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Items: 9

1.

The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer.

Ghosh P, Swanson L, Sayed IM, Mittal Y, Lim BB, Ibeawuchi SR, Foretz M, Viollet B, Sahoo D, Das S.

Life Sci Alliance. 2020 Feb 10;3(3). pii: e201900481. doi: 10.26508/lsa.201900481. Print 2020 Mar.

2.

Host engulfment pathway controls inflammation in inflammatory bowel disease.

Sayed IM, Suarez K, Lim E, Singh S, Pereira M, Ibeawuchi SR, Katkar G, Dunkel Y, Mittal Y, Chattopadhyay R, Guma M, Boland BS, Dulai PS, Sandborn WJ, Ghosh P, Das S.

FEBS J. 2020 Jan 30. doi: 10.1111/febs.15236. [Epub ahead of print]

PMID:
32003126
3.

RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity.

Mukohda M, Fang S, Wu J, Agbor LN, Nair AR, Ibeawuchi SC, Hu C, Liu X, Lu KT, Guo DF, Davis DR, Keen HL, Quelle FW, Sigmund CD.

J Clin Invest. 2019 Mar 21;129(6):2318-2332. doi: 10.1172/JCI123462.

4.

Retinol-binding protein 7 is an endothelium-specific PPAR╬│ cofactor mediating an antioxidant response through adiponectin.

Hu C, Keen HL, Lu KT, Liu X, Wu J, Davis DR, Ibeawuchi SC, Vogel S, Quelle FW, Sigmund CD.

JCI Insight. 2017 Mar 23;2(6):e91738. doi: 10.1172/jci.insight.91738.

5.

Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism.

Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD.

JCI Insight. 2016 Nov 17;1(19):e91015. doi: 10.1172/jci.insight.91015.

6.

RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation.

Yang J, Platt LT, Maity B, Ahlers KE, Luo Z, Lin Z, Chakravarti B, Ibeawuchi SR, Askeland RW, Bondaruk J, Czerniak BA, Fisher RA.

Oncotarget. 2016 Oct 25;7(43):69159-69172. doi: 10.18632/oncotarget.12473.

7.

Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.

Ibeawuchi SR, Agbor LN, Quelle FW, Sigmund CD.

J Biol Chem. 2015 Jul 31;290(31):19208-17. doi: 10.1074/jbc.M115.645358. Epub 2015 Jun 22.

8.

Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPAR╬│ and RhoA/Rho-kinase.

Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi SR, Keen HL, Weatherford ET, Faraci FM, Sigmund CD.

Cell Metab. 2012 Oct 3;16(4):462-72. doi: 10.1016/j.cmet.2012.08.011.

9.

RGS6, a modulator of parasympathetic activation in heart.

Yang J, Huang J, Maity B, Gao Z, Lorca RA, Gudmundsson H, Li J, Stewart A, Swaminathan PD, Ibeawuchi SR, Shepherd A, Chen CK, Kutschke W, Mohler PJ, Mohapatra DP, Anderson ME, Fisher RA.

Circ Res. 2010 Nov 26;107(11):1345-9. doi: 10.1161/CIRCRESAHA.110.224220. Epub 2010 Sep 23.

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