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Items: 1 to 50 of 83

1.

Hepatocyte growth control by SOCS1 and SOCS3.

Khan MGM, Ghosh A, Variya B, Santharam MA, Kandhi R, Ramanathan S, Ilangumaran S.

Cytokine. 2019 Sep;121:154733. doi: 10.1016/j.cyto.2019.154733. Epub 2019 May 30.

PMID:
31154249
2.

Phosphorylation of SOCS1 Inhibits the SOCS1-p53 Tumor Suppressor Axis.

Saint-Germain E, Mignacca L, Huot G, Acevedo M, Moineau-Vallée K, Calabrese V, Bourdeau V, Rowell MC, Ilangumaran S, Lessard F, Ferbeyre G.

Cancer Res. 2019 Jul 1;79(13):3306-3319. doi: 10.1158/0008-5472.CAN-18-1503. Epub 2019 May 17.

PMID:
31101761
3.

Editorial: Cytokines in liver diseases.

Ilangumaran S, Moriggl R, Kalvakolanu DV.

Cytokine. 2018 Dec 15. pii: S1043-4666(18)30466-6. doi: 10.1016/j.cyto.2018.12.001. [Epub ahead of print]

PMID:
30563739
4.

Corrigendum to "Inflammatory cytokine profiles in visceral and subcutaneous adipose tissues of obese patients undergoing bariatric surgery reveal lack of correlation with obesity or diabetes" EBioMedicine 30C (2018) 237-247.

Rakotoarivelo V, Lacraz G, Mayhue M, Brown C, Rottembourg D, Fradette J, Ilangumaran S, Menendez A, Langlois MF, Ramanathan S.

EBioMedicine. 2018 Nov;37:564-568. doi: 10.1016/j.ebiom.2018.10.025. Epub 2018 Oct 16. No abstract available.

5.

Inflammation in human adipose tissues-Shades of gray, rather than white and brown.

Rakotoarivelo V, Variya B, Ilangumaran S, Langlois MF, Ramanathan S.

Cytokine Growth Factor Rev. 2018 Dec;44:28-37. doi: 10.1016/j.cytogfr.2018.10.001. Epub 2018 Oct 4. Review.

PMID:
30301598
6.

Essential role of suppressor of cytokine signaling 1 (SOCS1) in hepatocytes and macrophages in the regulation of liver fibrosis.

Mafanda EK, Kandhi R, Bobbala D, Khan MGM, Nandi M, Menendez A, Ramanathan S, Ilangumaran S.

Cytokine. 2018 Aug 7. pii: S1043-4666(18)30330-2. doi: 10.1016/j.cyto.2018.07.032. [Epub ahead of print]

PMID:
30097285
7.

Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes.

Rakotoarivelo V, Lacraz G, Mayhue M, Brown C, Rottembourg D, Fradette J, Ilangumaran S, Menendez A, Langlois MF, Ramanathan S.

EBioMedicine. 2018 Apr;30:237-247. doi: 10.1016/j.ebiom.2018.03.004. Epub 2018 Mar 8. Erratum in: EBioMedicine. 2018 Nov;37:564-568.

8.

Meeting summary: 2nd Aegean Conference on Cytokine Signaling in Cancer.

Ilangumaran S, Williams BRG, Kalvakolanu DV.

Cytokine. 2018 Aug;108:225-231. doi: 10.1016/j.cyto.2017.10.025.

PMID:
29102683
9.

Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1.

Gui Y, Khan MGM, Bobbala D, Dubois C, Ramanathan S, Saucier C, Ilangumaran S.

World J Gastroenterol. 2017 Sep 28;23(36):6639-6649. doi: 10.3748/wjg.v23.i36.6639.

10.

SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes.

Saint-Germain E, Mignacca L, Vernier M, Bobbala D, Ilangumaran S, Ferbeyre G.

Aging (Albany NY). 2017 Oct 28;9(10):2137-2162. doi: 10.18632/aging.101306.

11.

SOCS1: Regulator of T Cells in Autoimmunity and Cancer.

Ilangumaran S, Bobbala D, Ramanathan S.

Curr Top Microbiol Immunol. 2017;410:159-189. doi: 10.1007/82_2017_63. Review.

PMID:
28900678
12.

Ileal antimicrobial peptide expression is dysregulated in old age.

Tremblay S, Côté NML, Grenier G, Duclos-Lasnier G, Fortier LC, Ilangumaran S, Menendez A.

Immun Ageing. 2017 Aug 29;14:19. doi: 10.1186/s12979-017-0101-8. eCollection 2017.

