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Items: 1 to 50 of 292

1.

A clinicopathological study of ALS with L126S mutation in the SOD1 gene presenting with isolated inferior olivary hypertrophy.

Hideshima M, Beck G, Yamadera M, Motoyama Y, Ikenaka K, Kakuda K, Tsuda H, Nagano S, Fujimura H, Morii E, Murayama S, Mochizuki H.

Neuropathology. 2019 Dec 20. doi: 10.1111/neup.12620. [Epub ahead of print]

PMID:
31863610
2.

Mitochondrial Dynamics in Physiology and Pathology of Myelinated Axons.

Sui Y, Nguyen HB, Thai TQ, Ikenaka K, Ohno N.

Adv Exp Med Biol. 2019;1190:145-163. doi: 10.1007/978-981-32-9636-7_10. Review.

PMID:
31760643
3.

Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.

Hayakawa H, Nakatani R, Ikenaka K, Aguirre C, Choong CJ, Tsuda H, Nagano S, Koike M, Ikeuchi T, Hasegawa M, Papa SM, Nagai Y, Mochizuki H, Baba K.

Mov Disord. 2019 Oct 23. doi: 10.1002/mds.27887. [Epub ahead of print]

PMID:
31643109
4.

Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells.

Takashima Y, Yoshimura T, Kano Y, Hayano A, Hondoh H, Ikenaka K, Yamanaka R.

BMC Cancer. 2019 Sep 11;19(1):910. doi: 10.1186/s12885-019-6129-8.

5.

Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity.

Kato D, Wake H, Lee PR, Tachibana Y, Ono R, Sugio S, Tsuji Y, Tanaka YH, Tanaka YR, Masamizu Y, Hira R, Moorhouse AJ, Tamamaki N, Ikenaka K, Matsukawa N, Fields RD, Nabekura J, Matsuzaki M.

Glia. 2020 Jan;68(1):193-210. doi: 10.1002/glia.23713. Epub 2019 Aug 29.

6.

Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson's Disease.

Ikenaka K, Suzuki M, Mochizuki H, Nagai Y.

Front Neurosci. 2019 Jul 3;13:693. doi: 10.3389/fnins.2019.00693. eCollection 2019. Review.

7.

A behavior-based drug screening system using a Caenorhabditis elegans model of motor neuron disease.

Ikenaka K, Tsukada Y, Giles AC, Arai T, Nakadera Y, Nakano S, Kawai K, Mochizuki H, Katsuno M, Sobue G, Mori I.

Sci Rep. 2019 Jul 12;9(1):10104. doi: 10.1038/s41598-019-46642-6.

8.

Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid.

Kakuda K, Ikenaka K, Araki K, So M, Aguirre C, Kajiyama Y, Konaka K, Noi K, Baba K, Tsuda H, Nagano S, Ohmichi T, Nagai Y, Tokuda T, El-Agnaf OMA, Ogi H, Goto Y, Mochizuki H.

Sci Rep. 2019 Apr 12;9(1):6001. doi: 10.1038/s41598-019-42399-0.

9.

MarmoDetector: A novel 3D automated system for the quantitative assessment of marmoset behavior.

Yabumoto T, Yoshida F, Miyauchi H, Baba K, Tsuda H, Ikenaka K, Hayakawa H, Koyabu N, Hamanaka H, Papa SM, Hirata M, Mochizuki H.

J Neurosci Methods. 2019 Jul 1;322:23-33. doi: 10.1016/j.jneumeth.2019.03.016. Epub 2019 Apr 1.

PMID:
30946879
10.

Increase of arginine dimethylation correlates with the progression and prognosis of ALS.

Ikenaka K, Atsuta N, Maeda Y, Hotta Y, Nakamura R, Kawai K, Yokoi D, Hirakawa A, Taniguchi A, Morita M, Mizoguchi K, Mochizuki H, Kimura K, Katsuno M, Sobue G.

Neurology. 2019 Apr 16;92(16):e1868-e1877. doi: 10.1212/WNL.0000000000007311. Epub 2019 Mar 13.

PMID:
30867270
11.

Region- and Cell Type-Specific Facilitation of Synaptic Function at Destination Synapses Induced by Oligodendrocyte Depolarization.

Yamazaki Y, Abe Y, Shibata S, Shindo T, Fujii S, Ikenaka K, Tanaka KF.

J Neurosci. 2019 May 22;39(21):4036-4050. doi: 10.1523/JNEUROSCI.1619-18.2019. Epub 2019 Mar 12.

12.

[Analysis of PEG-J associated complications in 14 adult patients treated with levodopa-carbidopa intestinal gel].

