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Items: 30


Activation of G-Protein Coupled Receptor-Gαi Signaling Increases Keratinocyte Proliferation and Reduces Differentiation, Leading to Epidermal Hyperplasia.

Pedro MP, Salinas Parra N, Gutkind JS, Iglesias-Bartolome R.

J Invest Dermatol. 2019 Nov 7. pii: S0022-202X(19)33386-X. doi: 10.1016/j.jid.2019.10.012. [Epub ahead of print]


Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy.

Sahu AD, S Lee J, Wang Z, Zhang G, Iglesias-Bartolome R, Tian T, Wei Z, Miao B, Nair NU, Ponomarova O, Friedman AA, Amzallag A, Moll T, Kasumova G, Greninger P, Egan RK, Damon LJ, Frederick DT, Jerby-Arnon L, Wagner A, Cheng K, Park SG, Robinson W, Gardner K, Boland G, Hannenhalli S, Herlyn M, Benes C, Flaherty K, Luo J, Gutkind JS, Ruppin E.

Mol Syst Biol. 2019 Mar 11;15(3):e8323. doi: 10.15252/msb.20188323.


Transcriptional signature primes human oral mucosa for rapid wound healing.

Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat ML, Onaitis MW, Moutsopoulos NM, Gutkind JS, Morasso MI.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaap8798. doi: 10.1126/scitranslmed.aap8798.


Assembly and activation of the Hippo signalome by FAT1 tumor suppressor.

Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS.

Nat Commun. 2018 Jul 9;9(1):2372. doi: 10.1038/s41467-018-04590-1.


Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance.

Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E428-E437. doi: 10.1073/pnas.1713710115. Epub 2017 Dec 27.


Policing Tumorigenesis within the Skin: Good Outs Bad.

Iglesias-Bartolome R, Morasso MI.

Cell Stem Cell. 2017 Oct 5;21(4):419-420. doi: 10.1016/j.stem.2017.08.019.


mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.

Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo AA, Gutkind JS.

Carcinogenesis. 2016 Oct;37(10):1014-25. doi: 10.1093/carcin/bgw086. Epub 2016 Aug 18.


Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands.

Zhu Z, Pang B, Iglesias-Bartolome R, Wu X, Hu L, Zhang C, Wang J, Gutkind JS, Wang S.

Oncotarget. 2016 Apr 12;7(15):20271-81. doi: 10.18632/oncotarget.7941.


A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers.

Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind JS.

Oncotarget. 2016 Mar 8;7(10):10696-709. doi: 10.18632/oncotarget.7372.


Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.

Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS.

Nat Cell Biol. 2015 Jun;17(6):793-803. doi: 10.1038/ncb3164. Epub 2015 May 11.


Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II.

Ruggiero FM, Vilcaes AA, Iglesias-Bartolomé R, Daniotti JL.

Biochem J. 2015 Jul 1;469(1):83-95. doi: 10.1042/BJ20150072. Epub 2015 Apr 28.


Fluorescent, bioactive protein nanoparticles (prodots) for rapid, improved cellular uptake.

Deshapriya IK, Stromer BS, Pattammattel A, Kim CS, Iglesias-Bartolome R, Gonzalez-Fajardo L, Patel V, Gutkind JS, Lu X, Kumar CV.

Bioconjug Chem. 2015 Mar 18;26(3):396-404. doi: 10.1021/bc500621h. Epub 2015 Feb 2.


mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations.

Wang Z, Martin D, Molinolo AA, Patel V, Iglesias-Bartolome R, Degese MS, Vitale-Cross L, Chen Q, Gutkind JS.

J Natl Cancer Inst. 2014 Aug 5;106(9). pii: dju215. doi: 10.1093/jnci/dju215. Print 2014 Sep.


Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind JS.

Cancer Cell. 2014 Jun 16;25(6):831-45. doi: 10.1016/j.ccr.2014.04.016. Epub 2014 May 29.


Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets.

Iglesias-Bartolome R, Martin D, Gutkind JS.

Cancer Discov. 2013 Jul;3(7):722-5. doi: 10.1158/2159-8290.CD-13-0239.


Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity.

Iglesias-Bartolome R, Callejas-Valera JL, Gutkind JS.

Curr Opin Cell Biol. 2013 Apr;25(2):162-9. doi: 10.1016/ Epub 2013 Feb 19. Review.


Targeted delivery of immunotoxin by antibody to ganglioside GD3: a novel drug delivery route for tumor cells.

Torres Demichelis V, Vilcaes AA, Iglesias-Bartolomé R, Ruggiero FM, Daniotti JL.

PLoS One. 2013;8(1):e55304. doi: 10.1371/journal.pone.0055304. Epub 2013 Jan 31.


A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

Vaqué JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind JS.

Mol Cell. 2013 Jan 10;49(1):94-108. doi: 10.1016/j.molcel.2012.10.018. Epub 2012 Nov 21.


Exploiting the mTOR paradox for disease prevention.

Iglesias-Bartolome R, Gutkind JS.

Oncotarget. 2012 Oct;3(10):1061-3. No abstract available.


mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, Gutkind JS.

Cell Stem Cell. 2012 Sep 7;11(3):401-14. doi: 10.1016/j.stem.2012.06.007.


Nuclear mapping of nanodrug delivery systems in dynamic cellular environments.

Bhirde AA, Kapoor A, Liu G, Iglesias-Bartolome R, Jin A, Zhang G, Xing R, Lee S, Leapman RD, Gutkind JS, Chen X.

ACS Nano. 2012 Jun 26;6(6):4966-72. doi: 10.1021/nn300516g. Epub 2012 May 2.


Cellular systems for studying human oral squamous cell carcinomas.

Patel V, Iglesias-Bartolome R, Siegele B, Marsh CA, Leelahavanichkul K, Molinolo AA, Gutkind JS.

Adv Exp Med Biol. 2011;720:27-38. doi: 10.1007/978-1-4614-0254-1_3. Review.


Signaling circuitries controlling stem cell fate: to be or not to be.

Iglesias-Bartolome R, Gutkind JS.

Curr Opin Cell Biol. 2011 Dec;23(6):716-23. doi: 10.1016/ Epub 2011 Aug 29. Review.


Combining portable Raman probes with nanotubes for theranostic applications.

Bhirde AA, Liu G, Jin A, Iglesias-Bartolome R, Sousa AA, Leapman RD, Gutkind JS, Lee S, Chen X.

Theranostics. 2011;1:310-21. Epub 2011 Jul 4.


Metabolic pathways and intracellular trafficking of gangliosides.

Daniotti JL, Iglesias-Bartolomé R.

IUBMB Life. 2011 Jul;63(7):513-20. doi: 10.1002/iub.477. Review.


Keeping the epidermal stem cell niche in shape.

Iglesias-Bartolome R, Gutkind JS.

Cell Stem Cell. 2010 Aug 6;7(2):143-5. doi: 10.1016/j.stem.2010.07.008.


Differential endocytic trafficking of neuropathy-associated antibodies to GM1 ganglioside and cholera toxin in epithelial and neural cells.

Iglesias-Bartolomé R, Trenchi A, Comín R, Moyano AL, Nores GA, Daniotti JL.

Biochim Biophys Acta. 2009 Dec;1788(12):2526-40. doi: 10.1016/j.bbamem.2009.09.018. Epub 2009 Oct 2.


Complex gangliosides are apically sorted in polarized MDCK cells and internalized by clathrin-independent endocytosis.

Crespo PM, von Muhlinen N, Iglesias-Bartolomé R, Daniotti JL.

FEBS J. 2008 Dec;275(23):6043-56. doi: 10.1111/j.1742-4658.2008.06732.x.


Ganglioside GD3 traffics from the trans-Golgi network to plasma membrane by a Rab11-independent and brefeldin A-insensitive exocytic pathway.

Crespo PM, Iglesias-Bartolomé R, Daniotti JL.

J Biol Chem. 2004 Nov 12;279(46):47610-8. Epub 2004 Aug 31.

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