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Items: 1 to 50 of 109

1.

Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.

Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T.

Proc Natl Acad Sci U S A. 2019 Nov 6. pii: 201915326. doi: 10.1073/pnas.1915326116. [Epub ahead of print]

PMID:
31694883
2.

Role of irisin in androgen-deficient muscle wasting and osteopenia in mice.

Iemura S, Kawao N, Okumoto K, Akagi M, Kaji H.

J Bone Miner Metab. 2019 Sep 7. doi: 10.1007/s00774-019-01043-7. [Epub ahead of print]

PMID:
31494773
3.

FAM48A mediates compensatory autophagy induced by proteasome impairment.

Arata Y, Watanabe A, Motosugi R, Iemura SI, Natsume T, Mukai K, Taguchi T, Hirayama S, Hamazaki J, Murata S.

Genes Cells. 2019 Aug;24(8):559-568. doi: 10.1111/gtc.12708. Epub 2019 Jul 3.

PMID:
31210371
4.

Clinical outcomes of patients with primary malignant bone and soft tissue tumor aged 65 years or older.

Hashimoto K, Nishimura S, Hara Y, Oka N, Tanaka H, Iemura S, Akagi M.

Exp Ther Med. 2019 Jan;17(1):888-894. doi: 10.3892/etm.2018.7013. Epub 2018 Nov 26.

5.

Salmonella Osteomyelitis of the Distal Tibia in a Healthy Woman.

Hashimoto K, Nishimura S, Iemura S, Akagi M.

Acta Med Okayama. 2018 Dec;72(6):601-604. doi: 10.18926/AMO/56379.

6.

MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs.

Okamoto K, Ohishi T, Kuroiwa M, Iemura SI, Natsume T, Seimiya H.

Oncotarget. 2018 Nov 9;9(88):35844-35855. doi: 10.18632/oncotarget.26312. eCollection 2018 Nov 9.

7.

Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B.

Hatta T, Iemura SI, Ohishi T, Nakayama H, Seimiya H, Yasuda T, Iizuka K, Fukuda M, Takeda J, Natsume T, Horikawa Y.

Sci Rep. 2018 Nov 13;8(1):16756. doi: 10.1038/s41598-018-35204-x.

8.

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase.

Yoneyama Y, Inamitsu T, Chida K, Iemura SI, Natsume T, Maeda T, Hakuno F, Takahashi SI.

iScience. 2018 Jul 27;5:1-18. doi: 10.1016/j.isci.2018.06.006. Epub 2018 Jun 18.

9.

β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.

Cheng R, Takeda K, Naguro I, Hatta T, Iemura SI, Natsume T, Ichijo H, Hattori K.

Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2271-2280. doi: 10.1016/j.bbagen.2018.07.015. Epub 2018 Jul 18.

PMID:
30031111
10.

Stratifin regulates stabilization of receptor tyrosine kinases via interaction with ubiquitin-specific protease 8 in lung adenocarcinoma.

Kim Y, Shiba-Ishii A, Nakagawa T, Iemura SI, Natsume T, Nakano N, Matsuoka R, Sakashita S, Lee S, Kawaguchi A, Sato Y, Noguchi M.

Oncogene. 2018 Oct;37(40):5387-5402. doi: 10.1038/s41388-018-0342-9. Epub 2018 Jun 7.

PMID:
29880877
11.

Nuclear export of ubiquitinated proteins via the UBIN-POST system.

Hirayama S, Sugihara M, Morito D, Iemura SI, Natsume T, Murata S, Nagata K.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4199-E4208. doi: 10.1073/pnas.1711017115. Epub 2018 Apr 16.

12.

Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells.

Matsudaira T, Mukai K, Noguchi T, Hasegawa J, Hatta T, Iemura SI, Natsume T, Miyamura N, Nishina H, Nakayama J, Semba K, Tomita T, Murata S, Arai H, Taguchi T.

Nat Commun. 2017 Nov 1;8(1):1246. doi: 10.1038/s41467-017-01255-3.

13.

Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation.

Fujimori T, Suno R, Iemura SI, Natsume T, Wada I, Hosokawa N.

Genes Cells. 2017 Aug;22(8):684-698. doi: 10.1111/gtc.12506. Epub 2017 Jun 9.

14.

Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.

Kotani Y, Morito D, Sakata K, Ainuki S, Sugihara M, Hatta T, Iemura SI, Takashima S, Natsume T, Nagata K.

Sci Rep. 2017 Mar 9;7:44293. doi: 10.1038/srep44293.

15.

Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion.

Ohishi T, Yoshida H, Katori M, Migita T, Muramatsu Y, Miyake M, Ishikawa Y, Saiura A, Iemura SI, Natsume T, Seimiya H.

Cancer Res. 2017 May 1;77(9):2328-2338. doi: 10.1158/0008-5472.CAN-16-1846. Epub 2017 Feb 15.

16.

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.

Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI.

Biochem Biophys Res Commun. 2017 Mar 11;484(3):522-528. doi: 10.1016/j.bbrc.2017.01.101. Epub 2017 Jan 23.

