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Items: 1 to 50 of 111

1.

Hepatocyte nuclear factor-1β regulates Wnt signaling through genome-wide competition with β-catenin/lymphoid enhancer binding factor.

Chan SC, Zhang Y, Pontoglio M, Igarashi P.

Proc Natl Acad Sci U S A. 2019 Nov 11. pii: 201909452. doi: 10.1073/pnas.1909452116. [Epub ahead of print]

PMID:
31712448
2.

Innate immune signaling contributes to tubular-cell senescence in the Glis2 knockout mouse model of nephronophthisis.

Jin H, Zhang Y, Liu D, Wang SS, Ding Q, Rastogi P, Purvis M, Wang A, Elhadi S, Ren C, Cao C, Chai Y, Igarashi P, Jetten AM, Lu D, Attanasio M.

Am J Pathol. 2019 Oct 29. pii: S0002-9440(19)30761-8. doi: 10.1016/j.ajpath.2019.09.013. [Epub ahead of print]

PMID:
31676329
3.

Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation.

Ferrè S, Deng Y, Huen SC, Lu CY, Scherer PE, Igarashi P, Moe OW.

Kidney Int. 2019 Aug 1. pii: S0085-2538(19)30775-6. doi: 10.1016/j.kint.2019.06.023. [Epub ahead of print]

PMID:
31601454
4.

Mechanism of Fibrosis in HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease.

Chan SC, Zhang Y, Shao A, Avdulov S, Herrera J, Aboudehen K, Pontoglio M, Igarashi P.

J Am Soc Nephrol. 2018 Oct;29(10):2493-2509. doi: 10.1681/ASN.2018040437. Epub 2018 Aug 10.

5.

New insights into the role of HNF-1β in kidney (patho)physiology.

Ferrè S, Igarashi P.

Pediatr Nephrol. 2019 Aug;34(8):1325-1335. doi: 10.1007/s00467-018-3990-7. Epub 2018 Jul 1. Review.

PMID:
29961928
6.

Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling.

Aboudehen K, Farahani S, Kanchwala M, Chan SC, Avdulov S, Mickelson A, Lee D, Gearhart MD, Patel V, Xing C, Igarashi P.

J Biol Chem. 2018 Jun 15;293(24):9388-9398. doi: 10.1074/jbc.RA118.001723. Epub 2018 May 1.

7.

Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria.

Wong DWL, Yiu WH, Chan KW, Li Y, Li B, Lok SWY, Taketo MM, Igarashi P, Chan LYY, Leung JCK, Lai KN, Tang SCW.

Kidney Int. 2018 Jun;93(6):1367-1383. doi: 10.1016/j.kint.2017.12.017. Epub 2018 Mar 28.

8.

Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.

Wang Q, Cobo-Stark P, Patel V, Somlo S, Han PL, Igarashi P.

Kidney Int. 2018 Feb;93(2):403-415. doi: 10.1016/j.kint.2017.08.005. Epub 2017 Oct 14.

9.

Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease.

Kompatscher A, de Baaij JHF, Aboudehen K, Hoefnagels APWM, Igarashi P, Bindels RJM, Veenstra GJC, Hoenderop JGJ.

Kidney Int. 2017 Nov;92(5):1145-1156. doi: 10.1016/j.kint.2017.03.034. Epub 2017 May 31.

10.

Hepatocyte Nuclear Factor-1β Regulates Urinary Concentration and Response to Hypertonicity.

Aboudehen K, Noureddine L, Cobo-Stark P, Avdulov S, Farahani S, Gearhart MD, Bichet DG, Pontoglio M, Patel V, Igarashi P.

J Am Soc Nephrol. 2017 Oct;28(10):2887-2900. doi: 10.1681/ASN.2016101095. Epub 2017 May 15.

11.

microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism.

Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, Aboudehen K, Zhang S, Kersjes K, Galasso R, Li J, Kaimal V, Lockton S, Davis S, Flaten A, Johnson JA, Holland WL, Kusminski CM, Scherer PE, Harris PC, Trudel M, Wallace DP, Igarashi P, Lee EC, Androsavich JR, Patel V.

