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PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury.

Takahata K, Kimura Y, Sahara N, Koga S, Shimada H, Ichise M, Saito F, Moriguchi S, Kitamura S, Kubota M, Umeda S, Niwa F, Mizushima J, Morimoto Y, Funayama M, Tabuchi H, Bieniek KF, Kawamura K, Zhang MR, Dickson DW, Mimura M, Kato M, Suhara T, Higuchi M.

Brain. 2019 Oct 1;142(10):3265-3279. doi: 10.1093/brain/awz238.


In vivo binding of a tau imaging probe, [11 C]PBB3, in patients with progressive supranuclear palsy.

Endo H, Shimada H, Sahara N, Ono M, Koga S, Kitamura S, Niwa F, Hirano S, Kimura Y, Ichise M, Shinotoh H, Zhang MR, Kuwabara S, Dickson DW, Toda T, Suhara T, Higuchi M.

Mov Disord. 2019 May;34(5):744-754. doi: 10.1002/mds.27643. Epub 2019 Mar 20.


Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula.

Shinotoh H, Shimada H, Kokubo Y, Tagai K, Niwa F, Kitamura S, Endo H, Ono M, Kimura Y, Hirano S, Mimuro M, Ichise M, Sahara N, Zhang MR, Suhara T, Higuchi M.

Neurology. 2019 Jan 8;92(2):e136-e147. doi: 10.1212/WNL.0000000000006736. Epub 2018 Dec 7.


Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans.

Ito T, Kimura Y, Seki C, Ichise M, Yokokawa K, Kawamura K, Takahashi H, Higuchi M, Zhang MR, Suhara T, Yamada M.

EJNMMI Res. 2018 Jun 14;8(1):48. doi: 10.1186/s13550-018-0406-4.


Neuromolecular basis of faded perception associated with unreality experience.

Yokokawa K, Ito T, Takahata K, Takano H, Kimura Y, Ichise M, Ikoma Y, Isato A, Zhang MR, Kawamura K, Ito H, Takahashi H, Suhara T, Yamada M.

Sci Rep. 2018 May 23;8(1):8062. doi: 10.1038/s41598-018-26382-9.


Correction: Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain.

Ishii T, Kimura Y, Ichise M, Takahata K, Kitamura S, Moriguchi S, Kubota M, Zhang MR, Yamada M, Higuchi M, Okubo Y, Suhara T.

PLoS One. 2018 May 7;13(5):e0197201. doi: 10.1371/journal.pone.0197201. eCollection 2018.


Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres.

Nørgaard M, Ganz M, Svarer C, Feng L, Ichise M, Lanzenberger R, Lubberink M, Parsey RV, Politis M, Rabiner EA, Slifstein M, Sossi V, Suhara T, Talbot PS, Turkheimer F, Strother SC, Knudsen GM.

J Cereb Blood Flow Metab. 2019 Feb;39(2):210-222. doi: 10.1177/0271678X18770107. Epub 2018 Apr 13.


Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes.

Naganawa M, Lim K, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Herold KC, Huang Y, Harris P, Ichise M, Cline GW, Carson RE.

Mol Imaging Biol. 2018 Oct;20(5):835-845. doi: 10.1007/s11307-018-1170-6.


Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain.

Ishii T, Kimura Y, Ichise M, Takahata K, Kitamura S, Moriguchi S, Kubota M, Zhang MR, Yamada M, Higuchi M, Okubo Y, Suhara T.

PLoS One. 2017 Dec 8;12(12):e0189318. doi: 10.1371/journal.pone.0189318. eCollection 2017. Erratum in: PLoS One. 2018 May 7;13(5):e0197201.


Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females.

Tuominen L, Miettunen J, Cannon DM, Drevets WC, Frokjaer VG, Hirvonen J, Ichise M, Jensen PS, Keltikangas-Järvinen L, Klaver JM, Knudsen GM, Takano A, Suhara T, Hietala J.

Int J Neuropsychopharmacol. 2017 Dec 1;20(12):963-970. doi: 10.1093/ijnp/pyx071.


Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D2.

Moriguchi S, Takano H, Kimura Y, Nagashima T, Takahata K, Kubota M, Kitamura S, Ishii T, Ichise M, Zhang MR, Shimada H, Mimura M, Meyer JH, Higuchi M, Suhara T.

Int J Neuropsychopharmacol. 2017 Dec 1;20(12):957-962. doi: 10.1093/ijnp/pyx069.


A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors.