PMID:
28126338
17.

TMED10 Protein Interferes with Transforming Growth Factor (TGF)-β Signaling by Disrupting TGF-β Receptor Complex Formation.

Nakano N, Tsuchiya Y, Kako K, Umezaki K, Sano K, Ikeno S, Otsuka E, Shigeta M, Nakagawa A, Sakata N, Itoh F, Nakano Y, Iemura SI, van Dinther M, Natsume T, Ten Dijke P, Itoh S.

J Biol Chem. 2017 Mar 10;292(10):4099-4112. doi: 10.1074/jbc.M116.769109. Epub 2017 Jan 23.

18.

Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair.

Ishida N, Nakagawa T, Iemura SI, Yasui A, Shima H, Katoh Y, Nagasawa Y, Natsume T, Igarashi K, Nakayama K.

Mol Cell Biol. 2017 Feb 1;37(4). pii: e00347-16. doi: 10.1128/MCB.00347-16. Print 2017 Feb 15.

19.

WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.

Goto T, Matsuzawa J, Iemura S, Natsume T, Shibuya H.

FEBS Lett. 2016 May;590(9):1291-303. doi: 10.1002/1873-3468.12180. Epub 2016 May 3.

20.

Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission.

Saita S, Ishihara T, Maeda M, Iemura S, Natsume T, Mihara K, Ishihara N.

Genes Cells. 2016 May;21(5):408-24. doi: 10.1111/gtc.12351. Epub 2016 Mar 3.

21.

Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi.

Fukuzono T, Pastuhov SI, Fukushima O, Li C, Hattori A, Iemura S, Natsume T, Shibuya H, Hanafusa H, Matsumoto K, Hisamoto N.

Genes Cells. 2016 Apr;21(4):311-24. doi: 10.1111/gtc.12338. Epub 2016 Feb 8.

22.

The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.

Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M.

Sci Signal. 2015 Nov 24;8(404):ra120. doi: 10.1126/scisignal.aad0667.

PMID:
26602019
23.

TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

J Cell Biochem. 2016 Feb;117(2):500-9. doi: 10.1002/jcb.25301.

PMID:
26239904
24.

CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2.

Kigoshi Y, Fukuda T, Endo T, Hayasaka N, Iemura S, Natsume T, Tsuruta F, Chiba T.

Sci Rep. 2015 Aug 4;5:12857. doi: 10.1038/srep12857.

25.

The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

Biochem Biophys Res Commun. 2015 Jul 10;462(4):383-8. doi: 10.1016/j.bbrc.2015.04.144. Epub 2015 May 12.

PMID:
25976671
26.

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

Fukushima T, Yoshihara H, Furuta H, Kamei H, Hakuno F, Luan J, Duan C, Saeki Y, Tanaka K, Iemura S, Natsume T, Chida K, Nakatsu Y, Kamata H, Asano T, Takahashi S.

Nat Commun. 2015 Apr 16;6:6780. doi: 10.1038/ncomms7780.

PMID:
25879670
27.

TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.

Tsukumo Y, Tsukahara S, Furuno A, Iemura S, Natsume T, Tomida A.

PLoS One. 2014 Nov 13;9(11):e112761. doi: 10.1371/journal.pone.0112761. eCollection 2014.

28.

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

Adachi S, Homoto M, Tanaka R, Hioki Y, Murakami H, Suga H, Matsumoto M, Nakayama KI, Hatta T, Iemura S, Natsume T.

Nucleic Acids Res. 2014 Sep;42(15):10037-49. doi: 10.1093/nar/gku652. Epub 2014 Aug 8.

29.

Structure-activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201.

Hayakawa N, Noguchi M, Takeshita S, Eviryanti A, Seki Y, Nishio H, Yokoyama R, Noguchi M, Shuto M, Shima Y, Kuribayashi K, Kageyama S, Eda H, Suzuki M, Hatta T, Iemura S, Natsume T, Tanabe I, Nakagawa R, Shiozaki M, Sakurai K, Shoji M, Andou A, Yamamoto T.

Bioorg Med Chem. 2014 Jun 1;22(11):3021-9. doi: 10.1016/j.bmc.2014.03.036. Epub 2014 Apr 13.

PMID:
24767819
30.

IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling.

Goto T, Sato A, Adachi S, Iemura S, Natsume T, Shibuya H.

J Biol Chem. 2013 Dec 20;288(51):36351-60. doi: 10.1074/jbc.M113.520528. Epub 2013 Nov 6.

31.

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.

Hoshi T, Tezuka T, Yokoyama K, Iemura S, Natsume T, Yamanashi Y.

FEBS Lett. 2013 Nov 29;587(23):3749-54. doi: 10.1016/j.febslet.2013.10.001. Epub 2013 Oct 15.

32.

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases.

Araki K, Iemura S, Kamiya Y, Ron D, Kato K, Natsume T, Nagata K.

J Cell Biol. 2013 Sep 16;202(6):861-74. doi: 10.1083/jcb.201303027.

33.

