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An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.

Pelletier S, Gingras S, Howell S, Vogel P, Ihle JN.

J Neurosci. 2012 Nov 21;32(47):16560-73. doi: 10.1523/JNEUROSCI.1787-12.2012.


Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence.

Rawlings JS, Gatzka M, Thomas PG, Ihle JN.

EMBO J. 2011 Jan 19;30(2):263-76. doi: 10.1038/emboj.2010.314. Epub 2010 Dec 17.


Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.

Gruber JJ, Zatechka DS, Sabin LR, Yong J, Lum JJ, Kong M, Zong WX, Zhang Z, Lau CK, Rawlings J, Cherry S, Ihle JN, Dreyfuss G, Thompson CB.

Cell. 2009 Jul 23;138(2):328-39. doi: 10.1016/j.cell.2009.04.046.


Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway.

Funakoshi-Tago M, Tago K, Kasahara T, Parganas E, Ihle JN.

Cell Signal. 2008 Nov;20(11):1995-2001. doi: 10.1016/j.cellsig.2008.07.008. Epub 2008 Jul 17.


Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway.

Takahashi Y, Takahashi M, Carpino N, Jou ST, Chao JR, Tanaka S, Shigeyoshi Y, Parganas E, Ihle JN.

Mol Endocrinol. 2008 Jul;22(7):1673-81. doi: 10.1210/me.2008-0058. Epub 2008 May 1.


Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.

Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN.

Nature. 2008 Mar 6;452(7183):98-102. doi: 10.1038/nature06604. Epub 2008 Feb 20. Erratum in: Nature. 2008 Apr 17;452(7189):900.


Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity.

Funakoshi-Tago M, Pelletier S, Moritake H, Parganas E, Ihle JN.

Mol Cell Biol. 2008 Mar;28(5):1792-801. Epub 2007 Dec 26.


Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP).

Gingras S, Pelletier S, Boyd K, Ihle JN.

PLoS One. 2007 Aug 29;2(8):e808.


Jak2: normal function and role in hematopoietic disorders.

Ihle JN, Gilliland DG.

Curr Opin Genet Dev. 2007 Feb;17(1):8-14. Epub 2007 Jan 8. Review.


Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2.

Funakoshi-Tago M, Pelletier S, Matsuda T, Parganas E, Ihle JN.

EMBO J. 2006 Oct 18;25(20):4763-72. Epub 2006 Oct 5.


Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function.

Pelletier S, Gingras S, Funakoshi-Tago M, Howell S, Ihle JN.

Mol Cell Biol. 2006 Nov;26(22):8527-38. Epub 2006 Sep 18.


A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling.

Gatzka M, Piekorz R, Moriggl R, Rawlings J, Ihle JN.

Cytokine. 2006 May;34(3-4):143-54. Epub 2006 Jun 6.


Trophoblast stem cells rescue placental defect in SOCS3-deficient mice.

Takahashi Y, Dominici M, Swift J, Nagy C, Ihle JN.

J Biol Chem. 2006 Apr 28;281(17):11444-5. Epub 2006 Mar 3.


Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia.

Zhang J, Randall MS, Loyd MR, Li W, Schweers RL, Persons DA, Rehg JE, Noguchi CT, Ihle JN, Ney PA.

Blood. 2006 Jan 1;107(1):73-8. Epub 2005 Sep 20.


Evi-1 expression in Xenopus.

Mead PE, Parganas E, Ohtsuka S, Morishita K, Gamer L, Kuliyev E, Wright CV, Ihle JN.

Gene Expr Patterns. 2005 Jun;5(5):601-8.


Stat5 tetramer formation is associated with leukemogenesis.

Moriggl R, Sexl V, Kenner L, Duntsch C, Stangl K, Gingras S, Hoffmeyer A, Bauer A, Piekorz R, Wang D, Bunting KD, Wagner EF, Sonneck K, Valent P, Ihle JN, Beug H.

Cancer Cell. 2005 Jan;7(1):87-99.


Determination of the transphosphorylation sites of Jak2 kinase.

Matsuda T, Feng J, Witthuhn BA, Sekine Y, Ihle JN.

Biochem Biophys Res Commun. 2004 Dec 10;325(2):586-94.


Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling.

Gingras S, Parganas E, de Pauw A, Ihle JN, Murray PJ.

J Biol Chem. 2004 Dec 24;279(52):54702-7. Epub 2004 Oct 18.


Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

Piekorz RP, Gingras S, Hoffmeyer A, Ihle JN, Weinstein Y.

Mol Endocrinol. 2005 Feb;19(2):431-40. Epub 2004 Oct 7.


The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer.

Schuendeln MM, Piekorz RP, Wichmann C, Lee Y, McKinnon PJ, Boyd K, Takahashi Y, Ihle JN.

Mol Cell Biol. 2004 Jul;24(14):6403-9.


Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development.

Carpino N, Thierfelder WE, Chang MS, Saris C, Turner SJ, Ziegler SF, Ihle JN.

Mol Cell Biol. 2004 Mar;24(6):2584-92.


Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2.

Carpino N, Turner S, Mekala D, Takahashi Y, Zang H, Geiger TL, Doherty P, Ihle JN.

Immunity. 2004 Jan;20(1):37-46.


Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.

Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, MacLean KH, Han J, Chittenden T, Ihle JN, McKinnon PJ, Cleveland JL, Zambetti GP.

Cancer Cell. 2003 Oct;4(4):321-8.


SOCS3 regulates the plasticity of gp130 signaling.

