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Items: 1 to 50 of 85

1.

Slowing ribosome velocity restores folding and function of mutant CFTR.

Oliver KE, Rauscher R, Mijnders M, Wang W, Wolpert MJ, Maya J, Sabusap CM, Kesterson RA, Kirk KL, Rab A, Braakman I, Hong JS, Hartman JL 4th, Ignatova Z, Sorscher EJ.

J Clin Invest. 2019 Dec 2;129(12):5236-5253. doi: 10.1172/JCI124282.

2.

Polymerase III transcription is necessary for T cell priming by dendritic cells.

Reverendo M, Argüello RJ, Polte C, Valečka J, Camosseto V, Auphan-Anezin N, Ignatova Z, Gatti E, Pierre P.

Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22721-22729. doi: 10.1073/pnas.1904396116. Epub 2019 Oct 21.

PMID:
31636192
3.

Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging.

Amirbeigiarab S, Kiani P, Velazquez Sanchez A, Krisp C, Kazantsev A, Fester L, Schlüter H, Ignatova Z.

Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22567-22572. doi: 10.1073/pnas.1912060116. Epub 2019 Oct 21. Erratum in: Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24907.

PMID:
31636180
4.

CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression.

Cano-Crespo S, Chillarón J, Junza A, Fernández-Miranda G, García J, Polte C, R de la Ballina L, Ignatova Z, Yanes Ó, Zorzano A, Stephan-Otto Attolini C, Palacín M.

Sci Rep. 2019 Oct 1;9(1):14065. doi: 10.1038/s41598-019-50547-9.

5.

A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2.

Karsak M, Glebov K, Scheffold M, Bajaj T, Kawalia A, Karaca I, Rading S, Kornhuber J, Peters O, Diez-Fairen M, Frölich L, Hüll M, Wiltfang J, Scherer M, Riedel-Heller S, Schneider A, Heneka MT, Fliessbach K, Sharaf A, Thiele H, Lennarz M, Jessen F, Maier W, Kubisch C, Ignatova Z, Nürnberg P, Pastor P, Walter J, Ramirez A.

Hum Mutat. 2019 Aug 29. doi: 10.1002/humu.23904. [Epub ahead of print]

PMID:
31464095
6.

Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.

Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salinas CS, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C.

Nat Cell Biol. 2019 Aug;21(8):1052. doi: 10.1038/s41556-019-0370-x.

PMID:
31316187
7.

Assessing cell-specific effects of genetic variations using tRNA microarrays.

Polte C, Wedemeyer D, Oliver KE, Wagner J, Bijvelds MJC, Mahoney J, de Jonge HR, Sorscher EJ, Ignatova Z.

BMC Genomics. 2019 Jul 16;20(Suppl 8):549. doi: 10.1186/s12864-019-5864-1.

8.

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.

Tameire F, Verginadis II, Leli NM, Polte C, Conn CS, Ojha R, Salas Salinas C, Chinga F, Monroy AM, Fu W, Wang P, Kossenkov A, Ye J, Amaravadi RK, Ignatova Z, Fuchs SY, Diehl JA, Ruggero D, Koumenis C.

Nat Cell Biol. 2019 Jul;21(7):889-899. doi: 10.1038/s41556-019-0347-9. Epub 2019 Jul 1. Erratum in: Nat Cell Biol. 2019 Aug;21(8):1052.

PMID:
31263264
9.

Computational Aminoacyl-tRNA Synthetase Library Design for Photocaged Tyrosine.

Baumann T, Hauf M, Richter F, Albers S, Möglich A, Ignatova Z, Budisa N.

Int J Mol Sci. 2019 May 11;20(9). pii: E2343. doi: 10.3390/ijms20092343.

10.

Absolute quantification of translational regulation and burden using combined sequencing approaches.

Gorochowski TE, Chelysheva I, Eriksen M, Nair P, Pedersen S, Ignatova Z.

Mol Syst Biol. 2019 May 3;15(5):e8719. doi: 10.15252/msb.20188719.

11.

A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging.

