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Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model.

Fu CH, Iascone DM, Petrof I, Hazra A, Zhang X, Pyfer MS, Tosi U, Corbett BF, Cai J, Lee J, Park J, Iacovitti L, Scharfman HE, Enikolopov G, Chin J.

Cell Rep. 2019 Jun 25;27(13):3741-3751.e4. doi: 10.1016/j.celrep.2019.05.101.


Sphenopalatine ganglion stimulation is a reversible and frequency-dependent modulator of the blood-brain barrier.

Schmidt RF, Theofanis TN, Lang MJ, Stricsek GP, Lin R, Lebrun A, Hooper DC, Rosenwasser RH, Sharan AD, Iacovitti L.

Brain Res. 2019 Sep 1;1718:231-241. doi: 10.1016/j.brainres.2019.04.030. Epub 2019 Apr 26.


Subregional differences in astrocytes underlie selective neurodegeneration or protection in Parkinson's disease models in culture.

Kostuk EW, Cai J, Iacovitti L.

Glia. 2019 Aug;67(8):1542-1557. doi: 10.1002/glia.23627. Epub 2019 Apr 26.


Systemic Factors Trigger Vasculature Cells to Drive Notch Signaling and Neurogenesis in Neural Stem Cells in the Adult Brain.

Lin R, Cai J, Kenyon L, Iozzo R, Rosenwasser R, Iacovitti L.

Stem Cells. 2019 Mar;37(3):395-406. doi: 10.1002/stem.2947. Epub 2018 Dec 30.


Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson's disease.

Kostuk EW, Cai J, Iacovitti L.

J Neuroinflammation. 2018 May 11;15(1):139. doi: 10.1186/s12974-018-1181-x.


Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke.

Lin R, Lang M, Heinsinger N, Stricsek G, Zhang J, Iozzo R, Rosenwasser R, Iacovitti L.

Neurobiol Dis. 2018 Jul;115:49-58. doi: 10.1016/j.nbd.2018.03.013. Epub 2018 Mar 29.


Differential Response in Novel Stem Cell Niches of the Brain after Cervical Spinal Cord Injury and Traumatic Brain Injury.

Falnikar A, Stratton J, Lin R, Andrews CE, Tyburski A, Trovillion VA, Gottschalk C, Ghosh B, Iacovitti L, Elliott MB, Lepore AC.

J Neurotrauma. 2018 Sep 15;35(18):2195-2207. doi: 10.1089/neu.2017.5497. Epub 2018 Jun 7.


Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.

Xiong Y, Neifert S, Karuppagounder SS, Liu Q, Stankowski JN, Lee BD, Ko HS, Lee Y, Grima JC, Mao X, Jiang H, Kang SU, Swing DA, Iacovitti L, Tessarollo L, Dawson TM, Dawson VL.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1635-1640. doi: 10.1073/pnas.1712648115. Epub 2018 Jan 31.


Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation.

Petruk S, Cai J, Sussman R, Sun G, Kovermann SK, Mariani SA, Calabretta B, McMahon SB, Brock HW, Iacovitti L, Mazo A.

Mol Cell. 2017 Apr 20;66(2):247-257.e5. doi: 10.1016/j.molcel.2017.03.006. Epub 2017 Apr 11.


Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification.

Petruk S, Mariani SA, De Dominici M, Porazzi P, Minieri V, Cai J, Iacovitti L, Flomenberg N, Calabretta B, Mazo A.

Cell Rep. 2017 Apr 11;19(2):295-306. doi: 10.1016/j.celrep.2017.03.035.


The versatility of RhoA activities in neural differentiation.

Horowitz A, Yang J, Cai J, Iacovitti L.

Small GTPases. 2019 Jan;10(1):26-32. doi: 10.1080/21541248.2016.1273171. Epub 2017 Jan 27.


Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats.

Lin R, Cai J, Kostuk EW, Rosenwasser R, Iacovitti L.

J Neuroinflammation. 2016 Oct 13;13(1):269.


Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD.

Westergard T, Jensen BK, Wen X, Cai J, Kropf E, Iacovitti L, Pasinelli P, Trotti D.

Cell Rep. 2016 Oct 11;17(3):645-652. doi: 10.1016/j.celrep.2016.09.032.


N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data.