Nat Commun. 2017 Feb 16;8:14395. doi: 10.1038/ncomms14395.

12.

Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning.

Brzóska HŁ, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA.

Kidney Int. 2016 Dec;90(6):1274-1284. doi: 10.1016/j.kint.2016.07.011. Epub 2016 Sep 2.

13.

Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.

Lu D, Rauhauser A, Li B, Ren C, McEnery K, Zhu J, Chaki M, Vadnagara K, Elhadi S, Jetten AM, Igarashi P, Attanasio M.

Kidney Int. 2016 Jun;89(6):1307-23. doi: 10.1016/j.kint.2016.03.006.

14.

Transcription Factor Hepatocyte Nuclear Factor-1β Regulates Renal Cholesterol Metabolism.

Aboudehen K, Kim MS, Mitsche M, Garland K, Anderson N, Noureddine L, Pontoglio M, Patel V, Xie Y, DeBose-Boyd R, Igarashi P.

J Am Soc Nephrol. 2016 Aug;27(8):2408-21. doi: 10.1681/ASN.2015060607. Epub 2015 Dec 28.

15.

Transcription Factor Hepatocyte Nuclear Factor-1β (HNF-1β) Regulates MicroRNA-200 Expression through a Long Noncoding RNA.

Hajarnis SS, Patel V, Aboudehen K, Attanasio M, Cobo-Stark P, Pontoglio M, Igarashi P.

J Biol Chem. 2015 Oct 9;290(41):24793-805. doi: 10.1074/jbc.M115.670646. Epub 2015 Aug 19.

16.

Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1.

Boddu R, Yang C, O'Connor AK, Hendrickson RC, Boone B, Cui X, Garcia-Gonzalez M, Igarashi P, Onuchic LF, Germino GG, Guay-Woodford LM.

J Mol Med (Berl). 2014 Oct;92(10):1045-56. doi: 10.1007/s00109-014-1185-7. Epub 2014 Jul 3.

17.

Filling the holes in cystic kidney disease research.

Guay-Woodford LM, Henske E, Igarashi P, Perrone RD, Reed-Gitomer B, Somlo S, Torres VE, Ketchum CJ, Star RA, Flessner MF, Rasooly RS.

Clin J Am Soc Nephrol. 2014 Oct 7;9(10):1799-801. doi: 10.2215/CJN.03410414. Epub 2014 Jun 5. Review.

18.

Tissue-specific regulation of the mouse Pkhd1 (ARPKD) gene promoter.

Williams SS, Cobo-Stark P, Hajarnis S, Aboudehen K, Shao X, Richardson JA, Patel V, Igarashi P.

Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F356-68. doi: 10.1152/ajprenal.00422.2013. Epub 2014 Jun 4.

19.

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease.

Ma M, Tian X, Igarashi P, Pazour GJ, Somlo S.

Nat Genet. 2013 Sep;45(9):1004-12. doi: 10.1038/ng.2715. Epub 2013 Jul 28.

20.

miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease.

Patel V, Williams D, Hajarnis S, Hunter R, Pontoglio M, Somlo S, Igarashi P.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10765-70. doi: 10.1073/pnas.1301693110. Epub 2013 Jun 12.

21.

Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1β.

Choi YH, McNally BT, Igarashi P.

Am J Physiol Renal Physiol. 2013 Jul 1;305(1):F100-10. doi: 10.1152/ajprenal.00582.2012. Epub 2013 May 8.

22.

Generation and characterization of KsprtTA and KsptTA transgenic mice.

Pan X, Small EV, Igarashi P, Carroll TJ.

Genesis. 2013 Jun;51(6):430-5. doi: 10.1002/dvg.22381. Epub 2013 Mar 28.

23.

Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis.

Shao X, Yang R, Yan M, Li Y, Du Y, Raman I, Zhang B, Wakeland EK, Igarashi P, Mohan C, Li QZ.

Arthritis Rheum. 2013 Mar;65(3):780-91. doi: 10.1002/art.37798. Erratum in: Arthritis Rheum. 2013 Apr;65(4):1106. Wakeland, Ward [corrected to Wakeland, Edward K].

