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Items: 1 to 50 of 154

1.
2.

Squalene Inhibits ATM-Dependent Signaling in ╬│IR-Induced DNA Damage Response through Induction of Wip1 Phosphatase.

Tatewaki N, Konishi T, Nakajima Y, Nishida M, Saito M, Eitsuka T, Sakamaki T, Ikekawa N, Nishida H.

PLoS One. 2016 Jan 29;11(1):e0147570. doi: 10.1371/journal.pone.0147570. eCollection 2016.

3.

Reminiscences of research on the chemistry and biology of natural sterols in insects, plants and humans.

Ikekawa N, Fujimoto Y, Ishiguro M.

Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(8):349-69. Review.

4.

Non-thermal DNA damage of cancer cells using near-infrared irradiation.

Tanaka Y, Tatewaki N, Nishida H, Eitsuka T, Ikekawa N, Nakayama J.

Cancer Sci. 2012 Aug;103(8):1467-73. doi: 10.1111/j.1349-7006.2012.02310.x. Epub 2012 May 17.

5.

Formal synthesis of squalamine from desmosterol.

Okumura K, Nakamura Y, Takeuchi S, Kato I, Fujimoto Y, Ikekawa N.

Chem Pharm Bull (Tokyo). 2003 Oct;51(10):1177-82.

6.

[Studies on the biosynthesis of sterol side chain in higher plants].

Fujimoto Y, Morisaki M, Ikekawa N.

Yakugaku Zasshi. 2000 Oct;120(10):863-73. Review. Japanese.

PMID:
11082699
7.

[Scientific research work of Prof. Kyosuke Tsuda].

Ikekawa N.

Yakugaku Zasshi. 2000 Oct;120(10):817-24. Japanese. No abstract available. Erratum in: Yakugaku Zasshi 2000 Dec;120(12):1441.

PMID:
11082695
8.

Scientific contribution by Prof. Tsuda.

Ikekawa N.

Chem Pharm Bull (Tokyo). 2000 Oct;48(10):viii-xvi. No abstract available.

PMID:
11045438
9.

[Colon cancer and vitamin D--in vivo growth inhibition of colon cancer by a fluorinated analogue of 1,25-(OH)2D3, DD-003].

Tanaka N, Ikekawa N, Kobayashi Y.

Seikagaku. 1996 Mar;68(3):214-9. Review. Japanese. No abstract available.

PMID:
8642212
10.
11.

Elongation of the side chain of analogs of 1 alpha,25-dihydroxyvitamin D3 prevents osteopenia in a rat model.

Harada M, Takamura T, Kajita-Kondo S, Kozakai A, Miyahara T, Kozuka H, Ikekawa N, Higuchi S, Otomo S.

Calcif Tissue Int. 1995 Mar;56(3):220-6.

PMID:
7750028
12.
13.

Sex pheromones in marine polychaetes: steroids from ripe Nereis succinea.

Zeeck E, Hardege JD, Willig A, Ikekawa N, Fujimoto Y.

Steroids. 1994 May;59(5):341-4.

PMID:
8073448
14.
15.

Effect of hexafluoro-1,25-dihydroxyvitamin D3 and sodium butyrate combination on differentiation and proliferation of HL-60 leukemia cells.

Yoshida M, Tanaka Y, Eguchi T, Ikekawa N, Saijo N.

Anticancer Res. 1992 Nov-Dec;12(6B):1947-52.

PMID:
1363510
16.

Calcium regulating activity of 26,27-dialkyl analogs of 1 alpha,25-dihydroxyvitamin D3.

Miyahara T, Harada M, Miyata M, Sugure A, Ikemoto Y, Takamura T, Higuchi S, Otomo S, Kozuka H, Ikekawa N.

Calcif Tissue Int. 1992 Sep;51(3):218-22.

PMID:
1330237
17.

Effect of 22R-hydroxycholesterol on the action of sphingomyelinase from Bacillus cereus toward bovine erythrocytes.

Tomita M, Togami J, Fujimoto Y, Ikekawa N, Taguchi R, Ikezawa H.

Toxicon. 1992 Aug;30(8):801-13.

PMID:
1523674
18.

Effects on cultured neonatal mouse calvaria of 1 alpha,25-dihydroxyvitamin D3, 26,26,26,27,27,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 and 26,26,26,27,27,27-hexafluoro-1 alpha,23S,25-trihydroxyvitamin D3.

Harada M, Miyahara T, Miyata M, Tomita I, Okayachi H, Ikemoto Y, Higuchi S, Otomo S, Kozuka H, Ikekawa N.

Bone Miner. 1992 Jul;18(1):41-9.

PMID:
1422297
20.

Biological activity of 1 alpha, 25-dihydroxyvitamin D derivatives--24-epi-1 alpha, 25-dihydroxyvitamin D-2 and 1 alpha,25-dihydroxyvitamin D-7.

Sato F, Okamoto Y, Ouchi Y, Kaneki M, Nakamura T, Ikekawa N, Orimo H.

