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Items: 1 to 50 of 215

1.

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P.

Cell. 2018 Oct 4;175(2):514-529.e20. doi: 10.1016/j.cell.2018.08.033. Epub 2018 Sep 13.

PMID:
30220461
2.

Association of tamoxifen resistance and lipid reprogramming in breast cancer.

Hultsch S, Kankainen M, Paavolainen L, Kovanen RM, Ikonen E, Kangaspeska S, Pietiäinen V, Kallioniemi O.

BMC Cancer. 2018 Aug 24;18(1):850. doi: 10.1186/s12885-018-4757-z.

3.

Mechanisms of cellular cholesterol compartmentalization: recent insights.

Ikonen E.

Curr Opin Cell Biol. 2018 Aug;53:77-83. doi: 10.1016/j.ceb.2018.06.002. Epub 2018 Jun 28. Review.

4.

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism.

Kentala H, Koponen A, Vihinen H, Pirhonen J, Liebisch G, Pataj Z, Kivelä A, Li S, Karhinen L, Jääskeläinen E, Andrews R, Meriläinen L, Matysik S, Ikonen E, Zhou Y, Jokitalo E, Olkkonen VM.

Cell Mol Life Sci. 2018 Nov;75(21):4041-4057. doi: 10.1007/s00018-018-2850-8. Epub 2018 Jun 12.

PMID:
29947926
5.

A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction.

Zhou K, Dichlberger A, Martinez-Seara H, Nyholm TKM, Li S, Kim YA, Vattulainen I, Ikonen E, Blom T.

ACS Cent Sci. 2018 May 23;4(5):548-558. doi: 10.1021/acscentsci.7b00582. Epub 2018 May 9.

6.

Concerted regulation of npc2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin.

Enkavi G, Mikkolainen H, Güngör B, Ikonen E, Vattulainen I.

PLoS Comput Biol. 2017 Oct 30;13(10):e1005831. doi: 10.1371/journal.pcbi.1005831. eCollection 2017 Oct.

7.

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network.

Capasso S, Sticco L, Rizzo R, Pirozzi M, Russo D, Dathan NA, Campelo F, van Galen J, Hölttä-Vuori M, Turacchio G, Hausser A, Malhotra V, Riezman I, Riezman H, Ikonen E, Luberto C, Parashuraman S, Luini A, D'Angelo G.

EMBO J. 2017 Jun 14;36(12):1736-1754. doi: 10.15252/embj.201696048. Epub 2017 May 10.

8.

Nonlinearity characterization of array spectroradiometers for the solar UV measurements.

Pulli T, Nevas S, El Gawhary O, van den Berg S, Askola J, Kärhä P, Manoocheri F, Ikonen E.

Appl Opt. 2017 Apr 10;56(11):3077-3086. doi: 10.1364/AO.56.003077.

PMID:
28414366
9.

Introducing inducible fluorescent split cholesterol oxidase to mammalian cells.

Chernov KG, Neuvonen M, Brock I, Ikonen E, Verkhusha VV.

J Biol Chem. 2017 May 26;292(21):8811-8822. doi: 10.1074/jbc.M116.761718. Epub 2017 Apr 7.

10.

The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together.

Bäck N, Kanerva K, Kurutihalli V, Yanik A, Ikonen E, Mains RE, Eipper BA.

Eur J Cell Biol. 2017 Aug;96(5):407-417. doi: 10.1016/j.ejcb.2017.03.007. Epub 2017 Mar 28.

11.

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.

Pfisterer SG, Gateva G, Horvath P, Pirhonen J, Salo VT, Karhinen L, Varjosalo M, Ryhänen SJ, Lappalainen P, Ikonen E.

Nat Commun. 2017 Mar 31;8:14858. doi: 10.1038/ncomms14858.

12.

Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A.

Kara B, Köroğlu Ç, Peltonen K, Steinberg RC, Maraş Genç H, Hölttä-Vuori M, Güven A, Kanerva K, Kotil T, Solakoğlu S, Zhou Y, Olkkonen VM, Ikonen E, Laiho M, Tolun A.

Eur J Hum Genet. 2017 Feb;25(3):315-323. doi: 10.1038/ejhg.2016.183. Epub 2017 Jan 4.

13.

Seipin regulates ER-lipid droplet contacts and cargo delivery.

Salo VT, Belevich I, Li S, Karhinen L, Vihinen H, Vigouroux C, Magré J, Thiele C, Hölttä-Vuori M, Jokitalo E, Ikonen E.

EMBO J. 2016 Dec 15;35(24):2699-2716. Epub 2016 Nov 22.

14.

