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Items: 1 to 50 of 125

1.

Severe T2-high asthma in the biologics era: European experts' opinion.

Pavord I, Bahmer T, Braido F, Cosío BG, Humbert M, Idzko M, Adamek L.

Eur Respir Rev. 2019 Jul 8;28(152). pii: 190054. doi: 10.1183/16000617.0054-2019. Print 2019 Jun 30. Review.

2.

Research highlights from the 2018 European Respiratory Society International Congress: airway disease.

Schleich F, Bikov A, Mathioudakis AG, McDonnell M, Andersson C, Bonini M, Uller L, Idzko M, Singh D, Lopez-Campos JL, Bossios A, Adcock IM, Usmani O, Spanevello A, Bonvini SJ.

ERJ Open Res. 2019 Mar 18;5(1). pii: 00225-2018. doi: 10.1183/23120541.00225-2018. eCollection 2019 Feb. Review.

3.

Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2 × 7 receptor.

Garcia M, Santos-Dias A, Bachi ALL, Oliveira-Junior MC, Andrade-Souza AS, Ferreira SC, Aquino-Junior JCJ, Almeida FM, Rigonato-Oliveira NC, Oliveira APL, Savio LEB, Coutinho-Silva R, Müller T, Idzko M, Siepmann T, Vieira RP.

Eur J Immunol. 2019 Jun;49(6):928-939. doi: 10.1002/eji.201847657. Epub 2019 Apr 18.

PMID:
30888047
4.

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus.

Faliti CE, Gualtierotti R, Rottoli E, Gerosa M, Perruzza L, Romagnani A, Pellegrini G, De Ponte Conti B, Rossi RL, Idzko M, Mazza EMC, Bicciato S, Traggiai E, Meroni PL, Grassi F.

J Exp Med. 2019 Feb 4;216(2):317-336. doi: 10.1084/jem.20171976. Epub 2019 Jan 17.

5.

Purinergic receptor Y2 (P2Y2)- dependent VCAM-1 expression promotes immune cell infiltration in metabolic syndrome.

Merz J, Albrecht P, von Garlen S, Ahmed I, Dimanski D, Wolf D, Hilgendorf I, Härdtner C, Grotius K, Willecke F, Heidt T, Bugger H, Hoppe N, Kintscher U, von Zur Mühlen C, Idzko M, Bode C, Zirlik A, Stachon P.

Basic Res Cardiol. 2018 Oct 18;113(6):45. doi: 10.1007/s00395-018-0702-1.

PMID:
30338362
6.

Purinergic Signaling: A New Pharmacological Target Against Viruses?

Ferrari D, Idzko M, Müller T, Manservigi R, Marconi P.

Trends Pharmacol Sci. 2018 Nov;39(11):926-936. doi: 10.1016/j.tips.2018.09.004. Epub 2018 Oct 3. Review.

PMID:
30292585
7.

Kinetics of Torque Teno Virus-DNA Plasma Load Predict Rejection in Lung Transplant Recipients.

Frye BC, Bierbaum S, Falcone V, Köhler TC, Gasplmayr M, Hettich I, Dürk T, Idzko M, Zissel G, Hengel H, Müller-Quernheim J.

Transplantation. 2019 Apr;103(4):815-822. doi: 10.1097/TP.0000000000002436.

PMID:
30234787
8.

Extracellular ATP is a danger signal activating P2X7 receptor in a LPS mediated inflammation (ARDS/ALI).

Cicko S, Köhler TC, Ayata CK, Müller T, Ehrat N, Meyer A, Hossfeld M, Zech A, Di Virgilio F, Idzko M.

Oncotarget. 2018 Jul 17;9(55):30635-30648. doi: 10.18632/oncotarget.25761. eCollection 2018 Jul 17.

9.

P2Y2R Signaling Is Involved in the Onset of Glomerulonephritis.

Rennert L, Zschiedrich S, Sandner L, Hartleben B, Cicko S, Ayata CK, Meyer C, Zech A, Zeiser R, Huber TB, Idzko M, Grahammer F.

Front Immunol. 2018 Jul 16;9:1589. doi: 10.3389/fimmu.2018.01589. eCollection 2018.

10.

Lack of biglycan reduces contact hypersensitivity in mice.