13.

Bezlotoxumab for the prevention of Clostridium difficile recurrence.

Couture-Cossette A, Carignan A, Ilangumaran S, Valiquette L.

Expert Opin Biol Ther. 2017 Nov;17(11):1439-1445. doi: 10.1080/14712598.2017.1363886. Epub 2017 Aug 13. Review.

PMID:
28805081
14.

Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer.

Chevrier M, Bobbala D, Villalobos-Hernandez A, Khan MG, Ramanathan S, Saucier C, Ferbeyre G, Geha S, Ilangumaran S.

BMC Cancer. 2017 Feb 24;17(1):157. doi: 10.1186/s12885-017-3141-8.

15.

GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes.

Serrano D, Ghobadi F, Boulay G, Ilangumaran S, Lavoie C, Ramanathan S.

Front Immunol. 2017 Feb 7;8:94. doi: 10.3389/fimmu.2017.00094. eCollection 2017.

16.

Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2016 Nov 16;17(12):1479. doi: 10.1038/ni1216-1479c. No abstract available.

PMID:
27849203
17.

Correction: Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.

Lacraz G, Rakotoarivelo V, Labbé SM, Vernier M, Noll C, Mayhue M, Stankova J, Schwertani A, Grenier G, Carpentier A, Richard D, Ferbeyre G, Fradette J, Rola-Pleszczynski M, Menendez A, Langlois MF, Ilangumaran S, Ramanathan S.

PLoS One. 2016 Nov 8;11(11):e0166537. doi: 10.1371/journal.pone.0166537. eCollection 2016.

18.

USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2017 Jan;18(1):54-63. doi: 10.1038/ni.3581. Epub 2016 Oct 10. Erratum in: Nat Immunol. 2016 Nov 16;17 (12 ):1479.

PMID:
27721430
19.

SOCS1 inhibits migration and invasion of prostate cancer cells, attenuates tumor growth and modulates the tumor stroma.

Villalobos-Hernandez A, Bobbala D, Kandhi R, Khan MG, Mayhue M, Dubois CM, Ferbeyre G, Saucier C, Ramanathan S, Ilangumaran S.

Prostate Cancer Prostatic Dis. 2017 Mar;20(1):36-47. doi: 10.1038/pcan.2016.50. Epub 2016 Oct 25.

PMID:
27779203
20.

Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.

Lacraz G, Rakotoarivelo V, Labbé SM, Vernier M, Noll C, Mayhue M, Stankova J, Schwertani A, Grenier G, Carpentier A, Richard D, Ferbeyre G, Fradette J, Rola-Pleszczynski M, Menendez A, Langlois MF, Ilangumaran S, Ramanathan S.

PLoS One. 2016 Sep 29;11(9):e0162995. doi: 10.1371/journal.pone.0162995. eCollection 2016. Erratum in: PLoS One. 2016 Nov 8;11(11):e0166537.

21.

NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8(+) T lymphocytes.

Rodriguez GM, Bobbala D, Serrano D, Mayhue M, Champagne A, Saucier C, Steimle V, Kufer TA, Menendez A, Ramanathan S, Ilangumaran S.

Oncoimmunology. 2016 Mar 28;5(6):e1151593. doi: 10.1080/2162402X.2016.1151593. eCollection 2016 Jun.

22.

Interleukin-21-dependent modulation of T cell antigen receptor reactivity towards low affinity peptide ligands in autoreactive CD8(+) T lymphocytes.

Bobbala D, Orkhis S, Kandhi R, Ramanathan S, Ilangumaran S.

Cytokine. 2016 Sep;85:83-91. doi: 10.1016/j.cyto.2016.06.011. Epub 2016 Jun 11.

PMID:
27300756
23.

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).

Chen XL, Serrano D, Ghobadi F, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S.

PLoS One. 2016 Mar 29;11(3):e0151837. doi: 10.1371/journal.pone.0151837. eCollection 2016.

24.

Editorial: Cytokines in inflammation, aging, cancer and obesity.

Ilangumaran S, Ferbeyre G.

Cytokine. 2016 Jun;82:1-3. doi: 10.1016/j.cyto.2016.03.011. Epub 2016 Mar 17. No abstract available.

PMID:
26997465
25.

Interleukin-15 deficiency promotes the development of T-cell acute lymphoblastic leukemia in non-obese diabetes mice with severe combined immunodeficiency.

Bobbala D, Kandhi R, Chen X, Mayhue M, Bouchard E, Yan J, Knecht H, Barabé F, Ramanathan S, Ilangumaran S.

