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Items: 1 to 50 of 133

1.

Descending necrotizing mediastinitis in a healthy young adult.

Ochi N, Wakabayashi T, Urakami A, Yamatsuji T, Ikemoto N, Nagasaki Y, Nakagawa N, Honda Y, Nakanishi H, Yamane H, Monobe Y, Akisada T, Katayama H, Naomoto Y, Takigawa N.

Ther Clin Risk Manag. 2018 Oct 17;14:2013-2017. doi: 10.2147/TCRM.S176520. eCollection 2018.

2.

Designing antioxidant peptides based on the antioxidant properties of the amino acid side-chains.

Matsui R, Honda R, Kanome M, Hagiwara A, Matsuda Y, Togitani T, Ikemoto N, Terashima M.

Food Chem. 2018 Apr 15;245:750-755. doi: 10.1016/j.foodchem.2017.11.119. Epub 2017 Dec 5.

PMID:
29287436
3.

Antioxidant activities of a peptide derived from chicken dark meat.

Fukada Y, Mizutani S, Nomura S, Hara W, Matsui R, Nagai K, Murakami Y, Washio N, Ikemoto N, Terashima M.

J Food Sci Technol. 2016 May;53(5):2476-81. doi: 10.1007/s13197-016-2233-9. Epub 2016 Jun 1.

4.

Improving the in vivo therapeutic index of siRNA polymer conjugates through increasing pH responsiveness.

Guidry EN, Farand J, Soheili A, Parish CA, Kevin NJ, Pipik B, Calati KB, Ikemoto N, Waldman JH, Latham AH, Howell BJ, Leone A, Garbaccio RM, Barrett SE, Parmar RG, Truong QT, Mao B, Davies IW, Colletti SL, Sepp-Lorenzino L.

Bioconjug Chem. 2014 Feb 19;25(2):296-307. doi: 10.1021/bc400442p. Epub 2014 Jan 10.

PMID:
24409989
5.

Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts.

Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.

Cardiovasc Res. 2012 Dec 1;96(3):433-43. doi: 10.1093/cvr/cvs271. Epub 2012 Aug 14.

6.

Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.

Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M.

Circulation. 2011 Aug 9;124(6):682-94. doi: 10.1161/CIRCULATIONAHA.111.023259. Epub 2011 Jul 18.

7.

Aberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyte.

Gangopadhyay JP, Ikemoto N.

Biochem J. 2011 Sep 1;438(2):379-87. doi: 10.1042/BJ20110203.

8.

Effects of conformational peptide probe DP4 on bidirectional signaling between DHPR and RyR1 calcium channels in voltage-clamped skeletal muscle fibers.

Olojo RO, Hernández-Ochoa EO, Ikemoto N, Schneider MF.

Biophys J. 2011 May 18;100(10):2367-77. doi: 10.1016/j.bpj.2011.04.012.

9.

Novel angiotensin-converting enzyme (ACE) inhibitory peptides derived from boneless chicken leg meat.

Terashima M, Baba T, Ikemoto N, Katayama M, Morimoto T, Matsumura S.

J Agric Food Chem. 2010 Jun 23;58(12):7432-6. doi: 10.1021/jf100977z.

PMID:
20509692
10.

Intracellular translocation of calmodulin and Ca2+/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes.

Gangopadhyay JP, Ikemoto N.

Biochem Biophys Res Commun. 2010 May 28;396(2):515-21. doi: 10.1016/j.bbrc.2010.04.129. Epub 2010 Apr 28.

11.

Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor.

Liu Z, Wang R, Tian X, Zhong X, Gangopadhyay J, Cole R, Ikemoto N, Chen SR, Wagenknecht T.

J Cell Sci. 2010 May 15;123(Pt 10):1775-84. doi: 10.1242/jcs.064071. Epub 2010 Apr 27.

12.

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.

Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.

Cardiovasc Res. 2010 Sep 1;87(4):609-17. doi: 10.1093/cvr/cvq108. Epub 2010 Apr 13.

13.

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.

Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):660-6. doi: 10.1016/j.bbrc.2010.03.046. Epub 2010 Mar 10.

14.

Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.

Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.

Circ Res. 2010 Apr 30;106(8):1413-24. doi: 10.1161/CIRCRESAHA.109.209312. Epub 2010 Mar 11.

15.

