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Items: 1 to 50 of 81


Excitable Signal Transduction Networks in Directed Cell Migration.

Devreotes PN, Bhattacharya S, Edwards M, Iglesias PA, Lampert T, Miao Y.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:103-125. doi: 10.1146/annurev-cellbio-100616-060739. Epub 2017 Aug 9. Review.


Sphingolipids facilitate age asymmetry of membrane proteins in dividing yeast cells.

Singh P, Ramachandran SK, Zhu J, Kim BC, Biswas D, Ha T, Iglesias PA, Li R.

Mol Biol Cell. 2017 Oct 1;28(20):2712-2722. doi: 10.1091/mbc.E17-05-0335. Epub 2017 Aug 2.


Altering the threshold of an excitable signal transduction network changes cell migratory modes.

Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias PA, Devreotes PN.

Nat Cell Biol. 2017 Apr;19(4):329-340. doi: 10.1038/ncb3495. Epub 2017 Mar 27.


Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks.

Artemenko Y, Axiotakis L Jr, Borleis J, Iglesias PA, Devreotes PN.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7500-E7509. Epub 2016 Nov 7. Erratum in: Proc Natl Acad Sci U S A. 2018 Jun 25;:.


Endoplasmic Reticulum Lipid Flux Influences Enterocyte Nuclear Morphology and Lipid-dependent Transcriptional Responses.

Zeituni EM, Wilson MH, Zheng X, Iglesias PA, Sepanski MA, Siddiqi MA, Anderson JL, Zheng Y, Farber SA.

J Biol Chem. 2016 Nov 4;291(45):23804-23816. Epub 2016 Sep 21.


Modeling Excitable Dynamics of Chemotactic Networks.

Bhattacharya S, Iglesias PA.

Methods Mol Biol. 2016;1407:397-415. doi: 10.1007/978-1-4939-3480-5_27.


Mechanoaccumulative Elements of the Mammalian Actin Cytoskeleton.

Schiffhauer ES, Luo T, Mohan K, Srivastava V, Qian X, Griffis ER, Iglesias PA, Robinson DN.

Curr Biol. 2016 Jun 6;26(11):1473-1479. doi: 10.1016/j.cub.2016.04.007. Epub 2016 May 12.


Cytokinesis: Robust cell shape regulation.

Srivastava V, Iglesias PA, Robinson DN.

Semin Cell Dev Biol. 2016 May;53:39-44. doi: 10.1016/j.semcdb.2015.10.023. Epub 2015 Oct 19. Review.


Cell shape regulation through mechanosensory feedback control.

Mohan K, Luo T, Robinson DN, Iglesias PA.

J R Soc Interface. 2015 Aug 6;12(109):20150512. doi: 10.1098/rsif.2015.0512.


Novel protein Callipygian defines the back of migrating cells.

Swaney KF, Borleis J, Iglesias PA, Devreotes PN.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3845-54. doi: 10.1073/pnas.1509098112. Epub 2015 Jun 30.


Comparison of adaptation motifs: temporal, stochastic and spatial responses.

Iglesias PA, Shi C.

IET Syst Biol. 2014 Dec;8(6):268-81. doi: 10.1049/iet-syb.2014.0026.


The directional response of chemotactic cells depends on a balance between cytoskeletal architecture and the external gradient.

Wang MJ, Artemenko Y, Cai WJ, Iglesias PA, Devreotes PN.

Cell Rep. 2014 Nov 6;9(3):1110-21. doi: 10.1016/j.celrep.2014.09.047. Epub 2014 Oct 23.


Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis.

Tang M, Wang M, Shi C, Iglesias PA, Devreotes PN, Huang CH.

Nat Commun. 2014 Oct 27;5:5175. doi: 10.1038/ncomms6175.


Cell memory and adaptation in chemotaxis.

Huang CH, Iglesias PA.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15287-8. doi: 10.1073/pnas.1418077111. Epub 2014 Oct 15. No abstract available.


A computational model for the formation of lamin-B mitotic spindle envelope and matrix.

Shi C, Channels WE, Zheng Y, Iglesias PA.

Interface Focus. 2014 Jun 6;4(3):20130063. doi: 10.1098/rsfs.2013.0063.


Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer.

Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, Devreotes PN.

Science. 2014 Mar 21;343(6177):1249531. doi: 10.1126/science.1249531.


An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration.