Comparison of Atmospheric Pressure Chemical Ionization and Field Ionization Mass Spectrometry for the Analysis of Large Saturated Hydrocarbons.

Jin C, Viidanoja J, Li M, Zhang Y, Ikonen E, Root A, Romanczyk M, Manheim J, Dziekonski E, Kenttämaa HI.

Anal Chem. 2016 Nov 1;88(21):10592-10598. Epub 2016 Oct 12.

PMID:
27700066
15.

Language-Agnostic Reproducible Data Analysis Using Literate Programming.

Vassilev B, Louhimo R, Ikonen E, Hautaniemi S.

PLoS One. 2016 Oct 6;11(10):e0164023. doi: 10.1371/journal.pone.0164023. eCollection 2016.

16.

Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation.

Hölttä-Vuori M, Sezgin E, Eggeling C, Ikonen E.

Traffic. 2016 Sep;17(9):1054-7. doi: 10.1111/tra.12414. Epub 2016 Jun 13.

17.

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.

Motazacker MM, Pirhonen J, van Capelleveen JC, Weber-Boyvat M, Kuivenhoven JA, Shah S, Hovingh GK, Metso J, Li S, Ikonen E, Jauhiainen M, Dallinga-Thie GM, Olkkonen VM.

Atherosclerosis. 2016 Jun;249:140-7. doi: 10.1016/j.atherosclerosis.2016.04.005. Epub 2016 Apr 11.

PMID:
27105157
18.

LDL-cholesterol transport to the endoplasmic reticulum: current concepts.

Pfisterer SG, Peränen J, Ikonen E.

Curr Opin Lipidol. 2016 Jun;27(3):282-7. doi: 10.1097/MOL.0000000000000292. Review.

19.

Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism.

Kettunen KM, Karikoski R, Hämäläinen RH, Toivonen TT, Antonenkov VD, Kulesskaya N, Voikar V, Hölttä-Vuori M, Ikonen E, Sainio K, Jalanko A, Karlberg S, Karlberg N, Lipsanen-Nyman M, Toppari J, Jauhiainen M, Hiltunen JK, Jalanko H, Lehesjoki AE.

Biol Open. 2016 May 15;5(5):584-95. doi: 10.1242/bio.016246.

20.

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study.

Pirhonen J, Arola J, Sädevirta S, Luukkonen P, Karppinen SM, Pihlajaniemi T, Isomäki A, Hukkanen M, Yki-Järvinen H, Ikonen E.

PLoS One. 2016 Jan 25;11(1):e0147804. doi: 10.1371/journal.pone.0147804. eCollection 2016.

21.

Plant sterols, cholesterol precursors and oxysterols: Minute concentrations-Major physiological effects.

Olkkonen VM, Gylling H, Ikonen E.

J Steroid Biochem Mol Biol. 2017 May;169:4-9. doi: 10.1016/j.jsbmb.2015.12.026. Epub 2015 Dec 28. Review.

PMID:
26733205
22.

D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage.

Alfonso-García A, Pfisterer SG, Riezman H, Ikonen E, Potma EO.

J Biomed Opt. 2016 Jun;21(6):61003. doi: 10.1117/1.JBO.21.6.061003.

23.

High-resolution setup for measuring wavelength sensitivity of photoyellowing of translucent materials.

Vaskuri A, Kärhä P, Heikkilä A, Ikonen E.

Rev Sci Instrum. 2015 Oct;86(10):103103. doi: 10.1063/1.4931682.

PMID:
26520936
24.

Lipoprotein-mediated delivery of BODIPY-labeled sterol and sphingolipid analogs reveals lipid transport mechanisms in mammalian cells.

Ikonen E, Blom T.

Chem Phys Lipids. 2016 Jan;194:29-36. doi: 10.1016/j.chemphyslip.2015.08.013. Epub 2015 Sep 4. Review.

PMID:
26343174
25.

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways.

Blom T, Li S, Dichlberger A, Bäck N, Kim YA, Loizides-Mangold U, Riezman H, Bittman R, Ikonen E.

Nat Chem Biol. 2015 Oct;11(10):799-806. doi: 10.1038/nchembio.1889. Epub 2015 Aug 17.

PMID:
26280656
26.

[Plant sterols, cholesterol precursors and oxysterols: small amounts, big effects].

Olkkonen VM, Gylling H, Ikonen E.

Duodecim. 2015;131(3):235-41. Review. Finnish.

PMID:
26245073
27.

Lipid transport takes the 'omics' highway.

Pfisterer SG, Ikonen E.

Curr Opin Lipidol. 2015 Aug;26(4):348-9. doi: 10.1097/MOL.0000000000000201. No abstract available.

PMID:
26164728
28.