Monti DA, Zabrecky G, Kremens D, Liang TW, Wintering NA, Cai J, Wei X, Bazzan AJ, Zhong L, Bowen B, Intenzo CM, Iacovitti L, Newberg AB.

PLoS One. 2016 Jun 16;11(6):e0157602. doi: 10.1371/journal.pone.0157602. eCollection 2016.


Neuroprotection: Basic mechanisms and translational potential.

Iacovitti L.

Brain Res. 2015 Dec 2;1628(Pt B):245-246. doi: 10.1016/j.brainres.2015.10.047. No abstract available.


A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses.

Gu H, Lazarenko RM, Koktysh D, Iacovitti L, Zhang Q.

Stem Cells Transl Med. 2015 Aug;4(8):887-93. doi: 10.5966/sctm.2015-0005. Epub 2015 May 29.


Classic and novel stem cell niches in brain homeostasis and repair.

Lin R, Iacovitti L.

Brain Res. 2015 Dec 2;1628(Pt B):327-342. doi: 10.1016/j.brainres.2015.04.029. Epub 2015 Apr 28. Review.


Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability.

Lin R, Cai J, Nathan C, Wei X, Schleidt S, Rosenwasser R, Iacovitti L.

Neurobiol Dis. 2015 Feb;74:229-39. doi: 10.1016/j.nbd.2014.11.016. Epub 2014 Dec 5.


The hTH-GFP reporter rat model for the study of Parkinson's disease.

Iacovitti L, Wei X, Cai J, Kostuk EW, Lin R, Gorodinsky A, Roman P, Kusek G, Das SS, Dufour A, Martinez TN, Dave KD.

PLoS One. 2014 Dec 2;9(12):e113151. doi: 10.1371/journal.pone.0113151. eCollection 2014.


Stem cell therapy for glaucoma: science or snake oil?

Sun Y, Williams A, Waisbourd M, Iacovitti L, Katz LJ.

Surv Ophthalmol. 2015 Mar-Apr;60(2):93-105. doi: 10.1016/j.survophthal.2014.07.001. Epub 2014 Jul 16. Review.


Evolutionary conservation of an atypical glucocorticoid-responsive element in the human tyrosine hydroxylase gene.

Sheela Rani CS, Soto-Pina A, Iacovitti L, Strong R.

J Neurochem. 2013 Jul;126(1):19-28. doi: 10.1111/jnc.12294. Epub 2013 May 28.


Tracking transplanted bone marrow stem cells and their effects in the rat MCAO stroke model.

Goldmacher GV, Nasser R, Lee DY, Yigit S, Rosenwasser R, Iacovitti L.

PLoS One. 2013;8(3):e60049. doi: 10.1371/journal.pone.0060049. Epub 2013 Mar 29.


BMP and TGF-β pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells.

Cai J, Schleidt S, Pelta-Heller J, Hutchings D, Cannarsa G, Iacovitti L.

Dev Biol. 2013 Apr 1;376(1):62-73. doi: 10.1016/j.ydbio.2013.01.012. Epub 2013 Jan 23.


Gremlin is a novel VTA derived neuroprotective factor for dopamine neurons.

Phani S, Jablonski M, Pelta-Heller J, Cai J, Iacovitti L.

Brain Res. 2013 Mar 15;1500:88-98. doi: 10.1016/j.brainres.2013.01.017. Epub 2013 Jan 21.


VTA neurons show a potentially protective transcriptional response to MPTP.

Phani S, Gonye G, Iacovitti L.

Brain Res. 2010 Jul 9;1343:1-13. doi: 10.1016/j.brainres.2010.04.061. Epub 2010 May 10.


Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice.

Page ME, Bao L, Andre P, Pelta-Heller J, Sluzas E, Gonzalez-Alegre P, Bogush A, Khan LE, Iacovitti L, Rice ME, Ehrlich ME.

Neurobiol Dis. 2010 Sep;39(3):318-26. doi: 10.1016/j.nbd.2010.04.016. Epub 2010 May 10.


Changes in host blood factors and brain glia accompanying the functional recovery after systemic administration of bone marrow stem cells in ischemic stroke rats.

Yang M, Wei X, Li J, Heine LA, Rosenwasser R, Iacovitti L.

Cell Transplant. 2010;19(9):1073-84. doi: 10.3727/096368910X503415. Epub 2010 Apr 21.


Heterotopically transplanted CVO neural stem cells generate neurons and migrate with SVZ cells in the adult mouse brain.