Esser PR, Zech A, Idzko M, Martin SF.

Contact Dermatitis. 2018 Nov;79(5):326-328. doi: 10.1111/cod.13082. Epub 2018 Jul 23. No abstract available.

PMID:
30039623
11.

Research highlights from the 2017 ERS International Congress: airway diseases in focus.

Andersson C, Bonvini SJ, Horvath P, Marquez E, Satia I, Kirkham P, Schleich F, Idzko M, Gosens R, Lopez-Campos JL, Bossios A, Usmani O, Spanevello A, Adcock IM, Mathioudakis AG.

ERJ Open Res. 2018 Mar 13;4(1). pii: 00163-2017. doi: 10.1183/23120541.00163-2017. eCollection 2018 Jan. Review.

12.

P2Y6 Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata CK, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Lazarowski ER, Blackburn MR, Idzko M.

Front Immunol. 2017 Aug 22;8:1028. doi: 10.3389/fimmu.2017.01028. eCollection 2017.

13.

Feasibility of a Supraglottic Airway Device for Transbronchial Lung Cryobiopsy-A Retrospective Analysis.

Schmutz A, Dürk T, Idzko M, Koehler T, Kalbhenn J, Loop T.

J Cardiothorac Vasc Anesth. 2017 Aug;31(4):1343-1347. doi: 10.1053/j.jvca.2017.02.055. Epub 2017 Feb 16.

PMID:
28550957
14.

Lipopolysaccharide (LPS) induced pulmonary neutrophil recruitment and platelet activation is mediated via the P2Y1 and P2Y14 receptors in mice.

Amison RT, Arnold S, O'Shaughnessy BG, Cleary SJ, Ofoedu J, Idzko M, Page CP, Pitchford SC.

Pulm Pharmacol Ther. 2017 Aug;45:62-68. doi: 10.1016/j.pupt.2017.05.005. Epub 2017 May 6.

PMID:
28487256
15.

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression.

Andrlová H, Mastroianni J, Madl J, Kern JS, Melchinger W, Dierbach H, Wernet F, Follo M, Technau-Hafsi K, Has C, Rao Mittapalli V, Idzko M, Herr R, Brummer T, Ungefroren H, Busch H, Boerries M, Narr A, Ihorst G, Vennin C, Schmitt-Graeff A, Minguet S, Timpson P, Duyster J, Meiss F, Römer W, Zeiser R.

Oncotarget. 2017 Jun 27;8(26):42901-42916. doi: 10.18632/oncotarget.17160.

16.

The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease.

Müller T, Fay S, Vieira RP, Karmouty-Quintana H, Cicko S, Ayata K, Zissel G, Goldmann T, Lungarella G, Ferrari D, Di Virgilio F, Robaye B, Boeynaems JM, Blackburn MR, Idzko M.

Oncotarget. 2017 May 30;8(22):35962-35972. doi: 10.18632/oncotarget.16414.

17.

P2X7 Deficiency Blocks Lesional Inflammasome Activity and Ameliorates Atherosclerosis in Mice.

Stachon P, Heidenreich A, Merz J, Hilgendorf I, Wolf D, Willecke F, von Garlen S, Albrecht P, Härdtner C, Ehrat N, Hoppe N, Reinöhl J, von Zur Mühlen C, Bode C, Idzko M, Zirlik A.

Circulation. 2017 Jun 20;135(25):2524-2533. doi: 10.1161/CIRCULATIONAHA.117.027400. Epub 2017 Apr 4.

PMID:
28377486
18.

Role of purinergic signaling in experimental pneumococcal meningitis.

Zierhut M, Dyckhoff S, Masouris I, Klein M, Hammerschmidt S, Pfister HW, Ayata K, Idzko M, Koedel U.

Sci Rep. 2017 Mar 16;7:44625. doi: 10.1038/srep44625.

19.

P2rx4 deficiency in mice alleviates allergen-induced airway inflammation.

Zech A, Wiesler B, Ayata CK, Schlaich T, Dürk T, Hoßfeld M, Ehrat N, Cicko S, Idzko M.

Oncotarget. 2016 Dec 6;7(49):80288-80297. doi: 10.18632/oncotarget.13375.

20.

Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway.

