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Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat.

Feng W, Guan Z, Xing D, Li X, Ying WZ, Remedies CE, Inscho EW, Sanders PW.

Kidney Int. 2020 Mar;97(3):528-537. doi: 10.1016/j.kint.2019.09.025. Epub 2019 Oct 22.


Extracellular Nucleotides and P2 Receptors in Renal Function.

Vallon V, Unwin R, Inscho EW, Leipziger J, Kishore BK.

Physiol Rev. 2020 Jan 1;100(1):211-269. doi: 10.1152/physrev.00038.2018. Epub 2019 Aug 22.


Rho kinase inhibitors reduce voltage-dependent Ca2+ channel signaling in aortic and renal microvascular smooth muscle cells.

Guan Z, Baty JJ, Zhang S, Remedies CE, Inscho EW.

Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1132-F1141. doi: 10.1152/ajprenal.00212.2018. Epub 2019 Aug 21.


Antagonism of major histocompatibility complex class II invariant chain peptide during chronic lipopolysaccharide treatment rescues autoregulatory behavior.

Van Beusecum JP, Zhang S, Beltran E, Cook AK, Tobin RP, Newell-Rogers MK, Inscho EW.

Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F957-F966. doi: 10.1152/ajprenal.00164.2019. Epub 2019 Aug 21.


Afferent arteriole responsiveness to endothelin receptor activation: does sex matter?

Gohar EY, Cook AK, Pollock DM, Inscho EW.

Biol Sex Differ. 2019 Jan 3;10(1):1. doi: 10.1186/s13293-018-0218-2.


Mechanisms of sphingosine-1-phosphate-mediated vasoconstriction of rat afferent arterioles.

Guan Z, Wang F, Cui X, Inscho EW.

Acta Physiol (Oxf). 2018 Feb;222(2). doi: 10.1111/apha.12913. Epub 2017 Jul 13.


Acute toll-like receptor 4 activation impairs rat renal microvascular autoregulatory behaviour.

Van Beusecum JP, Zhang S, Cook AK, Inscho EW.

Acta Physiol (Oxf). 2017 Nov;221(3):204-220. doi: 10.1111/apha.12899. Epub 2017 Jun 27.


Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats.

Guan Z, Singletary ST, Cha H, Van Beusecum JP, Cook AK, Pollock JS, Pollock DM, Inscho EW.

Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F456-65. doi: 10.1152/ajprenal.00110.2015. Epub 2015 Dec 23.


Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.

Li X, Knight J, Fargue S, Buchalski B, Guan Z, Inscho EW, Liebow A, Fitzgerald K, Querbes W, Todd Lowther W, Holmes RP.

Biochim Biophys Acta. 2016 Feb;1862(2):233-9. doi: 10.1016/j.bbadis.2015.12.001. Epub 2015 Dec 2.


Endothelin contributes to blunted renal autoregulation observed with a high-salt diet.

Fellner RC, Guan Z, Cook AK, Pollock DM, Inscho EW.

Am J Physiol Renal Physiol. 2015 Oct 15;309(8):F687-96. doi: 10.1152/ajprenal.00641.2014. Epub 2015 Aug 5.


Endothelin and the renal microcirculation.

Guan Z, VanBeusecum JP, Inscho EW.

Semin Nephrol. 2015 Mar;35(2):145-55. doi: 10.1016/j.semnephrol.2015.02.004. Review.


Regulation of renal function and blood pressure control by P2 purinoceptors in the kidney.

Van Beusecum J, Inscho EW.

Curr Opin Pharmacol. 2015 Apr;21:82-8. doi: 10.1016/j.coph.2015.01.003. Epub 2015 Jan 20. Review.


Flow regulation of endothelin-1 production in the inner medullary collecting duct.

Pandit MM, Inscho EW, Zhang S, Seki T, Rohatgi R, Gusella L, Kishore B, Kohan DE.

Am J Physiol Renal Physiol. 2015 Mar 15;308(6):F541-52. doi: 10.1152/ajprenal.00456.2014. Epub 2015 Jan 13.


High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism.

Fellner RC, Cook AK, O'Connor PM, Zhang S, Pollock DM, Inscho EW.

Am J Physiol Renal Physiol. 2014 Jul 1;307(1):F33-40. doi: 10.1152/ajprenal.00040.2014. Epub 2014 May 28.


Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.

Giachini FR, Leite R, Osmond DA, Lima VV, Inscho EW, Webb RC, Tostes RC.

PLoS One. 2014 Mar 17;9(3):e91890. doi: 10.1371/journal.pone.0091890. eCollection 2014.


Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature.

Guan Z, Singletary ST, Cook AK, Hobbs JL, Pollock JS, Inscho EW.

J Am Soc Nephrol. 2014 Aug;25(8):1774-85. doi: 10.1681/ASN.2013060656. Epub 2014 Feb 27.


Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension.

Osmond DA, Zhang S, Pollock JS, Yamamoto T, De Miguel C, Inscho EW.

Am J Physiol Renal Physiol. 2014 Mar 15;306(6):F619-28. doi: 10.1152/ajprenal.00444.2013. Epub 2014 Jan 29.


P2 receptors in renal autoregulation.

Guan Z, Fellner RC, Van Beusecum J, Inscho EW.

Curr Vasc Pharmacol. 2014;12(6):818-28. Review.


Immunosuppression preserves renal autoregulatory function and microvascular P2X(1) receptor reactivity in ANG II-hypertensive rats.

Guan Z, Giddens MI, Osmond DA, Cook AK, Hobbs JL, Zhang S, Yamamoto T, Pollock JS, Pollock DM, Inscho EW.

Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F801-7. doi: 10.1152/ajprenal.00286.2012. Epub 2012 Dec 26.


Endothelin and the renal vasculature.

Guan Z, Inscho EW.

Contrib Nephrol. 2011;172:35-49. doi: 10.1159/000328720. Epub 2011 Aug 30. Review.


Role of adenosine 5'-triphosphate in regulating renal microvascular function and in hypertension.

Guan Z, Inscho EW.

Hypertension. 2011 Sep;58(3):333-40. doi: 10.1161/HYPERTENSIONAHA.110.155952. Epub 2011 Jul 18. Review.


Physiology of endothelin and the kidney.

Kohan DE, Inscho EW, Wesson D, Pollock DM.

Compr Physiol. 2011 Apr;1(2):883-919. doi: 10.1002/cphy.c100039. Review.


P2X1 receptor-mediated vasoconstriction of afferent arterioles in angiotensin II-infused hypertensive rats fed a high-salt diet.

Inscho EW, Cook AK, Clarke A, Zhang S, Guan Z.

Hypertension. 2011 Apr;57(4):780-7. doi: 10.1161/HYPERTENSIONAHA.110.168955. Epub 2011 Feb 14.


Regulation of blood pressure and salt homeostasis by endothelin.

Kohan DE, Rossi NF, Inscho EW, Pollock DM.

Physiol Rev. 2011 Jan;91(1):1-77. doi: 10.1152/physrev.00060.2009. Review.


Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activation.

Brands MW, Banes-Berceli AK, Inscho EW, Al-Azawi H, Allen AJ, Labazi H.

Hypertension. 2010 Nov;56(5):879-84. doi: 10.1161/HYPERTENSIONAHA.110.158071. Epub 2010 Oct 4.


p38 Mitogen-activated protein kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated mice.

Toque HA, Romero MJ, Tostes RC, Shatanawi A, Chandra S, Carneiro ZN, Inscho EW, Webb RC, Caldwell RB, Caldwell RW.

J Sex Med. 2010 Dec;7(12):3857-67. doi: 10.1111/j.1743-6109.2010.01996.x. Epub 2010 Aug 30.


Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.

Luo P, Chang HH, Zhou Y, Zhang S, Hwang SH, Morisseau C, Wang CY, Inscho EW, Hammock BD, Wang MH.

J Pharmacol Exp Ther. 2010 Aug;334(2):430-8. doi: 10.1124/jpet.110.167544. Epub 2010 May 3.


P2X(1) receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo.

Osmond DA, Inscho EW.

Am J Physiol Renal Physiol. 2010 Jun;298(6):F1360-8. doi: 10.1152/ajprenal.00016.2010. Epub 2010 Mar 24.


Pentosan polysulfate treatment preserves renal autoregulation in ANG II-infused hypertensive rats via normalization of P2X1 receptor activation.

Guan Z, Fuller BS, Yamamoto T, Cook AK, Pollock JS, Inscho EW.

Am J Physiol Renal Physiol. 2010 May;298(5):F1276-84. doi: 10.1152/ajprenal.00743.2009. Epub 2010 Mar 3.


Response to Role of Epithelial Sodium Channels in the Renal Myogenic Response?

Guan Z, Pollock JS, Cook AK, Hobbs JL, Inscho EW.

Hypertension. 2010 Feb;55(2):e8-9. No abstract available.


Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats.

Giachini FR, Osmond DA, Zhang S, Carneiro FS, Lima VV, Inscho EW, Webb RC, Tostes RC.

Clin Sci (Lond). 2010 Apr;118(7):463-71. Epub 2009 Oct 7.


Purinoceptor regulation of renal tubular transport is coming of age.

Inscho EW.

Am J Physiol Renal Physiol. 2009 Nov;297(5):F1166-7. doi: 10.1152/ajprenal.00506.2009. Epub 2009 Sep 9. No abstract available.


Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arterioles.

Guan Z, Pollock JS, Cook AK, Hobbs JL, Inscho EW.

