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Items: 44

1.

B7-H4 Modulates Regulatory CD4+ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex.

Podojil JR, Chiang MY, Ifergan I, Copeland R, Liu LN, Maloveste S, Langermann S, Liebenson D, Balabanov R, Chi H, Chen L, Vignali DAA, Miller SD.

J Immunol. 2018 Aug 1;201(3):897-907. doi: 10.4049/jimmunol.1700811. Epub 2018 Jun 13.

2.

Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy.

Xu D, Robinson AP, Ishii T, Duncan DS, Alden TD, Goings GE, Ifergan I, Podojil JR, Penaloza-MacMaster P, Kearney JA, Swanson GT, Miller SD, Koh S.

J Exp Med. 2018 Apr 2;215(4):1169-1186. doi: 10.1084/jem.20171285. Epub 2018 Feb 27.

3.

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche.

Plebanek MP, Angeloni NL, Vinokour E, Li J, Henkin A, Martinez-Marin D, Filleur S, Bhowmick R, Henkin J, Miller SD, Ifergan I, Lee Y, Osman I, Thaxton CS, Volpert OV.

Nat Commun. 2017 Nov 6;8(1):1319. doi: 10.1038/s41467-017-01433-3.

4.

Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice.

Jeong SJ, Cooper JG, Ifergan I, McGuire TL, Xu D, Hunter Z, Sharma S, McCarthy D, Miller SD, Kessler JA.

Neurobiol Dis. 2017 Dec;108:73-82. doi: 10.1016/j.nbd.2017.08.006. Epub 2017 Aug 18.

5.

Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.

Ifergan I, Davidson TS, Kebir H, Xu D, Palacios-Macapagal D, Cann J, Rodgers JM, Hunter ZN, Pittet CL, Beddow S, Jones CA, Prat A, Sleeman MA, Miller SD.

J Autoimmun. 2017 Nov;84:1-11. doi: 10.1016/j.jaut.2017.06.005. Epub 2017 Jun 20.

6.

Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy.

Edwards RG, Kopp SJ, Ifergan I, Shui JW, Kronenberg M, Miller SD, Longnecker R.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):282-291. doi: 10.1167/iovs.16-20668.

7.

Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization.

Smarr CB, Yap WT, Neef TP, Pearson RM, Hunter ZN, Ifergan I, Getts DR, Bryce PJ, Shea LD, Miller SD.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):5059-64. doi: 10.1073/pnas.1505782113. Epub 2016 Apr 18.

8.

Cutting Edge: MicroRNA-223 Regulates Myeloid Dendritic Cell-Driven Th17 Responses in Experimental Autoimmune Encephalomyelitis.

Ifergan I, Chen S, Zhang B, Miller SD.

J Immunol. 2016 Feb 15;196(4):1455-1459. doi: 10.4049/jimmunol.1501965. Epub 2016 Jan 18.

9.

Experimental Autoimmune Encephalomyelitis in Mice.

Terry RL, Ifergan I, Miller SD.

Methods Mol Biol. 2016;1304:145-60. doi: 10.1007/7651_2014_88.

10.

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system.

Larochelle C, Cayrol R, Kebir H, Alvarez JI, Lécuyer MA, Ifergan I, Viel É, Bourbonnière L, Beauseigle D, Terouz S, Hachehouche L, Gendron S, Poirier J, Jobin C, Duquette P, Flanagan K, Yednock T, Arbour N, Prat A.

Brain. 2012 Oct;135(Pt 10):2906-24. doi: 10.1093/brain/aws212. Epub 2012 Sep 13.

PMID:
22975388
11.

Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions.

Ifergan I, Kebir H, Terouz S, Alvarez JI, Lécuyer MA, Gendron S, Bourbonnière L, Dunay IR, Bouthillier A, Moumdjian R, Fontana A, Haqqani A, Klopstein A, Prinz M, López-Vales R, Birchler T, Prat A.

Ann Neurol. 2011 Nov;70(5):751-63. doi: 10.1002/ana.22519.

PMID:
22162058
12.

The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.

Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonnière L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A.