Biochim Biophys Acta. 1991 Jan 31;1091(2):188-92.

PMID:
1995078
21.

Effects of vitamin D2 analogs on calcium metabolism in vitamin D-deficient rats and in MC3T3-E1 osteoblastic cells.

Sato F, Ouchi Y, Okamoto Y, Kaneki M, Nakamura T, Ikekawa N, Orimo H.

Res Exp Med (Berl). 1991;191(4):235-42.

PMID:
1788469
22.

26,27-Hexafluoro-1,25-dihydroxyvitamin D3 (F6-1,25(OH)2D3) prevents osteoporosis induced by immobilization combined with ovariectomy in the rat.

Okumura H, Yamamuro T, Higuchi S, Harada M, Takamura T, Otomo S, Aihara H, Ikekawa N, Kobayashi T.

Bone Miner. 1990 May;9(2):101-9.

PMID:
2350614
23.

Effect on carbon lengthening at the side chain terminal of 1 alpha,25-dihydroxyvitamin D3 for calcium regulating activity.

Eguchi T, Ikekawa N, Sumitani K, Kumegawa M, Higuchi S, Otomo S.

Chem Pharm Bull (Tokyo). 1990 May;38(5):1246-9.

PMID:
2168297
24.

Synthesis and biological activity of (22E,25R)- and (22,25S)-22-dehydro- 1 alpha,25-dihydroxy-26-methylvitamin D3.

Hara N, Eguchi T, Ikekawa N, Ishizuka S, Sato J.

J Steroid Biochem. 1990 May;35(6):655-64.

PMID:
2163469
26.

Effects of 1,25-dihydroxyvitamin D3 and its analogs on butyrate-induced differentiation of HT-29 human colonic carcinoma cells and on the reversal of the differentiated phenotype.

Tanaka Y, Bush KK, Eguchi T, Ikekawa N, Taguchi T, Kobayashi Y, Higgins PJ.

Arch Biochem Biophys. 1990 Feb 1;276(2):415-23.

PMID:
2306105
27.

Elimination of C-6-hydrogen during the formation of ecdysteroids from cholesterol in Locusta migratoria ovaries.

Fujimoto Y, Hiramoto M, Kakinuma K, Ikekawa N.

Steroids. 1989 Mar-May;53(3-5):477-85.

PMID:
2799855
28.

Squamocin, a new cytotoxic bis-tetrahydrofuran containing acetogenin from Annona squamosa.

Fujimoto Y, Eguchi T, Kakinuma K, Ikekawa N, Sahai M, Gupta YK.

Chem Pharm Bull (Tokyo). 1988 Dec;36(12):4802-6. No abstract available.

PMID:
3246042
29.

Studies on organic fluorine compounds. LII. Synthesis and biological activity of 26,26,26,27,27-pentafluoro-1 alpha-hydroxy-27-methoxyvitamin D3.

Kobayashi Y, Nakajima M, Nakazawa M, Taguchi T, Ikekawa N, Sai H, Tanaka Y, DeLuca HF.

Chem Pharm Bull (Tokyo). 1988 Oct;36(10):4144-7. No abstract available.

PMID:
3245988
30.

Synthesis of 26,27-dialkyl analogues of 1 alpha,25-dihydroxyvitamin D3.

Eguchi T, Sai H, Takatsuto S, Hara N, Ikekawa N.

Chem Pharm Bull (Tokyo). 1988 Jul;36(7):2303-11. No abstract available.

PMID:
3240463
31.

Electron paramagnetic resonance study of ferrous cytochrome P-450scc-nitric oxide complexes: effects of 20(R),22(R)-dihydroxycholesterol and reduced adrenodoxin.

Tsubaki M, Hiwatashi A, Ichikawa Y, Fujimoto Y, Ikekawa N, Hori H.

Biochemistry. 1988 Jun 28;27(13):4856-62.

PMID:
2844242
32.

26,27-Diethyl-1 alpha,25-dihydroxyvitamin D3 and 24,24-difluoro-24-homo-1 alpha,25-dihydroxyvitamin D3: highly potent inducer for differentiation of human leukemia cells HL-60.

Ikekawa N, Eguchi T, Hara N, Takatsuto S, Honda A, Mori Y, Otomo S.

Chem Pharm Bull (Tokyo). 1987 Oct;35(10):4362-5. No abstract available.

PMID:
3435961
33.

Structures and biological activities of vitamin D metabolites and their analogs.

Ikekawa N.

Med Res Rev. 1987 Jul-Sep;7(3):333-66. Review. No abstract available.

PMID:
3306217
34.

24- and 26-homo-1,25-dihydroxyvitamin D3: preferential activity in inducing differentiation of human leukemia cells HL-60 in vitro.

Ostrem VK, Tanaka Y, Prahl J, DeLuca HF, Ikekawa N.

Proc Natl Acad Sci U S A. 1987 May;84(9):2610-4.

35.

Fatty acids and sterols of the tunicate, Salpa thompsoni, from the Antarctic Ocean: chemical composition and hemolytic activity.

