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Items: 1 to 50 of 224

1.

An efficient auxin-inducible degron system with low basal degradation in human cells.

Li S, Prasanna X, Salo VT, Vattulainen I, Ikonen E.

Nat Methods. 2019 Sep;16(9):866-869. doi: 10.1038/s41592-019-0512-x. Epub 2019 Aug 26.

PMID:
31451765
2.

Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids.

Luukkonen PK, Nick A, Hölttä-Vuori M, Thiele C, Isokuortti E, Lallukka-Brück S, Zhou Y, Hakkarainen A, Lundbom N, Peltonen M, Orho-Melander M, Orešič M, Hyötyläinen T, Hodson L, Ikonen E, Yki-Järvinen H.

JCI Insight. 2019 Aug 22;4(16). pii: 127902. doi: 10.1172/jci.insight.127902.

3.

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.

Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D.

Nat Commun. 2019 Aug 6;10(1):3521. doi: 10.1038/s41467-019-11425-0.

4.

Shuttling HDL Cholesterol to the Membrane via Metastable Receptor Multimers.

Ikonen E, Kanerva K.

Dev Cell. 2019 Aug 5;50(3):257-258. doi: 10.1016/j.devcel.2019.07.018.

PMID:
31386858
5.

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo.

Gungor B, Vanharanta L, Hölttä-Vuori M, Pirhonen J, Petersen NHT, Gramolelli S, Ojala PM, Kirkegaard T, Ikonen E.

Mol Metab. 2019 Jul 6. pii: S2212-8778(19)30602-7. doi: 10.1016/j.molmet.2019.07.005. [Epub ahead of print]

6.

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.

Salo VT, Li S, Vihinen H, Hölttä-Vuori M, Szkalisity A, Horvath P, Belevich I, Peränen J, Thiele C, Somerharju P, Zhao H, Santinho A, Thiam AR, Jokitalo E, Ikonen E.

Dev Cell. 2019 Aug 19;50(4):478-493.e9. doi: 10.1016/j.devcel.2019.05.016. Epub 2019 Jun 6.

PMID:
31178403
7.

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases.

Yambire KF, Fernandez-Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, Raimundo N.

Elife. 2019 Feb 18;8. pii: e39598. doi: 10.7554/eLife.39598.

8.

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol.

Koponen A, Arora A, Takahashi K, Kentala H, Kivelä AM, Jääskeläinen E, Peränen J, Somerharju P, Ikonen E, Viitala T, Olkkonen VM.

Biochimie. 2019 Mar;158:90-101. doi: 10.1016/j.biochi.2018.12.013. Epub 2018 Dec 24.

PMID:
30590084
9.

Moving out but keeping in touch: contacts between endoplasmic reticulum and lipid droplets.

Salo VT, Ikonen E.

Curr Opin Cell Biol. 2019 Apr;57:64-70. doi: 10.1016/j.ceb.2018.11.002. Epub 2018 Nov 23. Review.

10.

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P.

Cell. 2018 Oct 4;175(2):514-529.e20. doi: 10.1016/j.cell.2018.08.033. Epub 2018 Sep 13.

PMID:
30220461
11.

Association of tamoxifen resistance and lipid reprogramming in breast cancer.

Hultsch S, Kankainen M, Paavolainen L, Kovanen RM, Ikonen E, Kangaspeska S, Pietiäinen V, Kallioniemi O.

BMC Cancer. 2018 Aug 24;18(1):850. doi: 10.1186/s12885-018-4757-z.

12.

Mechanisms of cellular cholesterol compartmentalization: recent insights.

Ikonen E.

Curr Opin Cell Biol. 2018 Aug;53:77-83. doi: 10.1016/j.ceb.2018.06.002. Epub 2018 Jun 28. Review.

13.

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism.

Kentala H, Koponen A, Vihinen H, Pirhonen J, Liebisch G, Pataj Z, Kivelä A, Li S, Karhinen L, Jääskeläinen E, Andrews R, Meriläinen L, Matysik S, Ikonen E, Zhou Y, Jokitalo E, Olkkonen VM.

Cell Mol Life Sci. 2018 Nov;75(21):4041-4057. doi: 10.1007/s00018-018-2850-8. Epub 2018 Jun 12.

PMID:
29947926
14.

A Ceramide-Regulated Element in the Late Endosomal Protein LAPTM4B Controls Amino Acid Transporter Interaction.

Zhou K, Dichlberger A, Martinez-Seara H, Nyholm TKM, Li S, Kim YA, Vattulainen I, Ikonen E, Blom T.

ACS Cent Sci. 2018 May 23;4(5):548-558. doi: 10.1021/acscentsci.7b00582. Epub 2018 May 9.

