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Items: 1 to 50 of 529

1.

Number of functional teeth more strongly predicts all-cause mortality than number of present teeth in Japanese older adults.

Maekawa K, Ikeuchi T, Shinkai S, Hirano H, Ryu M, Tamaki K, Yatani H, Kuboki T; Kusatsu ISLE Study Working Group Collaborators, Kimura-Ono A, Kikutani T, Suganuma T, Ayukawa Y, Gonda T, Ogawa T, Fujisawa M, Ishigaki S, Watanabe Y, Kitamura A, Taniguchi Y, Fujiwara Y, Edahiro A, Ohara Y, Furuya J, Nakajima J, Umeki K, Igarashi K, Horibe Y, Kugimiya Y, Kawai Y, Matsumura H, Ichikawa T, Ohkawa S.

Geriatr Gerontol Int. 2020 Mar 29. doi: 10.1111/ggi.13911. [Epub ahead of print]

PMID:
32227400
2.

Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's disease.

Suzuki K, Hirakawa A, Ihara R, Iwata A, Ishii K, Ikeuchi T, Sun CK, Donohue M, Iwatsubo T; Alzheimer's Disease Neuroimaging Initiative, Japanese Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement (N Y). 2020 Mar 20;6(1):e12007. doi: 10.1002/trc2.12007. eCollection 2020.

3.

Phase II study of α-galactosylceramide-pulsed antigen-presenting cells in patients with advanced or recurrent non-small cell lung cancer.

Toyoda T, Kamata T, Tanaka K, Ihara F, Takami M, Suzuki H, Nakajima T, Ikeuchi T, Kawasaki Y, Hanaoka H, Nakayama T, Yoshino I, Motohashi S.

J Immunother Cancer. 2020 Mar;8(1). pii: e000316. doi: 10.1136/jitc-2019-000316.

4.

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease.

Barthélemy NR, Li Y, Joseph-Mathurin N, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Perrin RJ, Goate AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Berman SB, Ikeuchi T, Mori H, Shimada H, Shoji M, Suzuki K, Noble J, Farlow M, Chhatwal J, Graff-Radford NR, Salloway S, Schofield PR, Masters CL, Martins RN, O'Connor A, Fox NC, Levin J, Jucker M, Gabelle A, Lehmann S, Sato C, Bateman RJ, McDade E; Dominantly Inherited Alzheimer Network.

Nat Med. 2020 Mar;26(3):398-407. doi: 10.1038/s41591-020-0781-z. Epub 2020 Mar 11.

PMID:
32161412
5.

[Impact of lifestyle-related diseases and frailty on the incidence of loss of independence in Japanese community-dwelling older adults: A Longitudinal Study on Aging and Health in Kusatsu].

Kitamura A, Seino S, Taniguchi Y, Yokoyama Y, Amano H, Nishi M, Nofuji Y, Narita M, Ikeuchi T, Abe T, Fujiwara Y, Shinkai S.

Nihon Koshu Eisei Zasshi. 2020;67(2):134-145. doi: 10.11236/jph.67.2_134. Japanese.

6.

Dose-Response Relationships Between Body Composition Indices and All-Cause Mortality in Older Japanese Adults.

Seino S, Kitamura A, Abe T, Taniguchi Y, Yokoyama Y, Amano H, Nishi M, Nofuji Y, Narita M, Ikeuchi T, Fujiwara Y, Shinkai S.

J Am Med Dir Assoc. 2020 Feb 14. pii: S1525-8610(19)30827-8. doi: 10.1016/j.jamda.2019.11.018. [Epub ahead of print]

PMID:
32067890
7.

Novel tau filament fold in corticobasal degeneration.

Zhang W, Tarutani A, Newell KL, Murzin AG, Matsubara T, Falcon B, Vidal R, Garringer HJ, Shi Y, Ikeuchi T, Murayama S, Ghetti B, Hasegawa M, Goedert M, Scheres SHW.

