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Clinical guidelines for the diagnosis and treatment of lower urinary tract dysfunction in patients with spinal cord injury.

Sekido N, Igawa Y, Kakizaki H, Kitta T, Sengoku A, Takahashi S, Takahashi R, Tanaka K, Namima T, Honda M, Mistui T, Yamanishi T, Watanabe T.

Int J Urol. 2020 Feb 19. doi: 10.1111/iju.14186. [Epub ahead of print]


Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys.

Ohura K, Igawa Y, Tanaka M, Matsumoto K, Kasahara A, Wada N, Kubota K, Uno Y, Imai T.

Drug Metab Dispos. 2020 Mar;48(3):146-152. doi: 10.1124/dmd.119.089011. Epub 2019 Dec 13.


Cardiovascular safety of antimuscarinic add-on therapy in patients with overactive bladder who had a suboptimal response to mirabegron monotherapy: A post hoc analysis from the Japanese MILAI II study.

Katoh T, Igawa Y, Yamaguchi O, Kato D, Hamada T, Kuroishi K.

Low Urin Tract Symptoms. 2020 Jan;12(1):68-80. doi: 10.1111/luts.12286. Epub 2019 Sep 30.


Discovery of 1,2,3-triazole-based fibroblast growth factor receptor modulators.

Sakai H, Inoue H, Toba T, Murata K, Narii N, Shimmyo Y, Igawa Y, Matsumoto T, Takemoto N.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2332-2337. doi: 10.1016/j.bmcl.2019.06.016. Epub 2019 Jun 18.


Immune-related adverse events predict the therapeutic efficacy of pembrolizumab in urothelial cancer patients.

Kawai T, Sato Y, Makino K, Yamada Y, Nomiya A, Nakamura M, Yamada D, Suzuki M, Igawa Y, Kume H.

Eur J Cancer. 2019 Jul;116:114-115. doi: 10.1016/j.ejca.2019.05.017. Epub 2019 Jun 10. No abstract available.


Longitudinal change of comprehensive lower urinary tract symptoms and various types of urinary incontinence during robot-assisted radical prostatectomy.

Fujimura T, Igawa Y, Aizawa N, Niimi A, Yamada Y, Sugihara T, Kamei J, Sato Y, Matsunaga A, Yoshida M, Shinoda Y, Fukuhara H, Nakagawa T, Homma Y, Kume H.

Neurourol Urodyn. 2019 Apr;38(4):1067-1075. doi: 10.1002/nau.23952. Epub 2019 Mar 14.


β3 -Adrenoceptors in the normal and diseased urinary bladder-What are the open questions?

Igawa Y, Aizawa N, Michel MC.

Br J Pharmacol. 2019 Jul;176(14):2525-2538. doi: 10.1111/bph.14658. Epub 2019 May 3. Review.


Molecular Taxonomy of Interstitial Cystitis/Bladder Pain Syndrome Based on Whole Transcriptome Profiling by Next-Generation RNA Sequencing of Bladder Mucosal Biopsies.

Akiyama Y, Maeda D, Katoh H, Morikawa T, Niimi A, Nomiya A, Sato Y, Kawai T, Goto A, Fujimura T, Fukuhara H, Nakagawa T, Igawa Y, Ishikawa S, Fukayama M, Kume H, Homma Y.

J Urol. 2019 Aug;202(2):290-300. doi: 10.1097/JU.0000000000000234. Epub 2019 Jul 8.


Feasibility of approximate measurement of bladder volume in male patients using the Lilium α-200 portable ultrasound bladder scanner.

Kamei J, Watanabe D, Homma Y, Kume H, Igawa Y.

Low Urin Tract Symptoms. 2019 May;11(3):169-173. doi: 10.1111/luts.12258. Epub 2019 Mar 10.


Ultrasound-assisted prompted voiding care for managing urinary incontinence in nursing homes: A randomized clinical trial.

Suzuki M, Miyazaki H, Kamei J, Yoshida M, Taniguchi T, Nishimura K, Igawa Y, Sanada H, Homma Y.

Neurourol Urodyn. 2019 Feb;38(2):757-763. doi: 10.1002/nau.23913. Epub 2019 Jan 8.