Lang R, Pauleau AL, Parganas E, Takahashi Y, Mages J, Ihle JN, Rutschman R, Murray PJ.

Nat Immunol. 2003 Jun;4(6):546-50. Epub 2003 May 18.


Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation.

Sexl V, Kovacic B, Piekorz R, Moriggl R, Stoiber D, Hoffmeyer A, Liebminger R, Kudlacek O, Weisz E, Rothammer K, Ihle JN.

Blood. 2003 Jun 15;101(12):4937-43. Epub 2003 Feb 6.


SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation.

Takahashi Y, Carpino N, Cross JC, Torres M, Parganas E, Ihle JN.

EMBO J. 2003 Feb 3;22(3):372-84.


Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

Jou ST, Carpino N, Takahashi Y, Piekorz R, Chao JR, Carpino N, Wang D, Ihle JN.

Mol Cell Biol. 2002 Dec;22(24):8580-91.


Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein.

Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN.

Mol Cell Biol. 2002 Nov;22(21):7491-500.


c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression.

Baudino TA, McKay C, Pendeville-Samain H, Nilsson JA, Maclean KH, White EL, Davis AC, Ihle JN, Cleveland JL.

Genes Dev. 2002 Oct 1;16(19):2530-43.


JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells.

Zhao S, Zoller K, Masuko M, Rojnuckarin P, Yang XO, Parganas E, Kaushansky K, Ihle JN, Papayannopoulou T, Willerford DM, Clackson T, Blau CA.

EMBO J. 2002 May 1;21(9):2159-67.


The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis.

Piekorz RP, Hoffmeyer A, Duntsch CD, McKay C, Nakajima H, Sexl V, Snyder L, Rehg J, Ihle JN.

EMBO J. 2002 Feb 15;21(4):653-64.


Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.

Bunting KD, Bradley HL, Hawley TS, Moriggl R, Sorrentino BP, Ihle JN.

Blood. 2002 Jan 15;99(2):479-87.


Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice.

Liao HJ, Kume T, McKay C, Xu MJ, Ihle JN, Carpenter G.

J Biol Chem. 2002 Mar 15;277(11):9335-41. Epub 2001 Dec 13.


Variations in the human phospholipase Cgamma2 gene in patients with B-cell defects of unknown etiology.

Wang D, Boylin EC, Minegishi Y, Wen R, Smith CI, Ihle JN, Conley ME.

Immunogenetics. 2001 Sep;53(7):550-6.


Membrane localization is not required for Mpl function in normal hematopoietic cells.

Otto KG, Broudy VC, Lin NL, Parganas E, Luthi JN, Drachman JG, Ihle JN, Blau CA.

Blood. 2001 Oct 1;98(7):2077-83.


The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis.

Zang H, Sato K, Nakajima H, McKay C, Ney PA, Ihle JN.

EMBO J. 2001 Jun 15;20(12):3156-66.


Gadd45gamma is dispensable for normal mouse development and T-cell proliferation.

Hoffmeyer A, Piekorz R, Moriggl R, Ihle JN.

Mol Cell Biol. 2001 May;21(9):3137-43.


The Stat family in cytokine signaling.

Ihle JN.

Curr Opin Cell Biol. 2001 Apr;13(2):211-7. Review.


Differential roles of cytokine signaling during T-cell development.

Moriggl R, Marine JC, Topham DJ, Teglund S, Sexl V, McKay C, Piekorz R, Wang D, Parganas E, Yoshimura A, Ihle JN.

Cold Spring Harb Symp Quant Biol. 1999;64:389-95. Review. No abstract available.


Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1.

Diehl S, Anguita J, Hoffmeyer A, Zapton T, Ihle JN, Fikrig E, Rincón M.

Immunity. 2000 Dec;13(6):805-15.


Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production.

Rutschman R, Lang R, Hesse M, Ihle JN, Wynn TA, Murray PJ.

J Immunol. 2001 Feb 15;166(4):2173-7. Erratum in: J Immunol 2001 Apr 1;166(7):4788.


Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development.

Wen R, Wang D, McKay C, Bunting KD, Marine JC, Vanin EF, Zambetti GP, Korsmeyer SJ, Ihle JN, Cleveland JL.

Mol Cell Biol. 2001 Jan;21(2):678-89.


Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.

Schwaller J, Parganas E, Wang D, Cain D, Aster JC, Williams IR, Lee CK, Gerthner R, Kitamura T, Frantsve J, Anastasiadou E, Loh ML, Levy DE, Ihle JN, Gilliland DG.

Mol Cell. 2000 Sep;6(3):693-704.


Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5.

Sexl V, Piekorz R, Moriggl R, Rohrer J, Brown MP, Bunting KD, Rothammer K, Roussel MF, Ihle JN.

Blood. 2000 Sep 15;96(6):2277-83.


The challenges of translating knockout phenotypes into gene function.

Ihle JN.

Cell. 2000 Jul 21;102(2):131-4. Review. No abstract available.


Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors.

Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JL, Murray PJ, Ihle JN.

Immunity. 2000 Jul;13(1):25-35.


A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5.

Wang D, Moriggl R, Stravopodis D, Carpino N, Marine JC, Teglund S, Feng J, Ihle JN.

EMBO J. 2000 Feb 1;19(3):392-9.


Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation.

Kieslinger M, Woldman I, Moriggl R, Hofmann J, Marine JC, Ihle JN, Beug H, Decker T.

Genes Dev. 2000 Jan 15;14(2):232-44.

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