Huang CH, Tang M, Shi C, Iglesias PA, Devreotes PN.

Nat Cell Biol. 2013 Nov;15(11):1307-16. doi: 10.1038/ncb2859. Epub 2013 Oct 20.


Molecular mechanisms of cellular mechanosensing.

Luo T, Mohan K, Iglesias PA, Robinson DN.

Nat Mater. 2013 Nov;12(11):1064-71. doi: 10.1038/nmat3772. Epub 2013 Oct 20.


Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells.

Shi C, Huang CH, Devreotes PN, Iglesias PA.

PLoS Comput Biol. 2013;9(7):e1003122. doi: 10.1371/journal.pcbi.1003122. Epub 2013 Jul 4.


Excitable behavior in amoeboid chemotaxis.

Shi C, Iglesias PA.

Wiley Interdiscip Rev Syst Biol Med. 2013 Sep-Oct;5(5):631-42. doi: 10.1002/wsbm.1230. Epub 2013 Jun 11. Review.


Nucleating new branches from old.

Zheng Y, Iglesias PA.

Cell. 2013 Feb 14;152(4):669-70. doi: 10.1016/j.cell.2013.01.040.


Systems biology: the role of engineering in the reverse engineering of biological signaling.

Iglesias PA.

Cells. 2013 May 31;2(2):393-413. doi: 10.3390/cells2020393.


Bringing the physical sciences into your cell biology research.

Robinson DN, Iglesias PA.

Mol Biol Cell. 2012 Nov;23(21):4167-70. doi: 10.1091/mbc.E12-05-0354.


Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation.

Porter JR, Lee CY, Espenshade PJ, Iglesias PA.

Mol Biol Cell. 2012 Sep;23(18):3764-74. doi: 10.1091/mbc.E12-06-0451. Epub 2012 Jul 25.


Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression.

Poirier CC, Ng WP, Robinson DN, Iglesias PA.

PLoS Comput Biol. 2012;8(4):e1002467. doi: 10.1371/journal.pcbi.1002467. Epub 2012 Apr 26.


Separation anxiety: stress, tension and cytokinesis.

Mohan K, Iglesias PA, Robinson DN.

Exp Cell Res. 2012 Jul 15;318(12):1428-34. doi: 10.1016/j.yexcr.2012.03.028. Epub 2012 Mar 31. Review.


A mechanosensory system governs myosin II accumulation in dividing cells.

Kee YS, Ren Y, Dorfman D, Iijima M, Firtel R, Iglesias PA, Robinson DN.

Mol Biol Cell. 2012 Apr;23(8):1510-23. doi: 10.1091/mbc.E11-07-0601. Epub 2012 Feb 29.


Chemoattractant signaling in dictyostelium: adaptation and amplification.

Iglesias PA.

Sci Signal. 2012 Feb 28;5(213):pe8. doi: 10.1126/scisignal.2002897. Review.


A framework for designing and analyzing binary decision-making strategies in cellular systems.

Porter JR, Andrews BW, Iglesias PA.

Integr Biol (Camb). 2012 Mar;4(3):310-7. doi: 10.1039/C2IB90009B. Epub 2012 Mar 1.


Understanding the cooperative interaction between myosin II and actin cross-linkers mediated by actin filaments during mechanosensation.

Luo T, Mohan K, Srivastava V, Ren Y, Iglesias PA, Robinson DN.

Biophys J. 2012 Jan 18;102(2):238-47. doi: 10.1016/j.bpj.2011.12.020.


Identifying a static nonlinear structure in a biological system using noisy, sparse data.

Porter JR, Burg JS, Espenshade PJ, Iglesias PA.

J Theor Biol. 2012 May 7;300:232-41. doi: 10.1016/j.jtbi.2012.01.037. Epub 2012 Feb 1.


A systems biology view of adaptation in sensory mechanisms.

Iglesias PA.

Adv Exp Med Biol. 2012;736:499-516. doi: 10.1007/978-1-4419-7210-1_29.


Biased excitable networks: how cells direct motion in response to gradients.

Iglesias PA, Devreotes PN.

Curr Opin Cell Biol. 2012 Apr;24(2):245-53. doi: 10.1016/ Epub 2011 Dec 10. Review.


Lineage mapping the pre-implantation mouse embryo by two-photon microscopy, new insights into the segregation of cell fates.

McDole K, Xiong Y, Iglesias PA, Zheng Y.