Highly efficient asymmetric synthesis of sitagliptin.

Hansen KB, Hsiao Y, Xu F, Rivera N, Clausen A, Kubryk M, Krska S, Rosner T, Simmons B, Balsells J, Ikemoto N, Sun Y, Spindler F, Malan C, Grabowski EJ, Armstrong JD 3rd.

J Am Chem Soc. 2009 Jul 1;131(25):8798-804. doi: 10.1021/ja902462q.

PMID:
19507853
16.

Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.

Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.

J Am Coll Cardiol. 2009 May 26;53(21):1993-2005. doi: 10.1016/j.jacc.2009.01.065.

17.

Defective regulation of the ryanodine receptor induces hypertrophy in cardiomyocytes.

Hamada T, Gangopadhyay JP, Mandl A, Erhardt P, Ikemoto N.

Biochem Biophys Res Commun. 2009 Mar 13;380(3):493-7. doi: 10.1016/j.bbrc.2009.01.152. Epub 2009 Jan 29.

18.

Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling.

Kimura T, Lueck JD, Harvey PJ, Pace SM, Ikemoto N, Casarotto MG, Dirksen RT, Dulhunty AF.

Cell Calcium. 2009 Mar;45(3):264-74. doi: 10.1016/j.ceca.2008.11.005. Epub 2009 Jan 7.

19.

Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle.

Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, LaFerla FM, Ikemoto N, Querfurth HW.

Neurobiol Aging. 2010 Dec;31(12):2080-90. doi: 10.1016/j.neurobiolaging.2008.11.003. Epub 2008 Dec 23.

20.

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.

Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.

Cardiovasc Res. 2009 Feb 15;81(3):536-45. doi: 10.1093/cvr/cvn303. Epub 2008 Nov 7.

21.

Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.

Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M.

Circulation. 2008 Feb 12;117(6):762-72. doi: 10.1161/CIRCULATIONAHA.107.718957. Epub 2008 Jan 28.

PMID:
18227387
23.

A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites.

Laver DR, Honen BN, Lamb GD, Ikemoto N.

Eur Biophys J. 2008 Apr;37(4):455-67. Epub 2007 Nov 24.

PMID:
18038129
24.

The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca(2+) binding site.

Laver DR, Hamada T, Fessenden JD, Ikemoto N.

J Membr Biol. 2007 Dec;220(1-3):11-20. Epub 2007 Sep 18.

PMID:
17879109
25.

Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.

Gardelli C, Nizi E, Muraglia E, Crescenzi B, Ferrara M, Orvieto F, Pace P, Pescatore G, Poma M, Ferreira Mdel R, Scarpelli R, Homnick CF, Ikemoto N, Alfieri A, Verdirame M, Bonelli F, Paz OG, Taliani M, Monteagudo E, Pesci S, Laufer R, Felock P, Stillmock KA, Hazuda D, Rowley M, Summa V.

J Med Chem. 2007 Oct 4;50(20):4953-75. Epub 2007 Sep 8.

PMID:
17824681
26.

Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca2+ leak via stabilization of ryanodine receptor in heart failure.

Mochizuki M, Yano M, Oda T, Tateishi H, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.

J Am Coll Cardiol. 2007 Apr 24;49(16):1722-32. Epub 2007 Apr 5.

27.
28.
29.

Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area.

Bannister ML, Hamada T, Murayama T, Harvey PJ, Casarotto MG, Dulhunty AF, Ikemoto N.

Biochem J. 2007 Jan 1;401(1):333-9.

30.

The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes.

Yang Z, Ikemoto N, Lamb GD, Steele DS.

Cardiovasc Res. 2006 Jun 1;70(3):475-85. Epub 2006 Mar 7. Erratum in: Cardiovasc Res. 2006 Aug 1;71(3):606.

PMID:
16624262
31.
32.

Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure.

Yano M, Okuda S, Oda T, Tokuhisa T, Tateishi H, Mochizuki M, Noma T, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.

Circulation. 2005 Dec 6;112(23):3633-43.

PMID:
16330705
34.

Production of cis-1,2-dihydroxy-3-methylcyclohexa-3,5-diene (toluene cis glycol) by Rhodococcus sp. MA 7249.

Chartrain M, Ikemoto N, Taylor C, Stahl S, Sandford V, Gbewonyo K, Chirdo C, Maxwell C, Osoria J, Buckland B, Greasham R.

