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Items: 34

1.

Consequences of analgesics use in early pregnancy: Results of tests on mice.

Iacob RE, Iacob D, Moleriu RD, Tit DM, Bungau S, Otrisal P, Aleya S, Judea-Pusta C, Cioca G, Bratu OG, Aleya L, Petre I.

Sci Total Environ. 2019 Nov 15;691:1059-1064. doi: 10.1016/j.scitotenv.2019.07.212. Epub 2019 Jul 15.

PMID:
31466187
2.

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. Review.

3.

Tissue-Specific Oncogenic Activity of KRASA146T.

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM.

Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5.

PMID:
30952657
4.

Fusion surface structure, function, and dynamics of gamete fusogen HAP2.

Feng J, Dong X, Pinello J, Zhang J, Lu C, Iacob RE, Engen JR, Snell WJ, Springer TA.

Elife. 2018 Oct 3;7. pii: e39772. doi: 10.7554/eLife.39772.

5.

Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes.

Kochert BA, Iacob RE, Wales TE, Makriyannis A, Engen JR.

Methods Mol Biol. 2018;1764:153-171. doi: 10.1007/978-1-4939-7759-8_10.

PMID:
29605914
6.

Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation.

Le VQ, Iacob RE, Tian Y, McConaughy W, Jackson J, Su Y, Zhao B, Engen JR, Pirruccello-Straub M, Springer TA.

EMBO J. 2018 Feb 1;37(3):384-397. doi: 10.15252/embj.201797931. Epub 2018 Jan 17.

7.

Molecular characterization of the β-amyloid(4-10) epitope of plaque specific Aβ antibodies by affinity-mass spectrometry using alanine site mutation.

Ștefănescu R, Lupu L, Manea M, Iacob RE, Przybylski M.

J Pept Sci. 2018 Jan;24(1). doi: 10.1002/psc.3047.

PMID:
29322650
8.

Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.

Lamberto I, Liu X, Seo HS, Schauer NJ, Iacob RE, Hu W, Das D, Mikhailova T, Weisberg EL, Engen JR, Anderson KC, Chauhan D, Dhe-Paganon S, Buhrlage SJ.

Cell Chem Biol. 2017 Dec 21;24(12):1490-1500.e11. doi: 10.1016/j.chembiol.2017.09.003. Epub 2017 Oct 19.

9.

Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry.

Huang RY, Iacob RE, Sankaranarayanan S, Yang L, Ahlijanian M, Tao L, Tymiak AA, Chen G.

J Am Soc Mass Spectrom. 2018 Jan;29(1):174-182. doi: 10.1007/s13361-017-1815-8. Epub 2017 Oct 2.

PMID:
28971440
10.

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.

Kerres N, Steurer S, Schlager S, Bader G, Berger H, Caligiuri M, Dank C, Engen JR, Ettmayer P, Fischerauer B, Flotzinger G, Gerlach D, Gerstberger T, Gmaschitz T, Greb P, Han B, Heyes E, Iacob RE, Kessler D, Kölle H, Lamarre L, Lancia DR, Lucas S, Mayer M, Mayr K, Mischerikow N, Mück K, Peinsipp C, Petermann O, Reiser U, Rudolph D, Rumpel K, Salomon C, Scharn D, Schnitzer R, Schrenk A, Schweifer N, Thompson D, Traxler E, Varecka R, Voss T, Weiss-Puxbaum A, Winkler S, Zheng X, Zoephel A, Kraut N, McConnell D, Pearson M, Koegl M.

Cell Rep. 2017 Sep 19;20(12):2860-2875. doi: 10.1016/j.celrep.2017.08.081.

11.

Force interacts with macromolecular structure in activation of TGF-β.

Dong X, Zhao B, Iacob RE, Zhu J, Koksal AC, Lu C, Engen JR, Springer TA.

Nature. 2017 Feb 2;542(7639):55-59. doi: 10.1038/nature21035. Epub 2017 Jan 25.

12.

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.

Huang RY, Iacob RE, Krystek SR, Jin M, Wei H, Tao L, Das TK, Tymiak AA, Engen JR, Chen G.

J Am Soc Mass Spectrom. 2017 May;28(5):795-802. doi: 10.1007/s13361-016-1452-7. Epub 2016 Aug 15.

PMID:
27527097
13.

Benefits of early enteral nutrition in extremely low birth weight infants.

Manea A, Boia M, Iacob D, Dima M, Iacob RE.

Singapore Med J. 2016 Nov;57(11):616-618. doi: 10.11622/smedj.2016002. Epub 2016 Jan 6.

14.

Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics.

Iacob RE, Krystek SR, Huang RY, Wei H, Tao L, Lin Z, Morin PE, Doyle ML, Tymiak AA, Engen JR, Chen G.

Expert Rev Proteomics. 2015 Apr;12(2):159-69. doi: 10.1586/14789450.2015.1018897. Epub 2015 Feb 24. Review.

15.

Applications of hydrogen/deuterium exchange MS from 2012 to 2014.

Pirrone GF, Iacob RE, Engen JR.

Anal Chem. 2015 Jan 6;87(1):99-118. doi: 10.1021/ac5040242. Epub 2014 Nov 14. Review. No abstract available.

16.

The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.

Iacob RE, Chen G, Ahn J, Houel S, Wei H, Mo J, Tao L, Cohen D, Xie D, Lin Z, Morin PE, Doyle ML, Tymiak AA, Engen JR.

