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Identification of an Upper Limit of Tumor Burden for Downstaging in Candidates with Hepatocellular Cancer Waiting for Liver Transplantation: A West-East Collaborative Effort.

Lai Q, Vitale A, Halazun K, Iesari S, Viveiros A, Bhangui P, Mennini G, Wong T, Uemoto S, Lin CC, Mittler J, Ikegami T, Zhe Y, Zheng SS, Soejima Y, Hoppe-Lotichius M, Chen CL, Kaido T, Lo CM, Rossi M, Soin AS, Finkenstedt A, Emond JC, Cillo U, Lerut J.

Cancers (Basel). 2020 Feb 14;12(2). pii: E452. doi: 10.3390/cancers12020452.


Multiple liver metastases originating from synchronous double cancer of neuroendocrine tumor and rectal cancer: a case report.

Omori S, Harada N, Toshima T, Takeishi K, Itoh S, Ikegami T, Yoshizumi T, Mori M.

Surg Case Rep. 2020 Feb 13;6(1):36. doi: 10.1186/s40792-020-0800-9.


Reactive, Proactive, and Inductive Agents: An Evolutionary Path for Biological and Artificial Spiking Networks.

Sinapayen L, Masumori A, Ikegami T.

Front Comput Neurosci. 2020 Jan 22;13:88. doi: 10.3389/fncom.2019.00088. eCollection 2019.


Anastomosis of the Common Hepatic Artery and Round Ligament as Portal Vein Arterialization for Hepatic Artery Occlusion After Deceased Donor Liver Transplantation: A Case Report.

Yoshiya S, Yoshizumi T, Iseda N, Takeishi K, Toshima T, Nagao Y, Itoh S, Harada N, Ikegami T, Mori M.

Transplant Proc. 2020 Feb 4. pii: S0041-1345(19)31304-1. doi: 10.1016/j.transproceed.2019.12.003. [Epub ahead of print]


An NRAS mutation in primary malignant melanoma of the lung: a case report.

Hibiya T, Tanaka M, Matsumura M, Aoki A, Ikegami T, Okudela K, Kawano N, Ohashi K.

Diagn Pathol. 2020 Feb 7;15(1):11. doi: 10.1186/s13000-020-0928-8.


Artificial Life-Next Generation Perspectives: Echoes from the 2018 Conference in Tokyo.

Witkowski O, Ikegami T, Virgo N, Oka M, Iizuka H.

Artif Life. 2020 Feb 6:1-4. doi: 10.1162/artl_e_00306. [Epub ahead of print] No abstract available.


Neural Autopoiesis: Organizing Self-Boundaries by Stimulus Avoidance in Biological and Artificial Neural Networks.

Masumori A, Sinapayen L, Maruyama N, Mita T, Bakkum D, Frey U, Takahashi H, Ikegami T.

Artif Life. 2020 Feb 6:1-22. doi: 10.1162/artl_a_00314. [Epub ahead of print]


Trans-gastric Endoscopic Lumen-apposing Metal Stents as a Reasonable Procedure for Internal Drainage.

Takeishi K, Ikegami T, Yoshizumi T, Fujimori N, Mori M.

Liver Transpl. 2020 Jan 30. doi: 10.1002/lt.25725. [Epub ahead of print]


Modulation of Nqo1 Activity Intercepts Anoikis Resistance and Reduces Metastatic Potential of Hepatocellular Carcinoma.

Shimokawa M, Yoshizumi T, Itoh S, Iseda N, Sakata K, Yugawa K, Toshima T, Harada N, Ikegami T, Mori M.

Cancer Sci. 2020 Jan 22. doi: 10.1111/cas.14320. [Epub ahead of print]


Marked heterogeneity in the diagnosis of compensated cirrhosis of patients with chronic hepatitis C virus infection in a real-world setting: A large, multicenter study from Japan.