Shimamura M, Shinzaki S, Ikenaka K, Konaka K, Hirozawa D, Ishikura T, Hideshima M, Nakano T, Kitano T, Takehara T, Mochizuki H.

Rinsho Shinkeigaku. 2019 Mar 28;59(3):153-156. doi: 10.5692/clinicalneurol.cn-001195. Epub 2019 Feb 28. Japanese.

PMID:
30814443
13.

Suppression of autophagic activity by Rubicon is a signature of aging.

Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S, Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima TS, Okada Y, Mochizuki H, Isaka Y, Antebi A, Yoshimori T.

Nat Commun. 2019 Feb 19;10(1):847. doi: 10.1038/s41467-019-08729-6.

14.

Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway.

Liu Q, Zhang Y, Liu S, Liu Y, Yang X, Liu G, Shimizu T, Ikenaka K, Fan K, Ma J.

J Neuroinflammation. 2019 Jan 16;16(1):10. doi: 10.1186/s12974-019-1398-3.

15.

Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas.

Shimizu T, Osanai Y, Tanaka KF, Thai TQ, Abe M, Natsume R, Sakimura K, Ikenaka K.

J Neurochem. 2019 Jul;150(2):158-172. doi: 10.1111/jnc.14657. Epub 2019 Jan 29.

PMID:
30589943
16.

Interactions between mitochondria and endoplasmic reticulum in demyelinated axons.

Thai TQ, Nguyen HB, Sui Y, Ikenaka K, Oda T, Ohno N.

Med Mol Morphol. 2019 Sep;52(3):135-146. doi: 10.1007/s00795-018-0212-0. Epub 2018 Nov 17.

PMID:
30448927
17.

Neuroprotective effects of microglial P2Y1 receptors against ischemic neuronal injury.

Fukumoto Y, Tanaka KF, Parajuli B, Shibata K, Yoshioka H, Kanemaru K, Gachet C, Ikenaka K, Koizumi S, Kinouchi H.

J Cereb Blood Flow Metab. 2019 Nov;39(11):2144-2156. doi: 10.1177/0271678X18805317. Epub 2018 Oct 18.

PMID:
30334687
18.

Length of myelin internodes of individual oligodendrocytes is controlled by microenvironment influenced by normal and input-deprived axonal activities in sensory deprived mouse models.

Osanai Y, Shimizu T, Mori T, Hatanaka N, Kimori Y, Kobayashi K, Koyama S, Yoshimura Y, Nambu A, Ikenaka K.

Glia. 2018 Nov;66(11):2514-2525. doi: 10.1002/glia.23502. Epub 2018 Sep 21.

PMID:
30240035
19.

Axonal and neuronal degeneration in myelin diseases.

Ohno N, Ikenaka K.

Neurosci Res. 2019 Feb;139:48-57. doi: 10.1016/j.neures.2018.08.013. Epub 2018 Sep 1. Review.

PMID:
30179642
20.

[Levodopa-carbidopa intestinal gel treatment introduced by surgical gastrostomy in a patient of Parkinson's disease after Billroth II gastrojejunostomy].

Nakano T, Hirozawa D, Shimamura M, Sasaki T, Ikenaka K, Mochizuki H.

Rinsho Shinkeigaku. 2018 Sep 28;58(9):570-573. doi: 10.5692/clinicalneurol.cn-001150. Epub 2018 Aug 31. Japanese.

PMID:
30175807
21.

Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.

Durose WW, Shimizu T, Li J, Abe M, Sakimura K, Chetsawang B, Tanaka KF, Suzumura A, Tohyama K, Ikenaka K.

J Neurochem. 2019 Feb;148(3):413-425. doi: 10.1111/jnc.14581. Epub 2018 Dec 3.

PMID:
30152001
22.

Branched Sialylated N-glycans Are Accumulated in Brain Synaptosomes and Interact with Siglec-H.

Handa-Narumi M, Yoshimura T, Konishi H, Fukata Y, Manabe Y, Tanaka K, Bao GM, Kiyama H, Fukase K, Ikenaka K.

Cell Struct Funct. 2018 Aug 25;43(2):141-152. doi: 10.1247/csf.18009. Epub 2018 Jul 20.

23.

Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranode influences neuronal viability.

Kunisawa K, Shimizu T, Kushima I, Aleksic B, Mori D, Osanai Y, Kobayashi K, Taylor AM, Bhat MA, Hayashi A, Baba H, Ozaki N, Ikenaka K.

J Neurochem. 2018 Nov;147(3):395-408. doi: 10.1111/jnc.14553. Epub 2018 Aug 29.

24.