Bennett LB, Cai J, Enikolopov G, Iacovitti L.

Neurosci Lett. 2010 May 7;475(1):1-6. doi: 10.1016/j.neulet.2010.03.019. Epub 2010 Mar 15.


Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain.

Jasmin JF, Yang M, Iacovitti L, Lisanti MP.

Cell Cycle. 2009 Dec;8(23):3978-83. Epub 2009 Dec 28.


Functional heterogeneity at dopamine release sites.

Daniel JA, Galbraith S, Iacovitti L, Abdipranoto A, Vissel B.

J Neurosci. 2009 Nov 18;29(46):14670-80. doi: 10.1523/JNEUROSCI.1349-09.2009.


Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats.

Cai J, Yang M, Poremsky E, Kidd S, Schneider JS, Iacovitti L.

Stem Cells Dev. 2010 Jul;19(7):1017-23. doi: 10.1089/scd.2009.0319.


Circumventricular organs: a novel site of neural stem cells in the adult brain.

Bennett L, Yang M, Enikolopov G, Iacovitti L.

Mol Cell Neurosci. 2009 Jul;41(3):337-47. doi: 10.1016/j.mcn.2009.04.007. Epub 2009 May 3.


Human amniotic fluid stem cells do not differentiate into dopamine neurons in vitro or after transplantation in vivo.

Donaldson AE, Cai J, Yang M, Iacovitti L.

Stem Cells Dev. 2009 Sep;18(7):1003-12. doi: 10.1089/scd.2008.0300.


The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model.

Cai J, Donaldson A, Yang M, German MS, Enikolopov G, Iacovitti L.

Stem Cells. 2009 Jan;27(1):220-9. doi: 10.1634/stemcells.2008-0734.


Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra.

Han BS, Iacovitti L, Katano T, Hattori N, Seol W, Kim KS.

Neurosci Lett. 2008 Sep 19;442(3):190-4. doi: 10.1016/j.neulet.2008.06.086. Epub 2008 Jul 10.


Adult human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease.

Suon S, Yang M, Iacovitti L.

Brain Res. 2006 Aug 23;1106(1):46-51. doi: 10.1016/j.brainres.2006.05.109. Epub 2006 Jul 10.


Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture.

Donaldson AE, Marshall CE, Yang M, Suon S, Iacovitti L.

Mol Cell Neurosci. 2005 Dec;30(4):601-10.


Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems.

Jin H, Romano G, Marshall C, Donaldson AE, Suon S, Iacovitti L.

J Cell Physiol. 2006 Apr;207(1):49-57.


Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture.

Donaldson AE, Marshall CE, Yang M, Suon S, Iacovitti L.

Mol Cell Neurosci. 2005 Sep;30(1):108-17. Erratum in: Mol Cell Neurosci. 2005 Dec;30(4):559. Corrected and republished in: Mol Cell Neurosci. 2005 Dec;30(4):601-10.


Studies on the differentiation of dopaminergic traits in human neural progenitor cells in vitro and in vivo.

Yang M, Donaldson AE, Marshall CE, Shen J, Iacovitti L.

Cell Transplant. 2004;13(5):535-47.


Factors influencing the differentiation of dopaminergic traits in transplanted neural stem cells.

Yang M, Donaldson AE, Jiang Y, Iacovitti L.

Cell Mol Neurobiol. 2003 Oct;23(4-5):851-64.


The human tyrosine hydroxylase gene promoter.

Kessler MA, Yang M, Gollomp KL, Jin H, Iacovitti L.

Brain Res Mol Brain Res. 2003 Apr 10;112(1-2):8-23.


Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat.

Yang M, Stull ND, Berk MA, Snyder EY, Iacovitti L.

Exp Neurol. 2002 Sep;177(1):50-60.


Antioxidant compounds protect dopamine neurons from death due to oxidative stress in vitro.

Stull ND, Polan DP, Iacovitti L.

Brain Res. 2002 Mar 29;931(2):181-5.


Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins.

Stull ND, Jung JW, Iacovitti L.

Brain Res Dev Brain Res. 2001 Sep 23;130(1):91-8.


Differentiation of human dopamine neurons from an embryonic carcinomal stem cell line.

Iacovitti L, Stull ND, Jin H.

Brain Res. 2001 Aug 31;912(1):99-104.


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