Hypertension. 2009 Nov;54(5):1062-9. doi: 10.1161/HYPERTENSIONAHA.109.137992. Epub 2009 Aug 31.


A true champion of Hungarian kidney research and nephrology education--tribute to László Rosivall.

Peti-Peterdi J, Navar LG, Darwin Bell P, Casellas D, Carmines PK, Inscho EW, Oparil S.

Acta Physiol Hung. 2009 Sep;96(3):375-82. doi: 10.1556/APhysiol.96.2009.3.12.


ATP, P2 receptors and the renal microcirculation.

Inscho EW.

Purinergic Signal. 2009 Dec;5(4):447-60. doi: 10.1007/s11302-009-9147-1. Epub 2009 Mar 18.


Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy.

Luo P, Zhou Y, Chang HH, Zhang J, Seki T, Wang CY, Inscho EW, Wang MH.

Am J Physiol Renal Physiol. 2009 Mar;296(3):F556-63. doi: 10.1152/ajprenal.90613.2008. Epub 2009 Jan 7.


Rho-kinase inhibition reduces pressure-mediated autoregulatory adjustments in afferent arteriolar diameter.

Inscho EW, Cook AK, Webb RC, Jin LM.

Am J Physiol Renal Physiol. 2009 Mar;296(3):F590-7. doi: 10.1152/ajprenal.90703.2008. Epub 2009 Jan 7.


Lewis K. Dahl Memorial Lecture. Mysteries of renal autoregulation.

Inscho EW.

Hypertension. 2009 Feb;53(2):299-306. doi: 10.1161/HYPERTENSIONAHA.108.119982. Epub 2008 Dec 8. No abstract available.


Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.

Carneiro FS, Giachini FRC, Lima VV, Carneiro ZN, Leite R, Inscho EW, Tostes RC, Webb RC.

J Sex Med. 2008 May;5(5):1156-1166. doi: 10.1111/j.1743-6109.2007.00752.x. Epub 2008 Jan 21.


P2X receptors as regulators of the renal microvasculature.

Guan Z, Osmond DA, Inscho EW.

Trends Pharmacol Sci. 2007 Dec;28(12):646-52. Epub 2007 Nov 19. Review.


Chemokine receptor 2b inhibition provides renal protection in angiotensin II - salt hypertension.

Elmarakby AA, Quigley JE, Olearczyk JJ, Sridhar A, Cook AK, Inscho EW, Pollock DM, Imig JD.

Hypertension. 2007 Dec;50(6):1069-76. Epub 2007 Oct 15.


Purinoceptors in the kidney.

Guan Z, Osmond DA, Inscho EW.

Exp Biol Med (Maywood). 2007 Jun;232(6):715-26. Review.


Determination of adenosine effects and adenosine receptors in murine corpus cavernosum.

Tostes RC, Giachini FR, Carneiro FS, Leite R, Inscho EW, Webb RC.

J Pharmacol Exp Ther. 2007 Aug;322(2):678-85. Epub 2007 May 9.


Attenuated vasoconstrictor responses to endothelin in afferent arterioles during a high-salt diet.

Schneider MP, Inscho EW, Pollock DM.

Am J Physiol Renal Physiol. 2007 Apr;292(4):F1208-14. Epub 2007 Jan 9.


P2 receptor regulation of [Ca2+]i in cultured mouse mesangial cells.

Rivera I, Zhang S, Fuller BS, Edwards B, Seki T, Wang MH, Marrero MB, Inscho EW.

Am J Physiol Renal Physiol. 2007 May;292(5):F1380-9. Epub 2007 Jan 9.


ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin.

Inscho EW, Imig JD, Cook AK, Pollock DM.

Br J Pharmacol. 2005 Dec;146(7):1019-26.


Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension.

Zhao X, Cook AK, Field M, Edwards B, Zhang S, Zhang Z, Pollock JS, Imig JD, Inscho EW.

Hypertension. 2005 Sep;46(3):562-8. Epub 2005 Aug 22.


Calcium and chloride channel activation by angiotensin II-AT1 receptors in preglomerular vascular smooth muscle cells.

Fuller AJ, Hauschild BC, Gonzalez-Villalobos R, Awayda MS, Imig JD, Inscho EW, Navar LG.

Am J Physiol Renal Physiol. 2005 Oct;289(4):F760-7. Epub 2005 Jun 7.


Role of interstitial ATP and adenosine in the regulation of renal hemodynamics and microvascular function.

Nishiyama A, Rahman M, Inscho EW.

Hypertens Res. 2004 Nov;27(11):791-804. Review.


TGF-beta impairs renal autoregulation via generation of ROS.

Sharma K, Cook A, Smith M, Valancius C, Inscho EW.

Am J Physiol Renal Physiol. 2005 May;288(5):F1069-77. Epub 2005 Jan 11.

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