RQ-00434739, a novel TRPM8 antagonist, inhibits prostaglandin E2-induced hyperactivity of the primary bladder afferent nerves in rats.

Aizawa N, Ohshiro H, Watanabe S, Kume H, Homma Y, Igawa Y.

Life Sci. 2019 Feb 1;218:89-95. doi: 10.1016/j.lfs.2018.12.031. Epub 2018 Dec 20.


Long-term safety and efficacy of antimuscarinic add-on therapy in patients with overactive bladder who had a suboptimal response to mirabegron monotherapy: A multicenter, randomized study in Japan (MILAI II study).

Yamaguchi O, Kakizaki H, Homma Y, Igawa Y, Takeda M, Nishizawa O, Gotoh M, Yoshida M, Yokoyama O, Seki N, Okitsu A, Hamada T, Kobayashi A, Kuroishi K.

Int J Urol. 2019 Mar;26(3):342-352. doi: 10.1111/iju.13868. Epub 2018 Dec 13.


Aggressive Cancer Behavior of Latent Gleason Pattern 5 in Prostatectomy Specimens.

Fujimura T, Fukuhara H, Yamada Y, Taguchi S, Sugihara T, Niimi A, Nakamura M, Nakagawa T, Igawa Y, Homma Y, Kume H.

Anticancer Res. 2018 Nov;38(11):6529-6535. doi: 10.21873/anticanres.13018.


May perioperative ultrasound-guided pelvic floor muscle training promote early recovery of urinary continence after robot-assisted radical prostatectomy?

Yoshida M, Matsunaga A, Igawa Y, Fujimura T, Shinoda Y, Aizawa N, Sato Y, Kume H, Homma Y, Haga N, Sanada H.

Neurourol Urodyn. 2019 Jan;38(1):158-164. doi: 10.1002/nau.23811. Epub 2018 Oct 30. Erratum in: Neurourol Urodyn. 2019 Feb;38(2):878.


Attenuated lipopolysaccharide-induced inflammatory bladder hypersensitivity in mice deficient of transient receptor potential ankilin1.

Kamei J, Aizawa N, Nakagawa T, Kaneko S, Kume H, Homma Y, Igawa Y.

Sci Rep. 2018 Oct 23;8(1):15622. doi: 10.1038/s41598-018-33967-x.


Gains in health utility associated with urinary catheter innovations.

Krassioukov A, Igawa Y, Averbeck MA, Madersbacher H, Lloyd AJ, Bøgelund M, Thiruchelvam N.

Med Devices (Auckl). 2018 Oct 1;11:345-351. doi: 10.2147/MDER.S165778. eCollection 2018.


The impact of different scenarios for intermittent bladder catheterization on health state utilities: results from an internet-based time trade-off survey.

Averbeck MA, Krassioukov A, Thiruchelvam N, Madersbacher H, Bøgelund M, Igawa Y.

J Med Econ. 2018 Oct;21(10):945-952. doi: 10.1080/13696998.2018.1486846. Epub 2018 Jul 6.


Clinical significance of random bladder biopsy in primary T1 bladder cancer.

Otsuka M, Taguchi S, Nakagawa T, Morikawa T, Maekawa S, Miyakawa J, Matsumoto A, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y.

Mol Clin Oncol. 2018 May;8(5):665-670. doi: 10.3892/mco.2018.1587. Epub 2018 Mar 8.


Inhibitory effects of silodosin on the bladder mechanosensitive afferent activities and their relation with bladder myogenic contractions in male rats with bladder outlet obstruction.

Aizawa N, Watanabe D, Fukuhara H, Fujimura T, Kume H, Homma Y, Igawa Y.

Neurourol Urodyn. 2018 Aug;37(6):1897-1903. doi: 10.1002/nau.23547. Epub 2018 Mar 6.


KPR-2579, a novel TRPM8 antagonist, inhibits acetic acid-induced bladder afferent hyperactivity in rats.

Aizawa N, Fujimori Y, Kobayashi JI, Nakanishi O, Hirasawa H, Kume H, Homma Y, Igawa Y.

Neurourol Urodyn. 2018 Jun;37(5):1633-1640. doi: 10.1002/nau.23532. Epub 2018 Feb 21.