Science. 2011 Dec 23;334(6063):1727-31. doi: 10.1126/science.1206936. Epub 2011 Dec 1.

13.

Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin.

Ifergan I, Kebir H, Alvarez JI, Marceau G, Bernard M, Bourbonnière L, Poirier J, Duquette P, Talbot PJ, Arbour N, Prat A.

Brain. 2011 Dec;134(Pt 12):3560-77. doi: 10.1093/brain/awr268. Epub 2011 Nov 4.

PMID:
22058139
14.

B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple sclerosis patients.

Schneider R, Mohebiany AN, Ifergan I, Beauseigle D, Duquette P, Prat A, Arbour N.

J Immunol. 2011 Oct 15;187(8):4119-28. doi: 10.4049/jimmunol.1100885. Epub 2011 Sep 12.

15.

Isolation of human brain endothelial cells and characterization of lipid raft-associated proteins by mass spectroscopy.

Cayrol R, Haqqani AS, Ifergan I, Dodelet-Devillers A, Prat A.

Methods Mol Biol. 2011;686:275-95. doi: 10.1007/978-1-60761-938-3_13.

PMID:
21082377
16.

Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.

Kebir H, Ifergan I, Alvarez JI, Bernard M, Poirier J, Arbour N, Duquette P, Prat A.

Ann Neurol. 2009 Sep;66(3):390-402. doi: 10.1002/ana.21748.

PMID:
19810097
17.

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.

Schulze-Topphoff U, Prat A, Prozorovski T, Siffrin V, Paterka M, Herz J, Bendix I, Ifergan I, Schadock I, Mori MA, Van Horssen J, Schröter F, Smorodchenko A, Han MH, Bader M, Steinman L, Aktas O, Zipp F.

Nat Med. 2009 Jul;15(7):788-93. doi: 10.1038/nm.1980. Epub 2009 Jun 28.

18.

Riboflavin concentration within ABCG2-rich extracellular vesicles is a novel marker for multidrug resistance in malignant cells.

Ifergan I, Goler-Baron V, Assaraf YG.

Biochem Biophys Res Commun. 2009 Feb 27;380(1):5-10. doi: 10.1016/j.bbrc.2008.12.168. Epub 2009 Jan 10.

PMID:
19138668
19.

IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.

Niemelä J, Ifergan I, Yegutkin GG, Jalkanen S, Prat A, Airas L.

Eur J Immunol. 2008 Oct;38(10):2718-26. doi: 10.1002/eji.200838437.

20.

Molecular mechanisms of adaptation to folate deficiency.

Ifergan I, Assaraf YG.

Vitam Horm. 2008;79:99-143. doi: 10.1016/S0083-6729(08)00404-4.

PMID:
18804693
21.

The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis.

Ifergan I, Jansen G, Assaraf YG.

J Biol Chem. 2008 Jul 25;283(30):20687-95. doi: 10.1074/jbc.M802812200. Epub 2008 May 22.

22.

Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system.

Cayrol R, Wosik K, Berard JL, Dodelet-Devillers A, Ifergan I, Kebir H, Haqqani AS, Kreymborg K, Krug S, Moumdjian R, Bouthillier A, Becher B, Arbour N, David S, Stanimirovic D, Prat A.

Nat Immunol. 2008 Feb;9(2):137-45. Epub 2007 Dec 23.

PMID:
18157132
23.

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells.

Ifergan I, Kébir H, Bernard M, Wosik K, Dodelet-Devillers A, Cayrol R, Arbour N, Prat A.

Brain. 2008 Mar;131(Pt 3):785-99. Epub 2007 Dec 20.

PMID:
18156156
24.

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.

Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B, Prat A.

Nat Med. 2007 Oct;13(10):1173-5. Epub 2007 Sep 9.

25.

C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.

Bram EE, Ifergan I, Grimberg M, Lemke K, Skladanowski A, Assaraf YG.

Biochem Pharmacol. 2007 Jun 30;74(1):41-53. Epub 2007 Apr 1.

PMID:
17481587
26.

Sulfasalazine sensitises human monocytic/macrophage cells for glucocorticoids by upregulation of glucocorticoid receptor alpha and glucocorticoid induced apoptosis.