24.

MicroRNAs regulate renal tubule maturation through modulation of Pkd1.

Patel V, Hajarnis S, Williams D, Hunter R, Huynh D, Igarashi P.

J Am Soc Nephrol. 2012 Dec;23(12):1941-8. doi: 10.1681/ASN.2012030321. Epub 2012 Nov 8.

25.

Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice.

Zhou D, Li Y, Lin L, Zhou L, Igarashi P, Liu Y.

Kidney Int. 2012 Sep;82(5):537-47. doi: 10.1038/ki.2012.173. Epub 2012 May 23. Erratum in: Kidney Int. 2013 Sep;84(3):626.

26.

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury.

Liu S, Hartleben B, Kretz O, Wiech T, Igarashi P, Mizushima N, Walz G, Huber TB.

Autophagy. 2012 May 1;8(5):826-37. doi: 10.4161/auto.19419. Epub 2012 May 1.

PMID:
22617445
27.

Genetic basis of prune belly syndrome: screening for HNF1β gene.

Granberg CF, Harrison SM, Dajusta D, Zhang S, Hajarnis S, Igarashi P, Baker LA.

J Urol. 2012 Jan;187(1):272-8. doi: 10.1016/j.juro.2011.09.036. Epub 2011 Nov 23.

28.

Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs.

Li B, Rauhauser AA, Dai J, Sakthivel R, Igarashi P, Jetten AM, Attanasio M.

Hum Mol Genet. 2011 Nov 1;20(21):4155-66. doi: 10.1093/hmg/ddr339. Epub 2011 Aug 4.

29.

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.

Choi YH, Suzuki A, Hajarnis S, Ma Z, Chapin HC, Caplan MJ, Pontoglio M, Somlo S, Igarashi P.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84. doi: 10.1073/pnas.1016214108. Epub 2011 Jun 13.

30.

Primary cilia regulate mTORC1 activity and cell size through Lkb1.

Boehlke C, Kotsis F, Patel V, Braeg S, Voelker H, Bredt S, Beyer T, Janusch H, Hamann C, Gödel M, Müller K, Herbst M, Hornung M, Doerken M, Köttgen M, Nitschke R, Igarashi P, Walz G, Kuehn EW.

Nat Cell Biol. 2010 Nov;12(11):1115-22. doi: 10.1038/ncb2117. Epub 2010 Oct 24.

31.

Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

Meng XM, Huang XR, Chung AC, Qin W, Shao X, Igarashi P, Ju W, Bottinger EP, Lan HY.

J Am Soc Nephrol. 2010 Sep;21(9):1477-87. doi: 10.1681/ASN.2009121244. Epub 2010 Jul 1.

32.

Kidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathway.

Zullo A, Iaconis D, Barra A, Cantone A, Messaddeq N, Capasso G, Dollé P, Igarashi P, Franco B.

Hum Mol Genet. 2010 Jul 15;19(14):2792-803. doi: 10.1093/hmg/ddq180. Epub 2010 May 5.

33.

A mitotic transcriptional switch in polycystic kidney disease.

Verdeguer F, Le Corre S, Fischer E, Callens C, Garbay S, Doyen A, Igarashi P, Terzi F, Pontoglio M.

Nat Med. 2010 Jan;16(1):106-10. doi: 10.1038/nm.2068. Epub 2009 Dec 6.

34.

Loss of oriented cell division does not initiate cyst formation.

Nishio S, Tian X, Gallagher AR, Yu Z, Patel V, Igarashi P, Somlo S.

J Am Soc Nephrol. 2010 Feb;21(2):295-302. doi: 10.1681/ASN.2009060603. Epub 2009 Dec 3.

35.

Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.

Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ.

Nat Genet. 2009 Jul;41(7):793-9. doi: 10.1038/ng.400. Epub 2009 Jun 21.

36.

Advances in the pathogenesis and treatment of polycystic kidney disease.

Patel V, Chowdhury R, Igarashi P.

Curr Opin Nephrol Hypertens. 2009 Mar;18(2):99-106. doi: 10.1097/MNH.0b013e3283262ab0. Review.