Takahata K, Kimura Y, Seki C, Tokunaga M, Ichise M, Kawamura K, Ono M, Kitamura S, Kubota M, Moriguchi S, Ishii T, Takado Y, Niwa F, Endo H, Nagashima T, Ikoma Y, Zhang MR, Suhara T, Higuchi M.

EJNMMI Res. 2017 Aug 16;7(1):63. doi: 10.1186/s13550-017-0313-0.


Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis.

Ito H, Ikoma Y, Seki C, Kimura Y, Kawaguchi H, Takuwa H, Ichise M, Suhara T, Kanno I.

Ann Nucl Med. 2017 May;31(4):273-282. doi: 10.1007/s12149-017-1155-6. Epub 2017 Feb 8.


PET Quantification of the Norepinephrine Transporter in Human Brain with (S,S)-18F-FMeNER-D2.

Moriguchi S, Kimura Y, Ichise M, Arakawa R, Takano H, Seki C, Ikoma Y, Takahata K, Nagashima T, Yamada M, Mimura M, Suhara T.

J Nucl Med. 2017 Jul;58(7):1140-1145. doi: 10.2967/jnumed.116.178913. Epub 2016 Dec 15.


Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons.

Naganawa M, Lin SF, Lim K, Labaree D, Ropchan J, Harris P, Huang Y, Ichise M, Carson RE, Cline GW.

Nucl Med Biol. 2016 Dec;43(12):743-751. doi: 10.1016/j.nucmedbio.2016.08.018. Epub 2016 Sep 2.


Positron Emission Tomography.

Lameka K, Farwell MD, Ichise M.

Handb Clin Neurol. 2016;135:209-227. doi: 10.1016/B978-0-444-53485-9.00011-8. Review.


Transient and chronic seizure-induced inflammation in human focal epilepsy.

Butler T, Li Y, Tsui W, Friedman D, Maoz A, Wang X, Harvey P, Tanzi E, Morim S, Kang Y, Mosconi L, Talos D, Kuzniecky R, Vallhabjosula S, Thesen T, Glodzik L, Ichise M, Silbersweig D, Stern E, de Leon MJ, French J.

Epilepsia. 2016 Sep;57(9):e191-4. doi: 10.1111/epi.13457. Epub 2016 Jul 6.


A new method to quantify tau pathologies with (11)C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter.

Kimura Y, Endo H, Ichise M, Shimada H, Seki C, Ikoma Y, Shinotoh H, Yamada M, Higuchi M, Zhang MR, Suhara T.

EJNMMI Res. 2016 Dec;6(1):24. doi: 10.1186/s13550-016-0182-y. Epub 2016 Mar 12.


[(11)C]TASP457, a novel PET ligand for histamine H3 receptors in human brain.

Kimura Y, Seki C, Ikoma Y, Ichise M, Kawamura K, Takahata K, Moriguchi S, Nagashima T, Ishii T, Kitamura S, Niwa F, Endo H, Yamada M, Higuchi M, Zhang MR, Suhara T.

Eur J Nucl Med Mol Imaging. 2016 Aug;43(9):1653-63. doi: 10.1007/s00259-016-3332-6. Epub 2016 Feb 23.


Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial.

Luchsinger JA, Perez T, Chang H, Mehta P, Steffener J, Pradabhan G, Ichise M, Manly J, Devanand DP, Bagiella E.

J Alzheimers Dis. 2016;51(2):501-14. doi: 10.3233/JAD-150493.


Cross-sectional and Test-Retest Characterization of PET with [(18)F]FP-(+)-DTBZ for β Cell Mass Estimates in Diabetes.

Freeby MJ, Kringas P, Goland RS, Leibel RL, Maffei A, Divgi C, Ichise M, Harris PE.

Mol Imaging Biol. 2016 Apr;18(2):292-301. doi: 10.1007/s11307-015-0888-7. Epub 2015 Sep 14.


Brain Amyloid Deposition and Longitudinal Cognitive Decline in Nondemented Older Subjects: Results from a Multi-Ethnic Population.

Gu Y, Razlighi QR, Zahodne LB, Janicki SC, Ichise M, Manly JJ, Devanand DP, Brickman AM, Schupf N, Mayeux R, Stern Y.

PLoS One. 2015 Jul 29;10(7):e0123743. doi: 10.1371/journal.pone.0123743. eCollection 2015.


PET Quantification of Tau Pathology in Human Brain with 11C-PBB3.

