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Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.

Sillen M, Weeks SD, Zhou X, Komissarov AA, Florova G, Idell S, Strelkov SV, Declerck PJ.

J Thromb Haemost. 2019 Dec 19. doi: 10.1111/jth.14716. [Epub ahead of print]


Glycogen Synthase Kinase-3β Inhibition with 9-ING-41 Attenuates the Progression of Pulmonary Fibrosis.

Jeffers A, Qin W, Owens S, Koenig KB, Komatsu S, Giles FJ, Schmitt DM, Idell S, Tucker TA.

Sci Rep. 2019 Dec 12;9(1):18925. doi: 10.1038/s41598-019-55176-w.


Caveolin-1-derived peptide limits development of pulmonary fibrosis.

Marudamuthu AS, Bhandary YP, Fan L, Radhakrishnan V, MacKenzie B, Maier E, Shetty SK, Nagaraja MR, Gopu V, Tiwari N, Zhang Y, Watts AB, Williams RO 3rd, Criner GJ, Bolla S, Marchetti N, Idell S, Shetty S.

Sci Transl Med. 2019 Dec 11;11(522). pii: eaat2848. doi: 10.1126/scitranslmed.aat2848.


Increased expression of plasminogen activator inhibitor-1 (PAI-1) is associated with depression and depressive phenotype in C57Bl/6J mice.

Girard RA, Chauhan PS, Tucker TA, Allen T, Kaur J, Jeffers A, Koenig K, Florova G, Komissarov AA, Gaidenko TA, Chamiso MB, Fowler J, Morris DE, Sarva K, Singh KP, Idell S, Idell RD.

Exp Brain Res. 2019 Dec;237(12):3419-3430. doi: 10.1007/s00221-019-05682-0. Epub 2019 Nov 16.


Influenza Virus Infection Induces ZBP1 Expression and Necroptosis in Mouse Lungs.

Wang Y, Hao Q, Florence JM, Jung BG, Kurdowska AK, Samten B, Idell S, Tang H.

Front Cell Infect Microbiol. 2019 Aug 7;9:286. doi: 10.3389/fcimb.2019.00286. eCollection 2019.


Phase 1 trial of intrapleural LTI-01; single chain urokinase in complicated parapneumonic effusions or empyema.

Beckert L, Brockway B, Simpson G, Southcott AM, Lee YCG, Rahman N, Light RW, Shoemaker S, Gillies J, Komissarov AA, Florova G, Ochran T, Bradley W, Ndetan H, Singh KP, Sarva K, Idell S.

JCI Insight. 2019 Apr 18;5. pii: 127470. doi: 10.1172/jci.insight.127470.


Short-duration hyperoxia causes genotoxicity in mouse lungs: protection by volatile anesthetic isoflurane.

Kundumani-Sridharan V, Subramani J, Raghavan S, Maiti GP, Owens C, Walker T, Wasnick J, Idell S, Das KC.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L903-L917. doi: 10.1152/ajplung.00142.2018. Epub 2019 Feb 27.


Myocardin Is Involved in Mesothelial-Mesenchymal Transition of Human Pleural Mesothelial Cells.

Tucker T, Tsukasaki Y, Sakai T, Mitsuhashi S, Komatsu S, Jeffers A, Idell S, Ikebe M.

Am J Respir Cell Mol Biol. 2019 Jul;61(1):86-96. doi: 10.1165/rcmb.2018-0121OC.


p53 Expression in Lung Fibroblasts Is Linked to Mitigation of Fibrotic Lung Remodeling.

Nagaraja MR, Tiwari N, Shetty SK, Marudamuthu AS, Fan L, Ostrom RS, Fu J, Gopu V, Radhakrishnan V, Idell S, Shetty S.

Am J Pathol. 2018 Oct;188(10):2207-2222. doi: 10.1016/j.ajpath.2018.07.005.


Nebulization of Single-Chain Tissue-Type and Single-Chain Urokinase Plasminogen Activator for Treatment of Inhalational Smoke-Induced Acute Lung Injury.

Surasarang SH, Sahakijpijarn S, Florova G, Komissarov AA, Nelson CL, Perenlei E, Fukuda S, Wolfson MR, Shaffer TH, Idell S, Williams RO 3rd.

J Drug Deliv Sci Technol. 2018 Aug;48:19-27. doi: 10.1016/j.jddst.2018.04.013. Epub 2018 Apr 30.


Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator.

