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Items: 49


Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HBV replication by enhancing microRNA-122 processing.

Liu G, Ma X, Wang Z, Wakae K, Yuan Y, He Z, Yoshiyama H, Iizasa H, Zhang H, Matsuda M, Sugiyama R, Yuan Z, Muramatsu M, Li L.

J Biol Chem. 2019 Jul 30. pii: jbc.RA119.007970. doi: 10.1074/jbc.RA119.007970. [Epub ahead of print]


Epstein-Barr virus detection using gastric biopsy specimens after rapid urease test for Helicobacter pylori.

Yanai H, Iizasa H, Chihara D, Murakami T, Nishikawa J, Yoshiyama H.

Endosc Int Open. 2019 Apr;7(4):E431-E432. doi: 10.1055/a-0859-7233. Epub 2019 Mar 21. No abstract available.


Dominant-negative p53 mutant R248Q increases the motile and invasive activities of oral squamous cell carcinoma cells.

Nakazawa S, Sakata KI, Liang S, Yoshikawa K, Iizasa H, Tada M, Hamada JI, Kashiwazaki H, Kitagawa Y, Yamazaki Y.

Biomed Res. 2019;40(1):37-49. doi: 10.2220/biomedres.40.37.


EBV-associated gastric cancer evades T-cell immunity by PD-1/PD-L1 interactions.

Sasaki S, Nishikawa J, Sakai K, Iizasa H, Yoshiyama H, Yanagihara M, Shuto T, Shimokuri K, Kanda T, Suehiro Y, Yamasaki T, Sakaida I.

Gastric Cancer. 2019 May;22(3):486-496. doi: 10.1007/s10120-018-0880-4. Epub 2018 Sep 28.


Identification of Novel Mycobacterial Inhibitors Against Mycobacterial Protein Kinase G.

Kanehiro Y, Tomioka H, Pieters J, Tatano Y, Kim H, Iizasa H, Yoshiyama H.

Front Microbiol. 2018 Jul 12;9:1517. doi: 10.3389/fmicb.2018.01517. eCollection 2018.


Clinical Importance of Epstein⁻Barr Virus-Associated Gastric Cancer.

Nishikawa J, Iizasa H, Yoshiyama H, Shimokuri K, Kobayashi Y, Sasaki S, Nakamura M, Yanai H, Sakai K, Suehiro Y, Yamasaki T, Sakaida I.

Cancers (Basel). 2018 May 29;10(6). pii: E167. doi: 10.3390/cancers10060167. Review.


Herpesviral microRNAs in Cellular Metabolism and Immune Responses.

Kim H, Iizasa H, Kanehiro Y, Fekadu S, Yoshiyama H.

Front Microbiol. 2017 Jul 18;8:1318. doi: 10.3389/fmicb.2017.01318. eCollection 2017. Review.


The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer.

Nishikawa J, Iizasa H, Yoshiyama H, Nakamura M, Saito M, Sasaki S, Shimokuri K, Yanagihara M, Sakai K, Suehiro Y, Yamasaki T, Sakaida I.

Int J Mol Sci. 2017 Jul 25;18(8). pii: E1606. doi: 10.3390/ijms18081606. Review.


[Pathophysiological role of A-to-I RNA editing enzyme ADAR1 in human diseases].

Iizasa H.

Seikagaku. 2016 Oct;88(5):593-9. Review. Japanese. No abstract available.


Sox2 functionally interacts with βAPP, the βAPP intracellular domain and ADAM10 at a transcriptional level in human cells.

Sarlak G, Htoo HH, Hernandez JF, Iizasa H, Checler F, Konietzko U, Song W, Vincent B.

Neuroscience. 2016 Jan 15;312:153-64. doi: 10.1016/j.neuroscience.2015.11.022. Epub 2015 Nov 17.


Dysbiotic infection in the stomach.

Iizasa H, Ishihara S, Richardo T, Kanehiro Y, Yoshiyama H.

World J Gastroenterol. 2015 Oct 28;21(40):11450-7. doi: 10.3748/wjg.v21.i40.11450. Review.


Clustered microRNAs of the Epstein-Barr virus cooperatively downregulate an epithelial cell-specific metastasis suppressor.

Kanda T, Miyata M, Kano M, Kondo S, Yoshizaki T, Iizasa H.

J Virol. 2015 Mar;89(5):2684-97. doi: 10.1128/JVI.03189-14. Epub 2014 Dec 17.


Epstein-barr virus in gastric carcinoma.

Nishikawa J, Yoshiyama H, Iizasa H, Kanehiro Y, Nakamura M, Nishimura J, Saito M, Okamoto T, Sakai K, Suehiro Y, Yamasaki T, Oga A, Yanai H, Sakaida I.