Age-related changes in function and gene expression of the male and female mouse bladder.

Kamei J, Ito H, Aizawa N, Hotta H, Kojima T, Fujita Y, Ito M, Homma Y, Igawa Y.

Sci Rep. 2018 Feb 1;8(1):2089. doi: 10.1038/s41598-018-20406-0.


Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver.

Uno Y, Igawa Y, Tanaka M, Ohura K, Hosokawa M, Imai T.

Xenobiotica. 2019 Feb;49(2):247-255. doi: 10.1080/00498254.2018.1435927. Epub 2018 Apr 27.


Extent of Hunner lesions: The relationships with symptom severity and clinical parameters in Hunner type interstitial cystitis patients.

Akiyama Y, Niimi A, Nomiya A, Yamada Y, Nakagawa T, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y.

Neurourol Urodyn. 2018 Apr;37(4):1441-1447. doi: 10.1002/nau.23467. Epub 2018 Jan 9.


Pathophysiology of the underactive bladder.

Aizawa N, Igawa Y.

Investig Clin Urol. 2017 Dec;58(Suppl 2):S82-S89. doi: 10.4111/icu.2017.58.S2.S82. Epub 2017 Nov 13. Review.


Preoperative chronic kidney disease is predictive of oncological outcome of radical cystectomy for bladder cancer.

Matsumoto A, Nakagawa T, Kanatani A, Ikeda M, Kawai T, Miyakawa J, Taguchi S, Naito A, Otsuka M, Nakanishi Y, Suzuki M, Koga F, Nagase Y, Kondo Y, Okaneya T, Tanaka Y, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y.

World J Urol. 2018 Feb;36(2):249-256. doi: 10.1007/s00345-017-2141-2. Epub 2017 Nov 28.


Digital quantitative analysis of mast cell infiltration in interstitial cystitis.

Akiyama Y, Maeda D, Morikawa T, Niimi A, Nomiya A, Yamada Y, Igawa Y, Goto A, Fukayama M, Homma Y.

Neurourol Urodyn. 2018 Feb;37(2):650-657. doi: 10.1002/nau.23365. Epub 2017 Oct 24.


Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis.

Niimi A, Igawa Y, Aizawa N, Honma T, Nomiya A, Akiyama Y, Kamei J, Fujimura T, Fukuhara H, Homma Y.

Neurourol Urodyn. 2018 Mar;37(3):1113-1119. doi: 10.1002/nau.23431. Epub 2017 Oct 19.


Effect of cerebrospinal fluid shunt surgery on lower urinary tract dysfunction in idiopathic normal pressure hydrocephalus.

Aruga S, Kuwana N, Shiroki Y, Takahashi S, Samejima N, Watanabe A, Seki Y, Igawa Y, Homma Y.

Neurourol Urodyn. 2018 Mar;37(3):1053-1059. doi: 10.1002/nau.23399. Epub 2017 Sep 11.


Characteristics of the mechanosensitive bladder afferent activities in relation with microcontractions in male rats with bladder outlet obstruction.

Aizawa N, Ichihara K, Fukuhara H, Fujimura T, Andersson KE, Homma Y, Igawa Y.

Sci Rep. 2017 Aug 9;7(1):7646. doi: 10.1038/s41598-017-07898-y.


Predictors of Early Continence after Robot-assisted Radical Prostatectomy.

Yamada Y, Fujimura T, Fukuhara H, Sugihara T, Nakagawa T, Kume H, Igawa Y, Homma Y.

Low Urin Tract Symptoms. 2018 Sep;10(3):287-291. doi: 10.1111/luts.12181. Epub 2017 Jul 11.


Overactive bladder is a negative predictor of achieving continence after robot-assisted radical prostatectomy.

Yamada Y, Fujimura T, Fukuhara H, Sugihara T, Miyazaki H, Nakagawa T, Kume H, Igawa Y, Homma Y.

Int J Urol. 2017 Oct;24(10):749-756. doi: 10.1111/iju.13411. Epub 2017 Jul 11.


Oncologic Outcome of Metastasectomy for Urothelial Carcinoma: Who Is the Best Candidate?