Leukemia. 2016 Aug;30(8):1749-52. doi: 10.1038/leu.2016.28. Epub 2016 Feb 15. No abstract available.

PMID:
26876593
26.

Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease.

Cepero-Donates Y, Lacraz G, Ghobadi F, Rakotoarivelo V, Orkhis S, Mayhue M, Chen YG, Rola-Pleszczynski M, Menendez A, Ilangumaran S, Ramanathan S.

Cytokine. 2016 Jun;82:102-11. doi: 10.1016/j.cyto.2016.01.020. Epub 2016 Feb 8.

PMID:
26868085
27.

Trans-presentation of interleukin-15 by interleukin-15 receptor alpha is dispensable for the pathogenesis of autoimmune type 1 diabetes.

Bobbala D, Mayhue M, Menendez A, Ilangumaran S, Ramanathan S.

Cell Mol Immunol. 2017 Jul;14(7):590-596. doi: 10.1038/cmi.2015.102. Epub 2016 Feb 8.

28.

The hepatocyte growth factor (HGF)-MET receptor tyrosine kinase signaling pathway: Diverse roles in modulating immune cell functions.

Ilangumaran S, Villalobos-Hernandez A, Bobbala D, Ramanathan S.

Cytokine. 2016 Jun;82:125-39. doi: 10.1016/j.cyto.2015.12.013. Epub 2016 Jan 25. Review.

PMID:
26822708
29.

Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1.

Kandhi R, Bobbala D, Yeganeh M, Mayhue M, Menendez A, Ilangumaran S.

Cytokine. 2016 Jun;82:58-69. doi: 10.1016/j.cyto.2015.12.007. Epub 2015 Dec 31.

PMID:
26748724
30.

Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21(CIP1/WAF1) in the liver.

Yeganeh M, Gui Y, Kandhi R, Bobbala D, Tobelaim WS, Saucier C, Yoshimura A, Ferbeyre G, Ramanathan S, Ilangumaran S.

Oncogene. 2016 Aug 11;35(32):4200-11. doi: 10.1038/onc.2015.485. Epub 2016 Jan 4.

PMID:
26725321
31.

The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis.

Gharagozloo M, Mahvelati TM, Imbeault E, Gris P, Zerif E, Bobbala D, Ilangumaran S, Amrani A, Gris D.

J Neuroinflammation. 2015 Oct 31;12:198. doi: 10.1186/s12974-015-0414-5.

32.

GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes.

Chen XL, Serrano D, Mayhue M, Hoebe K, Ilangumaran S, Ramanathan S.

PLoS One. 2015 Oct 6;10(10):e0139019. doi: 10.1371/journal.pone.0139019. eCollection 2015.

33.

Tumour-promoting role of SOCS1 in colorectal cancer cells.

Tobelaim WS, Beaurivage C, Champagne A, Pomerleau V, Simoneau A, Chababi W, Yeganeh M, Thibault P, Klinck R, Carrier JC, Ferbeyre G, Ilangumaran S, Saucier C.

Sci Rep. 2015 Sep 22;5:14301. doi: 10.1038/srep14301.

34.

Regulation of MET receptor tyrosine kinase signaling by suppressor of cytokine signaling 1 in hepatocellular carcinoma.

Gui Y, Yeganeh M, Donates YC, Tobelaim WS, Chababi W, Mayhue M, Yoshimura A, Ramanathan S, Saucier C, Ilangumaran S.

Oncogene. 2015 Nov 12;34(46):5718-28. doi: 10.1038/onc.2015.20. Epub 2015 Mar 2.

PMID:
25728680
35.

IL-15 trans-presentation regulates homeostasis of CD4(+) T lymphocytes.

Chen XL, Bobbala D, Cepero Donates Y, Mayhue M, Ilangumaran S, Ramanathan S.

Cell Mol Immunol. 2014 Jul;11(4):387-97. doi: 10.1038/cmi.2014.13. Epub 2014 Mar 24.

36.

Regulation of MET receptor signaling by SOCS1 and its implications for hepatocellular carcinoma.

Gui Y, Yeganeh M, Cepero-Donates Y, Ramanathan S, Saucier C, Ilangumaran S.

Curr Pharm Des. 2014;20(17):2922-33. Review.

PMID:
23944359
37.

Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells.

Chen XL, Bobbala D, Rodriguez GM, Mayhue M, Chen YG, Ilangumaran S, Ramanathan S.

Clin Exp Immunol. 2013 Aug;173(2):184-94. doi: 10.1111/cei.12108.

38.