Ectopic positioning of Bergmann glia and impaired cerebellar wiring in Mlc1-over-expressing mice.

Kikuchihara S, Sugio S, Tanaka KF, Watanabe T, Kano M, Yamazaki Y, Watanabe M, Ikenaka K.

J Neurochem. 2018 Nov;147(3):344-360. doi: 10.1111/jnc.14486. Epub 2018 Aug 8.

25.

Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes.

Kinoshita M, Hirayama Y, Fujishita K, Shibata K, Shinozaki Y, Shigetomi E, Takeda A, Le HPN, Hayashi H, Hiasa M, Moriyama Y, Ikenaka K, Tanaka KF, Koizumi S.

EBioMedicine. 2018 Jun;32:72-83. doi: 10.1016/j.ebiom.2018.05.036. Epub 2018 Jun 8.

26.

Decreased number and increased volume with mitochondrial enlargement of cerebellar synaptic terminals in a mouse model of chronic demyelination.

Nguyen HB, Sui Y, Thai TQ, Ikenaka K, Oda T, Ohno N.

Med Mol Morphol. 2018 Dec;51(4):208-216. doi: 10.1007/s00795-018-0193-z. Epub 2018 May 23.

PMID:
29796936
27.

Correction: Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model.

Liang J, Li N, Zhang Y, Hou C, Yang X, Shimizu T, Wang X, Ikenaka K, Fan K, Ma J.

Front Mol Neurosci. 2018 Apr 12;11:115. doi: 10.3389/fnmol.2018.00115. eCollection 2018.

28.

Aberrant astrocyte Ca2+ signals "AxCa signals" exacerbate pathological alterations in an Alexander disease model.

Saito K, Shigetomi E, Yasuda R, Sato R, Nakano M, Tashiro K, Tanaka KF, Ikenaka K, Mikoshiba K, Mizuta I, Yoshida T, Nakagawa M, Mizuno T, Koizumi S.

Glia. 2018 May;66(5):1053-1067. doi: 10.1002/glia.23300. Epub 2018 Jan 31.

PMID:
29383757
29.

Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca2+ Dynamics in Astrocytes.

Shigetomi E, Hirayama YJ, Ikenaka K, Tanaka KF, Koizumi S.

J Neurosci. 2018 Feb 7;38(6):1383-1395. doi: 10.1523/JNEUROSCI.2625-17.2017. Epub 2018 Jan 5.

30.

Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation.

Hashimoto H, Jiang W, Yoshimura T, Moon KH, Bok J, Ikenaka K.

Neurochem Int. 2018 Oct;119:178-183. doi: 10.1016/j.neuint.2017.11.003. Epub 2017 Nov 6.

PMID:
29122585
31.

Minocycline Directly Enhances the Self-Renewal of Adult Neural Precursor Cells.

Kuroda A, Fuchigami T, Fuke S, Koyama N, Ikenaka K, Hitoshi S.

Neurochem Res. 2018 Jan;43(1):219-226. doi: 10.1007/s11064-017-2422-6. Epub 2017 Oct 28.

PMID:
29081002
32.

Origin of Oligodendrocytes in the Vertebrate Optic Nerve: A Review.

Ono K, Hirahara Y, Gotoh H, Nomura T, Takebayashi H, Yamada H, Ikenaka K.

Neurochem Res. 2018 Jan;43(1):3-11. doi: 10.1007/s11064-017-2404-8. Epub 2017 Oct 4. Review.

PMID:
28980095
33.

Oligodendrocyte-Neuron Interactions: Impact on Myelination and Brain Function.

Shimizu T, Osanai Y, Ikenaka K.

Neurochem Res. 2018 Jan;43(1):190-194. doi: 10.1007/s11064-017-2387-5. Epub 2017 Sep 16.

PMID:
28918515
34.

Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation.

Katoh M, Wu B, Nguyen HB, Thai TQ, Yamasaki R, Lu H, Rietsch AM, Zorlu MM, Shinozaki Y, Saitoh Y, Saitoh S, Sakoh T, Ikenaka K, Koizumi S, Ransohoff RM, Ohno N.

Sci Rep. 2017 Jul 10;7(1):4942. doi: 10.1038/s41598-017-05232-0.

35.

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation.

Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S.

Cell Rep. 2017 May 9;19(6):1151-1164. doi: 10.1016/j.celrep.2017.04.047.

36.

Sulfatase 2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase 1.

Jiang W, Ishino Y, Hashimoto H, Keino-Masu K, Masu M, Uchimura K, Kadomatsu K, Yoshimura T, Ikenaka K.

Dev Neurosci. 2017;39(5):361-374. doi: 10.1159/000464284. Epub 2017 May 11.