J Biosci Bioeng. 2000;90(3):321-7.

PMID:
16232863
35.

Asymmetric direduction of 1,2-indanedione to cis (1S,2R) indanediol by Trichosporon cutaneum MY 1506.

Stahl S, Ikemoto N, King A, Greasham R, Chartrain M.

J Biosci Bioeng. 1999;88(5):495-9.

PMID:
16232651
36.

Asymmetric hydrogenation of N-sulfonylated-alpha-dehydroamino acids: toward the synthesis of an anthrax lethal factor inhibitor.

Shultz CS, Dreher SD, Ikemoto N, Williams JM, Grabowski EJ, Krska SW, Sun Y, Dormer PG, Dimichele L.

Org Lett. 2005 Aug 4;7(16):3405-8.

PMID:
16048303
37.

Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure.

Oda T, Yano M, Yamamoto T, Tokuhisa T, Okuda S, Doi M, Ohkusa T, Ikeda Y, Kobayashi S, Ikemoto N, Matsuzaki M.

Circulation. 2005 Jun 28;111(25):3400-10. Epub 2005 Jun 20. Erratum in: Circulation. 2005 Oct 25;112(17):e291.

PMID:
15967847
38.

Abnormal ryanodine receptor function in heart failure.

Yano M, Yamamoto T, Ikemoto N, Matsuzaki M.

Pharmacol Ther. 2005 Sep;107(3):377-91. Review.

PMID:
15951021
39.
40.

Probing a putative dantrolene-binding site on the cardiac ryanodine receptor.

Paul-Pletzer K, Yamamoto T, Ikemoto N, Jimenez LS, Morimoto H, Williams PG, Ma J, Parness J.

Biochem J. 2005 May 1;387(Pt 3):905-9.

41.

Dantrolene stabilizes domain interactions within the ryanodine receptor.

Kobayashi S, Bannister ML, Gangopadhyay JP, Hamada T, Parness J, Ikemoto N.

J Biol Chem. 2005 Feb 25;280(8):6580-7. Epub 2004 Dec 16.

42.

Fluorescence probe study of Ca2+-dependent interactions of calmodulin with calmodulin-binding peptides of the ryanodine receptor.

Gangopadhyay JP, Grabarek Z, Ikemoto N.

Biochem Biophys Res Commun. 2004 Oct 22;323(3):760-8.

PMID:
15381065
43.

Antibody probe study of Ca2+ channel regulation by interdomain interaction within the ryanodine receptor.

Kobayashi S, Yamamoto T, Parness J, Ikemoto N.

Biochem J. 2004 Jun 1;380(Pt 2):561-9.

44.

Highly diastereoselective heterogeneously catalyzed hydrogenation of enamines for the synthesis of chiral beta-amino acid derivatives.

Ikemoto N, Tellers DM, Dreher SD, Liu J, Huang A, Rivera NR, Njolito E, Hsiao Y, McWilliams JC, Williams JM, Armstrong JD 3rd, Sun Y, Mathre DJ, Grabowski EJ, Tillyer RD.

J Am Chem Soc. 2004 Mar 17;126(10):3048-9.

PMID:
15012124
45.

Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor.

Paul-Pletzer K, Yamamoto T, Bhat MB, Ma J, Ikemoto N, Jimenez LS, Morimoto H, Williams PG, Parness J.

J Biol Chem. 2002 Sep 20;277(38):34918-23. Epub 2002 Jul 11.

46.

Peptide probe study of the critical regulatory domain of the cardiac ryanodine receptor.

Yamamoto T, Ikemoto N.

Biochem Biophys Res Commun. 2002 Mar 8;291(4):1102-8.

PMID:
11866478
47.

Regulation of calcium release by interdomain interaction within ryanodine receptors.

Ikemoto N, Yamamoto T.

Front Biosci. 2002 Mar 1;7:d671-83. Review.

PMID:
11861212
48.
49.

Interdomain interactions within ryanodine receptors regulate Ca2+ spark frequency in skeletal muscle.

Shtifman A, Ward CW, Yamamoto T, Wang J, Olbinski B, Valdivia HH, Ikemoto N, Schneider MF.

J Gen Physiol. 2002 Jan;119(1):15-32.

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