Nakagawa T, Taguchi S, Kanatani A, Kawai T, Ikeda M, Urakami S, Matsumoto A, Komemushi Y, Miyakawa J, Yamada D, Suzuki M, Enomoto Y, Nishimatsu H, Kondo Y, Nagase Y, Hirano Y, Okaneya T, Tanaka Y, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y.

Ann Surg Oncol. 2017 Sep;24(9):2794-2800. doi: 10.1245/s10434-017-5970-8. Epub 2017 Jul 7.


Robot-assisted radical prostatectomy significantly reduced biochemical recurrence compared to retro pubic radical prostatectomy.

Fujimura T, Fukuhara H, Taguchi S, Yamada Y, Sugihara T, Nakagawa T, Niimi A, Kume H, Igawa Y, Homma Y.

BMC Cancer. 2017 Jun 29;17(1):454. doi: 10.1186/s12885-017-3439-6.


Toll-like receptor 7 is overexpressed in the bladder of Hunner-type interstitial cystitis, and its activation in the mouse bladder can induce cystitis and bladder pain.

Ichihara K, Aizawa N, Akiyama Y, Kamei J, Masumori N, Andersson KE, Homma Y, Igawa Y.

Pain. 2017 Aug;158(8):1538-1545. doi: 10.1097/j.pain.0000000000000947.


Efficacy of post-nephroureterectomy cisplatin-based adjuvant chemotherapy for locally advanced upper tract urothelial carcinoma: a multi-institutional retrospective study.

Nakagawa T, Komemushi Y, Kawai T, Otsuka M, Miyakawa J, Uemura Y, Kanatani A, Taguchi S, Naito A, Suzuki M, Nishimatsu H, Hirano Y, Tanaka Y, Matsumoto A, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y.

World J Urol. 2017 Oct;35(10):1569-1575. doi: 10.1007/s00345-017-2032-6. Epub 2017 Apr 10.


Synergic Suppressive Effect of Silodosin and Imidafenacin on Non-Voiding Bladder Contractions in Male Rats with Subacute Bladder Outlet Obstruction.

Sugiyama R, Aizawa N, Ito H, Fujimura T, Suzuki M, Nakagawa T, Fukuhara H, Kume H, Homma Y, Igawa Y.

Low Urin Tract Symptoms. 2017 May;9(2):94-101. doi: 10.1111/luts.12109. Epub 2015 Jul 27.


Incontinence: How do β3-adrenoceptor agonists work in the bladder?

Igawa Y, Aizawa N.

Nat Rev Urol. 2017 Jun;14(6):330-332. doi: 10.1038/nrurol.2017.43. Epub 2017 Mar 21. No abstract available.


Incidence and risk factors of inguinal hernia after robot-assisted radical prostatectomy.

Yamada Y, Fujimura T, Fukuhara H, Sugihara T, Takemura K, Kakutani S, Suzuki M, Nakagawa T, Kume H, Igawa Y, Homma Y.

World J Surg Oncol. 2017 Mar 16;15(1):61. doi: 10.1186/s12957-017-1126-3.


Benefit of adjuvant immunotherapy in renal cell carcinoma: A myth or a reality?

Taguchi S, Buti S, Fukuhara H, Otsuka M, Bersanelli M, Morikawa T, Miyazaki H, Nakagawa T, Fujimura T, Kume H, Igawa Y, Homma Y.

PLoS One. 2017 Feb 27;12(2):e0172341. doi: 10.1371/journal.pone.0172341. eCollection 2017.


Muro-Neuro-Urodynamics; a Review of the Functional Assessment of Mouse Lower Urinary Tract Function.

Ito H, Pickering AE, Igawa Y, Kanai AJ, Fry CH, Drake MJ.

Front Physiol. 2017 Feb 6;8:49. doi: 10.3389/fphys.2017.00049. eCollection 2017. Review.


Effects of Sildenafil, a Phosphodiesterase Type 5 Inhibitor, on the Primary Single Afferent Activity of the Rat Bladder.

Aizawa N, Ito H, Sugiyama R, Fujimura T, Fukuhara H, Kume H, Homma Y, Igawa Y.