37.

Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion.

Lee HW, Verlander JW, Bishop JM, Igarashi P, Handlogten ME, Weiner ID.

Am J Physiol Renal Physiol. 2009 Jun;296(6):F1364-75. doi: 10.1152/ajprenal.90667.2008. Epub 2009 Mar 25.

38.

CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus.

Wang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C.

J Immunol. 2009 Apr 1;182(7):4448-58. doi: 10.4049/jimmunol.0801920.

39.

Basolateral expression of the ammonia transporter family member Rh C glycoprotein in the mouse kidney.

Kim HY, Verlander JW, Bishop JM, Cain BD, Han KH, Igarashi P, Lee HW, Handlogten ME, Weiner ID.

Am J Physiol Renal Physiol. 2009 Mar;296(3):F543-55. doi: 10.1152/ajprenal.90637.2008. Epub 2009 Jan 7.

40.

HNF-1beta regulates transcription of the PKD modifier gene Kif12.

Gong Y, Ma Z, Patel V, Fischer E, Hiesberger T, Pontoglio M, Igarashi P.

J Am Soc Nephrol. 2009 Jan;20(1):41-7. doi: 10.1681/ASN.2008020238. Epub 2008 Nov 12.

41.

Triptolide reduces cystogenesis in a model of ADPKD.

Leuenroth SJ, Bencivenga N, Igarashi P, Somlo S, Crews CM.

J Am Soc Nephrol. 2008 Sep;19(9):1659-62. doi: 10.1681/ASN.2008030259. Epub 2008 Jul 23.

42.

Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.

Tiwari S, Sharma N, Gill PS, Igarashi P, Kahn CR, Wade JB, Ecelbarger CM.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6469-74. doi: 10.1073/pnas.0711283105. Epub 2008 Apr 18.

43.

Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease.

Williams SS, Cobo-Stark P, James LR, Somlo S, Igarashi P.

Pediatr Nephrol. 2008 May;23(5):733-41. doi: 10.1007/s00467-007-0735-4. Epub 2008 Feb 20.

PMID:
18286309
44.

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.

Patel V, Li L, Cobo-Stark P, Shao X, Somlo S, Lin F, Igarashi P.

Hum Mol Genet. 2008 Jun 1;17(11):1578-90. doi: 10.1093/hmg/ddn045. Epub 2008 Feb 9.

45.

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S.

Hum Mol Genet. 2008 Jun 1;17(11):1505-16. doi: 10.1093/hmg/ddn039. Epub 2008 Feb 7.

46.

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.

Baba M, Furihata M, Hong SB, Tessarollo L, Haines DC, Southon E, Patel V, Igarashi P, Alvord WG, Leighty R, Yao M, Bernardo M, Ileva L, Choyke P, Warren MB, Zbar B, Linehan WM, Schmidt LS.

J Natl Cancer Inst. 2008 Jan 16;100(2):140-54. doi: 10.1093/jnci/djm288. Epub 2008 Jan 8.

47.

Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ.

Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, Mitani A, Nagase T, Yatomi Y, Aburatani H, Nakagawa O, Small EV, Cobo-Stark P, Igarashi P, Murakami M, Tominaga J, Sato T, Asano T, Kurihara Y, Kurihara H.

Am J Physiol Renal Physiol. 2008 Mar;294(3):F542-53. doi: 10.1152/ajprenal.00201.2007. Epub 2008 Jan 2.

48.

Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3.

Ma Z, Gong Y, Patel V, Karner CM, Fischer E, Hiesberger T, Carroll TJ, Pontoglio M, Igarashi P.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20386-91. Epub 2007 Dec 12.

49.

Renal and bone marrow cells fuse after renal ischemic injury.

Li L, Truong P, Igarashi P, Lin F.

J Am Soc Nephrol. 2007 Dec;18(12):3067-77. Epub 2007 Nov 14. No abstract available.

50.

Gastrointestinal amyloidosis associated with transthyretin Phe64Ser mutation.

Naderi AS, Farsian FN, Igarashi P.

Am J Med Sci. 2007 Sep;334(3):219-21.

PMID:
17873539

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