Alberca-Custódio RW, Greiffo FR, MacKenzie B, Oliveira-Junior MC, Andrade-Sousa AS, Graudenz GS, Santos AB, Damaceno-Rodrigues NR, Castro-Faria-Neto HC, Arantes-Costa FM, Martins Mde A, Abbasi A, Lin CJ, Idzko M, Ligeiro Oliveira AP, Northoff H, Vieira RP.

Front Immunol. 2016 Jun 14;7:237. doi: 10.3389/fimmu.2016.00237. eCollection 2016.

21.

Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens.

Gruenbacher G, Gander H, Rahm A, Idzko M, Nussbaumer O, Thurnher M.

Cell Rep. 2016 Jul 12;16(2):444-456. doi: 10.1016/j.celrep.2016.06.009. Epub 2016 Jun 23.

22.

Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via Purinergic Receptor Y2 in Mice.

Stachon P, Geis S, Peikert A, Heidenreich A, Michel NA, Ünal F, Hoppe N, Dufner B, Schulte L, Marchini T, Cicko S, Ayata K, Zech A, Wolf D, Hilgendorf I, Willecke F, Reinöhl J, von Zur Mühlen C, Bode C, Idzko M, Zirlik A.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1577-86. doi: 10.1161/ATVBAHA.115.307397. Epub 2016 Jun 23.

PMID:
27339459
23.

Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients.

Wawrzyniak P, Wawrzyniak M, Wanke K, Sokolowska M, Bendelja K, Rückert B, Globinska A, Jakiela B, Kast JI, Idzko M, Akdis M, Sanak M, Akdis CA.

J Allergy Clin Immunol. 2017 Jan;139(1):93-103. doi: 10.1016/j.jaci.2016.03.050. Epub 2016 May 11.

PMID:
27312821
24.

Acute exposure to air pollution particulate matter aggravates experimental myocardial infarction in mice by potentiating cytokine secretion from lung macrophages.

Marchini T, Wolf D, Michel NA, Mauler M, Dufner B, Hoppe N, Beckert J, Jäckel M, Magnani N, Duerschmied D, Tasat D, Alvarez S, Reinöhl J, von Zur Muhlen C, Idzko M, Bode C, Hilgendorf I, Evelson P, Zirlik A.

Basic Res Cardiol. 2016 Jul;111(4):44. doi: 10.1007/s00395-016-0562-5. Epub 2016 May 30.

25.

Purinergic Signaling During Immune Cell Trafficking.

Ferrari D, McNamee EN, Idzko M, Gambari R, Eltzschig HK.

Trends Immunol. 2016 Jun;37(6):399-411. doi: 10.1016/j.it.2016.04.004. Epub 2016 Apr 30. Review.

PMID:
27142306
26.

Dendritic Cells Are Involved in the Effects of Exercise in a Model of Asthma.

Mackenzie B, Andrade-Sousa AS, Oliveira-Junior MC, Assumpção-Neto E, Brandão-Rangel MA, Silva-Renno A, Santos-Dias A, Cicko S, Grimm M, Müller T, Oliveira AP, Martins MA, Idzko M, Vieira RP.

Med Sci Sports Exerc. 2016 Aug;48(8):1459-67. doi: 10.1249/MSS.0000000000000927.

PMID:
27015383
27.

Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling.

Pereira PR, Oliveira-Junior MC, Mackenzie B, Chiovatto JE, Matos Y, Greiffo FR, Rigonato-Oliveira NC, Brugemman TR, Delle H, Idzko M, Albertini R, Ligeiro Oliveira AP, Damaceno-Rodrigues NR, Caldini EG, Fernandez IE, Castro-Faria-Neto HC, Dolhnikoff M, Eickelberg O, Vieira RP.

Med Sci Sports Exerc. 2016 Jul;48(7):1276-84. doi: 10.1249/MSS.0000000000000907.

PMID:
26895395
28.

C1P Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Preventing NF-κB Activation in Neutrophils.

Baudiß K, de Paula Vieira R, Cicko S, Ayata K, Hossfeld M, Ehrat N, Gómez-Muñoz A, Eltzschig HK, Idzko M.

J Immunol. 2016 Mar 1;196(5):2319-26. doi: 10.4049/jimmunol.1402681. Epub 2016 Jan 22.

29.

NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD.

