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Items: 10


Drug responses are conserved across patient-derived xenograft models of melanoma leading to identification of novel drug combination therapies.

Ice RJ, Chen M, Sidorov M, Le Ho T, Woo RWL, Rodriguez-Brotons A, Luu T, Jian D, Kim KB, Leong SP, Kim H, Kim A, Stone D, Nazarian A, Oh A, Tranah GJ, Nosrati M, de Semir D, Dar AA, Chang S, Desprez PY, Kashani-Sabet M, Soroceanu L, McAllister SD.

Br J Cancer. 2019 Dec 20. doi: 10.1038/s41416-019-0696-y. [Epub ahead of print]


Durable multitransgene expression in vivo using systemic, nonviral DNA delivery.

Handumrongkul C, Ye AL, Chmura SA, Soroceanu L, Mack M, Ice RJ, Thistle R, Myers M, Ursu SJ, Liu Y, Kashani-Sabet M, Heath TD, Liggitt D, Lewis DB, Debs R.

Sci Adv. 2019 Nov 27;5(11):eaax0217. doi: 10.1126/sciadv.aax0217. eCollection 2019 Nov.


Combination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer.

Kozyreva VK, Kiseleva AA, Ice RJ, Jones BC, Loskutov YV, Matalkah F, Smolkin MB, Marinak K, Livengood RH, Salkeni MA, Wen S, Hazard HW, Layne GP, Walsh CM, Cantrell PS, Kilby GW, Mahavadi S, Shah N, Pugacheva EN.

Mol Cancer Ther. 2016 Aug;15(8):1809-22. doi: 10.1158/1535-7163.MCT-15-0688. Epub 2016 May 27.


Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival.

Lin CC, Sharma SB, Farrugia MK, McLaughlin SL, Ice RJ, Loskutov YV, Pugacheva EN, Brundage KM, Chen D, Ruppert JM.

Oncogenesis. 2015 Jun 8;4:e155. doi: 10.1038/oncsis.2015.8.


Prometastatic NEDD9 Regulates Individual Cell Migration via Caveolin-1-Dependent Trafficking of Integrins.

Kozyulina PY, Loskutov YV, Kozyreva VK, Rajulapati A, Ice RJ, Jones BC, Pugacheva EN.

Mol Cancer Res. 2015 Mar;13(3):423-38. doi: 10.1158/1541-7786.MCR-14-0353. Epub 2014 Oct 15.


NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer.

Loskutov YV, Kozyulina PY, Kozyreva VK, Ice RJ, Jones BC, Roston TJ, Smolkin MB, Ivanov AV, Wysolmerski RB, Pugacheva EN.

Oncogene. 2015 Jul;34(28):3662-75. doi: 10.1038/onc.2014.297. Epub 2014 Sep 22.


NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.

Kozyreva VK, McLaughlin SL, Livengood RH, Calkins RA, Kelley LC, Rajulapati A, Ice RJ, Smolkin MB, Weed SA, Pugacheva EN.

Mol Cancer Res. 2014 May;12(5):681-93. doi: 10.1158/1541-7786.MCR-13-0654. Epub 2014 Feb 26.


NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.

McLaughlin SL, Ice RJ, Rajulapati A, Kozyulina PY, Livengood RH, Kozyreva VK, Loskutov YV, Culp MV, Weed SA, Ivanov AV, Pugacheva EN.

Mol Cancer Res. 2014 Jan;12(1):69-81. doi: 10.1158/1541-7786.MCR-13-0300. Epub 2013 Nov 7.


NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors.

Ice RJ, McLaughlin SL, Livengood RH, Culp MV, Eddy ER, Ivanov AV, Pugacheva EN.

Cancer Res. 2013 May 15;73(10):3168-80. doi: 10.1158/0008-5472.CAN-12-4008. Epub 2013 Mar 28.


Comment on "Nervy links protein kinase A to plexin-mediated semaphorin repulsion".

Ice RJ, Wildonger J, Mann RS, Hiebert SW.

Science. 2005 Jul 22;309(5734):558; author reply 558. No abstract available.

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