Low Urin Tract Symptoms. 2017 Jan;9(1):57-61. doi: 10.1111/luts.12095. Epub 2015 Mar 19.


Nomogram for predicting survival of postcystectomy recurrent urothelial carcinoma of the bladder.

Nakagawa T, Taguchi S, Uemura Y, Kanatani A, Ikeda M, Matsumoto A, Yoshida K, Kawai T, Nagata M, Yamada D, Komemushi Y, Suzuki M, Enomoto Y, Nishimatsu H, Ishikawa A, Nagase Y, Kondo Y, Tanaka Y, Okaneya T, Hirano Y, Shinohara M, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Igawa Y, Homma Y.

Urol Oncol. 2017 Jul;35(7):457.e15-457.e21. doi: 10.1016/j.urolonc.2016.12.010. Epub 2017 Jan 16.


Direct influence of systemic desensitization by resiniferatoxin on the activities of Aδ- and C-fibers in the rat primary bladder mechanosensitive afferent nerves.

Aizawa N, Fukuhara H, Fujimura T, Homma Y, Igawa Y.

Int J Urol. 2016 Nov;23(11):952-956. doi: 10.1111/iju.13181. Epub 2016 Aug 10.


Preventive Effects of Long-Term Caloric Restriction on Aging Related In Vivo Bladder Dysfunction and Molecular Biological Changes in the Bladder and Dorsal Root Ganglia in Rats.

Ito H, Kamei J, Aizawa N, Fujita Y, Suzuki M, Fukuhara H, Fujimura T, Kojima T, Homma Y, Kubota Y, Ito M, Andersson KE, Igawa Y.

J Urol. 2016 Nov;196(5):1575-1583. doi: 10.1016/j.juro.2016.05.104. Epub 2016 May 31.


Translation and reliability and validity testing of a Japanese version of the Intermittent Self-Catheterization Questionnaire among disposable and reusable catheter users.

Yoshida M, Igawa Y, Higashimura S, Suzuki M, Niimi A, Sanada H.

Neurourol Urodyn. 2017 Jun;36(5):1356-1362. doi: 10.1002/nau.23111. Epub 2016 Oct 4.


Cessation of long-term adjuvant androgen deprivation therapy after radical prostatectomy: is it feasible?

Taguchi S, Fukuhara H, Morikawa T, Matsumoto A, Miyazaki H, Nakagawa T, Fujimura T, Kume H, Igawa Y, Homma Y.

Jpn J Clin Oncol. 2016 Dec;46(12):1143-1147. Epub 2016 Sep 12.


Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes.

Igawa Y, Fujiwara S, Ohura K, Hirokawa T, Nishizawa Y, Uehara S, Uno Y, Imai T.

Mol Pharm. 2016 Sep 6;13(9):3176-86. doi: 10.1021/acs.molpharmaceut.6b00394. Epub 2016 Aug 8.


Ethnic sensitivity assessment of the antibody-drug conjugate trastuzumab emtansine (T-DM1) in patients with HER2-positive locally advanced or metastatic breast cancer.

Li C, Wang B, Lu D, Jin JY, Gao Y, Matsunaga K, Igawa Y, Nijem I, Lu M, Strasak A, Chernyukhin N, Girish S.

Cancer Chemother Pharmacol. 2016 Sep;78(3):547-58. doi: 10.1007/s00280-016-3099-2. Epub 2016 Jul 16.


Ultrasound-assisted prompted voiding for management of urinary incontinence of nursing home residents: Efficacy and feasibility.

Suzuki M, Iguchi Y, Igawa Y, Yoshida M, Sanada H, Miyazaki H, Homma Y.

Int J Urol. 2016 Sep;23(9):786-90. doi: 10.1111/iju.13156. Epub 2016 Jul 11.


Bladder pain induced by prolonged peripheral alpha 1A adrenoceptor stimulation involves the enhancement of transient receptor potential vanilloid 1 activity and an increase of urothelial adenosine triphosphate release.

Matos R, Cordeiro JM, Coelho A, Ferreira S, Silva C, Igawa Y, Cruz F, Charrua A.

Acta Physiol (Oxf). 2016 Dec;218(4):265-275. doi: 10.1111/apha.12744. Epub 2016 Jul 20.


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