Kimura Y, Ichise M, Ito H, Shimada H, Ikoma Y, Seki C, Takano H, Kitamura S, Shinotoh H, Kawamura K, Zhang MR, Sahara N, Suhara T, Higuchi M.

J Nucl Med. 2015 Sep;56(9):1359-65. doi: 10.2967/jnumed.115.160127. Epub 2015 Jul 16.


Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated.

Brickman AM, Guzman VA, Gonzalez-Castellon M, Razlighi Q, Gu Y, Narkhede A, Janicki S, Ichise M, Stern Y, Manly JJ, Schupf N, Marshall RS.

Neurosci Lett. 2015 Apr 10;592:54-8. doi: 10.1016/j.neulet.2015.03.005. Epub 2015 Mar 4.


A case of immunogammaglobulin 4-related disease.

Miloushev VZ, Cabrera MR, Ichise M.

Clin Nucl Med. 2014 Jun;39(6):537-9. doi: 10.1097/RLU.0000000000000437.


Clinical utility of 18F-FDG positron emission tomography in malignant peritoneal mesothelioma.

Domènech-Vilardell A, Rasiej MJ, Taub RN, Ichise M.

Q J Nucl Med Mol Imaging. 2016 Mar;60(1):54-61. Epub 2014 Apr 14.


Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.

Farwell MD, Chong DJ, Iida Y, Bae SA, Easwaramoorthy B, Ichise M.

Ann Nucl Med. 2013 Aug;27(7):618-24. doi: 10.1007/s12149-013-0725-5. Epub 2013 Apr 10.


PET quantification of 18F-florbetaben binding to β-amyloid deposits in human brains.

Becker GA, Ichise M, Barthel H, Luthardt J, Patt M, Seese A, Schultze-Mosgau M, Rohde B, Gertz HJ, Reininger C, Sabri O.

J Nucl Med. 2013 May;54(5):723-31. doi: 10.2967/jnumed.112.107185. Epub 2013 Mar 7.


PET quantification of pancreatic VMAT 2 binding using (+) and (-) enantiomers of [¹⁸F]FP-DTBZ in baboons.

Harris PE, Farwell MD, Ichise M.

Nucl Med Biol. 2013 Jan;40(1):60-4. doi: 10.1016/j.nucmedbio.2012.09.003. Epub 2012 Oct 26.


Gender-specific abnormalities in the serotonin transporter system in panic disorder.

Cannon DM, Klaver JM, Klug SA, Carlson PJ, Luckenbaugh DA, Ichise M, Drevets WC.

Int J Neuropsychopharmacol. 2013 May;16(4):733-43. doi: 10.1017/S1461145712000776. Epub 2012 Sep 6.


The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis.

Holland CM, Charil A, Csapo I, Liptak Z, Ichise M, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR.

J Neuroimaging. 2012 Apr;22(2):129-36. doi: 10.1111/j.1552-6569.2011.00585.x. Epub 2011 Mar 29.


Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia.

Butler T, Ichise M, Teich AF, Gerard E, Osborne J, French J, Devinsky O, Kuzniecky R, Gilliam F, Pervez F, Provenzano F, Goldsmith S, Vallabhajosula S, Stern E, Silbersweig D.

J Neuroimaging. 2013 Jan;23(1):129-31. doi: 10.1111/j.1552-6569.2010.00572.x. Epub 2011 Jan 11.


Kinetic analysis and quantification of the dopamine transporter in the nonhuman primate brain with 11C-PE2I and 18F-FE-PE2I.

Varrone A, Tóth M, Steiger C, Takano A, Guilloteau D, Ichise M, Gulyás B, Halldin C.

J Nucl Med. 2011 Jan;52(1):132-9. doi: 10.2967/jnumed.110.077651.


F-18 FDG PET imaging of chronic traumatic brain injury in boxers: a statistical parametric analysis.

Provenzano FA, Jordan B, Tikofsky RS, Saxena C, Van Heertum RL, Ichise M.

Nucl Med Commun. 2010 Nov;31(11):952-7. doi: 10.1097/MNM.0b013e32833e37c4.


Imaging of beta-cell mass and function.

Ichise M, Harris PE.

J Nucl Med. 2010 Jul;51(7):1001-4. doi: 10.2967/jnumed.109.068999. Epub 2010 Jun 16. Review.


Epilepsy duration impacts on brain glucose metabolism in temporal lobe epilepsy: results of voxel-based mapping.

Akman CI, Ichise M, Olsavsky A, Tikofsky RS, Van Heertum RL, Gilliam F.