15.

Concerted regulation of npc2 binding to endosomal/lysosomal membranes by bis(monoacylglycero)phosphate and sphingomyelin.

Enkavi G, Mikkolainen H, Güngör B, Ikonen E, Vattulainen I.

PLoS Comput Biol. 2017 Oct 30;13(10):e1005831. doi: 10.1371/journal.pcbi.1005831. eCollection 2017 Oct.

16.

Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network.

Capasso S, Sticco L, Rizzo R, Pirozzi M, Russo D, Dathan NA, Campelo F, van Galen J, Hölttä-Vuori M, Turacchio G, Hausser A, Malhotra V, Riezman I, Riezman H, Ikonen E, Luberto C, Parashuraman S, Luini A, D'Angelo G.

EMBO J. 2017 Jun 14;36(12):1736-1754. doi: 10.15252/embj.201696048. Epub 2017 May 10.

17.

Nonlinearity characterization of array spectroradiometers for the solar UV measurements.

Pulli T, Nevas S, El Gawhary O, van den Berg S, Askola J, Kärhä P, Manoocheri F, Ikonen E.

Appl Opt. 2017 Apr 10;56(11):3077-3086. doi: 10.1364/AO.56.003077.

PMID:
28414366
18.

Introducing inducible fluorescent split cholesterol oxidase to mammalian cells.

Chernov KG, Neuvonen M, Brock I, Ikonen E, Verkhusha VV.

J Biol Chem. 2017 May 26;292(21):8811-8822. doi: 10.1074/jbc.M116.761718. Epub 2017 Apr 7.

19.

The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together.

Bäck N, Kanerva K, Kurutihalli V, Yanik A, Ikonen E, Mains RE, Eipper BA.

Eur J Cell Biol. 2017 Aug;96(5):407-417. doi: 10.1016/j.ejcb.2017.03.007. Epub 2017 Mar 28.

20.

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.

Pfisterer SG, Gateva G, Horvath P, Pirhonen J, Salo VT, Karhinen L, Varjosalo M, Ryhänen SJ, Lappalainen P, Ikonen E.

Nat Commun. 2017 Mar 31;8:14858. doi: 10.1038/ncomms14858.

21.

Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A.

Kara B, Köroğlu Ç, Peltonen K, Steinberg RC, Maraş Genç H, Hölttä-Vuori M, Güven A, Kanerva K, Kotil T, Solakoğlu S, Zhou Y, Olkkonen VM, Ikonen E, Laiho M, Tolun A.

Eur J Hum Genet. 2017 Feb;25(3):315-323. doi: 10.1038/ejhg.2016.183. Epub 2017 Jan 4.

22.

Seipin regulates ER-lipid droplet contacts and cargo delivery.

Salo VT, Belevich I, Li S, Karhinen L, Vihinen H, Vigouroux C, Magré J, Thiele C, Hölttä-Vuori M, Jokitalo E, Ikonen E.

EMBO J. 2016 Dec 15;35(24):2699-2716. Epub 2016 Nov 22.

23.

Comparison of Atmospheric Pressure Chemical Ionization and Field Ionization Mass Spectrometry for the Analysis of Large Saturated Hydrocarbons.

Jin C, Viidanoja J, Li M, Zhang Y, Ikonen E, Root A, Romanczyk M, Manheim J, Dziekonski E, Kenttämaa HI.

Anal Chem. 2016 Nov 1;88(21):10592-10598. Epub 2016 Oct 12.

PMID:
27700066
24.

Language-Agnostic Reproducible Data Analysis Using Literate Programming.

Vassilev B, Louhimo R, Ikonen E, Hautaniemi S.

PLoS One. 2016 Oct 6;11(10):e0164023. doi: 10.1371/journal.pone.0164023. eCollection 2016.

25.

Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation.

Hölttä-Vuori M, Sezgin E, Eggeling C, Ikonen E.

Traffic. 2016 Sep;17(9):1054-7. doi: 10.1111/tra.12414. Epub 2016 Jun 13.

26.

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.

Motazacker MM, Pirhonen J, van Capelleveen JC, Weber-Boyvat M, Kuivenhoven JA, Shah S, Hovingh GK, Metso J, Li S, Ikonen E, Jauhiainen M, Dallinga-Thie GM, Olkkonen VM.

Atherosclerosis. 2016 Jun;249:140-7. doi: 10.1016/j.atherosclerosis.2016.04.005. Epub 2016 Apr 11.

PMID:
27105157
27.

LDL-cholesterol transport to the endoplasmic reticulum: current concepts.

Pfisterer SG, Peränen J, Ikonen E.

