Sort by
Items per page

Send to

Choose Destination

Search results

Items: 29


MAPK Erk5 in leptin receptor-expressing neurons controls body weight and systemic energy homeostasis in female mice.

Horie T, Park G, Inaba Y, Hashiuchi E, Iezaki T, Tokumura K, Fukasawa K, Yamada T, Hiraiwa M, Kitaguchi Y, Kamada H, Kaneda K, Tanaka T, Inoue H, Hinoi E.

Endocrinology. 2019 Sep 25. pii: en.2019-00090. doi: 10.1210/en.2019-00090. [Epub ahead of print]


The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway.

Ozaki K, Yamada T, Horie T, Ishizaki A, Hiraiwa M, Iezaki T, Park G, Fukasawa K, Kamada H, Tokumura K, Motono M, Kaneda K, Ogawa K, Ochi H, Sato S, Kobayashi Y, Shi YB, Taylor PM, Hinoi E.

Sci Signal. 2019 Jul 9;12(589). pii: eaaw3921. doi: 10.1126/scisignal.aaw3921.


mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis.

Hiraiwa M, Ozaki K, Yamada T, Iezaki T, Park G, Fukasawa K, Horie T, Kamada H, Tokumura K, Motono M, Kaneda K, Hinoi E.

Front Pharmacol. 2019 Jun 13;10:684. doi: 10.3389/fphar.2019.00684. eCollection 2019.


Hypoxia affects Slc7a5 expression through HIF-2α in differentiated neuronal cells.

Onishi Y, Hiraiwa M, Kamada H, Iezaki T, Yamada T, Kaneda K, Hinoi E.

FEBS Open Bio. 2019 Jan 7;9(2):241-247. doi: 10.1002/2211-5463.12559. eCollection 2019 Feb.


[Transcription Regulators and Bone Metabolism].

Hinoi E, Iezaki T, Fukasawa K, Kaneda K.

Yakugaku Zasshi. 2019;139(1):15-18. doi: 10.1248/yakushi.18-00154-1. Review. Japanese.


Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis.

Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Manabe T, Ishigaki Y, Ohno M, Hinoi E.

Stem Cell Reports. 2018 Jul 10;11(1):228-241. doi: 10.1016/j.stemcr.2018.05.020. Epub 2018 Jun 28.


The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis.

Iezaki T, Fukasawa K, Horie T, Park G, Robinson S, Nakaya M, Fujita H, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Yoneda Y, Takarada T, Guo XE, Kurose H, Hinoi E.

Development. 2018 Jul 26;145(14). pii: dev164004. doi: 10.1242/dev.164004.


Hypoxic Stress Upregulates the Expression of Slc38a1 in Brown Adipocytes via Hypoxia-Inducible Factor-1α.

Horie T, Fukasawa K, Iezaki T, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Hinoi E.

Pharmacology. 2018;101(1-2):64-71. doi: 10.1159/000480405. Epub 2017 Oct 25.


Amelioration of the Development of Osteoarthritis by Daily Intake of β-Cryptoxanthin.

Park G, Horie T, Fukasawa K, Ozaki K, Onishi Y, Kanayama T, Iezaki T, Kaneda K, Sugiura M, Hinoi E.

Biol Pharm Bull. 2017;40(7):1116-1120. doi: 10.1248/bpb.b17-00161.


Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain.

Park G, Horie T, Iezaki T, Okamoto M, Fukasawa K, Kanayama T, Ozaki K, Onishi Y, Sugiura M, Hinoi E.

Biosci Biotechnol Biochem. 2017 May;81(5):1014-1017. doi: 10.1080/09168451.2017.1280661. Epub 2017 Jan 23.


The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes.

Park G, Horie T, Kanayama T, Fukasawa K, Iezaki T, Onishi Y, Ozaki K, Nakamura Y, Yoneda Y, Takarada T, Hinoi E.

FEBS J. 2017 Mar;284(5):784-795. doi: 10.1111/febs.14019. Epub 2017 Feb 10.


Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.

Takarada T, Xu C, Ochi H, Nakazato R, Yamada D, Nakamura S, Kodama A, Shimba S, Mieda M, Fukasawa K, Ozaki K, Iezaki T, Fujikawa K, Yoneda Y, Numano R, Hida A, Tei H, Takeda S, Hinoi E.

J Bone Miner Res. 2017 Apr;32(4):872-881. doi: 10.1002/jbmr.3053. Epub 2017 Mar 3.


The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.

Onishi Y, Park G, Iezaki T, Horie T, Kanayama T, Fukasawa K, Ozaki K, Hinoi E.

Biochem Biophys Res Commun. 2017 Jan 8;482(2):329-334. doi: 10.1016/j.bbrc.2016.11.063. Epub 2016 Nov 14.


ATF3 controls proliferation of osteoclast precursor and bone remodeling.

Fukasawa K, Park G, Iezaki T, Horie T, Kanayama T, Ozaki K, Onishi Y, Takahata Y, Yoneda Y, Takarada T, Kitajima S, Vacher J, Hinoi E.

Sci Rep. 2016 Aug 2;6:30918. doi: 10.1038/srep30918.


Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-κB/NFATc1 Pathway.

Iezaki T, Fukasawa K, Park G, Horie T, Kanayama T, Ozaki K, Onishi Y, Takahata Y, Nakamura Y, Takarada T, Yoneda Y, Nakamura T, Vacher J, Hinoi E.

Mol Cell Biol. 2016 Sep 12;36(19):2451-63. doi: 10.1128/MCB.01075-15. Print 2016 Oct 1.


ATF3 deficiency in chondrocytes alleviates osteoarthritis development.

Iezaki T, Ozaki K, Fukasawa K, Inoue M, Kitajima S, Muneta T, Takeda S, Fujita H, Onishi Y, Horie T, Yoneda Y, Takarada T, Hinoi E.

J Pathol. 2016 Aug;239(4):426-37. doi: 10.1002/path.4739. Epub 2016 Jun 14.


GDF1 is a novel mediator of macrophage infiltration in brown adipose tissue of obese mice.

Onishi Y, Fukasawa K, Ozaki K, Iezaki T, Yoneda Y, Hinoi E.

Biochem Biophys Rep. 2015 Dec 21;5:216-223. doi: 10.1016/j.bbrep.2015.12.008. eCollection 2016 Mar.


Genetic analysis of Runx2 function during intramembranous ossification.

Takarada T, Nakazato R, Tsuchikane A, Fujikawa K, Iezaki T, Yoneda Y, Hinoi E.

Development. 2016 Jan 15;143(2):211-8. doi: 10.1242/dev.128793. Epub 2015 Dec 10.


The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption.

Iezaki T, Onishi Y, Ozaki K, Fukasawa K, Takahata Y, Nakamura Y, Fujikawa K, Takarada T, Yoneda Y, Yamashita Y, Shioi G, Hinoi E.

J Bone Miner Res. 2016 Mar;31(3):573-84. doi: 10.1002/jbmr.2720. Epub 2015 Oct 22.


Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice.

Ozaki K, Okamoto M, Fukasawa K, Iezaki T, Onishi Y, Yoneda Y, Sugiura M, Hinoi E.

J Pharmacol Sci. 2015 Sep;129(1):72-7. doi: 10.1016/j.jphs.2015.08.003. Epub 2015 Aug 22. Review.


Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate.

Hinoi E, Iezaki T, Ozaki K, Yoneda Y.

Biochem Biophys Res Commun. 2014 Oct 3;452(4):974-9. doi: 10.1016/j.bbrc.2014.09.022. Epub 2014 Sep 16.


PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway.

Hinoi E, Iezaki T, Fujita H, Watanabe T, Odaka Y, Ozaki K, Yoneda Y.

Biochem Biophys Res Commun. 2014 Jul 18;450(1):255-60. doi: 10.1016/j.bbrc.2014.05.108. Epub 2014 Jun 2.


Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure.

Hinoi E, Nakamura Y, Takada S, Fujita H, Iezaki T, Hashizume S, Takahashi S, Odaka Y, Watanabe T, Yoneda Y.

Diabetes. 2014 Jan;63(1):162-75. doi: 10.2337/db13-0808. Epub 2013 Sep 23.


Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia.

Nakamura Y, Hinoi E, Iezaki T, Takada S, Hashizume S, Takahata Y, Tsuruta E, Takahashi S, Yoneda Y.

Biochim Biophys Acta. 2013 Aug;1832(8):1117-28. doi: 10.1016/j.bbadis.2013.03.010. Epub 2013 Mar 18.


Prevention of bone loss after ovariectomy in mice with preferential overexpression of the transcription factor paired box-5 in osteoblasts.

Fujita H, Hinoi E, Watanabe T, Iezaki T, Takamori M, Ogawa S, Yoneda Y.

Biol Pharm Bull. 2013;36(3):481-4.


The transcription factor paired box-5 promotes osteoblastogenesis through direct induction of Osterix and Osteocalcin.

Hinoi E, Nakatani E, Yamamoto T, Iezaki T, Takahata Y, Fujita H, Ishiura R, Takamori M, Yoneda Y.

J Bone Miner Res. 2012 Dec;27(12):2526-34. doi: 10.1002/jbmr.1708.


Amelioration by the natural polyamine spermine of cartilage and bone destruction in rats with collagen-induced arthritis.

Iezaki T, Hinoi E, Yamamoto T, Ishiura R, Ogawa S, Yoneda Y.

J Pharmacol Sci. 2012;119(1):107-11. Epub 2012 Apr 28.


The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice.

Yamamoto T, Hinoi E, Fujita H, Iezaki T, Takahata Y, Takamori M, Yoneda Y.

Br J Pharmacol. 2012 Jun;166(3):1084-96. doi: 10.1111/j.1476-5381.2012.01856.x.


Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia.

Hinoi E, Ochi H, Takarada T, Nakatani E, Iezaki T, Nakajima H, Fujita H, Takahata Y, Hidano S, Kobayashi T, Takeda S, Yoneda Y.

J Bone Miner Res. 2012 Apr;27(4):938-49. doi: 10.1002/jbmr.1538.

Supplemental Content

Loading ...
Support Center