Nature. 2020 Feb 12. doi: 10.1038/s41586-020-2043-0. [Epub ahead of print]

PMID:
32050258
8.

Fibulin-7 C-terminal fragment and its active synthetic peptide suppress choroidal and retinal neovascularization.

Ikeuchi T, Kanan Y, Long D, de Vega S, Hozumi K, Nomizu M, Campochiaro PA, Yamada Y.

Microvasc Res. 2020 May;129:103986. doi: 10.1016/j.mvr.2020.103986. Epub 2020 Feb 1.

PMID:
32017943
9.

Disruption of a RAC1-centred network is associated with Alzheimer's disease pathology and causes age-dependent neurodegeneration.

Kikuchi M, Sekiya M, Hara N, Miyashita A, Kuwano R, Ikeuchi T, Iijima KM, Nakaya A.

Hum Mol Genet. 2020 Mar 27;29(5):817-833. doi: 10.1093/hmg/ddz320.

PMID:
31942999
10.

Different clinical and neuroimaging features of Japanese dementia siblings with a new N-terminal mutation (Val225Ala) of APP gene.

Ohta Y, Hishikawa N, Ikegami K, Sato K, Osakada Y, Takemoto M, Yamashita T, Omote Y, Ikeuchi T, Abe K.

J Clin Neurosci. 2020 Feb;72:482-484. doi: 10.1016/j.jocn.2019.11.009. Epub 2020 Jan 11.

PMID:
31937505
11.

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.

Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, Poliani PL, Cominelli M, Grover S, Gilfillan S, Cella M, Ulland TK, Zaitsev K, Miyashita A, Ikeuchi T, Sainouchi M, Kakita A, Bennett DA, Schneider JA, Nichols MR, Beausoleil SA, Ulrich JD, Holtzman DM, Artyomov MN, Colonna M.

Nat Med. 2020 Jan;26(1):131-142. doi: 10.1038/s41591-019-0695-9. Epub 2020 Jan 13.

PMID:
31932797
12.

Low-crosstalk few-mode EDFAs using retro-reflection for single-mode fiber trunk lines and networks.

Wang N, Kim I, Vassilieva O, Ikeuchi T, Wen H, Antonio-Lopez JE, Alvarado-Zacarias JC, Liu H, Fan S, Habib MS, Amezcua-Correa R, Li G.

Opt Express. 2019 Nov 25;27(24):35962-35970. doi: 10.1364/OE.27.035962.

PMID:
31878760
13.

Association of Dog and Cat Ownership with Incident Frailty among Community-Dwelling Elderly Japanese.

Taniguchi Y, Seino S, Nishi M, Tomine Y, Tanaka I, Yokoyama Y, Ikeuchi T, Kitamura A, Shinkai S.

Sci Rep. 2019 Dec 9;9(1):18604. doi: 10.1038/s41598-019-54955-9.

14.

Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease.

Hata S, Omori C, Kimura A, Saito H, Kimura N, Gupta V, Pedrini S, Hone E, Chatterjee P, Taddei K, Kasuga K, Ikeuchi T, Waragai M, Nishimura M, Hu A, Nakaya T, Meijer L, Maeda M, Yamamoto T, Masters CL, Rowe CC, Ames D, Yamamoto K, Martins RN, Gandy S, Suzuki T.

Alzheimers Dement (N Y). 2019 Nov 7;5:740-750. doi: 10.1016/j.trci.2019.09.015. eCollection 2019.

15.

Association of trajectories of cognitive function with cause-specific mortality and medical and long-term care costs.

Taniguchi Y, Kitamura A, Ishizaki T, Fujiwara Y, Shinozaki T, Seino S, Mitsutake S, Suzuki H, Yokoyama Y, Abe T, Ikeuchi T, Yokota I, Matsuyama Y, Shinkai S.