The impact of low-frequency and rare variants on lipid levels.

Surakka I, Horikoshi M, Mägi R, Sarin AP, Mahajan A, Lagou V, Marullo L, Ferreira T, Miraglio B, Timonen S, Kettunen J, Pirinen M, Karjalainen J, Thorleifsson G, Hägg S, Hottenga JJ, Isaacs A, Ladenvall C, Beekman M, Esko T, Ried JS, Nelson CP, Willenborg C, Gustafsson S, Westra HJ, Blades M, de Craen AJ, de Geus EJ, Deelen J, Grallert H, Hamsten A, Havulinna AS, Hengstenberg C, Houwing-Duistermaat JJ, Hyppönen E, Karssen LC, Lehtimäki T, Lyssenko V, Magnusson PK, Mihailov E, Müller-Nurasyid M, Mpindi JP, Pedersen NL, Penninx BW, Perola M, Pers TH, Peters A, Rung J, Smit JH, Steinthorsdottir V, Tobin MD, Tsernikova N, van Leeuwen EM, Viikari JS, Willems SM, Willemsen G, Schunkert H, Erdmann J, Samani NJ, Kaprio J, Lind L, Gieger C, Metspalu A, Slagboom PE, Groop L, van Duijn CM, Eriksson JG, Jula A, Salomaa V, Boomsma DI, Power C, Raitakari OT, Ingelsson E, Järvelin MR, Thorsteinsdottir U, Franke L, Ikonen E, Kallioniemi O, Pietiäinen V, Lindgren CM, Stefansson K, Palotie A, McCarthy MI, Morris AP, Prokopenko I, Ripatti S; ENGAGE Consortium.

Nat Genet. 2015 Jun;47(6):589-97. doi: 10.1038/ng.3300. Epub 2015 May 11.

29.

Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers.

Vassilev B, Sihto H, Li S, Hölttä-Vuori M, Ilola J, Lundin J, Isola J, Kellokumpu-Lehtinen PL, Joensuu H, Ikonen E.

Am J Pathol. 2015 Apr;185(4):987-1000. doi: 10.1016/j.ajpath.2014.12.018. Epub 2015 Feb 12.

PMID:
25681734
30.

Polarized THG microscopy identifies compositionally different lipid droplets in mammalian cells.

Bautista G, Pfisterer SG, Huttunen MJ, Ranjan S, Kanerva K, Ikonen E, Kauranen M.

Biophys J. 2014 Nov 18;107(10):2230-6. doi: 10.1016/j.bpj.2014.10.009.

31.

Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes.

Neuvonen M, Manna M, Mokkila S, Javanainen M, Rog T, Liu Z, Bittman R, Vattulainen I, Ikonen E.

PLoS One. 2014 Aug 26;9(8):e103743. doi: 10.1371/journal.pone.0103743. eCollection 2014.

32.

PNPLA3 mediates hepatocyte triacylglycerol remodeling.

Ruhanen H, Perttilä J, Hölttä-Vuori M, Zhou Y, Yki-Järvinen H, Ikonen E, Käkelä R, Olkkonen VM.

J Lipid Res. 2014 Apr;55(4):739-46. doi: 10.1194/jlr.M046607. Epub 2014 Feb 7.

33.

Cholesterol precursors: more than mere markers of biosynthesis.

Brown AJ, Ikonen E, Olkkonen VM.

Curr Opin Lipidol. 2014 Apr;25(2):133-9. doi: 10.1097/MOL.0000000000000038. Review.

PMID:
24378747
34.

Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2.

Wang W, Mutka AL, Zmrzljak UP, Rozman D, Tanila H, Gylling H, Remes AM, Huttunen HJ, Ikonen E.

FASEB J. 2014 Feb;28(2):849-60. doi: 10.1096/fj.13-239301. Epub 2013 Nov 18.

PMID:
24249638
35.

LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route.

Kanerva K, Uronen RL, Blom T, Li S, Bittman R, Lappalainen P, Peränen J, Raposo G, Ikonen E.

Dev Cell. 2013 Nov 11;27(3):249-62. doi: 10.1016/j.devcel.2013.09.016. Epub 2013 Oct 24.

36.

Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.

Zerenturk EJ, Sharpe LJ, Ikonen E, Brown AJ.

Prog Lipid Res. 2013 Oct;52(4):666-80. doi: 10.1016/j.plipres.2013.09.002. Epub 2013 Oct 2. Review.

PMID:
24095826
37.

Organohalogen concentrations and feeding status in Atlantic salmon (Salmo salar L.) of the Baltic Sea during the spawning run.