Fukuda S, Enkhbaatar P, Nelson C, Cox RA, Wolfson MR, Shaffer TH, Williams RO 3rd, Surasarang SH, Sawittree S, Florova G, Komissarov AA, Koenig K, Sarva K, Ndetan HT, Singh KP, Idell S.

Clin Transl Med. 2018 Jun 18;7(1):17. doi: 10.1186/s40169-018-0196-3.


Intrapleural Fibrinolytic Therapy for Empyema and Pleural Loculation: Knowns and Unknowns.

Idell S, Rahman NM.

Ann Am Thorac Soc. 2018 May;15(5):515-517. doi: 10.1513/AnnalsATS.201711-848PS. Review. No abstract available.


Fibrin turnover and pleural organization: bench to bedside.

Komissarov AA, Rahman N, Lee YCG, Florova G, Shetty S, Idell R, Ikebe M, Das K, Tucker TA, Idell S.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L757-L768. doi: 10.1152/ajplung.00501.2017. Epub 2018 Jan 18. Review.


Precision-guided, Personalized Intrapleural Fibrinolytic Therapy for Empyema and Complicated Parapneumonic Pleural Effusions: The Case for the Fibrinolytic Potential.

Idell S, Florova G, Shetty S, Tucker T, Idell R, Koenig K, Azghani A, Rahman NM, Komissarov A.

Clin Pulm Med. 2017 Jul;24(4):163-169. doi: 10.1097/CPM.0000000000000216.


Inhibition of Glycogen Synthase Kinase 3β Blocks Mesomesenchymal Transition and Attenuates Streptococcus pneumonia-Mediated Pleural Injury in Mice.

Boren J, Shryock G, Fergis A, Jeffers A, Owens S, Qin W, Koenig KB, Tsukasaki Y, Komatsu S, Ikebe M, Idell S, Tucker TA.

Am J Pathol. 2017 Nov;187(11):2461-2472. doi: 10.1016/j.ajpath.2017.07.007. Erratum in: Am J Pathol. 2018 Jan;188(1):264.


Pathogenesis of pleural infection: A complex warfare.

Popowicz N, Idell S, Lee YCG.

Respirology. 2018 Jan;23(1):8-9. doi: 10.1111/resp.13171. Epub 2017 Sep 19. No abstract available.


Targeting plasminogen activator inhibitor-1 in tetracycline-induced pleural injury in rabbits.

Florova G, Azghani AO, Karandashova S, Schaefer C, Yarovoi SV, Declerck PJ, Cines DB, Idell S, Komissarov AA.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L54-L68. doi: 10.1152/ajplung.00579.2016. Epub 2017 Aug 31.


Formulation for a novel inhaled peptide therapeutic for idiopathic pulmonary fibrosis.

Hengsawas Surasarang S, Florova G, Komissarov AA, Shetty S, Idell S, Williams RO 3rd.

Drug Dev Ind Pharm. 2018 Feb;44(2):184-198. doi: 10.1080/03639045.2017.1371736. Epub 2017 Nov 10.


KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis.

Kamata H, Tsukasaki Y, Sakai T, Ikebe R, Wang J, Jeffers A, Boren J, Owens S, Suzuki T, Higashihara M, Idell S, Tucker TA, Ikebe M.

Sci Rep. 2017 Jul 4;7(1):4556. doi: 10.1038/s41598-017-04437-7.


Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells.

Puthusseri B, Marudamuthu A, Tiwari N, Fu J, Idell S, Shetty S.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L783-L796. doi: 10.1152/ajplung.00291.2016. Epub 2017 Apr 6.


p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis.

Shetty SK, Tiwari N, Marudamuthu AS, Puthusseri B, Bhandary YP, Fu J, Levin J, Idell S, Shetty S.

Am J Pathol. 2017 May;187(5):1016-1034. doi: 10.1016/j.ajpath.2016.12.020. Epub 2017 Mar 6.


The fibrinolytic system: A new target for treatment of depression with psychedelics.

Idell RD, Florova G, Komissarov AA, Shetty S, Girard RB, Idell S.

Med Hypotheses. 2017 Mar;100:46-53. doi: 10.1016/j.mehy.2017.01.013. Epub 2017 Jan 23.


Interferon-γ promotes double-stranded RNA-induced TLR3-dependent apoptosis via upregulation of transcription factor Runx3 in airway epithelial cells.

Gan H, Hao Q, Idell S, Tang H.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1101-L1112. doi: 10.1152/ajplung.00278.2016. Epub 2016 Oct 28.


Translational Research in Pleural Infection and Beyond.

Lee YC, Idell S, Stathopoulos GT.