Dynamic regulation of Ero1α and peroxiredoxin 4 localization in the secretory pathway.

Kakihana T, Araki K, Vavassori S, Iemura S, Cortini M, Fagioli C, Natsume T, Sitia R, Nagata K.

J Biol Chem. 2013 Oct 11;288(41):29586-94. doi: 10.1074/jbc.M113.467845. Epub 2013 Aug 26.

34.

The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression.

Tsuchiya Y, Taniguchi H, Ito Y, Morita T, Karim MR, Ohtake N, Fukagai K, Ito T, Okamuro S, Iemura S, Natsume T, Nishida E, Kobayashi A.

Mol Cell Biol. 2013 Sep;33(17):3461-72. doi: 10.1128/MCB.01271-12. Epub 2013 Jul 1.

35.

PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

Ono Y, Iemura S, Novak SM, Doi N, Kitamura F, Natsume T, Gregorio CC, Sorimachi H.

J Mol Biol. 2013 Aug 23;425(16):2955-72. doi: 10.1016/j.jmb.2013.05.009. Epub 2013 May 21.

36.

IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling.

Goto T, Sato A, Shimizu M, Adachi S, Satoh K, Iemura S, Natsume T, Shibuya H.

PLoS One. 2013;8(4):e60865. doi: 10.1371/journal.pone.0060865. Epub 2013 Apr 5.

37.

VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels.

Murakami K, Ichinohe Y, Koike M, Sasaoka N, Iemura S, Natsume T, Kakizuka A.

PLoS One. 2013;8(2):e56012. doi: 10.1371/journal.pone.0056012. Epub 2013 Feb 14.

38.

The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

Sekine Y, Hatanaka R, Watanabe T, Sono N, Iemura S, Natsume T, Kuranaga E, Miura M, Takeda K, Ichijo H.

Mol Cell. 2012 Dec 14;48(5):692-704. doi: 10.1016/j.molcel.2012.09.018. Epub 2012 Oct 25.

39.

Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase.

Okatsu K, Iemura S, Koyano F, Go E, Kimura M, Natsume T, Tanaka K, Matsuda N.

Biochem Biophys Res Commun. 2012 Nov 9;428(1):197-202. doi: 10.1016/j.bbrc.2012.10.041. Epub 2012 Oct 13.

PMID:
23068103
40.

RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT.

Fujimoto M, Takaki E, Takii R, Tan K, Prakasam R, Hayashida N, Iemura S, Natsume T, Nakai A.

Mol Cell. 2012 Oct 26;48(2):182-94. doi: 10.1016/j.molcel.2012.07.026. Epub 2012 Aug 30.

41.

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S.

Biochem Biophys Res Commun. 2012 Jun 22;423(1):122-7. doi: 10.1016/j.bbrc.2012.05.093. Epub 2012 May 23.

PMID:
22634009
42.

Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications.

Kobayashi H, Harada H, Nakamura M, Futamura Y, Ito A, Yoshida M, Iemura SI, Shin-Ya K, Doi T, Takahashi T, Natsume T, Imoto M, Sakakibara Y.

BMC Chem Biol. 2012 Apr 5;12:2. doi: 10.1186/1472-6769-12-2.

43.

Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling.

Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, Katagiri T.

J Cell Biochem. 2012 Mar;113(3):808-14. doi: 10.1002/jcb.23408.

PMID:
22021003
44.

Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.

Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A.

Mol Cell Biol. 2011 Nov;31(22):4500-12. doi: 10.1128/MCB.05663-11. Epub 2011 Sep 12.

45.

Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.

Uchida Y, Hasegawa J, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura S, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer WI, Taguchi T, Arai H.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15846-51. doi: 10.1073/pnas.1109101108. Epub 2011 Sep 12.

46.

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.

Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7920-5. doi: 10.1073/pnas.1104423108. Epub 2011 Apr 25.

47.

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.

Oh KH, Yang SW, Park JM, Seol JH, Iemura S, Natsume T, Murata S, Tanaka K, Jeon YJ, Chung CH.

Cell Death Differ. 2011 Aug;18(8):1326-36. doi: 10.1038/cdd.2011.3. Epub 2011 Feb 4.

48.

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor.

Hanafusa H, Ishikawa K, Kedashiro S, Saigo T, Iemura S, Natsume T, Komada M, Shibuya H, Nara A, Matsumoto K.

Nat Commun. 2011 Jan 18;2:158.

49.

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

Inoue Y, Iemura S, Natsume T, Miyazawa K, Imamura T.

J Biol Chem. 2011 Feb 25;286(8):6311-20. doi: 10.1074/jbc.M110.177683. Epub 2010 Dec 13.

50.

A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.

Kunoh T, Noda T, Koseki K, Sekigawa M, Takagi M, Shin-ya K, Goshima N, Iemura S, Natsume T, Wada S, Mukai Y, Ohta S, Sasaki R, Mizukami T.

Mol Cancer Ther. 2010 Nov;9(11):2934-42. doi: 10.1158/1535-7163.MCT-10-0730. Epub 2010 Oct 26.

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