Mimura T, Okabe M, Satake M, Nakanishi T, Inada A, Fujimoto Y, Hata F, Matsumura Y, Ikekawa N.

Chem Pharm Bull (Tokyo). 1986 Nov;34(11):4562-8. No abstract available.

PMID:
3829182
36.

Synthesis of some side-chain homologues of 1 alpha,25-dihydroxyvitamin D3 and investigation of their biological activities.

Sai H, Takatsuto S, Ikekawa N, Tanaka Y, DeLuca HF.

Chem Pharm Bull (Tokyo). 1986 Nov;34(11):4508-15. No abstract available.

PMID:
3829179
37.

Unique rearrangement of ergocalciferol side chain in vitro: production of a biologically highly active homologue of 1,25-dihydroxyvitamin D3.

Tanaka Y, Sicinski RR, DeLuca HF, Sai H, Ikekawa N.

Biochemistry. 1986 Sep 23;25(19):5512-8.

PMID:
3022793
38.

Synthesis of a new amino acid-antibiotic, oxetin and its three stereoisomers.

Kawahata Y, Takatsuto S, Ikekawa N, Murata M, Omura S.

Chem Pharm Bull (Tokyo). 1986 Aug;34(8):3102-10. No abstract available.

PMID:
3098442
39.

[Studies on antitumor activity of squalene and its related compounds].

Ikekawa T, Umeji M, Manabe T, Yanoma S, Irinoda K, Mizunuma H, Ikekawa N.

Yakugaku Zasshi. 1986 Jul;106(7):578-82. Japanese. No abstract available.

PMID:
3772729
40.

Steroidal inhibitors of microbial degradation of sterol side chains.

Ohtsuka M, Fujimoto Y, Ikekawa N.

Chem Pharm Bull (Tokyo). 1986 Jul;34(7):2780-5. No abstract available.

PMID:
3769083
41.

Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidum.

Morigiwa A, Kitabatake K, Fujimoto Y, Ikekawa N.

Chem Pharm Bull (Tokyo). 1986 Jul;34(7):3025-8. No abstract available.

PMID:
3021351
42.

Studies on organic fluorine compounds. L. Synthesis and biological activity of 2 alpha-fluorovitamin D3.

Kobayashi Y, Nakazawa M, Kumadaki I, Taguchi T, Ohshima E, Ikekawa N, Tanaka Y, DeLuca HF.

Chem Pharm Bull (Tokyo). 1986 Apr;34(4):1568-72. No abstract available.

PMID:
3013440
43.

Glucosidation of estradiol-17 beta in the cultured ovaries of the silkworm, Bombyx mori.

Ogiso M, Fujimoto Y, Ikekawa N, Ohnishi E.

Gen Comp Endocrinol. 1986 Mar;61(3):393-401.

PMID:
3082710
44.

Inhibitory effect of 15-oxygenated sterols on cholesterol synthesis from 24,25-dihydrolanosterol.

Morisaki M, Sonoda Y, Makino T, Ogihara N, Ikekawa N, Sato Y.

J Biochem. 1986 Feb;99(2):597-600.

45.

Detection of natural bio-antimutagens and in vivo and in vitro analysis of their action.

Kada T, Shirasu Y, Ikekawa N, Nomoto M.

Prog Clin Biol Res. 1986;209A:385-93. No abstract available.

PMID:
3529105
46.

Synthesis and biological activity of 1 alpha-hydroxy-24,24-dimethyl-22E-dehydrovitamin D3 and 1 alpha, 25-dihydroxy-24,24-dimethyl-22E-dehydrovitamin D3.

Sai H, Takatsuto S, Ikekawa N.

Chem Pharm Bull (Tokyo). 1985 Nov;33(11):4815-20. No abstract available.

PMID:
3006936
47.

Identification of estradiol in the ovaries of the silkworm, Bombyx mori.

Ohnishi E, Ogiso M, Wakabayashi K, Fujimoto Y, Ikekawa N.

Gen Comp Endocrinol. 1985 Oct;60(1):35-8.

PMID:
4054586
48.

Biological activities and binding properties of 23,23-difluoro-25-hydroxyvitamin D3 and its 1 alpha-hydroxy derivative.

Nakada M, Tanaka Y, DeLuca HF, Kobayashi Y, Ikekawa N.

Arch Biochem Biophys. 1985 Aug 15;241(1):173-8.

PMID:
3839644
49.

Synthesis of 1 alpha,25-dihydroxy-26,27-dimethylvitamin D3, a highly active analogue of 1 alpha,25-dihydroxyvitamin D3.

Sai H, Takatsuto S, Hara N, Ikekawa N.

Chem Pharm Bull (Tokyo). 1985 Feb;33(2):878-81. No abstract available.

PMID:
3839441
50.

Side-chain cleavage of cholesterol by gas chromatography-mass spectrometry in a selected ion monitoring mode.

Morisaki M, Shikita M, Ikekawa N.

Methods Enzymol. 1985;111:352-64. No abstract available.

PMID:
4033438

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