Toyoda H, Atsukawa M, Watanabe T, Nakamuta M, Uojima H, Nozaki A, Takaguchi K, Fujioka S, Iio E, Shima T, Akahane T, Fukunishi S, Asano T, Michitaka K, Tsuji K, Abe H, Mikami S, Okubo H, Okubo T, Shimada N, Ishikawa T, Moriya A, Tani J, Morishita A, Ogawa C, Tachi Y, Ikeda H, Yamashita N, Yasuda S, Chuma M, Tsutsui A, Hiraoka A, Ikegami T, Genda T, Tsubota A, Masaki T, Iwakiri K, Kumada T, Tanaka Y, Okanoue T.

J Gastroenterol Hepatol. 2020 Jan 16. doi: 10.1111/jgh.14982. [Epub ahead of print]


The relationship between polymer structures on silica particles and the separation characteristics of the corresponding columns for hydrophilic interaction chromatography.

Taniguchi A, Tamura S, Ikegami T.

J Chromatogr A. 2019 Dec 31:460837. doi: 10.1016/j.chroma.2019.460837. [Epub ahead of print]


A co-infection of varicella-zoster virus and Pneumocystis jirovecii in a non-HIV immunocompromised patient: a case report.

Muramatsu H, Kuriyama A, Anzai Y, Ikegami T.

BMC Infect Dis. 2019 Dec 30;19(1):1092. doi: 10.1186/s12879-019-4715-7.


Analysis of factors associated with the prognosis of cirrhotic patients who were treated with tolvaptan for hepatic edema.

Atsukawa M, Tsubota A, Takaguchi K, Toyoda H, Iwasa M, Ikegami T, Chuma M, Nozaki A, Uojima H, Hiraoka A, Fukunishi S, Yokohama K, Tada T, Kato K, Abe H, Tani J, Okubo H, Watanabe T, Hattori N, Tsutsui A, Senoh T, Yoshida Y, Okubo T, Itokawa N, Nakagawa-Iwashita A, Kondo C, Arai T, Michitaka K, Iio E, Kumada T, Tanaka Y, Takei Y, Iwakiri K.

J Gastroenterol Hepatol. 2019 Dec 27. doi: 10.1111/jgh.14965. [Epub ahead of print]


Trans-gastric Endoscopic Lumen-apposing Metal Stents for Intra-abdominal Fluid Collections after Living Donor Liver Transplantation.

Takeishi K, Yoshizumi T, Ikegami T, Itoh S, Harada N, Fujimori N, Ohno T, Mori M.

Liver Transpl. 2019 Dec 23. doi: 10.1002/lt.25707. [Epub ahead of print]


Improved visualization of a fine intrahepatic biliary duct on drip infusion cholangiography-computed tomography: Impact of knowledge-based iterative model reconstruction.

Takao S, Nishie A, Asayama Y, Ishigami K, Ushijima Y, Kakihara D, Nakayama T, Fujita N, Morita K, Ishimatsu K, Yoshizumi T, Ikegami T, Kondo M, Honda H.

Hepatol Res. 2019 Dec 21. doi: 10.1111/hepr.13477. [Epub ahead of print]



Ikegami T, Yoshizumi T, Iseda N, Toshima T, Elshawy ME, Mori M.

Liver Transpl. 2020 Mar;26(3):463-464. doi: 10.1002/lt.25702. Epub 2020 Feb 7. No abstract available.


Calcium sensing via EF-hand 4 enables thioredoxin activity in the sensor-responder protein calredoxin in the green alga Chlamydomonas reinhardtii.

Charoenwattanasatien R, Zinzius K, Scholz M, Wicke S, Tanaka H, Brandenburg JS, Marchetti GM, Ikegami T, Matsumoto T, Oda T, Sato M, Hippler M, Kurisu G.

J Biol Chem. 2020 Jan 3;295(1):170-180. doi: 10.1074/jbc.RA119.008735. Epub 2019 Nov 27.


Rescue of infectious Arumowot virus from cloned cDNA: Posttranslational degradation of Arumowot virus NSs protein in human cells.

Hallam HJ, Lokugamage N, Ikegami T.

PLoS Negl Trop Dis. 2019 Nov 21;13(11):e0007904. doi: 10.1371/journal.pntd.0007904. eCollection 2019 Nov.