Epilepsy Behav. 2010 Mar;17(3):373-80. doi: 10.1016/j.yebeh.2009.12.007. Epub 2010 Feb 10.


Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [(11)C]PK11195 in rats.

Ito F, Toyama H, Kudo G, Suzuki H, Hatano K, Ichise M, Katada K, Ito K, Sawada M.

Ann Nucl Med. 2010 Apr;24(3):163-9. doi: 10.1007/s12149-009-0339-0. Epub 2010 Jan 26.


Procedure guideline for brain perfusion SPECT using (99m)Tc radiopharmaceuticals 3.0.

Juni JE, Waxman AD, Devous MD Sr, Tikofsky RS, Ichise M, Van Heertum RL, Carretta RF, Chen CC; Society for Nuclear Medicine.

J Nucl Med Technol. 2009 Sep;37(3):191-5. doi: 10.2967/jnmt.109.067850. Epub 2009 Aug 19. No abstract available.


Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study.

Matsumoto R, Ichise M, Ito H, Ando T, Takahashi H, Ikoma Y, Kosaka J, Arakawa R, Fujimura Y, Ota M, Takano A, Fukui K, Nakayama K, Suhara T.

Neuroimage. 2010 Jan 1;49(1):121-6. doi: 10.1016/j.neuroimage.2009.07.069. Epub 2009 Aug 4.


A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies.

Ito H, Yokoi T, Ikoma Y, Shidahara M, Seki C, Naganawa M, Takahashi H, Takano H, Kimura Y, Ichise M, Suhara T.

Neuroimage. 2010 Jan 1;49(1):578-86. doi: 10.1016/j.neuroimage.2009.07.021. Epub 2009 Jul 23.


11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.

Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, Butler PC, Van Heertum R, Leibel RL, Ichise M, Harris PE.

J Nucl Med. 2009 Mar;50(3):382-9. doi: 10.2967/jnumed.108.054866. Epub 2009 Feb 17. Erratum in: J Nucl Med. 2009 Oct;50(10):1578.


VMAT2 quantitation by PET as a biomarker for beta-cell mass in health and disease.

Freeby M, Goland R, Ichise M, Maffei A, Leibel R, Harris P.

Diabetes Obes Metab. 2008 Nov;10 Suppl 4:98-108. doi: 10.1111/j.1463-1326.2008.00943.x.


Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists.

Xie Y, Raffo A, Ichise M, Deng S, Harris PE, Landry DW.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5111-4. doi: 10.1016/j.bmcl.2008.07.129. Epub 2008 Aug 7.


In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [11C]PK-11195 and animal PET following ethanol injury in rat striatum.

Toyama H, Hatano K, Suzuki H, Ichise M, Momosaki S, Kudo G, Ito F, Kato T, Yamaguchi H, Katada K, Sawada M, Ito K.

Ann Nucl Med. 2008 Jun;22(5):417-24. doi: 10.1007/s12149-008-0136-1. Epub 2008 Jul 4.


Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder.

Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS, Manji HK, Drevets WC.

Biol Psychiatry. 2007 Oct 15;62(8):870-7. Epub 2007 Aug 2.


Noninvasive estimation of normalized distribution volume: application to the muscarinic-2 ligand [(18)F]FP-TZTP.

Ichise M, Cohen RM, Carson RE.

J Cereb Blood Flow Metab. 2008 Feb;28(2):420-30. Epub 2007 Jul 25.


Synthesis and initial evaluation of [11C](R)-RWAY in monkey-a new, simply labeled antagonist radioligand for imaging brain 5-HT1A receptors with PET.

McCarron JA, Zoghbi SS, Shetty HU, Vermeulen ES, Wikström HV, Ichise M, Yasuno F, Halldin C, Innis RB, Pike VW.

Eur J Nucl Med Mol Imaging. 2007 Oct;34(10):1670-82. Epub 2007 Jun 20.


Consensus nomenclature for in vivo imaging of reversibly binding radioligands.

Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE.

J Cereb Blood Flow Metab. 2007 Sep;27(9):1533-9. Epub 2007 May 9. Review.


PET imaging of neurokinin-1 receptors with [(18)F]SPA-RQ in human subjects: assessment of reference tissue models and their test-retest reproducibility.

Yasuno F, Sanabria SM, Burns D, Hargreaves RJ, Ghose S, Ichise M, Chin FT, Morse CL, Pike VW, Innis RB.

Synapse. 2007 Apr;61(4):242-51.

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