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Items: 1 to 50 of 280

1.

Coordination of a single calcium ion in the EF-hand maintains the off state of the stromal interaction molecule luminal domain.

Enomoto M, Nishikawa T, Back SI, Ishiyama N, Zheng L, Stathopulos PB, Ikura M.

J Mol Biol. 2019 Oct 15. pii: S0022-2836(19)30594-7. doi: 10.1016/j.jmb.2019.10.003. [Epub ahead of print]

PMID:
31626806
2.

Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.

Azoitei ML, Noh J, Marston DJ, Roudot P, Marshall CB, Daugird TA, Lisanza SL, Sandí MJ, Ikura M, Sondek J, Rottapel R, Hahn KM, Danuser G.

J Cell Biol. 2019 Sep 2;218(9):3077-3097. doi: 10.1083/jcb.201812073. Epub 2019 Aug 16.

PMID:
31420453
3.

Clotrimazole troches can alter everolimus pharmacokinetics in post-transplant patients: A case report.

Uno T, Wada K, Matsuda S, Ikura M, Takenaka H, Terakawa N, Oita A, Yokoyama S, Kawase A, Hosomi K, Takada M.

Br J Clin Pharmacol. 2019 Sep;85(9):2176-2178. doi: 10.1111/bcp.14017. Epub 2019 Jun 26. No abstract available.

PMID:
31243774
4.

Expression and Purification of Calmodulin for NMR and Other Biophysical Applications.

Grant BMM, Marshall CB, Ikura M.

Methods Mol Biol. 2019;1929:207-221. doi: 10.1007/978-1-4939-9030-6_13.

PMID:
30710275
5.

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.

Kano Y, Gebregiworgis T, Marshall CB, Radulovich N, Poon BPK, St-Germain J, Cook JD, Valencia-Sama I, Grant BMM, Herrera SG, Miao J, Raught B, Irwin MS, Lee JE, Yeh JJ, Zhang ZY, Tsao MS, Ikura M, Ohh M.

Nat Commun. 2019 Jan 15;10(1):224. doi: 10.1038/s41467-018-08115-8.

6.

Epigenetic interplays between DNA demethylation and histone methylation for protecting oncogenesis.

Furuya K, Ikura M, Ikura T.

J Biochem. 2019 Apr 1;165(4):297-299. doi: 10.1093/jb/mvy124. Review.

PMID:
30605533
7.

De novo malignancy in heart transplant recipients: A single center experience in Japan.

Kimura Y, Yanase M, Mochizuki H, Iwasaki K, Toda K, Matsuda S, Takenaka H, Kumai Y, Kuroda K, Nakajima S, Watanabe T, Ikura MM, Wada K, Matsumoto Y, Seguchi O, Fukushima S, Fujita T, Kobayashi J, Fukushima N.

J Cardiol. 2019 Mar;73(3):255-261. doi: 10.1016/j.jjcc.2018.11.011. Epub 2018 Dec 23.

PMID:
30587457
8.

Does stromal interaction molecule-1 have five senses?

Stathopulos PB, Ikura M.

Cell Calcium. 2019 Jan;77:79-80. doi: 10.1016/j.ceca.2018.12.001. Epub 2018 Dec 3.

PMID:
30528613
9.

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis.

Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, Huang SH, Waldron JN, Ikura M, Liu FF, Bratman SV.

Nat Commun. 2018 Nov 30;9(1):5116. doi: 10.1038/s41467-018-07550-x.

10.

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions.

Ishiyama N, Sarpal R, Wood MN, Barrick SK, Nishikawa T, Hayashi H, Kobb AB, Flozak AS, Yemelyanov A, Fernandez-Gonzalez R, Yonemura S, Leckband DE, Gottardi CJ, Tepass U, Ikura M.

Nat Commun. 2018 Nov 30;9(1):5121. doi: 10.1038/s41467-018-07481-7.

11.

Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.

Fang Z, Marshall CB, Nishikawa T, Gossert AD, Jansen JM, Jahnke W, Ikura M.

Cell Chem Biol. 2018 Nov 15;25(11):1327-1336.e4. doi: 10.1016/j.chembiol.2018.07.009. Epub 2018 Aug 16.

PMID:
30122370
12.

Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome.

Arimura Y, Ikura M, Fujita R, Noda M, Kobayashi W, Horikoshi N, Sun J, Shi L, Kusakabe M, Harata M, Ohkawa Y, Tashiro S, Kimura H, Ikura T, Kurumizaka H.