ERCC1 C8092A polymorphism predicts fair survival outcome in Japanese patients with pharyngo-laryngeal squamous cell carcinoma.

Hirakawa H, Ikegami T, Azechi S, Agena S, Uezato J, Kinjyo H, Yamashita Y, Tanaka K, Kondo S, Maeda H, Suzuki M, Gahana A.

Eur Arch Otorhinolaryngol. 2020 Feb;277(2):601-610. doi: 10.1007/s00405-019-05731-y. Epub 2019 Nov 20.


Extracorporeal Membrane Oxygenation for Hypokalemia and Refractory Ventricular Fibrillation Associated with Caffeine Intoxication.

Kato Y, Kuriyama A, Hata R, Ikegami T.

J Emerg Med. 2019 Nov 15. pii: S0736-4679(19)30806-6. doi: 10.1016/j.jemermed.2019.09.023. [Epub ahead of print]


Prognostic nutritional index is superior as a predictor of prognosis among various inflammation-based prognostic scores in patients with hepatocellular carcinoma after curative resection.

Imai D, Maeda T, Shimokawa M, Wang H, Yoshiya S, Takeishi K, Itoh S, Harada N, Ikegami T, Yoshizumi T, Mori M.

Hepatol Res. 2020 Jan;50(1):101-109. doi: 10.1111/hepr.13431. Epub 2019 Nov 14.


Extensive portal thrombectomy with secure shunt ligation should be more strongly emphasized in the real-world setting.

Ikegami T, Yoshizumi T, Tomiyama T, Inokuchi S, Mori M.

J Hepatol. 2020 Jan;72(1):199-201. doi: 10.1016/j.jhep.2019.09.009. Epub 2019 Nov 1. No abstract available.


Association of inflammatory biomarkers with long-term outcomes after curative surgery for mass-forming intrahepatic cholangiocarcinoma.

Ohira M, Yoshizumi T, Yugawa K, Kosai-Fujimoto Y, Inokuchi S, Motomura T, Mano Y, Toshima T, Itoh S, Harada N, Ikegami T, Soejima Y, Taketomi A, Mori M.

Surg Today. 2019 Oct 30. doi: 10.1007/s00595-019-01905-7. [Epub ahead of print]


Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

Honda A, Miyazaki T, Iwamoto J, Hirayama T, Morishita Y, Monma T, Ueda H, Mizuno S, Sugiyama F, Takahashi S, Ikegami T.

J Lipid Res. 2020 Jan;61(1):54-69. doi: 10.1194/jlr.RA119000395. Epub 2019 Oct 23.


Prognostic Impact of Osteopenia in Patients Who Underwent Living Donor Liver Transplantation for Hepatocellular Carcinoma.

Toshima T, Yoshizumi T, Kosai-Fujimoto Y, Inokuchi S, Yoshiya S, Takeishi K, Itoh S, Harada N, Ikegami T, Soejima Y, Mori M.

World J Surg. 2020 Jan;44(1):258-267. doi: 10.1007/s00268-019-05206-5.


Real-world experience of 12-week direct-acting antiviral regimen of glecaprevir and pibrentasvir in patients with chronic hepatitis C virus infection.

Toyoda H, Atsukawa M, Watanabe T, Nakamuta M, Uojima H, Nozaki A, Takaguchi K, Fujioka S, Iio E, Shima T, Akahane T, Fukunishi S, Asano T, Michitaka K, Tsuji K, Abe H, Mikami S, Okubo H, Okubo T, Shimada N, Ishikawa T, Moriya A, Tani J, Morishita A, Ogawa C, Tachi Y, Ikeda H, Yamashita N, Yasuda S, Chuma M, Tsutsui A, Hiraoka A, Ikegami T, Genda T, Tsubota A, Masaki T, Tanaka Y, Iwakiri K, Kumada T.

J Gastroenterol Hepatol. 2019 Oct 14. doi: 10.1111/jgh.14874. [Epub ahead of print]


Retroperitoneal schwannoma preoperatively diagnosed as liver metastasis from colon cancer: A case report.