Geriatr Gerontol Int. 2019 Dec;19(12):1236-1242. doi: 10.1111/ggi.13802. Epub 2019 Nov 19.

PMID:
31746115
16.

Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.

Hayakawa H, Nakatani R, Ikenaka K, Aguirre C, Choong CJ, Tsuda H, Nagano S, Koike M, Ikeuchi T, Hasegawa M, Papa SM, Nagai Y, Mochizuki H, Baba K.

Mov Disord. 2020 Feb;35(2):256-267. doi: 10.1002/mds.27887. Epub 2019 Oct 23.

PMID:
31643109
17.

Differences in the Prevalence of and Factors Associated with Frailty in Five Japanese Residential Areas.

Abe T, Kitamura A, Seino S, Yokoyama Y, Amano H, Taniguchi Y, Nishi M, Narita M, Ikeuchi T, Tomine Y, Fujiwara Y, Shinkai S.

Int J Environ Res Public Health. 2019 Oct 18;16(20). pii: E3974. doi: 10.3390/ijerph16203974.

18.

Morphological characterisation of glial and neuronal tau pathology in globular glial tauopathy (Types II and III).

Tanaka H, Toyoshima Y, Kawakatsu S, Kobayashi R, Yokota O, Terada S, Kuroda S, Miura T, Higuchi Y, Otsu H, Sanpei K, Otani K, Ikeuchi T, Onodera O, Kakita A, Takahashi H.

Neuropathol Appl Neurobiol. 2019 Oct 10. doi: 10.1111/nan.12581. [Epub ahead of print]

PMID:
31600825
19.

[Exploring Therapeutic Targets for Alzheimer's Disease by Comprehensive Genetic Analysis].

Ikeuchi T.

Brain Nerve. 2019 Oct;71(10):1081-1088. doi: 10.11477/mf.1416201407. Review. Japanese.

PMID:
31588052
20.

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs.

Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, Kimura T, Yoshimatsu S, Kisa F, Karch CM, Miyasaka T, Takashima A, Sahara N, Hisanaga SI, Ikeuchi T, Kaibuchi K, Okano H.

Stem Cell Reports. 2019 Oct 8;13(4):684-699. doi: 10.1016/j.stemcr.2019.08.011. Epub 2019 Sep 19.

21.

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.

Nakamura K, Ikeuchi T, Nara K, Rhodes CS, Zhang P, Chiba Y, Kazuno S, Miura Y, Ago T, Arikawa-Hirasawa E, Mukouyama YS, Yamada Y.

J Cell Biol. 2019 Oct 7;218(10):3506-3525. doi: 10.1083/jcb.201807178. Epub 2019 Sep 20.

PMID:
31541017
22.

Enhancer variants associated with Alzheimer's disease affect gene expression via chromatin looping.

Kikuchi M, Hara N, Hasegawa M, Miyashita A, Kuwano R, Ikeuchi T, Nakaya A.

BMC Med Genomics. 2019 Sep 9;12(1):128. doi: 10.1186/s12920-019-0574-8.

23.

APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer's Disease Risk in a Multiracial Sample.

Choi KY, Lee JJ, Gunasekaran TI, Kang S, Lee W, Jeong J, Lim HJ, Zhang X, Zhu C, Won SY, Choi YY, Seo EH, Lee SC, Gim J, Chung JY, Chong A, Byun MS, Seo S, Ko PW, Han JW, McLean C, Farrell J, Lunetta KL, Miyashita A, Hara N, Won S, Choi SM, Ha JM, Jeong JH, Kuwano R, Song MK, An SSA, Lee YM, Park KW, Lee HW, Choi SH, Rhee S, Song WK, Lee JS, Mayeux R, Haines JL, Pericak-Vance MA, Choo ILH, Nho K, Kim KW, Lee DY, Kim S, Kim BC, Kim H, Jun GR, Schellenberg GD, Ikeuchi T, Farrer LA, Lee KH, Neuroimaging Initative AD.

