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Items: 1 to 50 of 85

1.

Insights into the biology of fibrodysplasia ossificans progressiva using patient-derived induced pluripotent stem cells.

Nakajima T, Ikeya M.

Regen Ther. 2019 May 10;11:25-30. doi: 10.1016/j.reth.2019.04.004. eCollection 2019 Dec. Review.

2.

In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes.

Kawai S, Yoshitomi H, Sunaga J, Alev C, Nagata S, Nishio M, Hada M, Koyama Y, Uemura M, Sekiguchi K, Maekawa H, Ikeya M, Tamaki S, Jin Y, Harada Y, Fukiage K, Adachi T, Matsuda S, Toguchida J.

Nat Biomed Eng. 2019 Jun 10. doi: 10.1038/s41551-019-0410-7. [Epub ahead of print]

PMID:
31182836
3.

In Vitro Generation of Somite Derivatives from Human Induced Pluripotent Stem Cells.

Nakajima T, Sakurai H, Ikeya M.

J Vis Exp. 2019 Apr 25;(146). doi: 10.3791/59359.

PMID:
31081810
4.

Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells.

Iwashita M, Ohta H, Fujisawa T, Cho M, Ikeya M, Kidoaki S, Kosodo Y.

Sci Rep. 2019 Feb 28;9(1):3068. doi: 10.1038/s41598-018-38395-5.

5.

An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva.

Hino K, Zhao C, Horigome K, Nishio M, Okanishi Y, Nagata S, Komura S, Yamada Y, Toguchida J, Ohta A, Ikeya M.

Stem Cell Reports. 2018 Nov 13;11(5):1106-1119. doi: 10.1016/j.stemcr.2018.10.007. Epub 2018 Nov 1.

6.

Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells.

Zhao C, Ikeya M.

Stem Cells Int. 2018 Jul 31;2018:9601623. doi: 10.1155/2018/9601623. eCollection 2018. Review.

7.

Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells.

Nakajima T, Shibata M, Nishio M, Nagata S, Alev C, Sakurai H, Toguchida J, Ikeya M.

Development. 2018 Aug 23;145(16). pii: dev165431. doi: 10.1242/dev.165431.

8.

Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.

Hino K, Horigome K, Nishio M, Komura S, Nagata S, Zhao C, Jin Y, Kawakami K, Yamada Y, Ohta A, Toguchida J, Ikeya M.

J Clin Invest. 2017 Sep 1;127(9):3339-3352. doi: 10.1172/JCI93521. Epub 2017 Jul 31.

9.

Characterization of Mesenchymal Stem Cell-Like Cells Derived From Human iPSCs via Neural Crest Development and Their Application for Osteochondral Repair.

Chijimatsu R, Ikeya M, Yasui Y, Ikeda Y, Ebina K, Moriguchi Y, Shimomura K, Hart DA, Hideki Y, Norimasa N.

Stem Cells Int. 2017;2017:1960965. doi: 10.1155/2017/1960965. Epub 2017 May 10.

10.

SOX10-Nano-Lantern Reporter Human iPS Cells; A Versatile Tool for Neural Crest Research.

Horikiri T, Ohi H, Shibata M, Ikeya M, Ueno M, Sotozono C, Kinoshita S, Sato T.

PLoS One. 2017 Jan 20;12(1):e0170342. doi: 10.1371/journal.pone.0170342. eCollection 2017.

11.

BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.

Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13057-13062. Epub 2016 Oct 28.

12.

[Application of disease-specific iPS cells for intractable diseases-from pathomechanisms to drug discovery].

Toguchida J, Hino K, Ikeya M.

Clin Calcium. 2016 Apr;26(4):593-600. doi: CliCa1604593600. Japanese.

PMID:
27013631
13.

Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives.

Oceguera-Yanez F, Kim SI, Matsumoto T, Tan GW, Xiang L, Hatani T, Kondo T, Ikeya M, Yoshida Y, Inoue H, Woltjen K.

Methods. 2016 May 15;101:43-55. doi: 10.1016/j.ymeth.2015.12.012. Epub 2015 Dec 18.

14.

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.

Hino K, Ikeya M, Horigome K, Matsumoto Y, Ebise H, Nishio M, Sekiguchi K, Shibata M, Nagata S, Matsuda S, Toguchida J.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15438-43. doi: 10.1073/pnas.1510540112. Epub 2015 Nov 30.

15.

SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier.

Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J.

PLoS One. 2015 Nov 16;10(11):e0142991. doi: 10.1371/journal.pone.0142991. eCollection 2015.

16.

Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.

Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J.

PLoS One. 2015 Jul 10;10(7):e0131998. doi: 10.1371/journal.pone.0131998. eCollection 2015.

17.

Application of patients - derived iPS cells for intractable musculoskeletal diseases.

Toguchida J, Yokoyama K, Ikeya M, Heike T.