Wang H, Yoshizumi T, Itoh S, Ikegami T, Harada N, Oda Y, Mori M.

Int J Surg Case Rep. 2019;64:31-34. doi: 10.1016/j.ijscr.2019.09.031. Epub 2019 Sep 24.


Risk factors for the metabolic syndrome components of hypertension, diabetes mellitus, and dyslipidemia after living donor liver transplantation.

Toshima T, Yoshizumi T, Inokuchi S, Kosai-Fujimoto Y, Kurihara T, Yoshiya S, Mano Y, Takeishi K, Itoh S, Harada N, Ikegami T, Soejima Y, Shimokawa M, Maehara Y, Mori M.

HPB (Oxford). 2019 Sep 24. pii: S1365-182X(19)30695-1. doi: 10.1016/j.hpb.2019.08.008. [Epub ahead of print]


Elevation of Mac-2 binding protein glycosylation isomer after hepatectomy is associated with post-hepatectomy liver failure, total Pringle time, and renal dysfunction.

Imai D, Maeda T, Wang H, Sanefuji K, Kayashima H, Yoshiya S, Takeishi K, Itoh S, Harada N, Ikegami T, Yoshizumi T, Mori M.

Ann Gastroenterol Surg. 2019 Jul 8;3(5):515-522. doi: 10.1002/ags3.12271. eCollection 2019 Sep.


The evolution of surgical treatment for gastrointestinal cancers.

Maehara Y, Soejima Y, Yoshizumi T, Kawahara N, Oki E, Saeki H, Akahoshi T, Ikegami T, Yamashita YI, Furuyama T, Sugimachi K, Harada N, Tagawa T, Harimoto N, Itoh S, Sonoda H, Ando K, Nakashima Y, Nagao Y, Yamashita N, Kasagi Y, Yukaya T, Kurihara T, Tsutsumi R, Takamori S, Sasaki S, Ikeda T, Yonemitsu Y, Fukuhara T, Kitao H, Iimori M, Kataoka Y, Wakasa T, Suzuki M, Teraishi K, Yoshida Y, Mori M.

Int J Clin Oncol. 2019 Nov;24(11):1333-1349. doi: 10.1007/s10147-019-01499-7. Epub 2019 Sep 14.


Retention characteristics of poly(N-(1H-tetrazole-5-yl)-methacrylamide)-bonded stationary phase in hydrophilic interaction chromatography.

Fu X, Cebo M, Ikegami T, Lämmerhofer M.

J Chromatogr A. 2020 Jan 4;1609:460500. doi: 10.1016/j.chroma.2019.460500. Epub 2019 Aug 30.


Candidate vaccines for human Rift Valley fever.

Ikegami T.

Expert Opin Biol Ther. 2019 Dec;19(12):1333-1342. doi: 10.1080/14712598.2019.1662784. Epub 2019 Sep 6.


Influences of Taurine Deficiency on Bile Acids of the Bile in the Cat Model.

Miyazaki T, Sasaki SI, Toyoda A, Shirai M, Ikegami T, Matsuzaki Y, Honda A.

Adv Exp Med Biol. 2019;1155:35-44. doi: 10.1007/978-981-13-8023-5_4.


Extensive Thrombectomy as a Legitimate Strategy in Living Donor Liver Transplantation With Advanced Portal Vein Thrombosis.

Ikegami T, Yoshizumi T, Tsutsui Y, Harada N, Itoh S, Yoshiya S, Imai D, Uchiyama H, Mori M.

Liver Transpl. 2019 Dec;25(12):1768-1777. doi: 10.1002/lt.25623. Epub 2019 Sep 20.


Association of Susceptibility Genes for Adolescent Idiopathic Scoliosis and Intervertebral Disc Degeneration With Adult Spinal Deformity.