Adamla F, Rollins J, Newsom M, Snow S, Schosserer M, Heissenberger C, Horrocks J, Rogers AN, Ignatova Z.

Cell Physiol Biochem. 2019;52(5):970-983. doi: 10.33594/000000067.

12.

Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes.

Czech A, Konarev PV, Goebel I, Svergun DI, Wills PR, Ignatova Z.

Sci Rep. 2019 Feb 21;9(1):2465. doi: 10.1038/s41598-019-39213-2.

13.

Dynamic m6A methylation facilitates mRNA triaging to stress granules.

Anders M, Chelysheva I, Goebel I, Trenkner T, Zhou J, Mao Y, Verzini S, Qian SB, Ignatova Z.

Life Sci Alliance. 2018 Jul 3;1(4):e201800113. doi: 10.26508/lsa.201800113. eCollection 2018 Aug.

14.

DNA Aptamers for the Malignant Transformation Marker CD24.

Fafińska J, Czech A, Sitz T, Ignatova Z, Hahn U.

Nucleic Acid Ther. 2018 Dec;28(6):326-334. doi: 10.1089/nat.2018.0748. Epub 2018 Nov 8.

PMID:
30407110
15.

Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.

Beckert B, Turk M, Czech A, Berninghausen O, Beckmann R, Ignatova Z, Plitzko JM, Wilson DN.

Nat Microbiol. 2018 Oct;3(10):1115-1121. doi: 10.1038/s41564-018-0237-0. Epub 2018 Sep 3.

PMID:
30177741
16.

Timing during translation matters: synonymous mutations in human pathologies influence protein folding and function.

Rauscher R, Ignatova Z.

Biochem Soc Trans. 2018 Aug 20;46(4):937-944. doi: 10.1042/BST20170422. Epub 2018 Jul 31. Review.

PMID:
30065107
17.

The RNA-binding protein Hfq is important for ribosome biogenesis and affects translation fidelity.

Andrade JM, Dos Santos RF, Chelysheva I, Ignatova Z, Arraiano CM.

EMBO J. 2018 Jun 1;37(11). pii: e97631. doi: 10.15252/embj.201797631. Epub 2018 Apr 18.

18.

Examining tRNA 3'-ends in Escherichia coli: teamwork between CCA-adding enzyme, RNase T, and RNase R.

Wellner K, Czech A, Ignatova Z, Betat H, Mörl M.

RNA. 2018 Mar;24(3):361-370. doi: 10.1261/rna.064436.117. Epub 2017 Nov 27.

19.

Growth-Rate Dependent Regulation of tRNA Level and Charging in Bacillus licheniformis.

Ferro I, Liebeton K, Ignatova Z.

J Mol Biol. 2017 Oct 13;429(20):3102-3112. doi: 10.1016/j.jmb.2017.09.010. Epub 2017 Sep 14.

PMID:
28918092
20.

Alteration of protein function by a silent polymorphism linked to tRNA abundance.

Kirchner S, Cai Z, Rauscher R, Kastelic N, Anding M, Czech A, Kleizen B, Ostedgaard LS, Braakman I, Sheppard DN, Ignatova Z.

PLoS Biol. 2017 May 16;15(5):e2000779. doi: 10.1371/journal.pbio.2000779. eCollection 2017 May.

21.

Competition for amino acid flux among translation, growth and detoxification in bacteria.

Ferro I, Chelysheva I, Ignatova Z.

RNA Biol. 2018;15(8):991-994. doi: 10.1080/15476286.2017.1306174. Epub 2017 Apr 17.

22.

Systematic probing of the bacterial RNA structurome to reveal new functions.

Ignatova Z, Narberhaus F.

Curr Opin Microbiol. 2017 Apr;36:14-19. doi: 10.1016/j.mib.2017.01.003. Epub 2017 Feb 1. Review.

PMID:
28160611
23.
24.

Rewiring host activities for synthetic circuit production: a translation view.

Avcilar-Kucukgoze I, Ignatova Z.

Biotechnol Lett. 2017 Jan;39(1):25-31. doi: 10.1007/s10529-016-2229-6. Epub 2016 Oct 4. Review.