Nucleic Acids Res. 2018 Nov 2;46(19):10007-10018. doi: 10.1093/nar/gky661.

13.

Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.

Sun J, Shi L, Kinomura A, Fukuto A, Horikoshi Y, Oma Y, Harata M, Ikura M, Ikura T, Kanaar R, Tashiro S.

Elife. 2018 May 8;7. pii: e32222. doi: 10.7554/eLife.32222.

14.

Structural elements of stromal interaction molecule function.

Novello MJ, Zhu J, Feng Q, Ikura M, Stathopulos PB.

Cell Calcium. 2018 Jul;73:88-94. doi: 10.1016/j.ceca.2018.04.006. Epub 2018 Apr 18. Review.

PMID:
29698850
15.

Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.

Gebregiworgis T, Marshall CB, Nishikawa T, Radulovich N, Sandí MJ, Fang Z, Rottapel R, Tsao MS, Ikura M.

J Am Chem Soc. 2018 Apr 4;140(13):4473-4476. doi: 10.1021/jacs.7b13703. Epub 2018 Mar 22.

PMID:
29543440
16.

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state.

Fahrner M, Stadlbauer M, Muik M, Rathner P, Stathopulos P, Ikura M, Müller N, Romanin C.

Nat Commun. 2018 Feb 26;9(1):825. doi: 10.1038/s41467-018-03062-w.

17.

Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia.

Terakado M, Suzuki H, Hashimura K, Tanaka M, Ueda H, Hirai K, Asada M, Ikura M, Matsunaga N, Saga H, Shinozaki K, Karakawa N, Takada Y, Minami M, Egashira H, Sugiura Y, Yamada M, Nakade S, Takaoka Y.

ACS Med Chem Lett. 2017 Nov 20;8(12):1281-1286. doi: 10.1021/acsmedchemlett.7b00383. eCollection 2017 Dec 14.

18.

The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress.

Wakida T, Ikura M, Kuriya K, Ito S, Shiroiwa Y, Habu T, Kawamoto T, Okumura K, Ikura T, Furuya K.

Elife. 2017 Dec 19;6. pii: e29953. doi: 10.7554/eLife.29953.

19.

SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites.

Fukuto A, Ikura M, Ikura T, Sun J, Horikoshi Y, Shima H, Igarashi K, Kusakabe M, Harata M, Horikoshi N, Kurumizaka H, Kiuchi Y, Tashiro S.

Nucleus. 2018 Jan 1;9(1):87-94. doi: 10.1080/19491034.2017.1395543. Epub 2017 Dec 14.

20.

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

Sandí MJ, Marshall CB, Balan M, Coyaud É, Zhou M, Monson DM, Ishiyama N, Chandrakumar AA, La Rose J, Couzens AL, Gingras AC, Raught B, Xu W, Ikura M, Morrison DK, Rottapel R.

Sci Signal. 2017 Oct 31;10(503). pii: eaan3286. doi: 10.1126/scisignal.aan3286.

21.

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.

Smith MJ, Ottoni E, Ishiyama N, Goudreault M, Haman A, Meyer C, Tucholska M, Gasmi-Seabrook G, Menezes S, Laister RC, Minden MD, Marschalek R, Gingras AC, Hoang T, Ikura M.

Nat Commun. 2017 Oct 23;8(1):1099. doi: 10.1038/s41467-017-01326-5.

22.

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion.

Wood MN, Ishiyama N, Singaram I, Chung CM, Flozak AS, Yemelyanov A, Ikura M, Cho W, Gottardi CJ.

J Cell Biol. 2017 Nov 6;216(11):3767-3783. doi: 10.1083/jcb.201612006. Epub 2017 Sep 5.

23.

From Stores to Sinks: Structural Mechanisms of Cytosolic Calcium Regulation.

Enomoto M, Nishikawa T, Siddiqui N, Chung S, Ikura M, Stathopulos PB.

Adv Exp Med Biol. 2017;981:215-251. doi: 10.1007/978-3-319-55858-5_10. Review.

PMID:
29594864
24.

Store operated calcium entry: From concept to structural mechanisms.

Stathopulos PB, Ikura M.

Cell Calcium. 2017 May;63:3-7. doi: 10.1016/j.ceca.2016.11.005. Epub 2016 Nov 25. Review.

PMID:
27914753
25.

Inhibition of RAS function through targeting an allosteric regulatory site.

Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP.