Curr Opin Lipidol. 2016 Jun;27(3):282-7. doi: 10.1097/MOL.0000000000000292. Review.

28.

Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism.

Kettunen KM, Karikoski R, Hämäläinen RH, Toivonen TT, Antonenkov VD, Kulesskaya N, Voikar V, Hölttä-Vuori M, Ikonen E, Sainio K, Jalanko A, Karlberg S, Karlberg N, Lipsanen-Nyman M, Toppari J, Jauhiainen M, Hiltunen JK, Jalanko H, Lehesjoki AE.

Biol Open. 2016 May 15;5(5):584-95. doi: 10.1242/bio.016246.

29.

Continuous Grading of Early Fibrosis in NAFLD Using Label-Free Imaging: A Proof-of-Concept Study.

Pirhonen J, Arola J, Sädevirta S, Luukkonen P, Karppinen SM, Pihlajaniemi T, Isomäki A, Hukkanen M, Yki-Järvinen H, Ikonen E.

PLoS One. 2016 Jan 25;11(1):e0147804. doi: 10.1371/journal.pone.0147804. eCollection 2016.

30.

Plant sterols, cholesterol precursors and oxysterols: Minute concentrations-Major physiological effects.

Olkkonen VM, Gylling H, Ikonen E.

J Steroid Biochem Mol Biol. 2017 May;169:4-9. doi: 10.1016/j.jsbmb.2015.12.026. Epub 2015 Dec 28. Review.

PMID:
26733205
31.

D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage.

Alfonso-García A, Pfisterer SG, Riezman H, Ikonen E, Potma EO.

J Biomed Opt. 2016 Jun;21(6):61003. doi: 10.1117/1.JBO.21.6.061003.

32.

High-resolution setup for measuring wavelength sensitivity of photoyellowing of translucent materials.

Vaskuri A, Kärhä P, Heikkilä A, Ikonen E.

Rev Sci Instrum. 2015 Oct;86(10):103103. doi: 10.1063/1.4931682.

PMID:
26520936
33.

Lipoprotein-mediated delivery of BODIPY-labeled sterol and sphingolipid analogs reveals lipid transport mechanisms in mammalian cells.

Ikonen E, Blom T.

Chem Phys Lipids. 2016 Jan;194:29-36. doi: 10.1016/j.chemphyslip.2015.08.013. Epub 2015 Sep 4. Review.

PMID:
26343174
34.

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways.

Blom T, Li S, Dichlberger A, Bäck N, Kim YA, Loizides-Mangold U, Riezman H, Bittman R, Ikonen E.

Nat Chem Biol. 2015 Oct;11(10):799-806. doi: 10.1038/nchembio.1889. Epub 2015 Aug 17.

PMID:
26280656
35.

[Plant sterols, cholesterol precursors and oxysterols: small amounts, big effects].

Olkkonen VM, Gylling H, Ikonen E.

Duodecim. 2015;131(3):235-41. Review. Finnish.

PMID:
26245073
36.

Lipid transport takes the 'omics' highway.

Pfisterer SG, Ikonen E.

Curr Opin Lipidol. 2015 Aug;26(4):348-9. doi: 10.1097/MOL.0000000000000201. No abstract available.

PMID:
26164728
37.

The impact of low-frequency and rare variants on lipid levels.

Surakka I, Horikoshi M, Mägi R, Sarin AP, Mahajan A, Lagou V, Marullo L, Ferreira T, Miraglio B, Timonen S, Kettunen J, Pirinen M, Karjalainen J, Thorleifsson G, Hägg S, Hottenga JJ, Isaacs A, Ladenvall C, Beekman M, Esko T, Ried JS, Nelson CP, Willenborg C, Gustafsson S, Westra HJ, Blades M, de Craen AJ, de Geus EJ, Deelen J, Grallert H, Hamsten A, Havulinna AS, Hengstenberg C, Houwing-Duistermaat JJ, Hyppönen E, Karssen LC, Lehtimäki T, Lyssenko V, Magnusson PK, Mihailov E, Müller-Nurasyid M, Mpindi JP, Pedersen NL, Penninx BW, Perola M, Pers TH, Peters A, Rung J, Smit JH, Steinthorsdottir V, Tobin MD, Tsernikova N, van Leeuwen EM, Viikari JS, Willems SM, Willemsen G, Schunkert H, Erdmann J, Samani NJ, Kaprio J, Lind L, Gieger C, Metspalu A, Slagboom PE, Groop L, van Duijn CM, Eriksson JG, Jula A, Salomaa V, Boomsma DI, Power C, Raitakari OT, Ingelsson E, Järvelin MR, Thorsteinsdottir U, Franke L, Ikonen E, Kallioniemi O, Pietiäinen V, Lindgren CM, Stefansson K, Palotie A, McCarthy MI, Morris AP, Prokopenko I, Ripatti S; ENGAGE Consortium.