SOCS1 prevents potentially skin-reactive cytotoxic T lymphocytes from gaining the ability to cause inflammatory lesions.

Rodriguez GM, D'Urbano D, Bobbala D, Chen XL, Yeganeh M, Ramanathan S, Ilangumaran S.

J Invest Dermatol. 2013 Aug;133(8):2013-22. doi: 10.1038/jid.2013.86. Epub 2013 Feb 26.

39.

GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.

Chen XL, Serrano D, Mayhue M, Wieden HJ, Stankova J, Boulay G, Ilangumaran S, Ramanathan S.

Biochem J. 2013 Jan 15;449(2):353-64. doi: 10.1042/BJ20120516.

PMID:
23098229
40.

Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse.

Bobbala D, Chen XL, Leblanc C, Mayhue M, Stankova J, Tanaka T, Chen YG, Ilangumaran S, Ramanathan S.

Diabetologia. 2012 Nov;55(11):3010-20. doi: 10.1007/s00125-012-2675-1. Epub 2012 Aug 14. Erratum in: Diabetologia. 2012 Dec;55(12):3401.

PMID:
22890824
41.

SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes.

Gui Y, Yeganeh M, Ramanathan S, Leblanc C, Pomerleau V, Ferbeyre G, Saucier C, Ilangumaran S.

J Hepatol. 2011 Dec;55(6):1300-8. doi: 10.1016/j.jhep.2011.03.027. Epub 2011 May 19.

PMID:
21703184
42.

Exposure to IL-15 and IL-21 enables autoreactive CD8 T cells to respond to weak antigens and cause disease in a mouse model of autoimmune diabetes.

Ramanathan S, Dubois S, Chen XL, Leblanc C, Ohashi PS, Ilangumaran S.

J Immunol. 2011 May 1;186(9):5131-41. doi: 10.4049/jimmunol.1001221. Epub 2011 Mar 23.

43.

SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence.

Mallette FA, Calabrese V, Ilangumaran S, Ferbeyre G.

Aging (Albany NY). 2010 Jul;2(7):445-52.

44.

Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens.

Ramanathan S, Dubois S, Gagnon J, Leblanc C, Mariathasan S, Ferbeyre G, Rottapel R, Ohashi PS, Ilangumaran S.

J Immunol. 2010 Jul 1;185(1):357-66. doi: 10.4049/jimmunol.1000066. Epub 2010 Jun 2.

45.

Increased generation of CD8 single positive cells in SOCS1-deficient thymus does not proportionately increase their export.

Ilangumaran S, Gagnon J, Leblanc C, Poussier P, Ramanathan S.

Immunol Lett. 2010 Aug 16;132(1-2):12-7. doi: 10.1016/j.imlet.2010.04.009. Epub 2010 May 11.

PMID:
20438760
46.

Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression.

Gagnon J, Chen XL, Forand-Boulerice M, Leblanc C, Raman C, Ramanathan S, Ilangumaran S.

Immunol Cell Biol. 2010 May-Jun;88(4):451-60. doi: 10.1038/icb.2009.109. Epub 2010 Jan 12.

PMID:
20065997
47.

SOCS1 links cytokine signaling to p53 and senescence.

Calabrese V, Mallette FA, Deschênes-Simard X, Ramanathan S, Gagnon J, Moores A, Ilangumaran S, Ferbeyre G.

Mol Cell. 2009 Dec 11;36(5):754-67. doi: 10.1016/j.molcel.2009.09.044.

48.

Cytokine synergy in antigen-independent activation and priming of naive CD8+ T lymphocytes.

Ramanathan S, Gagnon J, Dubois S, Forand-Boulerice M, Richter MV, Ilangumaran S.

Crit Rev Immunol. 2009;29(3):219-39. Review.

PMID:
19538136
49.

Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes.

Ilangumaran S, Forand-Boulerice M, Bousquet SM, Savard A, Rocheleau P, Chen XL, Dupuis G, Poussier P, Boulay G, Ramanathan S.

Mol Immunol. 2009 Mar;46(6):1256-9. doi: 10.1016/j.molimm.2008.09.031. Epub 2008 Nov 12.

PMID:
19007993
50.

Antigen-nonspecific activation of CD8+ T lymphocytes by cytokines: relevance to immunity, autoimmunity, and cancer.

Ramanathan S, Gagnon J, Ilangumaran S.

Arch Immunol Ther Exp (Warsz). 2008 Sep-Oct;56(5):311-23. doi: 10.1007/s00005-008-0033-2. Review.

PMID:
18836862

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