Nat Chem Biol. 2017 Jan;13(1):62-68. doi: 10.1038/nchembio.2231. Epub 2016 Nov 7.

26.

Backbone resonance assignments of the F-actin binding domain of mouse αN-catenin.

Nishikawa T, Ishiyama N, Wang F, Ikura M.

Biomol NMR Assign. 2017 Apr;11(1):21-24. doi: 10.1007/s12104-016-9713-8. Epub 2016 Nov 1.

PMID:
27804064
27.

An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function.

Zheng W, Umitsu M, Jagan I, Tran CW, Ishiyama N, BeGora M, Araki K, Ohashi PS, Ikura M, Muthuswamy SK.

Nat Cell Biol. 2016 Nov;18(11):1244-1252. doi: 10.1038/ncb3413. Epub 2016 Oct 3.

PMID:
27694890
28.

Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.

DeFalco TA, Marshall CB, Munro K, Kang HG, Moeder W, Ikura M, Snedden WA, Yoshioka K.

Plant Cell. 2016 Jul;28(7):1738-51. doi: 10.1105/tpc.15.00870. Epub 2016 Jun 22.

29.

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith MJ, Nishikawa T, Xu Y, Neel BG, Ikura M.

J Biol Chem. 2016 Jul 22;291(30):15641-52. doi: 10.1074/jbc.M116.714196. Epub 2016 May 18.

30.

Coordinated Regulation of TIP60 and Poly(ADP-Ribose) Polymerase 1 in Damaged-Chromatin Dynamics.

Ikura M, Furuya K, Fukuto A, Matsuda R, Adachi J, Matsuda T, Kakizuka A, Ikura T.

Mol Cell Biol. 2016 May 2;36(10):1595-607. doi: 10.1128/MCB.01085-15. Print 2016 May 15.

31.

Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine.

Matsuda S, Matsuda Y, Yanagisawa SY, Ikura M, Ikura T, Matsuda T.

Toxicol Sci. 2016 Jun;151(2):224-35. doi: 10.1093/toxsci/kfw039. Epub 2016 Feb 28.

PMID:
26928355
32.

Cholesterol modulates Orai1 channel function.

Derler I, Jardin I, Stathopulos PB, Muik M, Fahrner M, Zayats V, Pandey SK, Poteser M, Lackner B, Absolonova M, Schindl R, Groschner K, Ettrich R, Ikura M, Romanin C.

Sci Signal. 2016 Jan 26;9(412):ra10. doi: 10.1126/scisignal.aad7808.

33.

Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans.

Park S, Bin NR, Michael Rajah M, Kim B, Chou TC, Kang SY, Sugita K, Parsaud L, Smith M, Monnier PP, Ikura M, Zhen M, Sugita S.

Mol Biol Cell. 2016 Feb 15;27(4):669-85. doi: 10.1091/mbc.E15-09-0638. Epub 2015 Dec 23.

34.

Acetylation of Histone H2AX at Lys 5 by the TIP60 Histone Acetyltransferase Complex Is Essential for the Dynamic Binding of NBS1 to Damaged Chromatin.

Ikura M, Furuya K, Matsuda S, Matsuda R, Shima H, Adachi J, Matsuda T, Shiraki T, Ikura T.

Mol Cell Biol. 2015 Dec;35(24):4147-57. doi: 10.1128/MCB.00757-15. Epub 2015 Oct 5.

35.

Occurrence of Deep Vein Thrombosis among Hospitalized Non-Surgical Japanese Patients.

Yamada N, Hanzawa K, Ota S, Nakamura M, Sato K, Ikura M, Suzuki T, Kaise T, Nakajima H, Ito M.

Ann Vasc Dis. 2015;8(3):203-9. doi: 10.3400/avd.oa.14-00132. Epub 2015 Jun 19.

36.

Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor.

Matsuda S, Adachi J, Ihara M, Tanuma N, Shima H, Kakizuka A, Ikura M, Ikura T, Matsuda T.

Nucleic Acids Res. 2016 Jan 29;44(2):636-47. doi: 10.1093/nar/gkv967. Epub 2015 Sep 23.

37.

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma.

Ghosh AP, Marshall CB, Coric T, Shim EH, Kirkman R, Ballestas ME, Ikura M, Bjornsti MA, Sudarshan S.

Oncotarget. 2015 Jul 20;6(20):17895-910.

38.

hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair.

