawa N, Masai H, Hoshikawa Y, Noda T, Nio M, Ochiai K, Igarashi K.

J Biol Chem. 2016 Mar 18;291(12):6316-30. doi: 10.1074/jbc.M116.713842. Epub 2016 Jan 19.

26.

Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds.

Watarai Y, Ishizawa M, Ikura T, Zacconi FC, Uno S, Ito N, Mouriño A, Tokiwa H, Makishima M, Yamada S.

J Med Chem. 2015 Dec 24;58(24):9510-21. doi: 10.1021/acs.jmedchem.5b00792. Epub 2015 Dec 15.

PMID:
26613420
27.

Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.

Anami Y, Sakamaki Y, Itoh T, Inaba Y, Nakabayashi M, Ikura T, Ito N, Yamamoto K.

Bioorg Med Chem. 2015 Nov 15;23(22):7274-81. doi: 10.1016/j.bmc.2015.10.026. Epub 2015 Oct 26.

28.

Acetylation of Histone H2AX at Lys 5 by the TIP60 Histone Acetyltransferase Complex Is Essential for the Dynamic Binding of NBS1 to Damaged Chromatin.

Ikura M, Furuya K, Matsuda S, Matsuda R, Shima H, Adachi J, Matsuda T, Shiraki T, Ikura T.

Mol Cell Biol. 2015 Dec;35(24):4147-57. doi: 10.1128/MCB.00757-15. Epub 2015 Oct 5.

29.

Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor.

Matsuda S, Adachi J, Ihara M, Tanuma N, Shima H, Kakizuka A, Ikura M, Ikura T, Matsuda T.

Nucleic Acids Res. 2016 Jan 29;44(2):636-47. doi: 10.1093/nar/gkv967. Epub 2015 Sep 23.

30.

Brain FDG-PET reflecting clinical course of depression induced by systemic lupus erythematosus: Two case reports.

Saito T, Hama M, Chiba Y, Katsuse O, Kamada A, Ikura T, Minegishi K, Ihata A, Takahashi Y, Ishigatsubo Y, Hirayasu Y.

J Neurol Sci. 2015 Nov 15;358(1-2):464-6. doi: 10.1016/j.jns.2015.08.015. Epub 2015 Aug 12. No abstract available.

PMID:
26318204
31.

Corrigendum: Structural basis of a nucleosome containing histone H2A.B/H2A.Bbd that transiently associates with reorganized chromatin.

Arimura Y, Kimura H, Oda T, Sato K, Osakabe A, Tachiwana H, Sato Y, Kinugasa Y, Ikura T, Sugiyama M, Sato M, Kurumizaka H.

Sci Rep. 2015 Jul 13;5:9628. doi: 10.1038/srep09628. No abstract available.

32.

[A Patient with Probable Dementia with Lewy Bodies and Positive Autoantibodies against the Anti-NH<sub>2</sub>-terminal of α-Enolase].

Ikura T, Fujishiro H, Takahashi Y, Yoneda M, Saito T, Chiba Y, Kamada A, Katsuse O, Hirayasu Y.

Brain Nerve. 2015 Jul;67(7):967-72. doi: 10.11477/mf.1416200239. Japanese.

PMID:
26160824
33.

hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair.

Okimoto S, Sun J, Fukuto A, Horikoshi Y, Matsuda S, Matsuda T, Ikura M, Ikura T, Machida S, Kurumizaka H, Miyamoto Y, Oka M, Yoneda Y, Kiuchi Y, Tashiro S.

Genes Cells. 2015 Sep;20(9):681-94. doi: 10.1111/gtc.12262. Epub 2015 Jun 30.

34.

Absolute quantification of acetylation and phosphorylation of the histone variant H2AX upon ionizing radiation reveals distinct cellular responses in two cancer cell lines.

Matsuda S, Furuya K, Ikura M, Matsuda T, Ikura T.

Radiat Environ Biophys. 2015 Nov;54(4):403-11. doi: 10.1007/s00411-015-0608-3. Epub 2015 Jun 19.

PMID:
26088617
35.

SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair.

Akita M, Tak YS, Shimura T, Matsumoto S, Okuda-Shimizu Y, Shimizu Y, Nishi R, Saitoh H, Iwai S, Mori T, Ikura T, Sakai W, Hanaoka F, Sugasawa K.

Sci Rep. 2015 Jun 4;5:10984. doi: 10.1038/srep10984.

36.

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.

Morooka S, Hoshina M, Kii I, Okabe T, Kojima H, Inoue N, Okuno Y, Denawa M, Yoshida S, Fukuhara J, Ninomiya K, Ikura T, Furuya T, Nagano T, Noda K, Ishida S, Hosoya T, Ito N, Yoshimura N, Hagiwara M.

Mol Pharmacol. 2015 Aug;88(2):316-25. doi: 10.1124/mol.114.097345. Epub 2015 May 20.

PMID:
25993998
37.

Absolute quantification of γH2AX using liquid chromatography-triple quadrupole tandem mass spectrometry.

Matsuda S, Ikura T, Matsuda T.