Dev Biol. 2011 Jul 15;355(2):239-49. doi: 10.1016/j.ydbio.2011.04.024. Epub 2011 Apr 22.


Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane.

de Keijzer S, Galloway J, Harms GS, Devreotes PN, Iglesias PA.

Biochim Biophys Acta. 2011 Jun;1808(6):1701-8. doi: 10.1016/j.bbamem.2011.02.009. Epub 2011 Feb 18.


Mitotic membrane helps to focus and stabilize the mitotic spindle.

Poirier CC, Zheng Y, Iglesias PA.

Biophys J. 2010 Nov 17;99(10):3182-90. doi: 10.1016/j.bpj.2010.09.053.


Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast.

Porter JR, Burg JS, Espenshade PJ, Iglesias PA.

J Biol Chem. 2010 Dec 24;285(52):41051-61. doi: 10.1074/jbc.M110.144337. Epub 2010 Oct 19.


14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis.

Zhou Q, Kee YS, Poirier CC, Jelinek C, Osborne J, Divi S, Surcel A, Will ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, Robinson DN.

Curr Biol. 2010 Nov 9;20(21):1881-9. doi: 10.1016/j.cub.2010.09.048. Epub 2010 Oct 14.


Tools for analyzing cell shape changes during chemotaxis.

Xiong Y, Iglesias PA.

Integr Biol (Camb). 2010 Nov;2(11-12):561-7. doi: 10.1039/c0ib00036a. Epub 2010 Oct 1. Review.


Cells navigate with a local-excitation, global-inhibition-biased excitable network.

Xiong Y, Huang CH, Iglesias PA, Devreotes PN.

Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17079-86. doi: 10.1073/pnas.1011271107. Epub 2010 Sep 23.


Spatial regulation of PI3K signaling during chemotaxis.

Iglesias PA.

Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct;1(2):247-253. doi: 10.1002/wsbm.13. Review.


Automated characterization of cell shape changes during amoeboid motility by skeletonization.

Xiong Y, Kabacoff C, Franca-Koh J, Devreotes PN, Robinson DN, Iglesias PA.

BMC Syst Biol. 2010 Mar 24;4:33. doi: 10.1186/1752-0509-4-33.


A method for determining the robustness of bio-molecular oscillator models.

Ghaemi R, Sun J, Iglesias PA, Del Vecchio D.

BMC Syst Biol. 2009 Sep 21;3:95. doi: 10.1186/1752-0509-3-95.


Modeling spatial and temporal dynamics of chemotactic networks.

Yang L, Iglesias PA.

Methods Mol Biol. 2009;571:489-505. doi: 10.1007/978-1-60761-198-1_32.


Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I.

Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock RS, Robinson DN.

Curr Biol. 2009 Sep 15;19(17):1421-8. doi: 10.1016/j.cub.2009.07.018. Epub 2009 Jul 30.


Basic principles of polarity establishment and maintenance. Conference on Mechanisms of Cell Polarity.

Arkowitz RA, Iglesias PA.

EMBO Rep. 2008 Sep;9(9):847-52. doi: 10.1038/embor.2008.164. No abstract available.


tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis.

Tang L, Franca-Koh J, Xiong Y, Chen MY, Long Y, Bickford RM, Knecht DA, Iglesias PA, Devreotes PN.

Genes Dev. 2008 Aug 15;22(16):2278-90. doi: 10.1101/gad.1694508.


Modeling cellular deformations using the level set formalism.

Yang L, Effler JC, Kutscher BL, Sullivan SE, Robinson DN, Iglesias PA.

BMC Syst Biol. 2008 Jul 24;2:68. doi: 10.1186/1752-0509-2-68.


PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis.

Kamimura Y, Xiong Y, Iglesias PA, Hoeller O, Bolourani P, Devreotes PN.

Curr Biol. 2008 Jul 22;18(14):1034-43. doi: 10.1016/j.cub.2008.06.068.


Interactions between myosin and actin crosslinkers control cytokinesis contractility dynamics and mechanics.

Reichl EM, Ren Y, Morphew MK, Delannoy M, Effler JC, Girard KD, Divi S, Iglesias PA, Kuo SC, Robinson DN.

Curr Biol. 2008 Apr 8;18(7):471-80. doi: 10.1016/j.cub.2008.02.056. Epub 2008 Mar 27.

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