Okimoto S, Sun J, Fukuto A, Horikoshi Y, Matsuda S, Matsuda T, Ikura M, Ikura T, Machida S, Kurumizaka H, Miyamoto Y, Oka M, Yoneda Y, Kiuchi Y, Tashiro S.

Genes Cells. 2015 Sep;20(9):681-94. doi: 10.1111/gtc.12262. Epub 2015 Jun 30.

39.

Absolute quantification of acetylation and phosphorylation of the histone variant H2AX upon ionizing radiation reveals distinct cellular responses in two cancer cell lines.

Matsuda S, Furuya K, Ikura M, Matsuda T, Ikura T.

Radiat Environ Biophys. 2015 Nov;54(4):403-11. doi: 10.1007/s00411-015-0608-3. Epub 2015 Jun 19.

PMID:
26088617
40.

Structural Determinants of the Mechanical Stability of α-Catenin.

Li J, Newhall J, Ishiyama N, Gottardi C, Ikura M, Leckband DE, Tajkhorshid E.

J Biol Chem. 2015 Jul 31;290(31):18890-903. doi: 10.1074/jbc.M115.647941. Epub 2015 Jun 12.

41.

Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a.

Wang F, Marshall CB, Ikura M.

Intrinsically Disord Proteins. 2015 Jun 3;3(1):e1056906. doi: 10.1080/21690707.2015.1056906. eCollection 2015. Review.

42.

Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum.

Marshall CB, Nishikawa T, Osawa M, Stathopulos PB, Ikura M.

Biochem Biophys Res Commun. 2015 Apr 24;460(1):5-21. doi: 10.1016/j.bbrc.2015.01.106. Review.

PMID:
25998729
43.

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Mazhab-Jafari MT, Marshall CB, Smith MJ, Gasmi-Seabrook GM, Stathopulos PB, Inagaki F, Kay LE, Neel BG, Ikura M.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6625-30. doi: 10.1073/pnas.1419895112. Epub 2015 May 4.

44.

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation.

Maus M, Jairaman A, Stathopulos PB, Muik M, Fahrner M, Weidinger C, Benson M, Fuchs S, Ehl S, Romanin C, Ikura M, Prakriya M, Feske S.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6206-11. doi: 10.1073/pnas.1418852112. Epub 2015 Apr 27.

45.

Real-time NMR monitoring of biological activities in complex physiological environments.

Smith MJ, Marshall CB, Theillet FX, Binolfi A, Selenko P, Ikura M.

Curr Opin Struct Biol. 2015 Jun;32:39-47. doi: 10.1016/j.sbi.2015.02.003. Epub 2015 Feb 27. Review.

PMID:
25727665
46.

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.

Escobar DJ, Desai R, Ishiyama N, Folmsbee SS, Novak MN, Flozak AS, Daugherty RL, Mo R, Nanavati D, Sarpal R, Leckband D, Ikura M, Tepass U, Gottardi CJ.

J Cell Sci. 2015 Mar 15;128(6):1150-65. doi: 10.1242/jcs.163824. Epub 2015 Feb 4.

47.

Structural insights into endoplasmic reticulum stored calcium regulation by inositol 1,4,5-trisphosphate and ryanodine receptors.

Seo MD, Enomoto M, Ishiyama N, Stathopulos PB, Ikura M.

Biochim Biophys Acta. 2015 Sep;1853(9):1980-91. doi: 10.1016/j.bbamcr.2014.11.023. Epub 2014 Nov 25. Review.

48.

A coiled-coil clamp controls both conformation and clustering of stromal interaction molecule 1 (STIM1).

Fahrner M, Muik M, Schindl R, Butorac C, Stathopulos P, Zheng L, Jardin I, Ikura M, Romanin C.

J Biol Chem. 2014 Nov 28;289(48):33231-44. doi: 10.1074/jbc.M114.610022. Epub 2014 Oct 23.

49.

Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1.

Meiri D, Marshall CB, Mokady D, LaRose J, Mullin M, Gingras AC, Ikura M, Rottapel R.

Nat Commun. 2014 Sep 11;5:4857. doi: 10.1038/ncomms5857.

PMID:
25209408
50.

Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.

Machida S, Takaku M, Ikura M, Sun J, Suzuki H, Kobayashi W, Kinomura A, Osakabe A, Tachiwana H, Horikoshi Y, Fukuto A, Matsuda R, Ura K, Tashiro S, Ikura T, Kurumizaka H.

Sci Rep. 2014 May 6;4:4863. doi: 10.1038/srep04863.

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