Oerlemans R, Vink J, Dijkmans BA, Assaraf YG, van Miltenburg M, van der Heijden J, Ifergan I, Lems WF, Scheper RJ, Kaspers GJ, Cloos J, Jansen G.

Ann Rheum Dis. 2007 Oct;66(10):1289-95. Epub 2007 Jan 31.

27.

Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis.

Ifergan I, Wosik K, Cayrol R, Kébir H, Auger C, Bernard M, Bouthillier A, Moumdjian R, Duquette P, Prat A.

Ann Neurol. 2006 Jul;60(1):45-55.

PMID:
16729291
28.

Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.

Bram E, Ifergan I, Shafran A, Berman B, Jansen G, Assaraf YG.

Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. Epub 2006 Apr 13.

PMID:
16612649
29.

Acquired resistance to chloroquine in human CEM T cells is mediated by multidrug resistance-associated protein 1 and provokes high levels of cross-resistance to glucocorticoids.

Oerlemans R, van der Heijden J, Vink J, Dijkmans BA, Kaspers GJ, Lems WF, Scheffer GL, Ifergan I, Scheper RJ, Cloos J, Assaraf YG, Jansen G.

Arthritis Rheum. 2006 Feb;54(2):557-68.

30.
31.

Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.

Assaraf YG, Ifergan I, Kadry WN, Pinter RY.

J Theor Biol. 2006 Jun 21;240(4):637-47. Epub 2005 Dec 13.

PMID:
16352313
32.

Novel extracellular vesicles mediate an ABCG2-dependent anticancer drug sequestration and resistance.

Ifergan I, Scheffer GL, Assaraf YG.

Cancer Res. 2005 Dec 1;65(23):10952-8.

33.

ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates.

Shafran A, Ifergan I, Bram E, Jansen G, Kathmann I, Peters GJ, Robey RW, Bates SE, Assaraf YG.

Cancer Res. 2005 Sep 15;65(18):8414-22.

34.

Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.

Magnus T, Schreiner B, Korn T, Jack C, Guo H, Antel J, Ifergan I, Chen L, Bischof F, Bar-Or A, Wiendl H.

J Neurosci. 2005 Mar 9;25(10):2537-46.

35.
36.

Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis.

Jansen G, van der Heijden J, Oerlemans R, Lems WF, Ifergan I, Scheper RJ, Assaraf YG, Dijkmans BA.

Arthritis Rheum. 2004 Jul;50(7):2130-9.

37.

Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis.

Kim HJ, Ifergan I, Antel JP, Seguin R, Duddy M, Lapierre Y, Jalili F, Bar-Or A.

J Immunol. 2004 Jun 1;172(11):7144-53.

38.

Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis.

Ifergan I, Shafran A, Jansen G, Hooijberg JH, Scheffer GL, Assaraf YG.

J Biol Chem. 2004 Jun 11;279(24):25527-34. Epub 2004 Mar 26.

39.

Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.

Kaufman Y, Drori S, Cole PD, Kamen BA, Sirota J, Ifergan I, Arush MW, Elhasid R, Sahar D, Kaspers GJ, Jansen G, Matherly LH, Rechavi G, Toren A, Assaraf YG.

Cancer. 2004 Feb 15;100(4):773-82.

40.
41.

Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.

Bar-Or A, Nuttall RK, Duddy M, Alter A, Kim HJ, Ifergan I, Pennington CJ, Bourgoin P, Edwards DR, Yong VW.

Brain. 2003 Dec;126(Pt 12):2738-49. Epub 2003 Sep 23.

PMID:
14506071
42.

Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells.

Assaraf YG, Rothem L, Hooijberg JH, Stark M, Ifergan I, Kathmann I, Dijkmans BA, Peters GJ, Jansen G.

J Biol Chem. 2003 Feb 28;278(9):6680-6. Epub 2002 Dec 16.

43.

Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians.

Ifergan I, Bernard NF, Bruneau J, Alary M, Tsoukas CM, Roger M.

AIDS. 2002 Nov 22;16(17):2340-2.

PMID:
12441809

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