PMID:
27704283
25.

Discharging tRNAs: a tug of war between translation and detoxification in Escherichia coli.

Avcilar-Kucukgoze I, Bartholomäus A, Cordero Varela JA, Kaml RF, Neubauer P, Budisa N, Ignatova Z.

Nucleic Acids Res. 2016 Sep 30;44(17):8324-34. doi: 10.1093/nar/gkw697. Epub 2016 Aug 9.

26.

An Expanded CAG Repeat in Huntingtin Causes +1 Frameshifting.

Saffert P, Adamla F, Schieweck R, Atkins JF, Ignatova Z.

J Biol Chem. 2016 Aug 26;291(35):18505-13. doi: 10.1074/jbc.M116.744326. Epub 2016 Jul 5.

27.

A Minimal Model of Ribosome Allocation Dynamics Captures Trade-offs in Expression between Endogenous and Synthetic Genes.

Gorochowski TE, Avcilar-Kucukgoze I, Bovenberg RA, Roubos JA, Ignatova Z.

ACS Synth Biol. 2016 Jul 15;5(7):710-20. doi: 10.1021/acssynbio.6b00040. Epub 2016 May 3.

28.

Bacteria differently regulate mRNA abundance to specifically respond to various stresses.

Bartholomäus A, Fedyunin I, Feist P, Sin C, Zhang G, Valleriani A, Ignatova Z.

Philos Trans A Math Phys Eng Sci. 2016 Mar 13;374(2063). pii: 20150069. doi: 10.1098/rsta.2015.0069.

PMID:
26857681
29.

Probing dimensionality beyond the linear sequence of mRNA.

Del Campo C, Ignatova Z.

Curr Genet. 2016 May;62(2):331-4. doi: 10.1007/s00294-015-0551-5. Epub 2015 Dec 9. Review.

PMID:
26650615
30.

Tuning innate immunity by translation.

Rauscher R, Ignatova Z.

Biochem Soc Trans. 2015 Dec;43(6):1247-52. doi: 10.1042/BST20150166. Review.

PMID:
26614668
31.

Quantifying the 'escapers' among RNA species.

Ferro I, Ignatova Z.

Biochem Soc Trans. 2015 Dec;43(6):1215-20. doi: 10.1042/BST20150158. Review.

PMID:
26614663
32.

Secondary Structure across the Bacterial Transcriptome Reveals Versatile Roles in mRNA Regulation and Function.

Del Campo C, Bartholomäus A, Fedyunin I, Ignatova Z.

PLoS Genet. 2015 Oct 23;11(10):e1005613. doi: 10.1371/journal.pgen.1005613. eCollection 2015 Oct.

33.

Mapping the non-standardized biases of ribosome profiling.

Bartholomäus A, Del Campo C, Ignatova Z.

Biol Chem. 2016 Jan;397(1):23-35. doi: 10.1515/hsz-2015-0197. Review.

PMID:
26351919
35.

Optimization of translation profiles enhances protein expression and solubility.

Hess AK, Saffert P, Liebeton K, Ignatova Z.

PLoS One. 2015 May 12;10(5):e0127039. doi: 10.1371/journal.pone.0127039. eCollection 2015.

36.

A flexible approach to assess fluorescence decay functions in complex energy transfer systems.

Roethlein C, Miettinen MS, Ignatova Z.

BMC Biophys. 2015 Apr 3;8:5. doi: 10.1186/s13628-015-0020-z. eCollection 2015.

37.

Trade-offs between tRNA abundance and mRNA secondary structure support smoothing of translation elongation rate.

Gorochowski TE, Ignatova Z, Bovenberg RA, Roubos JA.

Nucleic Acids Res. 2015 Mar 31;43(6):3022-32. doi: 10.1093/nar/gkv199. Epub 2015 Mar 12.

38.

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease.

Kirchner S, Ignatova Z.

Nat Rev Genet. 2015 Feb;16(2):98-112. doi: 10.1038/nrg3861. Epub 2014 Dec 23. Review.

PMID:
25534324
39.

Architecture of polyglutamine-containing fibrils from time-resolved fluorescence decay.