Anal Bioanal Chem. 2015 Jul;407(18):5521-7. doi: 10.1007/s00216-015-8725-z. Epub 2015 May 3.

PMID:
25935680
38.

Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage.

Liu NA, Sun J, Kono K, Horikoshi Y, Ikura T, Tong X, Haraguchi T, Tashiro S.

FASEB J. 2015 Jun;29(6):2514-25. doi: 10.1096/fj.14-265546. Epub 2015 Mar 2.

PMID:
25733566
39.

Reorganization of damaged chromatin by the exchange of histone variant H2A.Z-2.

Nishibuchi I, Suzuki H, Kinomura A, Sun J, Liu NA, Horikoshi Y, Shima H, Kusakabe M, Harata M, Fukagawa T, Ikura T, Ishida T, Nagata Y, Tashiro S.

Int J Radiat Oncol Biol Phys. 2014 Jul 15;89(4):736-44. doi: 10.1016/j.ijrobp.2014.03.031.

PMID:
24969791
40.

Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.

Machida S, Takaku M, Ikura M, Sun J, Suzuki H, Kobayashi W, Kinomura A, Osakabe A, Tachiwana H, Horikoshi Y, Fukuto A, Matsuda R, Ura K, Tashiro S, Ikura T, Kurumizaka H.

Sci Rep. 2014 May 6;4:4863. doi: 10.1038/srep04863.

41.

FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair.

Unno J, Itaya A, Taoka M, Sato K, Tomida J, Sakai W, Sugasawa K, Ishiai M, Ikura T, Isobe T, Kurumizaka H, Takata M.

Cell Rep. 2014 May 22;7(4):1039-47. doi: 10.1016/j.celrep.2014.04.005. Epub 2014 May 1.

42.

Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor.

Kudo T, Ishizawa M, Maekawa K, Nakabayashi M, Watarai Y, Uchida H, Tokiwa H, Ikura T, Ito N, Makishima M, Yamada S.

J Med Chem. 2014 May 22;57(10):4073-87. doi: 10.1021/jm401989c. Epub 2014 May 7.

PMID:
24773565
43.

Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20.

Oliveira DV, Kato A, Nakamura K, Ikura T, Okada M, Kobayashi J, Yanagihara H, Saito Y, Tauchi H, Komatsu K.

J Cell Sci. 2014 Feb 15;127(Pt 4):763-72. doi: 10.1242/jcs.135855. Epub 2013 Dec 19.

44.

Structural basis of a nucleosome containing histone H2A.B/H2A.Bbd that transiently associates with reorganized chromatin.

Arimura Y, Kimura H, Oda T, Sato K, Osakabe A, Tachiwana H, Sato Y, Kinugasa Y, Ikura T, Sugiyama M, Sato M, Kurumizaka H.

Sci Rep. 2013 Dec 16;3:3510. doi: 10.1038/srep03510. Erratum in: Sci Rep. 2015;5:9628.

45.

High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28.

Higo K, Ikura T, Oda M, Morii H, Takahashi J, Abe R, Ito N.

PLoS One. 2013 Sep 30;8(9):e74482. doi: 10.1371/journal.pone.0074482. eCollection 2013.

46.

Lymphopenia helps early diagnosis of systemic lupus erythematosus for patients with psychosis as an initial symptom.

Chiba Y, Katsuse O, Fujishiro H, Kamada A, Saito T, Ikura T, Takahashi Y, Kunii M, Takeno M, Hirayasu Y.

Psychosomatics. 2015 Jan-Feb;56(1):85-8. doi: 10.1016/j.psym.2013.07.001. Epub 2013 Sep 23. No abstract available.

PMID:
24070661
47.

Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage.

Shima H, Suzuki H, Sun J, Kono K, Shi L, Kinomura A, Horikoshi Y, Ikura T, Ikura M, Kanaar R, Igarashi K, Saitoh H, Kurumizaka H, Tashiro S.

J Cell Sci. 2013 Nov 15;126(Pt 22):5284-92. doi: 10.1242/jcs.133744. Epub 2013 Sep 17.

48.

Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition.

Sakogawa K, Aoki Y, Misumi K, Hamai Y, Emi M, Hihara J, Shi L, Kono K, Horikoshi Y, Sun J, Ikura T, Okada M, Tashiro S.

Cancer Sci. 2013 Dec;104(12):1593-9. doi: 10.1111/cas.12281. Epub 2013 Oct 10.

49.

Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands.

Nakabayashi M, Tsukahara Y, Iwasaki-Miyamoto Y, Mihori-Shimazaki M, Yamada S, Inaba S, Oda M, Shimizu M, Makishima M, Tokiwa H, Ikura T, Ito N.

J Med Chem. 2013 Sep 12;56(17):6745-60. doi: 10.1021/jm400537h. Epub 2013 Aug 29.

PMID:
23944708
50.

Peptidyl-prolyl isomerase activity of FK506 binding protein 12 prevents tau peptide from aggregating.

Ikura T, Ito N.

Protein Eng Des Sel. 2013 Sep;26(9):539-46. doi: 10.1093/protein/gzt033. Epub 2013 Jul 5.

PMID:
23832849

Supplemental Content

Support Center