Nihon Rinsho. 2015 Jun;73 Suppl 5:416-22. Japanese. No abstract available.

PMID:
30458090
18.

New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva.

Matsumoto Y, Ikeya M, Hino K, Horigome K, Fukuta M, Watanabe M, Nagata S, Yamamoto T, Otsuka T, Toguchida J.

Stem Cells. 2015 Jun;33(6):1730-42. doi: 10.1002/stem.1981.

19.

Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media.

Fukuta M, Nakai Y, Kirino K, Nakagawa M, Sekiguchi K, Nagata S, Matsumoto Y, Yamamoto T, Umeda K, Heike T, Okumura N, Koizumi N, Sato T, Nakahata T, Saito M, Otsuka T, Kinoshita S, Ueno M, Ikeya M, Toguchida J.

PLoS One. 2014 Dec 2;9(12):e112291. doi: 10.1371/journal.pone.0112291. eCollection 2014.

20.

Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway.

Yokoyama K, Ikeya M, Umeda K, Oda H, Nodomi S, Nasu A, Matsumoto Y, Izawa K, Horigome K, Kusaka T, Tanaka T, Saito MK, Yasumi T, Nishikomori R, Ohara O, Nakayama N, Nakahata T, Heike T, Toguchida J.

Arthritis Rheumatol. 2015 Jan;67(1):302-14. doi: 10.1002/art.38912.

21.

Orai-2 is localized on secretory granules and regulates antigen-evoked Ca²⁺ mobilization and exocytosis in mast cells.

Ikeya M, Yamanoue K, Mochizuki Y, Konishi H, Tadokoro S, Tanaka M, Suzuki R, Hirashima N.

Biochem Biophys Res Commun. 2014 Aug 15;451(1):62-7. doi: 10.1016/j.bbrc.2014.07.060. Epub 2014 Jul 17.

PMID:
25044118
22.

Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.

Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, Hsiao EC.

Orphanet J Rare Dis. 2013 Dec 9;8:190. doi: 10.1186/1750-1172-8-190.

23.

Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro.

Tanaka A, Woltjen K, Miyake K, Hotta A, Ikeya M, Yamamoto T, Nishino T, Shoji E, Sehara-Fujisawa A, Manabe Y, Fujii N, Hanaoka K, Era T, Yamashita S, Isobe K, Kimura E, Sakurai H.

PLoS One. 2013 Apr 23;8(4):e61540. doi: 10.1371/journal.pone.0061540. Print 2013.

24.

Genetically matched human iPS cells reveal that propensity for cartilage and bone differentiation differs with clones, not cell type of origin.

Nasu A, Ikeya M, Yamamoto T, Watanabe A, Jin Y, Matsumoto Y, Hayakawa K, Amano N, Sato S, Osafune K, Aoyama T, Nakamura T, Kato T, Toguchida J.

PLoS One. 2013;8(1):e53771. doi: 10.1371/journal.pone.0053771. Epub 2013 Jan 31.

25.

Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells.

Hayakawa K, Ikeya M, Fukuta M, Woltjen K, Tamaki S, Takahara N, Kato T Jr, Sato S, Otsuka T, Toguchida J.

Biochem Biophys Res Commun. 2013 Mar 22;432(4):713-9. doi: 10.1016/j.bbrc.2013.01.003. Epub 2013 Jan 10.

PMID:
23313505
26.

Unusual Childhood Waking as a Possible Precursor of the 1995 Kobe Earthquake.

Ikeya M, Whitehead NE.

Animals (Basel). 2013 Mar 5;3(1):228-37. doi: 10.3390/ani3010228.

27.

Lateral medullary syndrome in a boy with hereditary dysfibrinogenemia.

Kibe T, Ikeya M, Yokochi K, Okumura N.

Brain Dev. 2012 Nov;34(10):857-60. doi: 10.1016/j.braindev.2012.02.010. Epub 2012 Mar 24.

PMID:
22449744
28.

Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.

Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y.

Dev Biol. 2010 Jan 15;337(2):405-14. doi: 10.1016/j.ydbio.2009.11.013. Epub 2009 Nov 13.

29.

Analysis of plasmin generation and clot lysis of plasma fibrinogen purified from a heterozygous dysfibrinogenemia, BbetaGly15Cys (Hamamatsu II).

Kamijyo Y, Hirota-Kawadobora M, Yamauchi K, Terasawa F, Honda T, Ikeya M, Okumura N.

Blood Coagul Fibrinolysis. 2009 Dec;20(8):726-32. doi: 10.1097/MBC.0b013e328332aa09.

PMID:
19809304
30.

Changes in blood parameters and coagulation-related gene expression in pregnant rats.

Urasoko Y, He XJ, Ebata T, Kinoshita Y, Kobayashi J, Mochizuki M, Ikeya M.