Nat Genet. 2015 Jun;47(6):589-97. doi: 10.1038/ng.3300. Epub 2015 May 11.

38.

Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers.

Vassilev B, Sihto H, Li S, Hölttä-Vuori M, Ilola J, Lundin J, Isola J, Kellokumpu-Lehtinen PL, Joensuu H, Ikonen E.

Am J Pathol. 2015 Apr;185(4):987-1000. doi: 10.1016/j.ajpath.2014.12.018. Epub 2015 Feb 12.

PMID:
25681734
39.

Polarized THG microscopy identifies compositionally different lipid droplets in mammalian cells.

Bautista G, Pfisterer SG, Huttunen MJ, Ranjan S, Kanerva K, Ikonen E, Kauranen M.

Biophys J. 2014 Nov 18;107(10):2230-6. doi: 10.1016/j.bpj.2014.10.009.

40.

Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes.

Neuvonen M, Manna M, Mokkila S, Javanainen M, Rog T, Liu Z, Bittman R, Vattulainen I, Ikonen E.

PLoS One. 2014 Aug 26;9(8):e103743. doi: 10.1371/journal.pone.0103743. eCollection 2014.

41.

PNPLA3 mediates hepatocyte triacylglycerol remodeling.

Ruhanen H, Perttilä J, Hölttä-Vuori M, Zhou Y, Yki-Järvinen H, Ikonen E, Käkelä R, Olkkonen VM.

J Lipid Res. 2014 Apr;55(4):739-46. doi: 10.1194/jlr.M046607. Epub 2014 Feb 7.

42.

Cholesterol precursors: more than mere markers of biosynthesis.

Brown AJ, Ikonen E, Olkkonen VM.

Curr Opin Lipidol. 2014 Apr;25(2):133-9. doi: 10.1097/MOL.0000000000000038. Review.

PMID:
24378747
43.

Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2.

Wang W, Mutka AL, Zmrzljak UP, Rozman D, Tanila H, Gylling H, Remes AM, Huttunen HJ, Ikonen E.

FASEB J. 2014 Feb;28(2):849-60. doi: 10.1096/fj.13-239301. Epub 2013 Nov 18.

PMID:
24249638
44.

LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route.

Kanerva K, Uronen RL, Blom T, Li S, Bittman R, Lappalainen P, Peränen J, Raposo G, Ikonen E.

Dev Cell. 2013 Nov 11;27(3):249-62. doi: 10.1016/j.devcel.2013.09.016. Epub 2013 Oct 24.

45.

Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.

Zerenturk EJ, Sharpe LJ, Ikonen E, Brown AJ.

Prog Lipid Res. 2013 Oct;52(4):666-80. doi: 10.1016/j.plipres.2013.09.002. Epub 2013 Oct 2. Review.

PMID:
24095826
46.

Organohalogen concentrations and feeding status in Atlantic salmon (Salmo salar L.) of the Baltic Sea during the spawning run.

Vuorinen PJ, Kiviranta H, Koistinen J, Pöyhönen O, Ikonen E, Keinänen M.

Sci Total Environ. 2014 Jan 15;468-469:449-56. doi: 10.1016/j.scitotenv.2013.08.075. Epub 2013 Sep 20.

PMID:
24056447
47.

NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.

Pietiäinen V, Vassilev B, Blom T, Wang W, Nelson J, Bittman R, Bäck N, Zelcer N, Ikonen E.

J Cell Sci. 2013 Sep 1;126(Pt 17):3961-71. doi: 10.1242/jcs.128132. Epub 2013 Jun 26.

48.

Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway.

Siljamäki E, Rintanen N, Kirsi M, Upla P, Wang W, Karjalainen M, Ikonen E, Marjomäki V.

PLoS One. 2013;8(2):e55465. doi: 10.1371/journal.pone.0055465. Epub 2013 Feb 5.

49.

Alleviation of seipinopathy-related ER stress by triglyceride storage.

Hölttä-Vuori M, Salo VT, Ohsaki Y, Suster ML, Ikonen E.

Hum Mol Genet. 2013 Mar 15;22(6):1157-66. doi: 10.1093/hmg/dds523. Epub 2012 Dec 18.

PMID:
23250914
50.

What dictates the accumulation of desmosterol in the developing brain?

Jansen M, Wang W, Greco D, Bellenchi GC, di Porzio U, Brown AJ, Ikonen E.

FASEB J. 2013 Mar;27(3):865-70. doi: 10.1096/fj.12-211235. Epub 2012 Dec 10.

PMID:
23230282

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