Chest. 2016 Dec;150(6):1361-1370. doi: 10.1016/j.chest.2016.07.030. Epub 2016 Aug 10. Review.


Dose dependency of outcomes of intrapleural fibrinolytic therapy in new rabbit empyema models.

Komissarov AA, Florova G, Azghani AO, Buchanan A, Boren J, Allen T, Rahman NM, Koenig K, Chamiso M, Karandashova S, Henry J, Idell S.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L389-99. doi: 10.1152/ajplung.00171.2016. Epub 2016 Jun 24.


Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency.

Tucker TA, Jeffers A, Boren J, Quaid B, Owens S, Koenig KB, Tsukasaki Y, Florova G, Komissarov AA, Ikebe M, Idell S.

Clin Transl Med. 2016 Dec;5(1):17. doi: 10.1186/s40169-016-0097-2. Epub 2016 May 13.


Mitochondrial Reprogramming Regulates Breast Cancer Progression.

Kannan A, Wells RB, Sivakumar S, Komatsu S, Singh KP, Samten B, Philley JV, Sauter ER, Ikebe M, Idell S, Gupta S, Dasgupta S.

Clin Cancer Res. 2016 Jul 1;22(13):3348-60. doi: 10.1158/1078-0432.CCR-15-2456. Epub 2016 Feb 17.


Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.

Venkatasubramanian S, Tripathi D, Tucker T, Paidipally P, Cheekatla S, Welch E, Raghunath A, Jeffers A, Tvinnereim AR, Schechter ME, Andrade BB, Mackman N, Idell S, Vankayalapati R.

Eur J Immunol. 2016 Feb;46(2):464-79. doi: 10.1002/eji.201545817. Epub 2015 Nov 10.


The time course of resolution of adhesions during fibrinolytic therapy in tetracycline-induced pleural injury in rabbits.

Komissarov AA, Florova G, Azghani AO, Buchanan A, Bradley WM, Schaefer C, Koenig K, Idell S.

Am J Physiol Lung Cell Mol Physiol. 2015 Sep 15;309(6):L562-72. doi: 10.1152/ajplung.00136.2015. Epub 2015 Jul 10.


Plasminogen activator inhibitor-1 in cigarette smoke exposure and influenza A virus infection-induced lung injury.

Bhandary YP, Shetty SK, Marudamuthu AS, Midde KK, Ji HL, Shams H, Subramaniam R, Fu J, Idell S, Shetty S.

PLoS One. 2015 May 1;10(5):e0123187. doi: 10.1371/journal.pone.0123187. eCollection 2015.


Mesomesenchymal transition of pleural mesothelial cells is PI3K and NF-κB dependent.

Owens S, Jeffers A, Boren J, Tsukasaki Y, Koenig K, Ikebe M, Idell S, Tucker TA.

Am J Physiol Lung Cell Mol Physiol. 2015 Jun 15;308(12):L1265-73. doi: 10.1152/ajplung.00396.2014. Epub 2015 Apr 17.


Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrotic lungs.

Marudamuthu AS, Shetty SK, Bhandary YP, Karandashova S, Thompson M, Sathish V, Florova G, Hogan TB, Pabelick CM, Prakash YS, Tsukasaki Y, Fu J, Ikebe M, Idell S, Shetty S.

J Biol Chem. 2015 Apr 10;290(15):9428-41. doi: 10.1074/jbc.M114.601815. Epub 2015 Feb 3.


Correlation of apical fluid-regulating channel proteins with lung function in human COPD lungs.

Zhao R, Liang X, Zhao M, Liu SL, Huang Y, Idell S, Li X, Ji HL.

PLoS One. 2014 Oct 17;9(10):e109725. doi: 10.1371/journal.pone.0109725. eCollection 2014.


Thrombin down-regulates tissue factor pathway inhibitor expression in a PI3K/nuclear factor-κB-dependent manner in human pleural mesothelial cells.

Jeffers A, Owens S, Koenig K, Quaid B, Pendurthi UR, Rao VM, Idell S, Tucker TA.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):674-82. doi: 10.1165/rcmb.2014-0084OC.



Colice GL, Idell S.

Chest. 2014 Sep;146(3):e104-e105. doi: 10.1378/chest.14-0920. No abstract available.


Regulation of epithelial sodium channels in urokinase plasminogen activator deficiency.

Chen Z, Zhao R, Zhao M, Liang X, Bhattarai D, Dhiman R, Shetty S, Idell S, Ji HL.

Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L609-17. doi: 10.1152/ajplung.00126.2014. Epub 2014 Aug 29.


Targeting of plasminogen activator inhibitor 1 improves fibrinolytic therapy for tetracycline-induced pleural injury in rabbits.

Florova G, Azghani A, Karandashova S, Schaefer C, Koenig K, Stewart-Evans K, Declerck PJ, Idell S, Komissarov AA.

Am J Respir Cell Mol Biol. 2015 Apr;52(4):429-37. doi: 10.1165/rcmb.2014-0168OC.


Protein kinase D is increased and activated in lung epithelial cells and macrophages in idiopathic pulmonary fibrosis.

Gan H, McKenzie R, Hao Q, Idell S, Tang H.

PLoS One. 2014 Jul 7;9(7):e101983. doi: 10.1371/journal.pone.0101983. eCollection 2014.


Rebuttal from Drs Colice and Idell.

Colice GL, Idell S.

Chest. 2014 Jan;145(1):21-23. doi: 10.1378/chest.13-2357. No abstract available.


Counterpoint: should fibrinolytics be routinely administered intrapleurally for management of a complicated parapneumonic effusion? No.

Colice GL, Idell S.

Chest. 2014 Jan;145(1):17-20. doi: 10.1378/chest.13-2356. No abstract available.


Mechanism of fibroblast inflammatory responses to Pseudomonas aeruginosa elastase.

Azghani AO, Neal K, Idell S, Amaro R, Baker JW, Omri A, Pendurthi UR.

Microbiology. 2014 Mar;160(Pt 3):547-555. doi: 10.1099/mic.0.075325-0. Epub 2014 Jan 2.


Plasminogen activator inhibitor-1 deficiency augments visceral mesothelial organization, intrapleural coagulation, and lung restriction in mice with carbon black/bleomycin-induced pleural injury.

Tucker TA, Jeffers A, Alvarez A, Owens S, Koenig K, Quaid B, Komissarov AA, Florova G, Kothari H, Pendurthi U, Mohan Rao LV, Idell S.

Am J Respir Cell Mol Biol. 2014 Feb;50(2):316-27. doi: 10.1165/rcmb.2013-0300OC.


Active α-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids.

Komissarov AA, Florova G, Azghani A, Karandashova S, Kurdowska AK, Idell S.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L682-92. doi: 10.1152/ajplung.00102.2013. Epub 2013 Aug 30.


Remarkable stabilization of plasminogen activator inhibitor 1 in a "molecular sandwich" complex.

Florova G, Karandashova S, Declerck PJ, Idell S, Komissarov AA.

Biochemistry. 2013 Jul 9;52(27):4697-709. doi: 10.1021/bi400470s. Epub 2013 Jun 25.


Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1.

Bhandary YP, Shetty SK, Marudamuthu AS, Ji HL, Neuenschwander PF, Boggaram V, Morris GF, Fu J, Idell S, Shetty S.

Am J Pathol. 2013 Jul;183(1):131-43. doi: 10.1016/j.ajpath.2013.03.022. Epub 2013 May 8.


Endothelial cell protein C receptor opposes mesothelioma growth driven by tissue factor.

Keshava S, Sahoo S, Tucker TA, Idell S, Rao LV, Pendurthi UR.

Cancer Res. 2013 Jul 1;73(13):3963-73. doi: 10.1158/0008-5472.CAN-12-1690. Epub 2013 Mar 28.


Plasminogen-plasmin system in the pathogenesis and treatment of lung and pleural injury.

Tucker T, Idell S.

Semin Thromb Hemost. 2013 Jun;39(4):373-81. doi: 10.1055/s-0033-1334486. Epub 2013 Mar 16. Review.


Novel aspects of urokinase function in the injured lung: role of α2-macroglobulin.

Komissarov AA, Stankowska D, Krupa A, Fudala R, Florova G, Florence J, Fol M, Allen TC, Idell S, Matthay MA, Kurdowska AK.

Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15;303(12):L1037-45. doi: 10.1152/ajplung.00117.2012. Epub 2012 Oct 12.


Intrapleural adenoviral delivery of human plasminogen activator inhibitor-1 exacerbates tetracycline-induced pleural injury in rabbits.

Karandashova S, Florova G, Azghani AO, Komissarov AA, Koenig K, Tucker TA, Allen TC, Stewart K, Tvinnereim A, Idell S.

Am J Respir Cell Mol Biol. 2013 Jan;48(1):44-52. doi: 10.1165/rcmb.2012-0183OC. Epub 2012 Sep 20.

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