J Am Assoc Lab Anim Sci. 2009 May;48(3):272-8.

31.

5-fluorouracil-induced histopathological changes in the central nervous system of rat fetuses.

Yamaguchi Y, Aoki A, Fukunaga Y, Matsushima K, Ebata T, Ikeya M, Tamura K.

Histol Histopathol. 2009 Feb;24(2):133-9. doi: 10.14670/HH-24.133.

PMID:
19085829
32.

Studies of the toxicological potential of capsinoids: IX. Teratology studies of dihydrocapsiate in rats and rabbits.

Bernard BK, Watanabe E, Kodama T, Tsubuku S, Otabe A, Ikeya M, Matsuoka T, Masuyama T.

Int J Toxicol. 2008;27 Suppl 3:119-36. doi: 10.1080/10915810802513643.

PMID:
19037803
33.

Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice.

Ikeya M, Nosaka T, Fukushima K, Kawada M, Furuta Y, Kitamura T, Sasai Y.

Mech Dev. 2008 Sep-Oct;125(9-10):832-42. doi: 10.1016/j.mod.2008.06.011. Epub 2008 Jul 3.

34.

Galactosamine-induced acute liver injury in rats reduces hepatic alpha-tocopherol transfer protein production.

Takenaka A, Kita A, Ikeya M, Arai H, Igarashi K.

J Nutr Sci Vitaminol (Tokyo). 2007 Aug;53(4):366-71.

35.

The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo.

Arakawa A, Matsuo-Takasaki M, Takai A, Inomata H, Matsumura M, Ikeya M, Takahashi K, Miyachi Y, Sasai N, Sasai Y.

Dev Biol. 2007 Jun 1;306(1):160-9. Epub 2007 Mar 13.

36.

Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.

Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y.

Development. 2006 Nov;133(22):4463-73. Epub 2006 Oct 11.

37.

[A case report of autoimmune pancreatitis with abnormal elevation of CA19-9 and patholocal findings].

Kageyama F, Takehira Y, Yamada M, Murohisa G, Kataoka H, Sano M, Iwaoka Y, Kawata K, Takahashi Y, Ikeya M, Terai T, Noritake H, Watanabe S, Ogiku M, Nishiwaki Y, Ozawa T, Yasumi K.

Nihon Shokakibyo Gakkai Zasshi. 2006 Jan;103(1):57-63. Japanese. No abstract available.

PMID:
16444987
38.

Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors.

Sakuragi M, Sasai N, Ikeya M, Kawada M, Onai T, Katahira T, Nakamura H, Sasai Y.

Mech Dev. 2006 Feb;123(2):114-23. Epub 2006 Jan 18.

39.

Gene disruption/knock-in analysis of mONT3: vector construction by employing both in vivo and in vitro recombinations.

Ikeya M, Kawada M, Nakazawa Y, Sakuragi M, Sasai N, Ueno M, Kiyonari H, Nakao K, Sasai Y.

Int J Dev Biol. 2005;49(7):807-23.

42.

Comparison of an oxidative stress biomarker "urinary8-hydroxy-2'-deoxyguanosine," between smokers and non-smokers.

Kanaya S, Ikeya M, Yamamoto K, Moriya T, Furuhashi K, Sonoda M, Goto K, Ochi H.

Biofactors. 2004;22(1-4):255-8.

PMID:
15630293
43.
44.

ESR study of Gd3+ and Mn2+ ions sorbed on hydroxyapatite.

Matsuda T, Yamanaka C, Ikeya M.

Appl Radiat Isot. 2005 Feb;62(2):353-7.

PMID:
15607474
46.

Possibility of precipitated CaCO3 with vitamin C as a new dosimetric material.

Sato H, Ikeya M.

Appl Radiat Isot. 2005 Feb;62(2):337-41.

PMID:
15607471
47.

Electron spin resonance of particulate soot samples from automobiles to help environmental studies.

Yamanaka C, Matsuda T, Ikeya M.

Appl Radiat Isot. 2005 Feb;62(2):307-11.

PMID:
15607466
48.

Nitrogen dioxide (NO2) created by gamma-rays in Antarctic ice and rime ice.

Yada T, Norizawa K, Tani A, Ikeya M.

Appl Radiat Isot. 2005 Feb;62(2):255-9.

PMID:
15607458
49.

Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells.

Mizuseki K, Sakamoto T, Watanabe K, Muguruma K, Ikeya M, Nishiyama A, Arakawa A, Suemori H, Nakatsuji N, Kawasaki H, Murakami F, Sasai Y.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):5828-33. Epub 2003 Apr 30.

50.

Mouse circadian rhythm before the Kobe earthquake in 1995.

Yokoi S, Ikeya M, Yagi T, Nagai K.

Bioelectromagnetics. 2003 May;24(4):289-91.

PMID:
12696089

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