Cancers (Basel). 2014 Nov 7;6(4):2259-74. doi: 10.3390/cancers6042259. Review.


Basic fibroblast growth factor is essential to maintain endothelial progenitor cell phenotype in TR-BME2 cells.

Sai Y, Nishimura T, Muta M, Iizasa H, Miyata T, Nakashima E.

Biol Pharm Bull. 2014;37(4):688-93.


Colonization of an acid resistant Kingella denitrificans in the stomach may contribute to gastric dysbiosis by Helicobacter pylori.

Okamoto T, Hayashi Y, Mizuno H, Yanai H, Nishikawa J, Nakazawa T, Iizasa H, Jinushi M, Sakaida I, Yoshiyama H.

J Infect Chemother. 2014 Mar;20(3):169-74. doi: 10.1016/j.jiac.2013.09.007. Epub 2013 Dec 11.


Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway.

Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J.

Cancer Lett. 2013 Oct 1;339(1):82-92. doi: 10.1016/j.canlet.2013.07.020. Epub 2013 Jul 20.


Isolation and characterization of human breast cancer cells with SOX2 promoter activity.

Liang S, Furuhashi M, Nakane R, Nakazawa S, Goudarzi H, Hamada J, Iizasa H.

Biochem Biophys Res Commun. 2013 Jul 26;437(2):205-11. doi: 10.1016/j.bbrc.2013.06.038. Epub 2013 Jun 22.


ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing.

Ota H, Sakurai M, Gupta R, Valente L, Wulff BE, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K.

Cell. 2013 Apr 25;153(3):575-89. doi: 10.1016/j.cell.2013.03.024.


Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells.

Oda K, Nishimura T, Higuchi K, Ishido N, Ochi K, Iizasa H, Sai Y, Tomi M, Nakashima E.

J Pharm Sci. 2013 Sep;102(9):3364-72. doi: 10.1002/jps.23549. Epub 2013 Apr 16.


Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma.

Goudarzi H, Hida Y, Takano H, Teramae H, Iizasa H, Hamada J.

Biomed Res. 2013 Feb;34(1):13-21.


Epstein-Barr Virus (EBV)-associated gastric carcinoma.

Iizasa H, Nanbo A, Nishikawa J, Jinushi M, Yoshiyama H.

Viruses. 2012 Dec;4(12):3420-39. Review.


Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress.

Nishimura T, Sai Y, Fujii J, Muta M, Iizasa H, Tomi M, Deureh M, Kose N, Nakashima E.

Placenta. 2010 Nov;31(11):1003-9. doi: 10.1016/j.placenta.2010.08.003.


Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency.

Iizasa H, Wulff BE, Alla NR, Maragkakis M, Megraw M, Hatzigeorgiou A, Iwakiri D, Takada K, Wiedmer A, Showe L, Lieberman P, Nishikura K.

J Biol Chem. 2010 Oct 22;285(43):33358-70. doi: 10.1074/jbc.M110.138362. Epub 2010 Aug 17.


Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats.

Higuchi K, Iizasa H, Sai Y, Horieya S, Lee KE, Wada M, Deguchi M, Nishimura T, Wakayama T, Tamura A, Tsukita S, Kose N, Kang YS, Nakashima E.

Biol Pharm Bull. 2010;33(8):1400-6.


A new function for the RNA-editing enzyme ADAR1.

Iizasa H, Nishikura K.

Nat Immunol. 2009 Jan;10(1):16-8. doi: 10.1038/ni0109-16.


Frequency and fate of microRNA editing in human brain.

Kawahara Y, Megraw M, Kreider E, Iizasa H, Valente L, Hatzigeorgiou AG, Nishikura K.

Nucleic Acids Res. 2008 Sep;36(16):5270-80. doi: 10.1093/nar/gkn479. Epub 2008 Aug 6.


Altered expression of basement membrane-related molecules in rat brain pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta1 treatment.

Kose N, Asashima T, Muta M, Iizasa H, Sai Y, Terasaki T, Nakashima E.

Drug Metab Pharmacokinet. 2007 Aug;22(4):255-66.


Hepatocyte growth factor and c-Met expression in pericytes: implications for atherosclerotic plaque development.

Liu Y, Wilkinson FL, Kirton JP, Jeziorska M, Iizasa H, Sai Y, Nakashima E, Heagerty AM, Canfield AE, Alexander MY.

J Pathol. 2007 May;212(1):12-9.


Redirection of silencing targets by adenosine-to-inosine editing of miRNAs.

Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K.

Science. 2007 Feb 23;315(5815):1137-40.


Exacerbation of granuloma formation in IL-1 receptor antagonist-deficient mice with impaired dendritic cell maturation associated with Th2 cytokine production.

Iizasa H, Yoneyama H, Mukaida N, Katakoka Y, Naito M, Yoshida N, Nakashima E, Matsushima K.