Takeda K, Kou I, Hosogane N, Otomo N, Yagi M, Kaneko S, Kono H, Ishikawa M, Takahashi Y, Ikegami T, Nojiri K, Okada E, Funao H, Okuyama K, Tsuji T, Fujita N, Nagoshi N, Tsuji O, Ogura Y, Ishii K, Nakamura M, Matsumoto M, Ikegawa S, Watanabe K.

Spine (Phila Pa 1976). 2019 Dec 1;44(23):1623-1629. doi: 10.1097/BRS.0000000000003179.


Efficacy of Neoadjuvant Chemotherapy in Distal Pancreatectomy with En Bloc Celiac Axis Resection (DP-CAR) for Locally Advanced Pancreatic Cancer.

Yoshiya S, Fukuzawa K, Inokuchi S, Kosai-Fujimoto Y, Sanefuji K, Iwaki K, Motohiro A, Itoh S, Harada N, Ikegami T, Yoshizumi T, Mori M.

J Gastrointest Surg. 2019 Jul 19. doi: 10.1007/s11605-019-04324-8. [Epub ahead of print]


Adult T-Cell Leukemia After Deceased Donor Liver Transplantation for Acute Liver Failure: A Case Report.

Motomura T, Yoshizumi T, Kosai-Fujimoto Y, Mano Y, Toshima T, Takeishi K, Itoh S, Harada N, Ikegami T, Soejima Y, Yoshimoto G, Akashi K, Mori M.

Transplant Proc. 2019 Jul - Aug;51(6):1978-1981. doi: 10.1016/j.transproceed.2019.03.031. Epub 2019 Jul 11.


Afferent loop syndrome of 10 years' onset after gastrectomy.

Uriu Y, Kuriyama A, Ueno A, Ikegami T.

Asian J Surg. 2019 Oct;42(10):935-937. doi: 10.1016/j.asjsur.2019.06.008. Epub 2019 Jul 10. No abstract available.


Ectopic localization of autophagosome in fatty liver is a key factor for liver regeneration.

Matsumoto Y, Yoshizumi T, Toshima T, Takeishi K, Fukuhara T, Itoh S, Ikegami T, Soejima Y, Mori M.

Organogenesis. 2019;15(1):24-34. doi: 10.1080/15476278.2019.1633872. Epub 2019 Jul 6.


Evaluation of 8-week glecaprevir/pibrentasvir treatment in direct-acting antiviral-naïve noncirrhotic HCV genotype 1 and 2infected patients in a real-world setting in Japan.

Ikeda H, Watanabe T, Atsukawa M, Toyoda H, Takaguchi K, Nakamuta M, Matsumoto N, Okuse C, Tada T, Tsutsui A, Yamashita N, Kondo C, Hayama K, Kato K, Itokawa N, Arai T, Shimada N, Asano T, Uojima H, Ogawa C, Mikami S, Ikegami T, Fukunishi S, Asai A, Iio E, Tsubota A, Hiraoka A, Nozaki A, Okubo H, Tachi Y, Moriya A, Oikawa T, Matsumoto Y, Tsuruoka S, Tani J, Kikuchi K, Iwakiri K, Tanaka Y, Kumada T.

J Viral Hepat. 2019 Nov;26(11):1266-1275. doi: 10.1111/jvh.13170. Epub 2019 Aug 9.


Preparatory Mechanisms for Salinity Tolerance in Two Congeneric Anuran Species Inhabiting Distinct Osmotic Habitats.

Haramura T, Ikegami T, Wong MKS, Takei Y.

Zoolog Sci. 2019 Jun 1;36(3):215-222. doi: 10.2108/zs180091.


Charting the Path Forward for Risk Prediction in Liver Transplant for Hepatocellular Carcinoma: International Validation of HALTHCC Among 4,089 Patients.

Firl DJ, Sasaki K, Agopian VG, Gorgen A, Kimura S, Dumronggittigule W, McVey JC, Iesari S, Mennini G, Vitale A, Finkenstedt A, Onali S, Hoppe-Lotichius M, Vennarecci G, Manzia TM, Nicolini D, Avolio AW, Agnes S, Vivarelli M, Tisone G, Ettorre GM, Otto G, Tsochatzis E, Rossi M, Viveiros A, Cillo U, Markmann JF, Ikegami T, Kaido T, Lai Q, Sapisochin G, Lerut J; European Hepatocellular Cancer Liver Transplant Study Group, Aucejo FN.