J Clin Med. 2019 Aug 16;8(8). pii: E1236. doi: 10.3390/jcm8081236.

24.

Visualizing modules of coordinated structural brain atrophy during the course of conversion to Alzheimer's disease by applying methodology from gene co-expression analysis.

Sato K, Mano T, Matsuda H, Senda M, Ihara R, Suzuki K, Arai H, Ishii K, Ito K, Ikeuchi T, Kuwano R, Toda T, Iwatsubo T, Iwata A; Japanese Alzheimer's Disease Neuroimaging Initiative.

Neuroimage Clin. 2019;24:101957. doi: 10.1016/j.nicl.2019.101957. Epub 2019 Jul 25.

25.

USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.

Piatnitskaia S, Takahashi M, Kitaura H, Katsuragi Y, Kakihana T, Zhang L, Kakita A, Iwakura Y, Nawa H, Miura T, Ikeuchi T, Hara T, Fujii M.

Sci Rep. 2019 Jul 22;9(1):10591. doi: 10.1038/s41598-019-47033-7.

26.

Albumin and Hemoglobin Trajectories and Incident Disabling Dementia in Community-Dwelling Older Japanese.

Taniguchi Y, Kitamura A, Kaito S, Yokoyama Y, Yokota I, Shinozaki T, Seino S, Murayama H, Matsuyama Y, Ikeuchi T, Fujiwara Y, Shinkai S.

Dement Geriatr Cogn Disord. 2019;47(4-6):233-242. doi: 10.1159/000499837. Epub 2019 Jul 17.

PMID:
31315125
27.

Vertebrates originally possess four functional subtypes of G protein-coupled melatonin receptor.

Sakai K, Yamamoto Y, Ikeuchi T.

Sci Rep. 2019 Jul 1;9(1):9465. doi: 10.1038/s41598-019-45925-2.

28.

Single pembrolizumab treatment causing profound durable response in a patient with pulmonary pleomorphic carcinoma.

Tokuyasu H, Ishikawa S, Sakai H, Ikeuchi T, Miura H.

Respir Med Case Rep. 2019 Jun 11;28:100879. doi: 10.1016/j.rmcr.2019.100879. eCollection 2019.

29.

A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer's disease.

Asanomi Y, Shigemizu D, Miyashita A, Mitsumori R, Mori T, Hara N, Ito K, Niida S, Ikeuchi T, Ozaki K.

Mol Med. 2019 Jun 20;25(1):20. doi: 10.1186/s10020-019-0090-5.

30.

Critical Switching of Cyclization Modes of Polyepoxides in Acidic Aqueous Media and Neutral Water: Synthesis and Revised Structure of a Nerolidol-Type Sesquiterpenoid.

Nishikawa K, Morita K, Hashimoto S, Hoshino A, Ikeuchi T, Kumagai M, Morimoto Y.

Angew Chem Int Ed Engl. 2019 Jul 22;58(30):10168-10172. doi: 10.1002/anie.201906039. Epub 2019 Jul 3.

PMID:
31211481
31.

Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson's disease.

Murakami H, Tokuda T, El-Agnaf OMA, Ohmichi T, Miki A, Ohashi H, Owan Y, Saito Y, Yano S, Tsukie T, Ikeuchi T, Ono K.

BMC Neurol. 2019 Jun 4;19(1):113. doi: 10.1186/s12883-019-1346-y.

32.

Deep learning facilitates the diagnosis of adult asthma.

Tomita K, Nagao R, Touge H, Ikeuchi T, Sano H, Yamasaki A, Tohda Y.

Allergol Int. 2019 Oct;68(4):456-461. doi: 10.1016/j.alit.2019.04.010. Epub 2019 May 30.

33.

Molecular Network Analysis of the Urinary Proteome of Alzheimer's Disease Patients.