37.

Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area.

Ono K, Yoshii K, Tominaga H, Gotoh H, Nomura T, Takebayashi H, Ikenaka K.

Brain Struct Funct. 2017 Jul;222(5):2441-2448. doi: 10.1007/s00429-017-1394-2. Epub 2017 Mar 14.

PMID:
28293728
38.

The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model.

Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K.

Glia. 2017 Jun;65(6):917-930. doi: 10.1002/glia.23134. Epub 2017 Mar 2.

PMID:
28251676
39.

GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system.

Yoshimura T, Hayashi A, Handa-Narumi M, Yagi H, Ohno N, Koike T, Yamaguchi Y, Uchimura K, Kadomatsu K, Sedzik J, Kitamura K, Kato K, Trapp BD, Baba H, Ikenaka K.

Sci Rep. 2017 Feb 10;7:42257. doi: 10.1038/srep42257.

40.

Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes.

Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno M, Sobue G.

Cell Rep. 2017 Jan 31;18(5):1118-1131. doi: 10.1016/j.celrep.2017.01.013.

41.

Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model.

Liang J, Li N, Zhang Y, Hou C, Yang X, Shimizu T, Wang X, Ikenaka K, Fan K, Ma J.

Front Mol Neurosci. 2016 Dec 21;9:152. doi: 10.3389/fnmol.2016.00152. eCollection 2016. Erratum in: Front Mol Neurosci. 2018 Apr 12;11:115.

42.

Histological detection of dynamic glial responses in the dysmyelinating Tabby-jimpy mutant brain.

Ikeda M, Hossain MI, Zhou L, Horie M, Ikenaka K, Horii A, Takebayashi H.

Anat Sci Int. 2018 Jan;93(1):119-127. doi: 10.1007/s12565-016-0383-5. Epub 2016 Nov 25.

PMID:
27888476
43.

YAP functions as a mechanotransducer in oligodendrocyte morphogenesis and maturation.

Shimizu T, Osanai Y, Tanaka KF, Abe M, Natsume R, Sakimura K, Ikenaka K.

Glia. 2017 Feb;65(2):360-374. doi: 10.1002/glia.23096. Epub 2016 Nov 3.

PMID:
27807898
44.

Rabies virus-mediated oligodendrocyte labeling reveals a single oligodendrocyte myelinates axons from distinct brain regions.

Osanai Y, Shimizu T, Mori T, Yoshimura Y, Hatanaka N, Nambu A, Kimori Y, Koyama S, Kobayashi K, Ikenaka K.

Glia. 2017 Jan;65(1):93-105. doi: 10.1002/glia.23076. Epub 2016 Oct 19.

PMID:
27759175
45.

Astrocyte-mediated infantile-onset leukoencephalopathy mouse model.

Sugio S, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M, Fukata M, Ikenaka K, Tanaka KF.

Glia. 2017 Jan;65(1):150-168. doi: 10.1002/glia.23084. Epub 2016 Oct 17.

PMID:
27748972
46.

Origin of oligodendrocytes in mammalian forebrains: a revised perspective.

Naruse M, Ishizaki Y, Ikenaka K, Tanaka A, Hitoshi S.

J Physiol Sci. 2017 Jan;67(1):63-70. doi: 10.1007/s12576-016-0479-7. Epub 2016 Aug 29. Review.

47.

Microglia-induced activation of non-canonical Wnt signaling aggravates neurodegeneration in demyelinating disorders.

Shimizu T, Smits R, Ikenaka K.

Mol Cell Biol. 2016 Nov;36(21):2728-2741. doi: 10.1128/MCB.00139-16. Epub 2016 Aug 22.

48.

Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord.

Hashimoto H, Ishino Y, Jiang W, Yoshimura T, Takeda-Uchimura Y, Uchimura K, Kadomatsu K, Ikenaka K.

Neurochem Res. 2016 Feb;41(1-2):450-62. doi: 10.1007/s11064-016-1861-9. Epub 2016 Feb 11.

PMID:
26869039
49.

The Dorsoventral Boundary of the Germinal Zone is a Specialized Niche for the Generation of Cortical Oligodendrocytes during a Restricted Temporal Window.

Naruse M, Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S.

Cereb Cortex. 2016 Jun;26(6):2800-2810. doi: 10.1093/cercor/bhv141. Epub 2015 Jun 23.

PMID:
26108613
50.

Oligodendrocyte generation during mouse development.

Takebayashi H, Ikenaka K.

Glia. 2015 Aug;63(8):1350-6. doi: 10.1002/glia.22863. Epub 2015 May 25. Review.

PMID:
26013243

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