J Immunol. 2005 Mar 15;174(6):3273-80.


Conditionally immortalized syncytiotrophoblast cell lines as new tools for study of the blood-placenta barrier.

Kitano T, Iizasa H, Hwang IW, Hirose Y, Morita T, Maeda T, Nakashima E.

Biol Pharm Bull. 2004 Jun;27(6):753-9. Review.


Establishment of conditionally immortalized rat retinal pericyte cell lines (TR-rPCT) and their application in a co-culture system using retinal capillary endothelial cell line (TR-iBRB2).

Kondo T, Hosoya K, Hori S, Tomi M, Ohtsuki S, Takanaga H, Nakashima E, Iizasa H, Asashima T, Ueda M, Obinata M, Terasaki T.

Cell Struct Funct. 2003 Jun;28(3):145-53.


Altered expression and function of P-glycoprotein in dextran sodium sulfate-induced colitis in mice.

Iizasa H, Genda N, Kitano T, Tomita M, Nishihara K, Hayashi M, Nakamura K, Kobayashi S, Nakashima E.

J Pharm Sci. 2003 Mar;92(3):569-76.


Augmented expression of the tight junction protein occludin in brain endothelial cell line TR-BBB by rat angiopoietin-1 expressed in baculovirus-infected Sf plus insect cells.

Iizasa H, Bae SH, Asashima T, Kitano T, Matsunaga N, Terasaki T, Kang YS, Nakashima E.

Pharm Res. 2002 Nov;19(11):1757-60. No abstract available.


Polarized glucose transporters and mRNA expression properties in newly developed rat syncytiotrophoblast cell lines, TR-TBTs.

Kitano T, Iizasa H, Terasaki T, Asashima T, Matsunaga N, Utoguchi N, Watanabe Y, Obinata M, Ueda M, Nakashima E.

J Cell Physiol. 2002 Nov;193(2):208-18.


Newly developed rat brain pericyte cell line, TR-PCT1, responds to transforming growth factor-beta1 and beta-glycerophosphate.

Asashima T, Iizasa H, Terasaki T, Hosoya K, Tetsuka K, Ueda M, Obinata M, Nakashima E.

Eur J Cell Biol. 2002 Mar;81(3):145-52.


Application of the PKCYP-test to predict the amount of in vivo CYP2C11 using tolbutamide as a probe.

Matsunaga N, Nishijima T, Hattori K, Iizasa H, Yamamoto K, Kizu J, Takanaka A, Morikawa A, Nakashima E.

Biol Pharm Bull. 2001 Nov;24(11):1305-10.


Application of the PKCYP-test in cases of altered CYP1A2 for multiple CYP systems in rat models of disease.

Matsunaga N, Hattori K, Iizasa H, Kizu J, Takanaka A, Nakashima E.

Biol Pharm Bull. 2001 Sep;24(9):1037-43.


Synergistic effect of indomethacin and bleomycin on tumor growth produced by activating antitumor immunity.

Matsushita R, Hattori K, Hayashi K, Iizasa H, Ichimura F, Nakashima E.

Pharm Res. 2001 Feb;18(2):243-5. No abstract available.


Establishment of bone marrow-derived endothelial cell lines from ts-SV40 T-antigen gene transgenic rats.

Hattori K, Muta M, Toi M, Iizasa H, Shinsei M, Terasaki T, Obinata M, Ueda M, Nakashima E.

Pharm Res. 2001 Jan;18(1):9-15.


Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice.

Hirata A, Yoshida S, Inoue N, Matsumoto-Miyai K, Ninomiya A, Taniguchi M, Matsuyama T, Kato K, Iizasa H, Kataoka Y, Yoshida N, Shiosaka S.

Mol Cell Neurosci. 2001 Mar;17(3):600-10.


Physiologically-based pharmacokinetic analysis of grepafloxacin.

Nakajima Y, Hattori K, Shinsei M, Matsunaga N, Iizasa H, Sasabe H, Akiyama H, Miyanmoto G, Nakashima E.

Biol Pharm Bull. 2000 Sep;23(9):1077-83.


A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution.

Kawabata K, Ujikawa M, Egawa T, Kawamoto H, Tachibana K, Iizasa H, Katsura Y, Kishimoto T, Nagasawa T.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5663-7.


The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.

Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, Kishimoto T, Nagasawa T.

Nature. 1998 Jun 11;393(6685):591-4.


CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry.

Tachibana K, Nakajima T, Sato A, Igarashi K, Shida H, Iizasa H, Yoshida N, Yoshie O, Kishimoto T, Nagasawa T.

J Exp Med. 1997 May 19;185(10):1865-70.


Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin.

Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O, Matsushima K, Yoshida N, Springer TA, Kishimoto T.

Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14726-9.

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