Lazar Z, Müllner N, Lucattelli M, Ayata CK, Cicko S, Yegutkin GG, De Cunto G, Müller T, Meyer A, Hossfeld M, Sorichter S, Horvath I, Virchow CJ, Robson SC, Lungarella G, Idzko M.

Eur Respir J. 2016 Jan;47(1):254-63. doi: 10.1183/13993003.02144-2014. Epub 2015 Nov 5.

30.

A Novel Function for P2Y2 in Myeloid Recipient-Derived Cells during Graft-versus-Host Disease.

Klämbt V, Wohlfeil SA, Schwab L, Hülsdünker J, Ayata K, Apostolova P, Schmitt-Graeff A, Dierbach H, Prinz G, Follo M, Prinz M, Idzko M, Zeiser R.

J Immunol. 2015 Dec 15;195(12):5795-804. doi: 10.4049/jimmunol.1501357. Epub 2015 Nov 4.

31.

Altered purinergic signaling in the tumor associated immunologic microenvironment in metastasized non-small-cell lung cancer.

Schmid S, Kübler M, Korcan Ayata C, Lazar Z, Haager B, Hoßfeld M, Meyer A, Cicko S, Elze M, Wiesemann S, Zissel G, Passlick B, Idzko M.

Lung Cancer. 2015 Dec;90(3):516-21. doi: 10.1016/j.lungcan.2015.10.005. Epub 2015 Oct 9.

PMID:
26505137
32.

Uridine supplementation exerts anti-inflammatory and anti-fibrotic effects in an animal model of pulmonary fibrosis.

Cicko S, Grimm M, Ayata K, Beckert J, Meyer A, Hossfeld M, Zissel G, Idzko M, Müller T.

Respir Res. 2015 Sep 15;16:105. doi: 10.1186/s12931-015-0264-9.

33.

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons.

Steculorum SM, Paeger L, Bremser S, Evers N, Hinze Y, Idzko M, Kloppenburg P, Brüning JC.

Cell. 2015 Sep 10;162(6):1404-17. doi: 10.1016/j.cell.2015.08.032.

34.

Purinergic signaling in scarring.

Ferrari D, Gambari R, Idzko M, Müller T, Albanesi C, Pastore S, La Manna G, Robson SC, Cronstein B.

FASEB J. 2016 Jan;30(1):3-12. doi: 10.1096/fj.15-274563. Epub 2015 Sep 2. Review.

35.

Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33.

Calvén J, Akbarshahi H, Menzel M, Ayata CK, Idzko M, Bjermer L, Uller L.

J Transl Med. 2015 Aug 29;13:281. doi: 10.1186/s12967-015-0645-3.

36.

Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a.

Serchov T, Clement HW, Schwarz MK, Iasevoli F, Tosh DK, Idzko M, Jacobson KA, de Bartolomeis A, Normann C, Biber K, van Calker D.

Neuron. 2015 Aug 5;87(3):549-62. doi: 10.1016/j.neuron.2015.07.010.

37.

Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing.

Csóka B, Németh ZH, Törő G, Idzko M, Zech A, Koscsó B, Spolarics Z, Antonioli L, Cseri K, Erdélyi K, Pacher P, Haskó G.

FASEB J. 2015 Sep;29(9):3626-37. doi: 10.1096/fj.15-272450. Epub 2015 Jun 9.

38.

Role of platelets in allergic airway inflammation.

Idzko M, Pitchford S, Page C.

J Allergy Clin Immunol. 2015 Jun;135(6):1416-23. doi: 10.1016/j.jaci.2015.04.028. Review.

PMID:
26051948
39.

MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation.

Chen S, Smith BA, Iype J, Prestipino A, Pfeifer D, Grundmann S, Schmitt-Graeff A, Idzko M, Beck Y, Prinz G, Finke J, Duyster J, Zeiser R.

Blood. 2015 Jul 2;126(1):103-12. doi: 10.1182/blood-2014-12-617258. Epub 2015 May 13.

40.

MicroRNA-155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice.

Zech A, Ayata CK, Pankratz F, Meyer A, Baudiß K, Cicko S, Yegutkin GG, Grundmann S, Idzko M.

Allergy. 2015 Sep;70(9):1121-9. doi: 10.1111/all.12643. Epub 2015 May 28.