Röthlein C, Miettinen MS, Borwankar T, Bürger J, Mielke T, Kumke MU, Ignatova Z.

J Biol Chem. 2014 Sep 26;289(39):26817-28. doi: 10.1074/jbc.M114.581991. Epub 2014 Aug 4.

40.

Systematic identification of tRNAome and its dynamics in Lactococcus lactis.

Puri P, Wetzel C, Saffert P, Gaston KW, Russell SP, Cordero Varela JA, van der Vlies P, Zhang G, Limbach PA, Ignatova Z, Poolman B.

Mol Microbiol. 2014 Sep;93(5):944-56. doi: 10.1111/mmi.12710. Epub 2014 Aug 6.

41.

Stable polyglutamine dimers can contain β-hairpins with interdigitated side chains-but not α-helices, β-nanotubes, β-pseudohelices, or steric zippers.

Miettinen MS, Monticelli L, Nedumpully-Govindan P, Knecht V, Ignatova Z.

Biophys J. 2014 Apr 15;106(8):1721-8. doi: 10.1016/j.bpj.2014.02.027.

42.

GPER functions as a tumor suppressor in triple-negative breast cancer cells.

Weißenborn C, Ignatov T, Ochel HJ, Costa SD, Zenclussen AC, Ignatova Z, Ignatov A.

J Cancer Res Clin Oncol. 2014 May;140(5):713-23. doi: 10.1007/s00432-014-1620-8. Epub 2014 Feb 20.

PMID:
24553912
43.

Interplay between polymerase II- and polymerase III-assisted expression of overlapping genes.

Lukoszek R, Mueller-Roeber B, Ignatova Z.

FEBS Lett. 2013 Nov 15;587(22):3692-5. doi: 10.1016/j.febslet.2013.09.033. Epub 2013 Oct 7.

44.

Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress.

Czech A, Wende S, Mörl M, Pan T, Ignatova Z.

PLoS Genet. 2013 Aug;9(8):e1003767. doi: 10.1371/journal.pgen.1003767. Epub 2013 Aug 29.

45.

Efficient translation initiation dictates codon usage at gene start.

Bentele K, Saffert P, Rauscher R, Ignatova Z, Blüthgen N.

Mol Syst Biol. 2013 Jun 18;9:675. doi: 10.1038/msb.2013.32.

46.

Depletion of cognate charged transfer RNA causes translational frameshifting within the expanded CAG stretch in huntingtin.

Girstmair H, Saffert P, Rode S, Czech A, Holland G, Bannert N, Ignatova Z.

Cell Rep. 2013 Jan 31;3(1):148-59. doi: 10.1016/j.celrep.2012.12.019. Epub 2013 Jan 24.

47.

tRNA concentration fine tunes protein solubility.

Fedyunin I, Lehnhardt L, Böhmer N, Kaufmann P, Zhang G, Ignatova Z.

FEBS Lett. 2012 Sep 21;586(19):3336-40. doi: 10.1016/j.febslet.2012.07.012. Epub 2012 Jul 20.

48.

Assessing polyglutamine conformation in the nucleating event by molecular dynamics simulations.

Miettinen MS, Knecht V, Monticelli L, Ignatova Z.

J Phys Chem B. 2012 Aug 30;116(34):10259-65. doi: 10.1021/jp305065c. Epub 2012 Aug 16.

PMID:
22770401
49.

Crystallization and X-ray structure analysis of a thermostable penicillin G acylase from Alcaligenes faecalis.

Varshney NK, Kumar RS, Ignatova Z, Prabhune A, Pundle A, Dodson E, Suresh CG.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Mar 1;68(Pt 3):273-7. doi: 10.1107/S1744309111053930. Epub 2012 Feb 15.

50.

FANSe: an accurate algorithm for quantitative mapping of large scale sequencing reads.

Zhang G, Fedyunin I, Kirchner S, Xiao C, Valleriani A, Ignatova Z.

Nucleic Acids Res. 2012 Jun;40(11):e83. doi: 10.1093/nar/gks196. Epub 2012 Feb 29.

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