J Am Soc Mass Spectrom. 2014 Dec;25(12):2093-102. doi: 10.1007/s13361-014-0973-1. Epub 2014 Sep 16.

17.

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE.

PLoS One. 2014 Aug 21;9(8):e105629. doi: 10.1371/journal.pone.0105629. eCollection 2014.

18.

Electron transfer control in soluble methane monooxygenase.

Wang W, Iacob RE, Luoh RP, Engen JR, Lippard SJ.

J Am Chem Soc. 2014 Jul 9;136(27):9754-62. doi: 10.1021/ja504688z. Epub 2014 Jun 24.

19.

Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements.

Iacob RE, Bou-Assaf GM, Makowski L, Engen JR, Berkowitz SA, Houde D.

J Pharm Sci. 2013 Dec;102(12):4315-29. doi: 10.1002/jps.23754. Epub 2013 Oct 17.

20.

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications.

Wei H, Mo J, Tao L, Russell RJ, Tymiak AA, Chen G, Iacob RE, Engen JR.

Drug Discov Today. 2014 Jan;19(1):95-102. doi: 10.1016/j.drudis.2013.07.019. Epub 2013 Aug 6. Review.

21.

Structure and dynamic regulation of Abl kinases.

Panjarian S, Iacob RE, Chen S, Engen JR, Smithgall TE.

J Biol Chem. 2013 Feb 22;288(8):5443-50. doi: 10.1074/jbc.R112.438382. Epub 2013 Jan 11. Review.

22.

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors.

Panjarian S, Iacob RE, Chen S, Wales TE, Engen JR, Smithgall TE.

J Biol Chem. 2013 Mar 1;288(9):6116-29. doi: 10.1074/jbc.M112.431312. Epub 2013 Jan 9.

23.

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.

Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M.

Nat Commun. 2012;3:1288. doi: 10.1038/ncomms2304. Erratum in: Nat Commun. 2013;4:1893.

PMID:
23250418
24.

The natural product cucurbitacin E inhibits depolymerization of actin filaments.

Sörensen PM, Iacob RE, Fritzsche M, Engen JR, Brieher WM, Charras G, Eggert US.

ACS Chem Biol. 2012 Sep 21;7(9):1502-8. Epub 2012 Jul 9.

25.

Hydrogen exchange mass spectrometry: are we out of the quicksand?

Iacob RE, Engen JR.

J Am Soc Mass Spectrom. 2012 Jun;23(6):1003-10. doi: 10.1007/s13361-012-0377-z. Epub 2012 Apr 3. Review.

26.

Allosteric interactions between the myristate- and ATP-site of the Abl kinase.

Iacob RE, Zhang J, Gray NS, Engen JR.

PLoS One. 2011 Jan 10;6(1):e15929. doi: 10.1371/journal.pone.0015929.

27.

Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.

Zhang J, Adrián FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding Q, Okram B, Choi Y, Wojciechowski A, Deng X, Liu G, Fendrich G, Strauss A, Vajpai N, Grzesiek S, Tuntland T, Liu Y, Bursulaya B, Azam M, Manley PW, Engen JR, Daley GQ, Warmuth M, Gray NS.

Nature. 2010 Jan 28;463(7280):501-6. doi: 10.1038/nature08675. Epub 2010 Jan 13.

28.

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.

Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA.

Nature. 2009 Dec 24;462(7276):1070-4. doi: 10.1038/nature08622.

29.

Conformational disturbance in Abl kinase upon mutation and deregulation.

Iacob RE, Pene-Dumitrescu T, Zhang J, Gray NS, Smithgall TE, Engen JR.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1386-91. doi: 10.1073/pnas.0811912106. Epub 2009 Jan 21.

30.

Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange.

Iacob RE, Murphy JP 3rd, Engen JR.

Rapid Commun Mass Spectrom. 2008 Sep;22(18):2898-904. doi: 10.1002/rcm.3688.

PMID:
18727141
31.

Structural elucidation of critical residues involved in binding of human monoclonal antibodies to hepatitis C virus E2 envelope glycoprotein.

Iacob RE, Keck Z, Olson O, Foung SK, Tomer KB.

Biochim Biophys Acta. 2008 Mar;1784(3):530-42. doi: 10.1016/j.bbapap.2007.12.015. Epub 2008 Jan 11.

32.

Mass spectrometric characterization of glycosylation of hepatitis C virus E2 envelope glycoprotein reveals extended microheterogeneity of N-glycans.

Iacob RE, Perdivara I, Przybylski M, Tomer KB.

J Am Soc Mass Spectrom. 2008 Mar;19(3):428-44. doi: 10.1016/j.jasms.2007.11.022. Epub 2007 Dec 8.

33.

Mass spectrometric approaches for elucidation of antigenantibody recognition structures in molecular immunology.

Stefanescu R, Iacob RE, Damoc EN, Marquardt A, Amstalden E, Manea M, Perdivara I, Maftei M, Paraschiv G, Przybylski M.

Eur J Mass Spectrom (Chichester). 2007;13(1):69-75.

PMID:
17878542
34.

Determination of the mechanical requirements for a progressive correction system of pectus excavatum in children.

Boia ES, Susan-Resiga R, Raicov PC, Popoiu CM, Iacob RE.

J Laparoendosc Adv Surg Tech A. 2005 Oct;15(5):478-81.

PMID:
16185120

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