Watanabe Y, Hirao Y, Kasuga K, Tokutake T, Semizu Y, Kitamura K, Ikeuchi T, Nakamura K, Yamamoto T.

Dement Geriatr Cogn Dis Extra. 2019 Feb 8;9(1):53-65. doi: 10.1159/000496100. eCollection 2019 Jan-Apr.

34.

Pathway from gait speed to incidence of disability and mortality in older adults: A mediating role of physical activity.

Abe T, Kitamura A, Taniguchi Y, Amano H, Seino S, Yokoyama Y, Nishi M, Narita M, Ikeuchi T, Fujiwara Y, Shinkai S.

Maturitas. 2019 May;123:32-36. doi: 10.1016/j.maturitas.2019.02.002. Epub 2019 Feb 7.

PMID:
31027674
35.

Gold(I)-Catalyzed Cascade Cyclization Reactions of Allenynes for the Synthesis of Fused Cyclopropanes and Acenaphthenes.

Ikeuchi T, Inuki S, Oishi S, Ohno H.

Angew Chem Int Ed Engl. 2019 Jun 3;58(23):7792-7796. doi: 10.1002/anie.201903384. Epub 2019 May 6.

PMID:
30985049
36.

Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1.

de Vega S, Kondo A, Suzuki M, Arai H, Jiapaer S, Sabit H, Nakada M, Ikeuchi T, Ishijima M, Arikawa-Hirasawa E, Yamada Y, Okada Y.

Int J Cancer. 2019 Oct 15;145(8):2157-2169. doi: 10.1002/ijc.32306. Epub 2019 Apr 15.

PMID:
30924128
37.

Lower Serum Calcium as a Potentially Associated Factor for Conversion of Mild Cognitive Impairment to Early Alzheimer's Disease in the Japanese Alzheimer's Disease Neuroimaging Initiative.

Sato K, Mano T, Ihara R, Suzuki K, Tomita N, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Iwatsubo T, Toda T, Iwata A; Alzheimer’s Disease Neuroimaging Initiative, and Japanese Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2019;68(2):777-788. doi: 10.3233/JAD-181115.

PMID:
30814351
38.

Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer's disease with cotton wool plaques due to a novel presenilin1 G417S mutation.

Miki T, Yokota O, Haraguchi T, Ikeuchi T, Zhu B, Takenoshita S, Terada S, Yamada N.

Acta Neuropathol Commun. 2019 Feb 12;7(1):19. doi: 10.1186/s40478-019-0672-z. No abstract available.

39.

Cerebral hemorrhagic stroke associated with cerebral amyloid angiopathy in young adults about 3 decades after neurosurgeries in their infancy.

Hamaguchi T, Komatsu J, Sakai K, Noguchi-Shinohara M, Aoki S, Ikeuchi T, Yamada M.

J Neurol Sci. 2019 Apr 15;399:3-5. doi: 10.1016/j.jns.2019.01.051. Epub 2019 Feb 1. No abstract available.

PMID:
30735884
40.

Duplication and deletion upstream of LMNB1 in autosomal dominant adult-onset leukodystrophy.

Mezaki N, Miura T, Ogaki K, Eriguchi M, Mizuno Y, Komatsu K, Yamazaki H, Suetsugi N, Kawajiri S, Yamasaki R, Ishiguro T, Konno T, Nozaki H, Kasuga K, Okuma Y, Kira JI, Hara H, Onodera O, Ikeuchi T.

Neurol Genet. 2018 Dec 7;4(6):e292. doi: 10.1212/NXG.0000000000000292. eCollection 2018 Dec.

41.

Effects of sex, educational background, and chronic kidney disease grading on longitudinal cognitive and functional decline in patients in the Japanese Alzheimer's Disease Neuroimaging Initiative study.

Iwata A, Iwatsubo T, Ihara R, Suzuki K, Matsuyama Y, Tomita N, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H; Alzheimer's Disease Neuroimaging Initiative; Japanese Alzheimer’s Disease Neuroimaging Initiative.