Hepatology. 2020 Feb;71(2):569-582. doi: 10.1002/hep.30838. Epub 2019 Aug 19.


Peritransplant kinetics of Mac-2-binding protein glycosylation isomer levels in living donor liver transplantation: its implication of posttransplant small-for-size syndrome.

Uchiyama H, Shirabe K, Bekki Y, Toshima T, Harimoto N, Ikegami T, Yoshizumi T.

Transl Gastroenterol Hepatol. 2019 May 25;4:41. doi: 10.21037/tgh.2019.05.08. eCollection 2019.


Electrohydraulic lithotripsy and rendezvous nasal endoscopic cholangiography for common bile duct stone: A case report.

Kimura K, Kudo K, Yoshizumi T, Kurihara T, Yoshiya S, Mano Y, Takeishi K, Itoh S, Harada N, Ikegami T, Ikeda T.

World J Clin Cases. 2019 May 26;7(10):1149-1154. doi: 10.12998/wjcc.v7.i10.1149.


The Role of DNA Repair Glycosylase OGG1 in Intrahepatic Cholangiocarcinoma.

Sakata K, Yoshizumi T, Izumi T, Shimokawa M, Itoh S, Ikegami T, Harada N, Toshima T, Mano Y, Mori M.

Anticancer Res. 2019 Jun;39(6):3241-3248. doi: 10.21873/anticanres.13465.


Hypopharyngeal cancer risk in Japanese: Genetic polymorphisms related to the metabolism of alcohol- and tobacco-associated carcinogens.

Yamashita Y, Ikegami T, Suzuki M, Hirakawa H, Maeda H, Yamada S, Deng Z, Kondo S, Kinjyo H, Kiyuna A, Agena S, Uehara T, Ganaha A.

J Cancer Res Ther. 2019 Jul-Sep;15(3):556-563. doi: 10.4103/jcrt.JCRT_980_17.


Open-Ended Evolution and a Mechanism of Novelties in Web Services.

Ikegami T, Hashimoto Y, Oka M.

Artif Life. 2019 Spring;25(2):168-177. doi: 10.1162/artl_a_00287.


How to Make Swarms Open-Ended? Evolving Collective Intelligence Through a Constricted Exploration of Adjacent Possibles.

Witkowski O, Ikegami T.

Artif Life. 2019 Spring;25(2):178-197. doi: 10.1162/artl_a_00288.


An Overview of Open-Ended Evolution: Editorial Introduction to the Open-Ended Evolution II Special Issue.

Packard N, Bedau MA, Channon A, Ikegami T, Rasmussen S, Stanley KO, Taylor T.

Artif Life. 2019 Spring;25(2):93-103. doi: 10.1162/artl_a_00291.


Trends and Efficacy of Interferon-Free Anti-hepatitis C Virus Therapy in the Region of High Prevalence of Elderly Patients, Cirrhosis, and Hepatocellular Carcinoma: A Real-World, Nationwide, Multicenter Study of 10 688 Patients in Japan.

Toyoda H, Atsukawa M, Uojima H, Nozaki A, Tamai H, Takaguchi K, Fujioka S, Nakamuta M, Tada T, Yasuda S, Chuma M, Senoh T, Tsutsui A, Yamashita N, Hiraoka A, Michitaka K, Shima T, Akahane T, Itobayashi E, Watanabe T, Ikeda H, Iio E, Fukunishi S, Asano T, Tachi Y, Ikegami T, Tsuji K, Abe H, Kato K, Mikami S, Okubo H, Shimada N, Ishikawa T, Matsumoto Y, Itokawa N, Arai T, Tsubota A, Iwakiri K, Tanaka Y, Kumada T.

Open Forum Infect Dis. 2019 Apr 15;6(5):ofz185. doi: 10.1093/ofid/ofz185. eCollection 2019 May.

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