Vuorinen PJ, Kiviranta H, Koistinen J, Pöyhönen O, Ikonen E, Keinänen M.

Sci Total Environ. 2014 Jan 15;468-469:449-56. doi: 10.1016/j.scitotenv.2013.08.075. Epub 2013 Sep 20.

PMID:
24056447
38.

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.

Pietiäinen V, Vassilev B, Blom T, Wang W, Nelson J, Bittman R, Bäck N, Zelcer N, Ikonen E.

J Cell Sci. 2013 Sep 1;126(Pt 17):3961-71. doi: 10.1242/jcs.128132. Epub 2013 Jun 26.

39.

Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway.

Siljamäki E, Rintanen N, Kirsi M, Upla P, Wang W, Karjalainen M, Ikonen E, Marjomäki V.

PLoS One. 2013;8(2):e55465. doi: 10.1371/journal.pone.0055465. Epub 2013 Feb 5.

40.

Alleviation of seipinopathy-related ER stress by triglyceride storage.

Hölttä-Vuori M, Salo VT, Ohsaki Y, Suster ML, Ikonen E.

Hum Mol Genet. 2013 Mar 15;22(6):1157-66. doi: 10.1093/hmg/dds523. Epub 2012 Dec 18.

PMID:
23250914
41.

What dictates the accumulation of desmosterol in the developing brain?

Jansen M, Wang W, Greco D, Bellenchi GC, di Porzio U, Brown AJ, Ikonen E.

FASEB J. 2013 Mar;27(3):865-70. doi: 10.1096/fj.12-211235. Epub 2012 Dec 10.

PMID:
23230282
42.

Lipid-protein interactions: finding the perfect match.

Blom T, Ikonen E.

Curr Opin Lipidol. 2012 Dec;23(6):581-3. doi: 10.1097/MOL.0b013e32835a4166. No abstract available.

PMID:
23160403
43.

ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion.

Nissilä E, Ohsaki Y, Weber-Boyvat M, Perttilä J, Ikonen E, Olkkonen VM.

Biochim Biophys Acta. 2012 Dec;1821(12):1472-84. doi: 10.1016/j.bbalip.2012.08.004. Epub 2012 Aug 11.

PMID:
22906437
44.

Fatty acyl esterification and deesterification of 17β-estradiol in human breast subcutaneous adipose tissue.

Wang F, Vihma V, Badeau M, Savolainen-Peltonen H, Leidenius M, Mikkola T, Turpeinen U, Hämäläinen E, Ikonen E, Wähälä K, Fledelius C, Jauhiainen M, Tikkanen MJ.

J Clin Endocrinol Metab. 2012 Sep;97(9):3349-56. doi: 10.1210/jc.2012-1762. Epub 2012 Jun 21.

PMID:
22723316
45.

Tracking sphingosine metabolism and transport in sphingolipidoses: NPC1 deficiency as a test case.

Blom T, Li Z, Bittman R, Somerharju P, Ikonen E.

Traffic. 2012 Sep;13(9):1234-43. doi: 10.1111/j.1600-0854.2012.01379.x. Epub 2012 Jun 11.

46.

Endosomal actin remodeling by coronin-1A controls lipoprotein uptake and degradation in macrophages.

Hölttä-Vuori M, Vainio S, Kauppi M, Van Eck M, Jokitalo E, Ikonen E.

Circ Res. 2012 Feb 3;110(3):450-5. doi: 10.1161/CIRCRESAHA.111.256842. Epub 2012 Jan 5.

PMID:
22223354
47.

Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism.

Schmiedt ML, Blom T, Blom T, Kopra O, Wong A, von Schantz-Fant C, Ikonen E, Kuronen M, Jauhiainen M, Cooper JD, Jalanko A.

Neurobiol Dis. 2012 Apr;46(1):19-29. doi: 10.1016/j.nbd.2011.12.009. Epub 2011 Dec 13.

PMID:
22182690
48.

Lipid droplet biogenesis: when the endoplasmic reticulum starts to fatten up.

Salo VT, Ohsaki Y, Ikonen E.

Curr Opin Lipidol. 2011 Dec;22(6):505-6. doi: 10.1097/MOL.0b013e32834d1729. No abstract available.

PMID:
22101561
49.

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M; ITALSGEN Consortium, Heckerman D, Rogaeva E, Zinman L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ.

Neuron. 2011 Oct 20;72(2):257-68. doi: 10.1016/j.neuron.2011.09.010. Epub 2011 Sep 21.

50.

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.

Pykäläinen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakanen J, Koskela EV, Peränen J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R, Lappalainen P.

Nat Struct Mol Biol. 2011 Jul 10;18(8):902-7. doi: 10.1038/nsmb.2079.

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