Alzheimers Dement (N Y). 2018 Jul 12;4:765-774. doi: 10.1016/j.trci.2018.06.008. eCollection 2018.

42.

Globular glial tauopathy Type II: Clinicopathological study of two autopsy cases.

Tanaka H, Kawakatsu S, Toyoshima Y, Miura T, Mezaki N, Mano A, Sanpei K, Kobayashi R, Hayashi H, Otani K, Ikeuchi T, Onodera O, Kakita A, Takahashi H.

Neuropathology. 2019 Apr;39(2):111-119. doi: 10.1111/neup.12532. Epub 2019 Jan 15.

PMID:
30646429
43.

Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation.

Harada K, Ihara F, Takami M, Kamata T, Mise N, Yoshizawa H, Hishiki T, Saito T, Terui K, Nakata M, Komatsu S, Ikeuchi T, Nakayama T, Yoshida H, Motohashi S.

Cancer Sci. 2019 Mar;110(3):888-902. doi: 10.1111/cas.13933. Epub 2019 Feb 1.

44.

Successful Treatment of Lung Adenocarcinoma with Epidermal Growth Factor Receptor Compound Mutations Involving Exon 19 Deletion and Exon 20 Insertion by Afatinib.

Ikeuchi T, Tokuyasu H, Ishikawa S.

Intern Med. 2019;58(1):101-104. doi: 10.2169/internalmedicine.0927-18. Epub 2019 Jan 1.

45.

Differential gene expression analysis and SNP/InDel marker discovery in resistant wild Asparagus kiusianus and susceptible A. officinalis in response to Phomopsis asparagi infection.

Abdelrahman M, Mitoma M, Ikeuchi T, Mori M, Murakami K, Ozaki Y, Matsumoto M, Uragami A, Kanno A.

Data Brief. 2018 Nov 13;21:2117-2121. doi: 10.1016/j.dib.2018.11.034. eCollection 2018 Dec.

46.

Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity.

Ikeuchi T, de Vega S, Forcinito P, Doyle AD, Amaral J, Rodriguez IR, Arikawa-Hirasawa E, Yamada Y.

Sci Rep. 2018 Dec 5;8(1):17654. doi: 10.1038/s41598-018-36182-w.

47.

Clinical and cognitive characteristics of preclinical Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative cohort.

Ihara R, Iwata A, Suzuki K, Ikeuchi T, Kuwano R, Iwatsubo T; Japanese Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement (N Y). 2018 Nov 26;4:645-651. doi: 10.1016/j.trci.2018.10.004. eCollection 2018.

48.

Frequency of Balanced-Meal Consumption and Frailty in Community-Dwelling Older Japanese: A Cross-Sectional Study.

Yokoyama Y, Kitamura A, Nishi M, Seino S, Taniguchi Y, Amano H, Ikeuchi T, Shinkai S.

J Epidemiol. 2019 Oct 5;29(10):370-376. doi: 10.2188/jea.JE20180076. Epub 2018 Nov 17.

49.

Soluble LR11 competes with amyloid β in binding to cerebrospinal fluid-high-density lipoprotein.

Yano K, Hirayama S, Misawa N, Furuta A, Ueno T, Motoi Y, Seino U, Ebinuma H, Ikeuchi T, Schneider WJ, Bujo H, Miida T.

Clin Chim Acta. 2019 Feb;489:29-34. doi: 10.1016/j.cca.2018.11.024. Epub 2018 Nov 15.

PMID:
30448281
50.

CSF1R-related leukoencephalopathy: A major player in primary microgliopathies.

Konno T, Kasanuki K, Ikeuchi T, Dickson DW, Wszolek ZK.

Neurology. 2018 Dec 11;91(24):1092-1104. doi: 10.1212/WNL.0000000000006642. Epub 2018 Nov 14. Review.

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