PMID:
25944053
41.

Purinergic signaling in atherosclerosis.

Ferrari D, Vitiello L, Idzko M, la Sala A.

Trends Mol Med. 2015 Mar;21(3):184-92. doi: 10.1016/j.molmed.2014.12.008. Epub 2015 Jan 27. Review.

PMID:
25637413
42.

Ceramide-1-phosphate inhibits cigarette smoke-induced airway inflammation.

Baudiß K, Ayata CK, Lazar Z, Cicko S, Beckert J, Meyer A, Zech A, Vieira RP, Bittman R, Gómez-Muñoz A, Merfort I, Idzko M.

Eur Respir J. 2015 Jun;45(6):1669-80. doi: 10.1183/09031936.00080014. Epub 2015 Jan 22.

43.

CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cells.

Kuhny M, Hochdörfer T, Ayata CK, Idzko M, Huber M.

Cell Commun Signal. 2014 Jul 16;12:40. doi: 10.1186/s12964-014-0040-3.

44.

P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice.

Stachon P, Peikert A, Michel NA, Hergeth S, Marchini T, Wolf D, Dufner B, Hoppe N, Ayata CK, Grimm M, Cicko S, Schulte L, Reinöhl J, von zur Muhlen C, Bode C, Idzko M, Zirlik A.

Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2237-45. doi: 10.1161/ATVBAHA.114.303585. Epub 2014 Aug 7.

PMID:
25104800
45.

Extracellular nucleotide and nucleoside signaling in vascular and blood disease.

Idzko M, Ferrari D, Riegel AK, Eltzschig HK.

Blood. 2014 Aug 14;124(7):1029-37. doi: 10.1182/blood-2013-09-402560. Epub 2014 Jul 7. Review.

46.

Dual-contrast molecular imaging allows noninvasive characterization of myocardial ischemia/reperfusion injury after coronary vessel occlusion in mice by magnetic resonance imaging.

von Elverfeldt D, Maier A, Duerschmied D, Braig M, Witsch T, Wang X, Mauler M, Neudorfer I, Menza M, Idzko M, Zirlik A, Heidt T, Bronsert P, Bode C, Peter K, von Zur Muhlen C.

Circulation. 2014 Aug 19;130(8):676-87. doi: 10.1161/CIRCULATIONAHA.113.008157. Epub 2014 Jun 20.

PMID:
24951772
47.

Nucleotide signalling during inflammation.

Idzko M, Ferrari D, Eltzschig HK.

Nature. 2014 May 15;509(7500):310-7. doi: 10.1038/nature13085. Review.

48.

The Nlrp3 inflammasome regulates acute graft-versus-host disease.

Jankovic D, Ganesan J, Bscheider M, Stickel N, Weber FC, Guarda G, Follo M, Pfeifer D, Tardivel A, Ludigs K, Bouazzaoui A, Kerl K, Fischer JC, Haas T, Schmitt-Gräff A, Manoharan A, Müller L, Finke J, Martin SF, Gorka O, Peschel C, Ruland J, Idzko M, Duyster J, Holler E, French LE, Poeck H, Contassot E, Zeiser R.

J Exp Med. 2013 Sep 23;210(10):1899-910. doi: 10.1084/jem.20130084. Epub 2013 Aug 26.

49.

Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK.

Geissler A, Haun F, Frank DO, Wieland K, Simon MM, Idzko M, Davis RJ, Maurer U, Borner C.

Cell Death Differ. 2013 Oct;20(10):1317-29. doi: 10.1038/cdd.2013.78. Epub 2013 Jul 5.

50.

Dependence of immunoglobulin class switch recombination in B cells on vesicular release of ATP and CD73 ectonucleotidase activity.

Schena F, Volpi S, Faliti CE, Penco F, Santi S, Proietti M, Schenk U, Damonte G, Salis A, Bellotti M, Fais F, Tenca C, Gattorno M, Eibel H, Rizzi M, Warnatz K, Idzko M, Ayata CK, Rakhmanov M, Galli T, Martini A, Canossa M, Grassi F, Traggiai E.

Cell Rep. 2013 Jun 27;3(6):1824-31. doi: 10.1016/j.celrep.2013.05.022. Epub 2013 Jun 13.

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